{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:06:01Z","timestamp":1789149961989,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,11]]},"DOI":"10.7759\/cureus.116104","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:10:19Z","timestamp":1789146619000},"source":"Crossref","is-referenced-by-count":0,"title":["Nasopharyngeal Leiomyosarcoma: Diagnostic Challenges and Management of a Rare Head and Neck Sarcoma"],"prefix":"10.7759","author":[{"given":"Timothy","family":"Morley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Ridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Bunevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight E","family":"Heron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cco.0000127880.69877.75","article-title":"Update in management of head and neck sarcoma","volume":"16","author":"Hoffman HT","year":"2004","unstructured":"Hoffman HT, Robinson RA, Spiess JL, Buatti J. Update in management of head and neck sarcoma. Curr Opin Oncol. 2004, 16:333-41. 10.1097\/01.cco.0000127880.69877.75","journal-title":"Curr Opin Oncol"},{"key":"ref2","article-title":"Leiomyosarcoma of the ethmoidal cells","volume":"39","author":"Keck T","year":"2001","unstructured":"Keck T, Mattfeldt T, K\u00fchnemann S. Leiomyosarcoma of the ethmoidal cells. Rhinology. 2001, 39:115-17.","journal-title":"Rhinology"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-224110","article-title":"Leiomyosarcoma: a rare sinonasal malignancy","volume":"2018","author":"Kwok MM","year":"2018","unstructured":"Kwok MM, Lee S, Hosking P. Leiomyosarcoma: a rare sinonasal malignancy. BMJ Case Rep. 2018, 2018:bcr2017224110. 10.1136\/bcr-2017-224110","journal-title":"BMJ Case Rep"},{"key":"ref4","article-title":"Leiomyosarcoma of the larynx","volume":"20","author":"Chen JM","year":"1991","unstructured":"Chen JM, Novick WH, Logan CA. Leiomyosarcoma of the larynx. J Otolaryngol. 1991, 20:345-8.","journal-title":"J Otolaryngol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.151350","article-title":"Primary leiomyosarcoma of the maxilla: an investigative loom-report of a challenging case and review of literature","volume":"18","author":"Sandhu SV","year":"2014","unstructured":"Sandhu SV, Sodhi SP, Rai S, Bansal H. Primary leiomyosarcoma of the maxilla: an investigative loom-report of a challenging case and review of literature. J Oral Maxillofac Pathol. 2014, 18:453-9. 10.4103\/0973-029X.151350","journal-title":"J Oral Maxillofac Pathol"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1177\/014556130108000710","article-title":"Superficial leiomyosarcoma of the head and neck: case report and review of the literature","volume":"80","author":"Snowden RT","year":"2001","unstructured":"Snowden RT, Osborn FD, Wong FS, Sebelik ME. Superficial leiomyosarcoma of the head and neck: case report and review of the literature. Ear Nose Throat J. 2001, 80:449-53.","journal-title":"Ear Nose Throat J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000183767.97518.09","article-title":"Sinonasal leiomyosarcoma: review of literature and case report","volume":"115","author":"Ulrich CT","year":"2005","unstructured":"Ulrich CT, Feiz-Erfan I, Spetzler RF, et al.. Sinonasal leiomyosarcoma: review of literature and case report. Laryngoscope. 2005, 115:2242-8. 10.1097\/01.mlg.0000183767.97518.09","journal-title":"Laryngoscope"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2023.12.004","article-title":"Unraveling the myth of radiation resistance in soft tissue sarcomas","volume":"34","author":"Wiltink LM","year":"2024","unstructured":"Wiltink LM, Miah AB, Scholten AN, Haas RL. Unraveling the myth of radiation resistance in soft tissue sarcomas. Semin Radiat Oncol. 2024, 34:172-9. 10.1016\/j.semradonc.2023.12.004","journal-title":"Semin Radiat Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0360-3016(02)04573-x","article-title":"Significance of dose in postoperative radiotherapy for soft tissue sarcoma","volume":"1","author":"Zagars GK","year":"2003","unstructured":"Zagars GK, Ballo MT. Significance of dose in postoperative radiotherapy for soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 2003, 1:473-81. 