{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:58:55Z","timestamp":1792180735461,"version":"4.4.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,3]]},"DOI":"10.7759\/cureus.11882","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:21:16Z","timestamp":1607041276000},"source":"Crossref","is-referenced-by-count":24,"title":["Comparison of the Efficacy of the Various Treatment Modalities in the Management of Perianal Crohn\u2019s Fistula: A Review"],"prefix":"10.7759","author":[{"given":"Shah Huzaifa","family":"Feroz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abilash","family":"Muralidharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragatheeshwar","family":"Thirunavukarasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-014-1186-0","article-title":"The role of loose seton in the management of anal fistula: a multicenter study of 200 patients","volume":"18","author":"Kelly ME","year":"2014","unstructured":"Kelly ME, Heneghan HM, McDermott FD, Nason GJ, Freeman C, Martin ST, Winter DC. The role of loose seton in the management of anal fistula: a multicenter study of 200 patients. Tech Coloproctol. 2014, 18:915-9. 10.1007\/s10151-014-1186-0","journal-title":"Tech Coloproctol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6542a3","article-title":"Prevalence of inflammatory bowel disease among adults aged \u226518 years\u2014United States, 2015","volume":"65","author":"Dahlhamer JM","year":"2015","unstructured":"Dahlhamer JM, Zammitti EP, Ward BW, Wheaton AG, Croft JB. Prevalence of inflammatory bowel disease among adults aged \u226518 years\u2014United States, 2015. MMWR Morb Mortal Wkly Rep. 2015, 65:1166-1169. 10.15585\/mmwr.mm6542a3","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.09.001","article-title":"National estimates of the burden of inflammatory bowel disease among racial and ethnic groups in the United States","volume":"8","author":"Nguyen GC","year":"2014","unstructured":"Nguyen GC, Chong CA, Chong RY. National estimates of the burden of inflammatory bowel disease among racial and ethnic groups in the United States. J Crohns Colitis. 2014, 8:288-295. 10.1016\/j.crohns.2013.09.001","journal-title":"J Crohns Colitis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6614a1","article-title":"Hospitalizations for Crohn\u2019s disease\u2014United States, 2003-2013","volume":"66","author":"Malarcher CA","year":"2017","unstructured":"Malarcher CA, Wheaton AG, Liu Y, Greenlund SF, Greenlund SJ, Lu H, Croft JB. Hospitalizations for Crohn\u2019s disease\u2014United States, 2003-2013. MMWR Morb Mortal Wkly Rep. 2017, 66:377-381. 10.15585\/mmwr.mm6614a1","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-018-0432-4","article-title":"Trends and factors associated with hospitalization costs for inflammatory bowel disease in the United States","volume":"17","author":"Xu F","year":"2019","unstructured":"Xu F, Liu Y, Wheaton AG, Rabarison KM, Croft JB. Trends and factors associated with hospitalization costs for inflammatory bowel disease in the United States. Appl Health Econ Health Policy. 2019, 17:77-91. 10.1007\/s40258-018-0432-4","journal-title":"Appl Health Econ Health Policy"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz056","article-title":"Prevalence of fistulizing Crohn's disease in the United States: estimate from a systematic literature review attempt and population-based database analysis","volume":"25","author":"Schwartz DA","year":"2019","unstructured":"Schwartz DA, Tagarro I, D\u00edez MC, Sandborn WJ. Prevalence of fistulizing Crohn's disease in the United States: estimate from a systematic literature review attempt and population-based database analysis. Inflamm Bowel Dis. 2019, 25:1773-1779. 10.1093\/ibd\/izz056","journal-title":"Inflamm Bowel Dis"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000148","article-title":"Disappointing durable remission rates in complex Crohn's disease fistula","volume":"20","author":"Molendijk I","year":"2014","unstructured":"Molendijk I, Nuij VJ, van der Meulen-de Jong AE, van der Woude CJ. Disappointing durable remission rates in complex Crohn's disease fistula. Inflamm Bowel Dis. 2014, 20:2022-8. 10.1097\/MIB.0000000000000148","journal-title":"Inflamm Bowel Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31825228b0","article-title":"The spectrum of perianal Crohn's disease in a population-based cohort","volume":"55","author":"Eglinton TW","year":"2012","unstructured":"Eglinton TW, Barclay ML, Gearry RB, Frizelle FA. The spectrum of perianal Crohn's disease in a population-based cohort. Dis Colon Rectum. 2012, 55:773-7. 