{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:41:37Z","timestamp":1792255297255,"version":"4.4.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,17]]},"DOI":"10.7759\/cureus.118070","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:52:28Z","timestamp":1792252348000},"source":"Crossref","is-referenced-by-count":0,"title":["Phyllodes Tumors of the Breast in 2026: A Contemporary Narrative Review of Diagnosis, Surgical Margins, Prognosis, and Emerging Therapies"],"prefix":"10.7759","author":[{"given":"George","family":"Mpourazanis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Alefragkis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Siafaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iliana G","family":"Lialiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios Theofanis","family":"Valakostas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Poptsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantelina-Danai","family":"Korkontzelou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Christodoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Schulz-Wendtland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Ntaflou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Tsirkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Korkontzelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kosmas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951X-754","article-title":"Malignant phyllodes tumor of the breast: a systematic review","volume":"114","author":"Lissidini G","year":"2022","unstructured":"Lissidini G, Mul\u00e8 A, Santoro A, et al.. Malignant phyllodes tumor of the breast: a systematic review. Pathologica. 2022, 114:111-20. 10.32074\/1591-951X-754","journal-title":"Pathologica"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2025.105863","article-title":"Current understanding of phyllodes tumors of the breast: tumor classification, molecular landscape, and best pathology practice","volume":"162","author":"Packer MD","year":"2025","unstructured":"Packer MD, Lester SC. Current understanding of phyllodes tumors of the breast: tumor classification, molecular landscape, and best pathology practice. Hum Pathol. 2025, 162:105863. 10.1016\/j.humpath.2025.105863","journal-title":"Hum Pathol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/his.12876","article-title":"Phyllodes tumours of the breast: a consensus review","volume":"68","author":"Tan BY","year":"2016","unstructured":"Tan BY, Acs G, Apple SK, et al.. Phyllodes tumours of the breast: a consensus review. Histopathology. 2016, 68:5-21. 10.1111\/his.12876","journal-title":"Histopathology"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/his.70149","article-title":"World Health Organization classification of tumours of the breast 6th edition 2026","volume":"89","author":"Quinn C","year":"2026","unstructured":"Quinn C, Tan PH, Allison KH, et al.. World Health Organization classification of tumours of the breast 6th edition 2026. Histopathology. 2026, 89:199-218. 10.1111\/his.70149","journal-title":"Histopathology"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s43055-024-01207-0","article-title":"Case series on phyllodes tumour of breast in young females: unusual clinico-radiological presentations in unusual age group\u2014thinking beyond fibroadenomas!","volume":"55","author":"Gupta J","year":"2024","unstructured":"Gupta J, Bhayana A, Gupta P, et al.. Case series on phyllodes tumour of breast in young females: unusual clinico-radiological presentations in unusual age group\u2014thinking beyond fibroadenomas!. Egypt J Radiol Nucl Med. 2024, 55:33. 10.1186\/s43055-024-01207-0","journal-title":"Egypt J Radiol Nucl Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2017-204827","article-title":"Mammary phyllodes tumour: a 15-year multicentre clinical review","volume":"71","author":"Co M","year":"2018","unstructured":"Co M, Chen C, Tsang JY, Tse G, Kwong A. Mammary phyllodes tumour: a 15-year multicentre clinical review. J Clin Pathol. 2018, 71:493-7. 10.1136\/jclinpath-2017-204827","journal-title":"J Clin Pathol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22228","article-title":"Malignant phyllodes tumor of the female breast: association of primary therapy with cause-specific survival from the Surveillance, Epidemiology, and End Results (SEER) program","volume":"107","author":"Macdonald OK","year":"2006","unstructured":"Macdonald OK, Lee CM, Tward JD, Chappel CD, Gaffney DK. Malignant phyllodes tumor of the female breast: association of primary therapy with cause-specific survival from the Surveillance, Epidemiology, and End Results (SEER) program. Cancer. 