{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:22:29Z","timestamp":1788967349648,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"DOI":"10.7759\/cureus.116000","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:57:40Z","timestamp":1788965860000},"source":"Crossref","is-referenced-by-count":0,"title":["Analgesic Efficacy of Celecoxib Versus Ibuprofen After Third Molar Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.7759","author":[{"given":"Dana Saleh","family":"Tumaiheer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawaa M","family":"Buloushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah Ahmad","family":"Alenezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahraa Bader","family":"Khasroh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam S J","family":"AlNeamah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhari","family":"Mohammed Alhajri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Bader Alzamanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abdelaziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-026-00502-2","article-title":"Effects of impacted mandibular third molar surgery performed with piezosurgery and conventional systems on postoperative sequelae and quality of life: a randomized controlled trial","volume":"48","author":"Acikan I","year":"2026","unstructured":"Acikan I, Balkanlioglu AC. Effects of impacted mandibular third molar surgery performed with piezosurgery and conventional systems on postoperative sequelae and quality of life: a randomized controlled trial. Maxillofac Plast Reconstr Surg. 2026, 48:3. 10.1186\/s40902-026-00502-2","journal-title":"Maxillofac Plast Reconstr Surg"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2021.47.5.341","article-title":"Review of dexamethasone administration for management of complications in postoperative third molar surgery","volume":"47","author":"Selvido DI","year":"2021","unstructured":"Selvido DI, Bhattarai BP, Niyomtham N, Riddhabhaya A, Vongsawan K, Pairuchvej V, Wongsirichat N. Review of dexamethasone administration for management of complications in postoperative third molar surgery. J Korean Assoc Oral Maxillofac Surg. 2021, 47:341-50. 10.5125\/jkaoms.2021.47.5.341","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.12.008","article-title":"Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council","volume":"17","author":"Chou R","year":"2016","unstructured":"Chou R, Gordon DB, de Leon-Casasola OA, et al.. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016, 17:131-57. 10.1016\/j.jpain.2015.12.008","journal-title":"J Pain"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520914254","article-title":"Nonsteroidal anti-inflammatory drugs and opioids in postsurgical dental pain","volume":"99","author":"Hersh EV","year":"2020","unstructured":"Hersh EV, Moore PA, Grosser T, et al.. Nonsteroidal anti-inflammatory drugs and opioids in postsurgical dental pain. J Dent Res. 2020, 99:777-86. 10.1177\/0022034520914254","journal-title":"J Dent Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/oral5030072","article-title":"Analgesic efficacy of postoperative ibuprofen in third molar surgery: a meta-analysis","volume":"5","author":"Mora-Falc\u00f3n IJ","year":"2025","unstructured":"Mora-Falc\u00f3n IJ, Amador-Beas IA, Bologna-Molina R, et al.. Analgesic efficacy of postoperative ibuprofen in third molar surgery: a meta-analysis. Oral. 2025, 5:72. 10.3390\/oral5030072","journal-title":"Oral"},{"key":"ref6","article-title":"Selective COX-2 inhibitors: a review of their structure-activity relationships","volume":"10","author":"Zarghi A","year":"2011","unstructured":"Zarghi A, Arfaei S. Selective COX-2 inhibitors: a review of their structure-activity relationships. Iran J Pharm Res. 2011, 10:655-83.","journal-title":"Iran J Pharm Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.634963","article-title":"Analgesics for dental implants: a systematic review","volume":"11","author":"Melini M","year":"2020","unstructured":"Melini M, Forni A, Cavallin F, Parotto M, Zanette G. Analgesics for dental implants: a systematic review. Front Pharmacol. 2020, 11:634963. 10.3389\/fphar.2020.634963","journal-title":"Front Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181cf9281","article-title":"Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain","volume":"110","author":"Ong CK","year":"2010","unstructured":"Ong CK, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010, 110:1170-9. 10.1213\/ANE.0b013e3181cf9281","journal-title":"Anesth Analg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref10","unstructured":"Cochrane Handbook for Systematic Reviews of Interventions version 6.5. (2024). Accessed. June 1, 2026: https:\/\/www.cochrane.org\/authors\/handbooks-and-manuals\/handbook."