10.1097\/DCR.0b013e31825228b0","journal-title":"Dis Colon Rectum"},{"key":"ref9","article-title":"Bailey & Love\u2019s Short Practice of Surgery, 26th Edition","year":"2012","unstructured":"Bailey &amp; Love\u2019s Short Practice of Surgery, 26th Edition. Williams N, O\u2019Connell PR (ed). CRC Press, Boca Raton; 2012."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa004","article-title":"Treatment of perianal fistulas in Crohn's disease, seton versus anti-TNF versus surgical closure following anti-TNF [PISA]: a randomised controlled trial","volume":"14","author":"Wasmann KA","year":"2020","unstructured":"Wasmann KA, de Groof EJ, Stellingwerf ME, et al.. Treatment of perianal fistulas in Crohn's disease, seton versus anti-TNF versus surgical closure following anti-TNF [PISA]: a randomised controlled trial. J Crohns Colitis. 2020, 14:1049-1056. 10.1093\/ecco-jcc\/jjaa004","journal-title":"J Crohns Colitis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21596","article-title":"Incidence and clinical outcomes of intersphincteric abscesses diagnosed by anal ultrasonography in patients with Crohn's disease","volume":"17","author":"Vigan\u00f2 C","year":"2011","unstructured":"Vigan\u00f2 C, Losco A, Caprioli F, Basilisco G. Incidence and clinical outcomes of intersphincteric abscesses diagnosed by anal ultrasonography in patients with Crohn's disease. Inflamm Bowel Dis. 2011, 17:2102-8. 10.1002\/ibd.21596","journal-title":"Inflamm Bowel Dis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.019","article-title":"Predictors of Crohn's disease","volume":"130","author":"Beaugerie L","year":"2006","unstructured":"Beaugerie L, Seksik P, Nion-Larmurier I, Gendre J-P, Cosnes J. Predictors of Crohn's disease. Gastroenterology. 2006, 130:650-6. 10.1053\/j.gastro.2005.12.019","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2016.210","article-title":"Evaluation of the cutting seton as a method of treatment for perianal fistula","volume":"36","author":"Raslan SM","year":"2016","unstructured":"Raslan SM, Aladwani M, Alsanea N. Evaluation of the cutting seton as a method of treatment for perianal fistula. Ann Saudi Med. 2016, 36:210-5. 10.5144\/0256-4947.2016.210","journal-title":"Ann Saudi Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0528","article-title":"Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis","volume":"3","author":"Sartor R","year":"2006","unstructured":"Sartor R. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Rev Gastroenterol Hepatol. 2006, 3:390-407. 10.1038\/ncpgasthep0528","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.104","article-title":"Perianal fistulizing Crohn's disease: pathogenesis, diagnosis and therapy","volume":"14","author":"Pan\u00e9s J","year":"2017","unstructured":"Pan\u00e9s J, Rimola J. Perianal fistulizing Crohn's disease: pathogenesis, diagnosis and therapy. Nat Rev Gastroenterol Hepatol. 2017, 14:652-664. 10.1038\/nrgastro.2017.104","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.1002\/bjs.1800630102","article-title":"A classification of fistula-in-ano","volume":"63","author":"Parks AG","year":"1976","unstructured":"Parks AG, Gordon PH, Hardcastle JD. A classification of fistula-in-ano. Br J Surg. 1976, 63:1-12.","journal-title":"Br J Surg"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.08.024","article-title":"American Gastroenterological Association medical position statement: perianal Crohn's disease","volume":"125","author":"American Gastroenterological Association","year":"2003","unstructured":"American Gastroenterological Association. American Gastroenterological Association medical position statement: perianal Crohn's disease. Gastroenterology. 2003, 125:1503-7. 10.1016\/j.gastro.2003.08.024","journal-title":"Gastroenterology"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.5402\/2011\/636952","article-title":"Treatment of complex fistula in ano with cable-tie seton: a prospective case series","volume":"2011","author":"Memon AA","year":"2011","unstructured":"Memon AA, Murtaza G, Azami R, Zafar H, Chawla T, Laghari AA. Treatment of complex fistula in ano with cable-tie seton: a prospective case series. ISRN Surg. 2011, 2011:636952.","journal-title":"ISRN Surg"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i28.3292","article-title":"Why do we have so much trouble treating anal fistula?","volume":"17","author":"Dudukgian H","year":"2011","unstructured":"Dudukgian H, Abcarian H. Why do we have so much trouble treating anal fistula?. World J Gastroenterol. 2011, 17:3292-6. 