2006, 107:2127-33. 10.1002\/cncr.22228","journal-title":"Cancer"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.04.007","article-title":"Phyllodes tumors of the breast: a case series of 106 patients","volume":"192","author":"Ben Hassouna J","year":"2006","unstructured":"Ben Hassouna J, Damak T, Gamoudi A, et al.. Phyllodes tumors of the breast: a case series of 106 patients. Am J Surg. 2006, 192:141-7. 10.1016\/j.amjsurg.2006.04.007","journal-title":"Am J Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.145872.2","article-title":"Clinical presentation and radiologic imaging findings of phyllodes tumors: benign and borderline\/malignant phyllodes tumors","volume":"13","author":"Lohitvisate W","year":"2024","unstructured":"Lohitvisate W, Rodjanakonkiat K, Kwankua A. Clinical presentation and radiologic imaging findings of phyllodes tumors: benign and borderline\/malignant phyllodes tumors. F1000Res. 2024, 13:210. 10.12688\/f1000research.145872.2","journal-title":"F1000Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-3262-7","article-title":"Treatment of patients with distant metastases from phyllodes tumor of the breast","volume":"40","author":"Mitu\u015b JW","year":"2016","unstructured":"Mitu\u015b JW, Blecharz P, Walasek T, Reinfuss M, Jakubowicz J, Kulpa J. Treatment of patients with distant metastases from phyllodes tumor of the breast. World J Surg. 2016, 40:323-8. 10.1007\/s00268-015-3262-7","journal-title":"World J Surg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140239","article-title":"Phyllodes tumours of the breast: radiological presentation, management and follow-up","volume":"87","author":"McCarthy E","year":"2014","unstructured":"McCarthy E, Kavanagh J, O'Donoghue Y, McCormack E, D'Arcy C, O'Keeffe SA. Phyllodes tumours of the breast: radiological presentation, management and follow-up. Br J Radiol. 2014, 87:20140239. 10.1259\/bjr.20140239","journal-title":"Br J Radiol"},{"key":"ref12","article-title":"Phyllodes tumor of the breast","author":"Limaiem F","year":"2023","unstructured":"Limaiem F, Kashyap S. Phyllodes tumor of the breast. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2023."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011412","article-title":"Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women","volume":"97","author":"Abdul Hamid S","year":"2018","unstructured":"Abdul Hamid S, Rahmat K, Ramli MT, et al.. Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women. Medicine (Baltimore). 2018, 97:e11412. 10.1097\/MD.0000000000011412","journal-title":"Medicine (Baltimore)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinsp.2025.100617","article-title":"Phyllodes tumors of the breast: a comprehensive review of diagnosis, treatment, and follow-up","volume":"80","author":"Donato AR","year":"2025","unstructured":"Donato AR, Goncalves R, Maesaka JY, et al.. Phyllodes tumors of the breast: a comprehensive review of diagnosis, treatment, and follow-up. Clinics (Sao Paulo). 2025, 80:100617. 10.1016\/j.clinsp.2025.100617","journal-title":"Clinics (Sao Paulo)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/ans.13056","article-title":"Phyllodes tumour among participants in screening mammography","volume":"87","author":"Farshid G","year":"2017","unstructured":"Farshid G, Gill PG. Phyllodes tumour among participants in screening mammography. ANZ J Surg. 2017, 87:E285-92. 10.1111\/ans.13056","journal-title":"ANZ J Surg"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000444377","article-title":"Differentiation between phyllodes tumors and fibroadenomas based on mammographic, sonographic, and MRI features","volume":"11","author":"Duman L","year":"2016","unstructured":"Duman L, Gezer NS, Balc\u0131 P, Altay C, Ba\u015fara I, Durak MG, Sevin\u00e7 AI. Differentiation between phyllodes tumors and fibroadenomas based on mammographic, sonographic, and MRI features. Breast Care (Basel). 2016, 11:123-7. 10.1159\/000444377","journal-title":"Breast Care (Basel)"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13654","article-title":"Mammographic and ultrasonographic concordance in pathologically proven phyllodes tumors: a retrospective study","volume":"26","author":"Arora M","year":"2020","unstructured":"Arora M, Gupta P, Syed A, et al.. Mammographic and ultrasonographic concordance in pathologically proven phyllodes tumors: a retrospective study. Breast J. 2020, 26:1087-9. 