10.1016\/s0360-3016(02)04573-x","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.12.7393-7398.1993","article-title":"The Ewing's sarcoma EWS\/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1","volume":"13","author":"May WA","year":"1993","unstructured":"May WA, Lessnick SL, Braun BS, et al.. The Ewing's sarcoma EWS\/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol. 1993, 13:7393-8. 10.1128\/mcb.13.12.7393-7398.1993","journal-title":"Mol Cell Biol"},{"key":"ref11","article-title":"The role of the SYT-SSX fusion gene in synovial sarcoma","volume":"19","author":"Thomas DM","year":"2000","unstructured":"Thomas DM, Skelton R, McCormack L. The role of the SYT-SSX fusion gene in synovial sarcoma. Oncogene. 2000, 19:7628-36.","journal-title":"Oncogene"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.9845","article-title":"Soft tissue and uterine leiomyosarcoma","volume":"36","author":"George S","year":"2018","unstructured":"George S, Serrano C, Hensley ML, Ray-Coquard I. Soft tissue and uterine leiomyosarcoma. J Clin Oncol. 2018, 36:144-50. 10.1200\/JCO.2017.75.9845","journal-title":"J Clin Oncol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15072099","article-title":"Targeting the molecular and immunologic features of leiomyosarcoma","volume":"15","author":"Cope BM","year":"2023","unstructured":"Cope BM, Traweek RS, Lazcano R, Keung EZ, Lazar AJ, Roland CL, Nassif EF. Targeting the molecular and immunologic features of leiomyosarcoma. Cancers (Basel). 2023, 15:2099. 10.3390\/cancers15072099","journal-title":"Cancers (Basel)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2018180006","article-title":"Retroperitoneal leiomyosarcoma from the Radiologic Pathology Archives","volume":"38","author":"Marko J","year":"2018","unstructured":"Marko J, Wolfman DJ. Retroperitoneal leiomyosarcoma from the Radiologic Pathology Archives. Radiographics. 2018, 38:1403-20. 10.1148\/rg.2018180006","journal-title":"Radiographics"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-2891","article-title":"The Nanocind signature is an independent prognosticator of recurrence and death in uterine leiomyosarcomas","volume":"26","author":"Croce S","year":"2020","unstructured":"Croce S, Lesluyes T, Valle C, et al.. The Nanocind signature is an independent prognosticator of recurrence and death in uterine leiomyosarcomas. Clin Cancer Res. 2020, 26:855-61. 10.1158\/1078-0432.CCR-19-2891","journal-title":"Clin Cancer Res"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-011-0305-8","article-title":"Head and neck leiomyosarcoma","volume":"65","author":"Yadav J","year":"2013","unstructured":"Yadav J, Bakshi J, Chouhan M, Modi R. Head and neck leiomyosarcoma. Indian J Otolaryngol Head Neck Surg. 2013, 65:1-5. 10.1007\/s12070-011-0305-8","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(89)90135-9","article-title":"Soft-tissue sarcomas of the head and neck","volume":"158","author":"Freedman AM","year":"1989","unstructured":"Freedman AM, Reiman HM, Woods JE. Soft-tissue sarcomas of the head and neck. Am J Surg. 1989, 158:367-72. 10.1016\/0002-9610(89)90135-9","journal-title":"Am J Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-022-03050-3","article-title":"Risk factors for lymph node metastasis of soft tissue sarcomas of the head, neck, and extremities, and the clinical significance of negative lymph node dissection","volume":"17","author":"Liu QK","year":"2022","unstructured":"Liu QK, Yu XJ, Wang YG, Lu R, Wang SX, Xu HR, Kang H. Risk factors for lymph node metastasis of soft tissue sarcomas of the head, neck, and extremities, and the clinical significance of negative lymph node dissection. J Orthop Surg Res. 2022, 17:167. 10.1186\/s13018-022-03050-3","journal-title":"J Orthop Surg Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/469746-nasopharyngeal-leiomyosarcoma-diagnostic-challenges-and-management-of-a-rare-head-and-neck-sarcoma","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:10:20Z","timestamp":1789146620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/469746-nasopharyngeal-leiomyosarcoma-diagnostic-challenges-and-management-of-a-rare-head-and-neck-sarcoma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.116104","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,11]]}}}