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-5900(03)00716-8","article-title":"Interpretation of visual analog scale ratings and change scores: a reanalysis of two clinical trials of postoperative pain","volume":"4","author":"Jensen M","year":"2003","unstructured":"Jensen M. Interpretation of visual analog scale ratings and change scores: a reanalysis of two clinical trials of postoperative pain. J Pain. 2003, 4:407-14. 10.1016\/S1526-5900(03)00716-8","journal-title":"J Pain"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2006.00719.x","article-title":"How high should total pain-relief score be to obviate the need for analgesic remedication in acute pain? Estimation using signal detection theory and individual-patient meta-analysis","volume":"31","author":"Li Wan Po A","year":"2006","unstructured":"Li Wan Po A, Petersen B. How high should total pain-relief score be to obviate the need for analgesic remedication in acute pain? Estimation using signal detection theory and individual-patient meta-analysis. J Clin Pharm Ther. 2006, 31:161-5. 10.1111\/j.1365-2710.2006.00719.x","journal-title":"J Clin Pharm Ther"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v25i3.22","article-title":"Assessment of pain intensity using summed pain intensity difference (SPID) in orthopedic operative patients","volume":"25","author":"Chukka S","year":"2025","unstructured":"Chukka S, Syeda ZB, Mohd A. Assessment of pain intensity using summed pain intensity difference (SPID) in orthopedic operative patients. Afr Health Sci. 2025, 25:173-83. 10.4314\/ahs.v25i3.22","journal-title":"Afr Health Sci"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019, 366:l4898. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.5005\/jp-journals-10024-2428","article-title":"Comparative analgesic effects of ibuprofen, celecoxib and tramadol after third molar surgery: a randomized double blind controlled trial","volume":"19","author":"Akinbade AO","year":"2018","unstructured":"Akinbade AO, Ndukwe KC, Owotade FJ. Comparative analgesic effects of ibuprofen, celecoxib and tramadol after third molar surgery: a randomized double blind controlled trial. J Contemp Dent Pract. 2018, 19:1334-40.","journal-title":"J Contemp Dent Pract"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31824cd4fb","article-title":"Preemptive analgesic effect of low doses of celecoxib is superior to low doses of traditional nonsteroidal anti-inflammatory drugs","volume":"23","author":"Al-Sukhun J","year":"2012","unstructured":"Al-Sukhun J, Al-Sukhun S, Penttil\u00e4 H, Ashammakhi N, Al-Sukhun R. Preemptive analgesic effect of low doses of celecoxib is superior to low doses of traditional nonsteroidal anti-inflammatory drugs. J Craniofac Surg. 2012, 23:526-9. 10.1097\/SCS.0b013e31824cd4fb","journal-title":"J Craniofac Surg"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.53687","article-title":"Comparative effect of celecoxib, diclofenac, and ibuprofen in controlling postoperative pain, edema, and trismus after third molar extraction: a double-blinded randomized controlled trial","volume":"16","author":"Bassyoni L","year":"2024","unstructured":"Bassyoni L. Comparative effect of celecoxib, diclofenac, and ibuprofen in controlling postoperative pain, edema, and trismus after third molar extraction: a double-blinded randomized controlled trial. Cureus. 2024, 16:e53687. 10.7759\/cureus.53687","journal-title":"Cureus"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.12.008","article-title":"Analgesic efficacy of celecoxib in postoperative oral surgery pain: a single-dose, two-center, randomized, double-blind, active- and placebo-controlled study","volume":"29 Suppl","author":"Cheung R","year":"2007","unstructured":"Cheung R, Krishnaswami S, Kowalski K. Analgesic efficacy of celecoxib in postoperative oral surgery pain: a single-dose, two-center, randomized, double-blind, active- and placebo-controlled study. Clin Ther. 2007, 29 Suppl:2498-510. 10.1016\/j.clinthera.2007.12.008","journal-title":"Clin Ther"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/009127002401102830","article-title":"Efficacy and tolerability of nonprescription ibuprofen versus celecoxib for dental pain","volume":"42","author":"Doyle G","year":"2002","unstructured":"Doyle G, Jayawardena S, Ashraf E, Cooper SA. Efficacy and tolerability of nonprescription ibuprofen versus celecoxib for dental pain. J Clin Pharmacol. 2002, 42:912-9. 