10.1111\/tbj.13654","journal-title":"Breast J"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210342","article-title":"Predicting the pathological grade of breast phyllodes tumors: a nomogram based on clinical and magnetic resonance imaging features","volume":"94","author":"Ma X","year":"2021","unstructured":"Ma X, Shen L, Hu F, Tang W, Gu Y, Peng W. Predicting the pathological grade of breast phyllodes tumors: a nomogram based on clinical and magnetic resonance imaging features. Br J Radiol. 2021, 94:20210342. 10.1259\/bjr.20210342","journal-title":"Br J Radiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13862","article-title":"How image-guided core needle biopsies altered the treatment of breast disease: challenges accepted and opportunities taken","volume":"26","author":"Lester SC","year":"2020","unstructured":"Lester SC. How image-guided core needle biopsies altered the treatment of breast disease: challenges accepted and opportunities taken. Breast J. 2020, 26:1156-9. 10.1111\/tbj.13862","journal-title":"Breast J"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.06.005","article-title":"Core needle biopsy diagnosis of fibroepithelial lesions of the breast: a diagnostic challenge","volume":"52","author":"Li JJ","year":"2020","unstructured":"Li JJ, Tse GM. Core needle biopsy diagnosis of fibroepithelial lesions of the breast: a diagnostic challenge. Pathology. 2020, 52:627-34. 10.1016\/j.pathol.2020.06.005","journal-title":"Pathology"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02786.x","article-title":"Histological features useful in the distinction of phyllodes tumour and fibroadenoma on needle core biopsy of the breast","volume":"51","author":"Lee AH","year":"2007","unstructured":"Lee AH, Hodi Z, Ellis IO, Elston CW. Histological features useful in the distinction of phyllodes tumour and fibroadenoma on needle core biopsy of the breast. Histopathology. 2007, 51:336-44. 10.1111\/j.1365-2559.2007.02786.x","journal-title":"Histopathology"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.10.109","article-title":"Diagnostic performance of core needle biopsy in identifying breast phyllodes tumors","volume":"8","author":"Zhou ZR","year":"2016","unstructured":"Zhou ZR, Wang CC, Sun XJ, Yang ZZ, Yu XL, Guo XM. Diagnostic performance of core needle biopsy in identifying breast phyllodes tumors. J Thorac Dis. 2016, 8:3139-51. 10.21037\/jtd.2016.10.109","journal-title":"J Thorac Dis"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.64997","article-title":"Accuracy and comparison of core needle biopsy diagnoses with excision specimen for diagnosing fibroepithelial lesions of the breast","volume":"16","author":"Tariq MU","year":"2024","unstructured":"Tariq MU, Rani A, Kayani N, Sattar AK, Vohra L, Idress R. Accuracy and comparison of core needle biopsy diagnoses with excision specimen for diagnosing fibroepithelial lesions of the breast. Cureus. 2024, 16:e64997. 10.7759\/cureus.64997","journal-title":"Cureus"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2025.100734","article-title":"Classification of fibroepithelial lesions of the breast in core needle biopsy with implications for further management","volume":"38","author":"Rakha EA","year":"2025","unstructured":"Rakha EA, Quinn C, Raymond W, et al.. Classification of fibroepithelial lesions of the breast in core needle biopsy with implications for further management. Mod Pathol. 2025, 38:100734. 10.1016\/j.modpat.2025.100734","journal-title":"Mod Pathol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-024-07378-8","article-title":"De-escalating indications for excision when breast core needle biopsy returns fibroepithelial lesion-not further characterized","volume":"207","author":"Soleimani T","year":"2024","unstructured":"Soleimani T, Euhus D, Sogunro O, et al.. De-escalating indications for excision when breast core needle biopsy returns fibroepithelial lesion-not further characterized. Breast Cancer Res Treat. 2024, 207:561-8. 