10.3748\/wjg.v17.i28.3292","journal-title":"World J Gastroenterol"},{"key":"ref20","doi-asserted-by":"crossref","DOI":"10.1111\/j.1463-1318.2008.01713.x","article-title":"Incontinence rates after cutting seton treatment for anal fistula","volume":"11","author":"Ritchie RD","year":"2009","unstructured":"Ritchie RD, Sackier JM, Hodde JP. Incontinence rates after cutting seton treatment for anal fistula. Colorectal Dis. 2009, 11:564-71.","journal-title":"Colorectal Dis"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1002\/bjs.1800820711","article-title":"Seton treatment of perianal fistula with high anal or rectal opening","volume":"82","author":"Van Tets WF","year":"1995","unstructured":"Van Tets WF, Kuijpers JH. Seton treatment of perianal fistula with high anal or rectal opening. Br J Surg. 1995, 82:895-7.","journal-title":"Br J Surg"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0830-6","article-title":"Long-term indwelling seton for complex anal fistulas in Crohn's disease","volume":"48","author":"Thornton M","year":"2005","unstructured":"Thornton M, Solomon MJ. Long-term indwelling seton for complex anal fistulas in Crohn's disease. Dis Colon Rectum. 2005, 48:459-63. 10.1007\/s10350-004-0830-6","journal-title":"Dis Colon Rectum"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.1111\/j.1463-1318.2005.00850.x","article-title":"Staged mucosal advancement flap for the treatment of complex anal fistulas: pretreatment with noncutting Setons and in case of recurrent multiple abscesses a diverting stoma","volume":"7","author":"Van Der Hagen SJ","year":"2005","unstructured":"Van Der Hagen SJ, Baeten CG, Soeters PB, Beets-Tan RG, Russel MM, van Gemert WG. Staged mucosal advancement flap for the treatment of complex anal fistulas: pretreatment with noncutting Setons and in case of recurrent multiple abscesses a diverting stoma. Colorectal Dis. 2005, 7:513-518.","journal-title":"Colorectal Dis"},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.1111\/j.1463-1318.2009.01796.x","article-title":"Long-term outcome of loose seton for complex anal fistula: a two-centre study of patients with and without Crohn's disease","volume":"12","author":"Galis-Rozen E","year":"2010","unstructured":"Galis-Rozen E, Tulchinsky H, Rosen A, et al.. Long-term outcome of loose seton for complex anal fistula: a two-centre study of patients with and without Crohn's disease. Colorectal Dis. 2010, 12:358-62.","journal-title":"Colorectal Dis"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.1016\/S0889-8553(21)00483-0","article-title":"Complex anal fistulae","volume":"16","author":"Fazio VW","year":"1987","unstructured":"Fazio VW. Complex anal fistulae. Gastroenterol Clin North Am. 1987, 16:93-114.","journal-title":"Gastroenterol Clin North Am"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1177\/1457496916665763","article-title":"Surgical management of fistula-in-ano among patients with Crohn's disease: analysis of outcomes after fistulotomy or seton placement-single-center experience","volume":"106","author":"Papaconstantinou I","year":"2017","unstructured":"Papaconstantinou I, Kontis E, Koutoulidis V, Mantzaris G, Vassiliou I. Surgical management of fistula-in-ano among patients with Crohn's disease: analysis of outcomes after fistulotomy or seton placement-single-center experience. Scand J Surg. 2017, 106:211-215. 10.1177\/1457496916665763","journal-title":"Scand J Surg"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3393\/jksc.2012.28.6.309","article-title":"The use of a staged drainage seton for the treatment of anal fistulae or fistulous abscesses","volume":"28","author":"Lim CH","year":"2012","unstructured":"Lim CH, Shin HK, Kang WH, et al.. The use of a staged drainage seton for the treatment of anal fistulae or fistulous abscesses. J Korean Soc Coloproctol. 2012, 28:309-14. 10.3393\/jksc.2012.28.6.309","journal-title":"J Korean Soc Coloproctol"},{"key":"ref28","doi-asserted-by":"crossref","DOI":"10.1002\/bjs.4466","article-title":"Long-term outcome following loose-seton technique for external sphincter preservation in complex anal fistula","volume":"91","author":"Buchanan GN","year":"2004","unstructured":"Buchanan GN, Owen HA, Torkington J, Lunniss PJ, Nicholls RJ, Cohen CR. Long-term outcome following loose-seton technique for external sphincter preservation in complex anal fistula. Br J Surg. 2004, 91:476-80.","journal-title":"Br J Surg"},{"key":"ref29","article-title":"Anal fistula","volume":"79","author":"Seow-Choen F","year":"1992","unstructured":"Seow-Choen F, Nicholls RJ. Anal fistula. Br J Surg. 1992, 79:197-205.","journal-title":"Br J Surg"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86501998000200007","article-title":"Perianal fistula: retrospective study of surgical treatment of 241 cases","volume":"13","author":"Drager LF","year":"1998","unstructured":"Drager LF, Andrade MN, Conceicao SA, Cunha-Melo JR. Perianal fistula: retrospective study of surgical treatment of 241 cases. Acta Cir Bras. 1998, 13:23-8. 