10.1177\/009127002401102830","journal-title":"J Clin Pharmacol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2019.02.006","article-title":"Evaluation of the efficacy of celecoxib and ibuprofen on postoperative pain, swelling, and mouth opening after surgical removal of impacted third molars: a randomized, controlled clinical trial","volume":"48","author":"Isola G","year":"2019","unstructured":"Isola G, Matarese M, Ramaglia L, Cicci\u00f9 M, Matarese G. Evaluation of the efficacy of celecoxib and ibuprofen on postoperative pain, swelling, and mouth opening after surgical removal of impacted third molars: a randomized, controlled clinical trial. Int J Oral Maxillofac Surg. 2019, 48:1348-54. 10.1016\/j.ijom.2019.02.006","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.125560","article-title":"In vivo selectivity of a selective cyclooxygenase 2 inhibitor in the oral surgery model","volume":"72","author":"Khan AA","year":"2002","unstructured":"Khan AA, Brahim JS, Rowan JS, Dionne RA. In vivo selectivity of a selective cyclooxygenase 2 inhibitor in the oral surgery model. Clin Pharmacol Ther. 2002, 72:44-9. 10.1067\/mcp.2002.125560","journal-title":"Clin Pharmacol Ther"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(99)80045-9","article-title":"Comparison of rofecoxib and celecoxib, two cyclooxygenase-2 inhibitors, in postoperative dental pain: a randomized, placebo- and active-comparator-controlled clinical trial","volume":"21","author":"Malmstrom K","year":"1999","unstructured":"Malmstrom K, Daniels S, Kotey P, Seidenberg BC, Desjardins PJ. Comparison of rofecoxib and celecoxib, two cyclooxygenase-2 inhibitors, in postoperative dental pain: a randomized, placebo- and active-comparator-controlled clinical trial. Clin Ther. 1999, 21:1653-63. 10.1016\/S0149-2918(99)80045-9","journal-title":"Clin Ther"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/s0149-2918(02)80059-5","article-title":"A comparison of rofecoxib versus celecoxib in treating pain after dental surgery: a single-center, randomized, double-blind, placebo- and active-comparator-controlled, parallel-group, single-dose study using the dental impaction pain model","volume":"24","author":"Malmstrom K","year":"2002","unstructured":"Malmstrom K, Fricke JR, Kotey P, Kress B, Morrison B. A comparison of rofecoxib versus celecoxib in treating pain after dental surgery: a single-center, randomized, double-blind, placebo- and active-comparator-controlled, parallel-group, single-dose study using the dental impaction pain model. Clin Ther. 2002, 24:1549-60. 10.1016\/s0149-2918(02)80059-5","journal-title":"Clin Ther"},{"key":"ref24","article-title":"Comparison of ibuprofen, celecoxib and tramadol in relief of pain after extraction of mandibular third molar teeth","volume":"11","author":"Zamiri B","year":"2009","unstructured":"Zamiri B, Mousavizadeh K, Tajoddini M, Mohammadinezhad C, Aarabi AM. Comparison of ibuprofen, celecoxib and tramadol in relief of pain after extraction of mandibular third molar teeth. Iranian Red Crescent Med J. 2009, 11:431-6.","journal-title":"Iranian Red Crescent Med J"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200828100-00006","article-title":"Prescriptions of NSAIDs to patients undergoing third molar surgery: an observational, prospective, multicentre survey","volume":"28","author":"Levrini L","year":"2008","unstructured":"Levrini L, Carraro M, Rizzo S, et al.. Prescriptions of NSAIDs to patients undergoing third molar surgery: an observational, prospective, multicentre survey. Clin Drug Investig. 2008, 28:657-68. 10.2165\/00044011-200828100-00006","journal-title":"Clin Drug Investig"},{"key":"ref26","article-title":"Longer use of COX-2-specific inhibitors compared to nonspecific nonsteroidal antiinflammatory drugs: a longitudinal study of 3639 patients in community practice","volume":"31","author":"Wolfe F","year":"2004","unstructured":"Wolfe F, Michaud K, Burke TA, Zhao SZ. Longer use of COX-2-specific inhibitors compared to nonspecific nonsteroidal antiinflammatory drugs: a longitudinal study of 3639 patients in community practice. J Rheumatol. 2004, 31:355-8.","journal-title":"J Rheumatol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2021.06.015","article-title":"Analgesic effectiveness and safety of celecoxib versus non-opioid active controls after third molar surgery: a meta-analytical evaluation","volume":"123","author":"Isiordia-Espinoza MA","year":"2022","unstructured":"Isiordia-Espinoza MA, Franco-Gonz\u00e1lez MA, Alonso-Castro \u00c1J, Franco-de la Torre L. Analgesic effectiveness and safety of celecoxib versus non-opioid active controls after third molar surgery: a meta-analytical evaluation. J Stomatol Oral Maxillofac Surg. 2022, 123:e1-9. 