10.1007\/s10549-024-07378-8","journal-title":"Breast Cancer Res Treat"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1177\/10668969261436011","article-title":"Measuring diagnostic accuracy and precision of core needle biopsies of fibroepithelial breast lesions to inform surgical management","volume":"34","author":"Salisbury T","year":"2026","unstructured":"Salisbury T, Oscilowicz K, Myles N, et al.. Measuring diagnostic accuracy and precision of core needle biopsies of fibroepithelial breast lesions to inform surgical management. Int J Surg Pathol. 2026, 34:1458-67. 10.1177\/10668969261436011","journal-title":"Int J Surg Pathol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/jbi\/wbaf070","article-title":"Factors associated with procedural complications in lactating patients undergoing image-guided core-needle breast biopsy","volume":"8","author":"Langman EL","year":"2026","unstructured":"Langman EL, Kim C, Yoon SC. Factors associated with procedural complications in lactating patients undergoing image-guided core-needle breast biopsy. J Breast Imaging. 2026, 8:255-68. 10.1093\/jbi\/wbaf070","journal-title":"J Breast Imaging"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-14-0578","article-title":"Next-gen sequencing exposes frequent MED12 mutations and actionable therapeutic targets in phyllodes tumors","volume":"13","author":"Cani AK","year":"2015","unstructured":"Cani AK, Hovelson DH, McDaniel AS, et al.. Next-gen sequencing exposes frequent MED12 mutations and actionable therapeutic targets in phyllodes tumors. Mol Cancer Res. 2015, 13:613-9. 10.1158\/1541-7786.MCR-14-0578","journal-title":"Mol Cancer Res"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2017.10.002","article-title":"Genetic and clinical characteristics of phyllodes tumors of the breast","volume":"11","author":"Kim JY","year":"2018","unstructured":"Kim JY, Yu JH, Nam SJ, et al.. Genetic and clinical characteristics of phyllodes tumors of the breast. Transl Oncol. 2018, 11:18-23. 10.1016\/j.tranon.2017.10.002","journal-title":"Transl Oncol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/path.4672","article-title":"Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression","volume":"238","author":"Piscuoglio S","year":"2016","unstructured":"Piscuoglio S, Ng CK, Murray M, et al.. Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression. J Pathol. 2016, 238:508-18. 10.1002\/path.4672","journal-title":"J Pathol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4156-1","article-title":"Comprehensive genomic profiling of malignant phyllodes tumors of the breast","volume":"162","author":"Nozad S","year":"2017","unstructured":"Nozad S, Sheehan CE, Gay LM, et al.. Comprehensive genomic profiling of malignant phyllodes tumors of the breast. Breast Cancer Res Treat. 2017, 162:597-602. 10.1007\/s10549-017-4156-1","journal-title":"Breast Cancer Res Treat"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyae218","article-title":"Genomic landscape of malignant phyllodes tumors reveals multiple targetable opportunities","volume":"29","author":"Rosenberger LH","year":"2024","unstructured":"Rosenberger LH, Riedel RF, Diego EJ, et al.. Genomic landscape of malignant phyllodes tumors reveals multiple targetable opportunities. Oncologist. 2024, 29:1024-31. 10.1093\/oncolo\/oyae218","journal-title":"Oncologist"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2024.0284","article-title":"Recent advances in malignant phyllodes tumors of the breast","volume":"28","author":"Lee ES","year":"2025","unstructured":"Lee ES. Recent advances in malignant phyllodes tumors of the breast. J Breast Cancer. 2025, 28:51-60. 10.4048\/jbc.2024.0284","journal-title":"J Breast Cancer"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/his.70098","article-title":"Molecular pathology of phyllodes tumours of the breast-much more than MED12","volume":"88","author":"Pang JB","year":"2026","unstructured":"Pang JB, Gorringe KL, Tan PH, Fox SB. Molecular pathology of phyllodes tumours of the breast-much more than MED12. Histopathology. 2026, 88:1115-25. 10.1111\/his.70098","journal-title":"Histopathology"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyaf012","article-title":"The pathologic and genomic evolution of primary malignant phyllodes tumors of the breast: retrospective cohort study and case-control genomic analysis","volume":"30","author":"Valenza C","year":"2025","unstructured":"Valenza C, Trapani D, Porta FM, et al.. The pathologic and genomic evolution of primary malignant phyllodes tumors of the breast: retrospective cohort study and case-control genomic analysis. Oncologist. 