10.1590\/S0102-86501998000200007","journal-title":"Acta Cir Bras"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-120","article-title":"Surgery for fistula-in-ano in a specialist colorectal unit: a critical appraisal","volume":"11","author":"Sileri P","year":"2011","unstructured":"Sileri P, Cadeddu F, D'Ugo S, et al.. Surgery for fistula-in-ano in a specialist colorectal unit: a critical appraisal. BMC Gastroenterol. 2011, 11:120. 10.1186\/1471-230X-11-120","journal-title":"BMC Gastroenterol"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.01.007","article-title":"Outcomes of anal fistula surgery in patients with inflammatory bowel disease","volume":"199","author":"Chung W","year":"2010","unstructured":"Chung W, Ko D, Sun C, et al.. Outcomes of anal fistula surgery in patients with inflammatory bowel disease. Am J Surg. 2010, 199:609-13. 10.1016\/j.amjsurg.2010.01.007","journal-title":"Am J Surg"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905063401804","article-title":"Infliximab for the treatment of fistulas in patients with Crohn's disease","volume":"340","author":"Present DH","year":"1999","unstructured":"Present DH, Rutgeerts P, Targan S, et al.. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med. 1999, 340:1398-405. 10.1056\/NEJM199905063401804","journal-title":"N Engl J Med"},{"key":"ref34","doi-asserted-by":"crossref","DOI":"10.1111\/j.1572-0241.2000.03366.x","article-title":"Clinical experience with infliximab therapy in 100 patients with Crohn's disease","volume":"95","author":"Farrell RJ","year":"2000","unstructured":"Farrell RJ, Shah SA, Lodhavia PJ, et al.. Clinical experience with infliximab therapy in 100 patients with Crohn's disease. Am J Gastroenterol. 2000, 95:3490-7.","journal-title":"Am J Gastroenterol"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.4321\/s1130-01082004000600003","article-title":"Predictors of response to infliximab in patients with fistulizing Crohn's disease","volume":"96","author":"Luna-Chadid M","year":"2004","unstructured":"Luna-Chadid M, P\u00e9rez Calle JL, Mendoza JL, et al.. Predictors of response to infliximab in patients with fistulizing Crohn's disease. Rev Esp Enferm Dig. 2004, 96:379-81. 10.4321\/s1130-01082004000600003","journal-title":"Rev Esp Enferm Dig"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030815","article-title":"Infliximab maintenance therapy for fistulizing Crohn's disease","volume":"350","author":"Sands BE","year":"2004","unstructured":"Sands BE, Anderson FH, Bernstein CN, et al.. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med. 2004, 350:876-85. 10.1056\/NEJMoa030815","journal-title":"N Engl J Med"},{"key":"ref37","doi-asserted-by":"crossref","DOI":"10.1111\/apt.13970","article-title":"Higher infliximab trough levels are associated with perianal fistula healing in patients with Crohn's disease","volume":"45","author":"Yarur AJ","year":"2017","unstructured":"Yarur AJ, Kanagala V, Stein DJ, et al.. Higher infliximab trough levels are associated with perianal fistula healing in patients with Crohn's disease. Aliment Pharmacol Ther. 2017, 45:933-940.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.030","article-title":"Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial","volume":"130","author":"Hanauer SB","year":"2006","unstructured":"Hanauer SB, Sandborn WJ, Rutgeerts P, et al.. Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology. 2006, 130:323-33. 10.1053\/j.gastro.2005.11.030","journal-title":"Gastroenterology"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.106781","article-title":"Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial","volume":"56","author":"Sandborn WJ","year":"2007","unstructured":"Sandborn WJ, Hanauer SB, Rutgeerts P, et al.. Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial. Gut. 2007, 56:1232-9. 10.1136\/gut.2006.106781","journal-title":"Gut"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-12-200706190-00159","article-title":"Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial","volume":"146","author":"Sandborn WJ","year":"2007","unstructured":"Sandborn WJ, Rutgeerts P, Enns R, et al.. Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial. Ann Intern Med. 2007, 146:829-38. 10.7326\/0003-4819-146-12-200706190-00159","journal-title":"Ann Intern Med"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.159251","article-title":"Adalimumab for the treatment of fistulas in patients with Crohn's disease","volume":"58","author":"Colombel JF","year":"2009","unstructured":"Colombel JF, Schwartz DA, Sandborn WJ, et al.. Adalimumab for the treatment of fistulas in patients with Crohn's disease. Gut. 2009, 58:940-8. 