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StatPearls Publishing, Treasure Island, FL; 2023."},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.4103\/jgid.jgid_360_20","article-title":"Facial nerve palsy as a neurological manifestation of COVID-19","volume":"13","author":"Martins AS","year":"2021","unstructured":"Martins AS, Losa FJ, Rueda HH, Garc\u00eda-Gasalla M. Facial nerve palsy as a neurological manifestation of COVID-19. J Glob Infect Dis. 2021, 13:183-5. 10.4103\/jgid.jgid_360_20","journal-title":"J Glob Infect Dis"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08117-y","article-title":"Viral reactivations and co-infections in COVID-19 patients: a systematic review","volume":"23","author":"Kim JY","year":"2023","unstructured":"Kim JY, Ragusa M, Tortosa F, et al.. Viral reactivations and co-infections in COVID-19 patients: a systematic review. 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