2025, 30:10.1093\/oncolo\/oyaf012","journal-title":"Oncologist"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-026-02238-3","article-title":"Prognostic value of Ki-67 index in malignant phyllodes tumor of the breast: a multi-center real-world study","volume":"28","author":"Zhou Y","year":"2026","unstructured":"Zhou Y, Guo C, Wang Y, et al.. Prognostic value of Ki-67 index in malignant phyllodes tumor of the breast: a multi-center real-world study. Breast Cancer Res. 2026, 28:10.1186\/s13058-026-02238-3","journal-title":"Breast Cancer Res"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znaf152","article-title":"Contemporary management of phyllodes tumours of the breast: recommendations from the UK Association of Breast Surgery","volume":"112","author":"Bishr MK","year":"2025","unstructured":"Bishr MK, Humphreys A, Ahmed M, et al.. Contemporary management of phyllodes tumours of the breast: recommendations from the UK Association of Breast Surgery. Br J Surg. 2025, 112:10.1093\/bjs\/znaf152","journal-title":"Br J Surg"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2026.00353","article-title":"Optimal surgical margin and the efficacy of adjuvant radiotherapy in borderline and malignant phyllodes tumors: a multicenter retrospective study","volume":"44","author":"Kang HB","year":"2026","unstructured":"Kang HB, Hong JH, Choi BO, et al.. Optimal surgical margin and the efficacy of adjuvant radiotherapy in borderline and malignant phyllodes tumors: a multicenter retrospective study. Radiat Oncol J. 2026, 44:174-83. 10.3857\/roj.2026.00353","journal-title":"Radiat Oncol J"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2025.104491","article-title":"Phyllodes tumors of the breast: real world data from a multi-institution cohort","volume":"82","author":"Sars C","year":"2025","unstructured":"Sars C, Frisell J, Dickman PW, et al.. Phyllodes tumors of the breast: real world data from a multi-institution cohort. Breast. 2025, 82:104491. 10.1016\/j.breast.2025.104491","journal-title":"Breast"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2024.113924","article-title":"Real-world data on malignant and borderline phyllodes tumors of the breast: a population-based study of all 921 cases in the Netherlands (1989-2020)","volume":"201","author":"Bartels SA","year":"2024","unstructured":"Bartels SA, van Olmen JP, Scholten AN, et al.. Real-world data on malignant and borderline phyllodes tumors of the breast: a population-based study of all 921 cases in the Netherlands (1989-2020). Eur J Cancer. 2024, 201:113924. 10.1016\/j.ejca.2024.113924","journal-title":"Eur J Cancer"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-024-15892-8","article-title":"Margin width and local recurrence in patients with phyllodes tumors of the breast","volume":"31","author":"Del Calvo H","year":"2024","unstructured":"Del Calvo H, Wu Y, Lin HY, et al.. Margin width and local recurrence in patients with phyllodes tumors of the breast. Ann Surg Oncol. 2024, 31:8048-56. 10.1245\/s10434-024-15892-8","journal-title":"Ann Surg Oncol"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.21037\/gs-21-877","article-title":"Surgical management and prognosis of phyllodes tumors of the breast","volume":"11","author":"Ji Y","year":"2022","unstructured":"Ji Y, Zhong Y, Zheng Y, et al.. Surgical management and prognosis of phyllodes tumors of the breast. Gland Surg. 2022, 11:981-91. 10.21037\/gs-21-877","journal-title":"Gland Surg"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2017.08.112","article-title":"Phyllodes tumors of the breast: The British Columbia Cancer Agency experience","volume":"22","author":"Rodrigues MF","year":"2018","unstructured":"Rodrigues MF, Truong PT, McKevitt EC, Weir LM, Knowling MA, Wai ES. Phyllodes tumors of the breast: The British Columbia Cancer Agency experience. Cancer Radiother. 2018, 22:112-9. 10.1016\/j.canrad.2017.08.112","journal-title":"Cancer Radiother"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1111\/ans.70585","article-title":"Impact of surgical approach on survival and recurrence in borderline and malignant phyllodes tumours: a systematic review and meta-analysis","volume":"96","author":"Harris CG","year":"2026","unstructured":"Harris CG, Heller G, Azimi F, et al.. Impact of surgical approach on survival and recurrence in borderline and malignant phyllodes tumours: a systematic review and meta-analysis. ANZ J Surg. 2026, 96:1450-8. 