10.1136\/gut.2008.159251","journal-title":"Gut"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067594","article-title":"Certolizumab pegol for the treatment of Crohn's disease","volume":"357","author":"Sandborn WJ","year":"2007","unstructured":"Sandborn WJ, Feagan BG, Stoinov S, et al.. Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med. 2007, 357:228-38. 10.1056\/NEJMoa067594","journal-title":"N Engl J Med"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062897","article-title":"Maintenance therapy with certolizumab pegol for Crohn's disease","volume":"357","author":"Schreiber S","year":"2007","unstructured":"Schreiber S, Khaliq-Kareemi M, Lawrance IC, et al.. Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med. 2007, 357:239-50. 10.1056\/NEJMoa062897","journal-title":"N Engl J Med"},{"key":"ref44","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2036.2010.04509.x","article-title":"Randomised clinical trial: certolizumab pegol for fistulas in Crohn's disease - subgroup results from a placebo-controlled study","volume":"33","author":"Schreiber S","year":"2011","unstructured":"Schreiber S, Lawrance IC, Thomsen O\u00d8, et al.. Randomised clinical trial: certolizumab pegol for fistulas in Crohn's disease - subgroup results from a placebo-controlled study. Aliment Pharmacol Ther. 2011, 33:185-93.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215739","article-title":"Vedolizumab as induction and maintenance therapy for Crohn's disease","volume":"369","author":"Sandborn WJ","year":"2013","unstructured":"Sandborn WJ, Feagan BG, Rutgeerts P, et al.. Vedolizumab as induction and maintenance therapy for Crohn's disease. N Engl J Med. 2013, 369:711-21. 10.1056\/NEJMoa1215739","journal-title":"N Engl J Med"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy019","article-title":"Efficacy of vedolizumab in fistulising Crohn's disease: exploratory analyses of data from GEMINI 2","volume":"12","author":"Feagan BG","year":"2018","unstructured":"Feagan BG, Schwartz D, Danese S, Rubin DT, Lissoos TW, Xu J, Lasch K. Efficacy of vedolizumab in fistulising Crohn's disease: exploratory analyses of data from GEMINI 2. J Crohns Colitis. 2018, 12:621-626. 10.1093\/ecco-jcc\/jjy019","journal-title":"J Crohns Colitis"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-015-0831-x","article-title":"Multimodal treatment of perianal fistulas in Crohn's disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial","volume":"16","author":"de Groof EJ","year":"2015","unstructured":"de Groof EJ, Buskens CJ, Ponsioen CY, et al.. Multimodal treatment of perianal fistulas in Crohn's disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial. Trials. 2015, 16:366. 10.1186\/s13063-015-0831-x","journal-title":"Trials"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2011.04.001","article-title":"Adalimumab is effective in long-term real life clinical practice in both luminal and perianal Crohn's disease. The Madrid experience","volume":"34","author":"Fortea-Ormaechea JI","year":"2011","unstructured":"Fortea-Ormaechea JI, Gonz\u00e1lez-Lama Y, Casis B, et al.. Adalimumab is effective in long-term real life clinical practice in both luminal and perianal Crohn's disease. The Madrid experience. Gastroenterol Hepatol. 2011, 34:443-8. 10.1016\/j.gastrohep.2011.04.001","journal-title":"Gastroenterol Hepatol"},{"key":"ref49","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2036.2010.04466.x","article-title":"The CHOICE trial: adalimumab demonstrates safety, fistula healing, improved quality of life and increased work productivity in patients with Crohn's disease who failed prior infliximab therapy","volume":"32","author":"Lichtiger S","year":"2010","unstructured":"Lichtiger S, Binion DG, Wolf DC, et al.. The CHOICE trial: adalimumab demonstrates safety, fistula healing, improved quality of life and increased work productivity in patients with Crohn's disease who failed prior infliximab therapy. Aliment Pharmacol Ther. 2010, 32:1228-39.","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/45216-comparison-of-the-efficacy-of-the-various-treatment-modalities-in-the-management-of-perianal-crohns-fistula-a-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:24:50Z","timestamp":1707506690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/45216-comparison-of-the-efficacy-of-the-various-treatment-modalities-in-the-management-of-perianal-crohns-fistula-a-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":49,"URL":"https:\/\/doi.org\/10.7759\/cureus.11882","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,3]]}}}