10.1016\/j.jormas.2021.06.015","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S144066","article-title":"Poorly controlled postoperative pain: prevalence, consequences, and prevention","volume":"10","author":"Gan TJ","year":"2017","unstructured":"Gan TJ. Poorly controlled postoperative pain: prevalence, consequences, and prevention. J Pain Res. 2017, 10:2287-98. 10.2147\/JPR.S144066","journal-title":"J Pain Res"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.70749\/ijbr.v3i3.2350","article-title":"Comparison between ibuprofen and celecoxib in controlling post-extraction pain","volume":"3","author":"Rahim N","year":"2025","unstructured":"Rahim N, Uppal A, Kakar ProfFD, Muhammad Bilal, Ghafoor Z, Aman S. Comparison between ibuprofen and celecoxib in controlling post-extraction pain. Indus J Biosci Res. 2025, 3:805-10. 10.70749\/ijbr.v3i3.2350","journal-title":"Indus J Biosci Res"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.03.015","article-title":"Assay sensitivity of pain intensity versus pain relief in acute pain clinical trials: ACTTION systematic review and meta-analysis","volume":"16","author":"Singla N","year":"2015","unstructured":"Singla N, Hunsinger M, Chang PD, et al.. Assay sensitivity of pain intensity versus pain relief in acute pain clinical trials: ACTTION systematic review and meta-analysis. J Pain. 2015, 16:683-91. 10.1016\/j.jpain.2015.03.015","journal-title":"J Pain"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)03032-1","article-title":"Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics","volume":"66","author":"Moore A","year":"1996","unstructured":"Moore A, McQuay H, Gavaghan D. Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics. Pain. 1996, 66:229-37. 10.1016\/0304-3959(96)03032-1","journal-title":"Pain"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-022-03355-6","article-title":"Strategies to manage auxiliary pain medications in chronic pain trials: a topical review","volume":"78","author":"Hasvik E","year":"2022","unstructured":"Hasvik E, Gran JM, Haugen AJ, Gr\u00f8vle L. Strategies to manage auxiliary pain medications in chronic pain trials: a topical review. Eur J Clin Pharmacol. 2022, 78:1377-84. 10.1007\/s00228-022-03355-6","journal-title":"Eur J Clin Pharmacol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001952","article-title":"Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations","volume":"161","author":"Smith SM","year":"2020","unstructured":"Smith SM, Dworkin RH, Turk DC, et al.. Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations. Pain. 2020, 161:2446-61. 10.1097\/j.pain.0000000000001952","journal-title":"Pain"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007744.pub2","article-title":"Tolerability of selective cyclooxygenase 2 inhibitors used for the treatment of rheumatological manifestations of inflammatory bowel disease","volume":"2014","author":"Miao XP","year":"2014","unstructured":"Miao XP, Li JS, Ouyang Q, Hu RW, Zhang Y, Li HY. Tolerability of selective cyclooxygenase 2 inhibitors used for the treatment of rheumatological manifestations of inflammatory bowel disease. Cochrane Database Syst Rev. 2014, 2014:CD007744. 10.1002\/14651858.CD007744.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2012.01.004","article-title":"Efficacy and safety of additional 200-mg dose of celecoxib in adult patients with postoperative pain following extraction of impacted third mandibular molar: a multicenter, randomized, double-blind, placebo-controlled, phase II study in Japan","volume":"34","author":"Saito K","year":"2012","unstructured":"Saito K, Kaneko A, Machii K, Ohta H, Ohkura M, Suzuki M. Efficacy and safety of additional 200-mg dose of celecoxib in adult patients with postoperative pain following extraction of impacted third mandibular molar: a multicenter, randomized, double-blind, placebo-controlled, phase II study in Japan. Clin Ther. 2012, 34:314-28. 10.1016\/j.clinthera.2012.01.004","journal-title":"Clin Ther"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.17085\/apm.21038","article-title":"Trial sequential analysis: novel approach for meta-analysis","volume":"16","author":"Kang H","year":"2021","unstructured":"Kang H. Trial sequential analysis: novel approach for meta-analysis. Anesth Pain Med (Seoul). 2021, 16:138-50. 10.17085\/apm.21038","journal-title":"Anesth Pain Med (Seoul)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/529527-analgesic-efficacy-of-celecoxib-versus-ibuprofen-after-third-molar-surgery-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:57:43Z","timestamp":1788965863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/529527-analgesic-efficacy-of-celecoxib-versus-ibuprofen-after-third-molar-surgery-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":36,"URL":"https:\/\/doi.org\/10.7759\/cureus.116000","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,9]]}}}