10.1111\/ans.70585","journal-title":"ANZ J Surg"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2021.03.013","article-title":"Phyllodes tumors of the breast: adjuvant radiation therapy revisited","volume":"58","author":"Boutrus RR","year":"2021","unstructured":"Boutrus RR, Khair S, Abdelazim Y, et al.. Phyllodes tumors of the breast: adjuvant radiation therapy revisited. Breast. 2021, 58:1-5. 10.1016\/j.breast.2021.03.013","journal-title":"Breast"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-025-01725-3","article-title":"The impact of adjuvant radiotherapy on borderline and malignant phyllodes tumors of the breast","volume":"32","author":"Charoenyothakun A","year":"2025","unstructured":"Charoenyothakun A, Shotelersuk K, Nantavithya C, Saksornchai K. The impact of adjuvant radiotherapy on borderline and malignant phyllodes tumors of the breast. Breast Cancer. 2025, 32:1006-12. 10.1007\/s12282-025-01725-3","journal-title":"Breast Cancer"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1177\/17588359251387556","article-title":"Effects of radiotherapy in borderline and malignant phyllodes tumors after R0 resection: a propensity score analysis","volume":"17","author":"Ma B","year":"2025","unstructured":"Ma B, Li X, Zhuang Z, et al.. Effects of radiotherapy in borderline and malignant phyllodes tumors after R0 resection: a propensity score analysis. Ther Adv Med Oncol. 2025, 17:10.1177\/17588359251387556","journal-title":"Ther Adv Med Oncol"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2025.104617","article-title":"Postoperative radiation therapy in localized breast malignant phyllodes tumors: RPA-derived risk model identifies high-benefit subgroups with local control improvement","volume":"84","author":"Zheng WH","year":"2025","unstructured":"Zheng WH, Long ZQ, Kou J, et al.. Postoperative radiation therapy in localized breast malignant phyllodes tumors: RPA-derived risk model identifies high-benefit subgroups with local control improvement. Breast. 2025, 84:104617. 10.1016\/j.breast.2025.104617","journal-title":"Breast"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-025-00879-9","article-title":"Hierarchical diagnosis of breast phyllodes tumors enabled by deep learning of ultrasound images: a retrospective multi-center study","volume":"25","author":"Yan Y","year":"2025","unstructured":"Yan Y, Liu Y, Wang Y, et al.. Hierarchical diagnosis of breast phyllodes tumors enabled by deep learning of ultrasound images: a retrospective multi-center study. Cancer Imaging. 2025, 25:61. 10.1186\/s40644-025-00879-9","journal-title":"Cancer Imaging"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1668793","article-title":"Intra-tumor and peritumoral radiomics and deep learning based on ultrasound for differentiating fibroadenoma and phyllodes tumor: a multicenter study","volume":"15","author":"Lu G","year":"2025","unstructured":"Lu G, Tian R, Yang W, et al.. Intra-tumor and peritumoral radiomics and deep learning based on ultrasound for differentiating fibroadenoma and phyllodes tumor: a multicenter study. Front Oncol. 2025, 15:1668793. 10.3389\/fonc.2025.1668793","journal-title":"Front Oncol"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-026-19179-y","article-title":"AI-FLEET: phase I-multimodal deep learning model for phyllodes tumor classification","volume":"33","author":"Holt L","year":"2026","unstructured":"Holt L, Chamberlain V, Shern T, et al.. AI-FLEET: phase I-multimodal deep learning model for phyllodes tumor classification. Ann Surg Oncol. 2026, 33:4503-9. 10.1245\/s10434-026-19179-y","journal-title":"Ann Surg Oncol"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2026.01.045","article-title":"Distinction between benign and borderline\/malignant phyllodes tumor in breast mammography and ultrasound based on radiomics methods","volume":"33","author":"Su X","year":"2026","unstructured":"Su X, Li C, Chen J, et al.. Distinction between benign and borderline\/malignant phyllodes tumor in breast mammography and ultrasound based on radiomics methods. Acad Radiol. 2026, 33:2005-18. 10.1016\/j.acra.2026.01.045","journal-title":"Acad Radiol"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1111\/his.70144","article-title":"Artificial intelligence modelling in grading breast phyllodes tumours","volume":"89","author":"Koong JE","year":"2026","unstructured":"Koong JE, Shafique A, Md Nasir ND, et al.. Artificial intelligence modelling in grading breast phyllodes tumours. Histopathology. 