{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:03:23Z","timestamp":1789351403500,"version":"build-2803163510"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,13]]},"DOI":"10.7759\/cureus.116194","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:28:58Z","timestamp":1789349338000},"source":"Crossref","is-referenced-by-count":0,"title":["Managing Cardiac Amyloidosis in a Rural Cardiology Practice: Bridging Gaps in Specialized Evaluation and Disease-Modifying Treatment"],"prefix":"10.7759","author":[{"given":"Arjun","family":"Khunger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5493","article-title":"Systemic amyloidosis recognition, prognosis, and therapy. A systematic review","volume":"324","author":"Gertz MA","year":"2020","unstructured":"Gertz MA, Dispenzieri A. Systemic amyloidosis recognition, prognosis, and therapy. A systematic review. JAMA. 2020, 324:79-89. 10.1001\/jama.2020.5493","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab072","article-title":"Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases","volume":"42","author":"Garcia-Pavia P","year":"2021","unstructured":"Garcia-Pavia P, Rapezzi C, Adler Y, et al.. Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2021, 42:1554-68. 10.1093\/eurheartj\/ehab072","journal-title":"Eur Heart J"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319877708","article-title":"Keys to early diagnosis of cardiac amyloidosis: red flags from clinical, laboratory and imaging findings","volume":"27","author":"Vergaro G","year":"2020","unstructured":"Vergaro G, Aimo A, Barison A, Genovesi D, Buda G, Passino C, Emdin M. Keys to early diagnosis of cardiac amyloidosis: red flags from clinical, laboratory and imaging findings. Eur J Prev Cardiol. 2020, 27:1806-15. 10.1177\/2047487319877708","journal-title":"Eur J Prev Cardiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeae021","article-title":"Limitations of apical sparing pattern in cardiac amyloidosis: a multicentre echocardiographic study","volume":"25","author":"Cotella J","year":"2024","unstructured":"Cotella J, Randazzo M, Maurer MS, et al.. Limitations of apical sparing pattern in cardiac amyloidosis: a multicentre echocardiographic study. Eur Heart J Cardiovasc Imaging. 2024, 25:754-61. 10.1093\/ehjci\/jeae021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.12.063","article-title":"Diagnostic delay in wild type transthyretin cardiac amyloidosis - a clinical challenge","volume":"304","author":"Ladefoged B","year":"2020","unstructured":"Ladefoged B, Dybro A, Povlsen JA, Vase H, Clemmensen TS, Poulsen SH. Diagnostic delay in wild type transthyretin cardiac amyloidosis - a clinical challenge. Int J Cardiol. 2020, 304:138-43. 10.1016\/j.ijcard.2019.12.063","journal-title":"Int J Cardiol"},{"key":"ref6","article-title":"A systematic review and meta-analysis of the prevalence of transthyretin amyloidosis in heart failure with preserved ejection fraction","volume":"12","author":"Magdi M","year":"2022","unstructured":"Magdi M, Mostafa MR, Abusnina W, et al.. A systematic review and meta-analysis of the prevalence of transthyretin amyloidosis in heart failure with preserved ejection fraction. Am J Cardiovasc Dis. 2022, 12:102-11.","journal-title":"Am J Cardiovasc Dis"},{"key":"ref7","unstructured":"AHA. Classes and stages of heart failure. (2025). Accessed. September 11, 2025: https:\/\/www.heart.org\/en\/health-topics\/heart-failure\/what-is-heart-failure\/classes-of-heart-failure."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.06.033","article-title":"Natural history of wild-type transthyretin cardiac amyloidosis and risk stratification using a novel staging system","volume":"68","author":"Grogan M","year":"2016","unstructured":"Grogan M, Scott CG, Kyle RA, et al.. Natural history of wild-type transthyretin cardiac amyloidosis and risk stratification using a novel staging system. J Am Coll Cardiol. 2016, 68:1014-20. 10.1016\/j.jacc.2016.06.033","journal-title":"J Am Coll Cardiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.15420\/usc.2025.11","article-title":"Transthyretin amyloid cardiomyopathy: the plot thickens as novel therapies emerge","volume":"19","author":"Dimza M","year":"2025","unstructured":"Dimza M, Vasilakis G, Grodin JL. Transthyretin amyloid cardiomyopathy: the plot thickens as novel therapies emerge. US Cardiol. 2025, 19:e21. 10.15420\/usc.2025.11","journal-title":"US Cardiol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805689","article-title":"Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy","volume":"379","author":"Maurer MS","year":"2018","unstructured":"Maurer MS, Schwartz JH, Gundapaneni B, et al.. Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy. N Engl J Med. 2018, 379:1007-16. 10.1056\/NEJMoa1805689","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2305434","article-title":"Efficacy and safety of acoramidis in transthyretin amyloid cardiomyopathy","volume":"390","author":"Gillmore JD","year":"2024","unstructured":"Gillmore JD, Judge DP, Cappelli F, et al.. Efficacy and safety of acoramidis in transthyretin amyloid cardiomyopathy. N Engl J Med. 2024, 390:132-42. 10.1056\/NEJMoa2305434","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2409134","article-title":"Vutrisiran in patients with transthyretin amyloidosis with cardiomyopathy","volume":"392","author":"Fontana M","year":"2025","unstructured":"Fontana M, Berk JL, Gillmore JD, et al.. Vutrisiran in patients with transthyretin amyloidosis with cardiomyopathy. N Engl J Med. 2025, 392:33-44. 10.1056\/NEJMoa2409134","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.70084","article-title":"Efficacy and safety of vutrisiran in transthyretin amyloid cardiomyopathy across the age spectrum: the HELIOS-B trial","volume":"27","author":"Sheikh A","year":"2025","unstructured":"Sheikh A, Miao ZM, Claggett B, et al.. Efficacy and safety of vutrisiran in transthyretin amyloid cardiomyopathy across the age spectrum: the HELIOS-B trial. Eur J Heart Fail. 2025, 27:2971-8. 10.1002\/ejhf.70084","journal-title":"Eur J Heart Fail"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/514508-managing-cardiac-amyloidosis-in-a-rural-cardiology-practice-bridging-gaps-in-specialized-evaluation-and-disease-modifying-treatment","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:29:00Z","timestamp":1789349340000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/514508-managing-cardiac-amyloidosis-in-a-rural-cardiology-practice-bridging-gaps-in-specialized-evaluation-and-disease-modifying-treatment"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,13]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.116194","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,13]]}}}