2026, 89:383-9. 10.1111\/his.70144","journal-title":"Histopathology"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-051222-113147","article-title":"Toward explainable artificial intelligence for precision pathology","volume":"19","author":"Klauschen F","year":"2024","unstructured":"Klauschen F, Dippel J, Keyl P, et al.. Toward explainable artificial intelligence for precision pathology. Annu Rev Pathol. 2024, 19:541-70. 10.1146\/annurev-pathmechdis-051222-113147","journal-title":"Annu Rev Pathol"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1177\/15330338241289474","article-title":"Differentiation between phyllodes tumor and fibroadenoma of the breast: a radiomics prediction model based on full-field digital mammography & digital tomosynthesis","volume":"23","author":"Zeng F","year":"2024","unstructured":"Zeng F, Zeng H, Yang J, et al.. Differentiation between phyllodes tumor and fibroadenoma of the breast: a radiomics prediction model based on full-field digital mammography & digital tomosynthesis. Technol Cancer Res Treat. 2024, 23:10.1177\/15330338241289474","journal-title":"Technol Cancer Res Treat"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2025.110325","article-title":"Application of MRI-based tumor heterogeneity analysis for identification and pathologic staging of breast phyllodes tumors","volume":"117","author":"Liang Y","year":"2025","unstructured":"Liang Y, Li QY, Li JH, et al.. Application of MRI-based tumor heterogeneity analysis for identification and pathologic staging of breast phyllodes tumors. Magn Reson Imaging. 2025, 117:110325. 10.1016\/j.mri.2025.110325","journal-title":"Magn Reson Imaging"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2024.05.006","article-title":"Predicting prognosis of phyllodes tumors using a mammography- and magnetic resonance imaging-based radiomics model: a preliminary study","volume":"24","author":"Ma X","year":"2024","unstructured":"Ma X, Zhang L, Xiao Q, et al.. Predicting prognosis of phyllodes tumors using a mammography- and magnetic resonance imaging-based radiomics model: a preliminary study. Clin Breast Cancer. 2024, 24:e571-82. 10.1016\/j.clbc.2024.05.006","journal-title":"Clin Breast Cancer"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00689-0","article-title":"Artificial intelligence modelling in differentiating core biopsies of fibroadenoma from phyllodes tumor","volume":"102","author":"Cheng CL","year":"2022","unstructured":"Cheng CL, Md Nasir ND, Ng GJ, et al.. Artificial intelligence modelling in differentiating core biopsies of fibroadenoma from phyllodes tumor. Lab Invest. 2022, 102:245-52. 10.1038\/s41374-021-00689-0","journal-title":"Lab Invest"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-026-04451-0","article-title":"CCL19 and CCR6 as diagnostic biomarkers for differentiating phyllodes tumors from breast fibroadenomas: a machine learning-driven approach integrating EMT biology","volume":"17","author":"Gao H","year":"2026","unstructured":"Gao H, Lan Y, Lv L, Liu H. CCL19 and CCR6 as diagnostic biomarkers for differentiating phyllodes tumors from breast fibroadenomas: a machine learning-driven approach integrating EMT biology. Discov Oncol. 2026, 17:10.1007\/s12672-026-04451-0","journal-title":"Discov Oncol"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1200\/PO.24.00289","article-title":"Genomic landscape of malignant phyllodes tumors identifies subsets for targeted therapy","volume":"8","author":"Bansal R","year":"2024","unstructured":"Bansal R, Adeyelu T, Elliott A, et al.. Genomic landscape of malignant phyllodes tumors identifies subsets for targeted therapy. JCO Precis Oncol. 2024, 8:e2400289. 10.1200\/PO.24.00289","journal-title":"JCO Precis Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/536120-phyllodes-tumors-of-the-breast-in-2026-a-contemporary-narrative-review-of-diagnosis-surgical-margins-prognosis-and-emerging-therapies","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:52:29Z","timestamp":1792252349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/536120-phyllodes-tumors-of-the-breast-in-2026-a-contemporary-narrative-review-of-diagnosis-surgical-margins-prognosis-and-emerging-therapies"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,17]]},"references-count":60,"URL":"https:\/\/doi.org\/10.7759\/cureus.118070","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,17]]}}}