{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T16:10:32Z","timestamp":1726762232454},"reference-count":24,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,28]]},"DOI":"10.7759\/cureus.12349","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T06:50:47Z","timestamp":1609224647000},"source":"Crossref","is-referenced-by-count":1,"title":["Insulin Resistance and Chronic Hepatitis C: Relationship With Serum Iron and Hepcidin"],"prefix":"10.7759","author":[{"given":"Misbah","family":"Ul Qamar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiza","family":"Ikram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaheena","family":"Naz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hina","family":"Sadaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zobiah","family":"Hafeez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2017.10.006","article-title":"Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease","volume":"46","author":"Daher R","year":"2017","unstructured":"Daher R, Manceau H, Karim Z. Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease. Presse M\u00e9d. 2017, 46:272-278. 10.1016\/j.lpm.2017.10.006","journal-title":"Presse M\u00e9d"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1016\/S0014-5793(00)01920-7","article-title":"LEAP-1, a novel highly disulfide bonded human peptide, exhibits antimicrobial activity","volume":"480","author":"Krause A","year":"2000","unstructured":"Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K. LEAP-1, a novel highly disulfide bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000, 480:147-150.","journal-title":"FEBS Lett"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1002\/hep.24267","article-title":"The hepcidin circuits act: balancing iron and inflammation","volume":"53","author":"Maliken BD","year":"2011","unstructured":"Maliken BD, Nelson JE, Kowdley KV. The hepcidin circuits act: balancing iron and inflammation. Hepatology. 2011, 53:1764-1766.","journal-title":"Hepatology"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-737411","article-title":"Hepcidin agonists as therapeutic tools","volume":"131","author":"Casu C","year":"2018","unstructured":"Casu C, Nemeth E, Rivella S. Hepcidin agonists as therapeutic tools. Blood. 2018, 131:1790-1794.  10.1182\/blood-2017-11-737411","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.050328-0","article-title":"Hepatitis C virus core+ 1\/ARF protein decreases hepcidin transcription through an AP1 binding site","volume":"94","author":"Kotta-Loizou I","year":"2013","unstructured":"Kotta-Loizou I, Vassilaki N, Pissas G, et al.. Hepatitis C virus core+ 1\/ARF protein decreases hepcidin transcription through an AP1 binding site. J Gen Virol. 2013, 94:1528-1534. 10.1099\/vir.0.050328-0","journal-title":"J Gen Virol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1007-3418.2011.12.004","article-title":"HCV NS5A protein down-regulates hepcidin gene expression and increases hepatic intracellular iron storage (in Chinese)","volume":"19","author":"Liu Y","year":"2011","unstructured":"Liu Y, Xiao X, Cheng D, Jiang Y, Gong G. HCV NS5A protein down-regulates hepcidin gene expression and increases hepatic intracellular iron storage (in Chinese). Zhonghua gan zang bing za zhi. 2011, 19:894-897.  10.3760\/cma.j.issn.1007-3418.2011.12.004","journal-title":"Zhonghua gan zang bing za zhi"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/290383","article-title":"The role of iron in the pathophysiology and treatment of chronic hepatitis C","volume":"23","author":"Price L","year":"2009","unstructured":"Price L, Kowdley KV. The role of iron in the pathophysiology and treatment of chronic hepatitis C. Can J Gastroenterol. 2009, 23:822-828. 10.1155\/2009\/290383","journal-title":"Can J Gastroenterol"},{"key":"ref8","unstructured":"Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection. (2018). Accessed. 2020: http:\/\/www.who.int\/hepatitis\/publications\/hepatitis-c-guidelines-2018\/en\/."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00143-X","article-title":"Risk factors for diabetes mellitus and early insulin resistance in chronic hepatitis C","volume":"35","author":"Petit J-M","year":"2001","unstructured":"Petit J-M, Bour J-B, Galland-Jos C, et al.. Risk factors for diabetes mellitus and early insulin resistance in chronic hepatitis C. J Hepatol. 2001, 35:279-283. 10.1016\/S0168-8278(01)00143-X","journal-title":"J Hepatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200130090703","article-title":"Dysmetabolic iron overload in metabolic syndrome","volume":"26","author":"Sachinidis A","year":"2020","unstructured":"Sachinidis A, Doumas M, Imprialos K, Stavropoulos K, Katsimardou A, Athyros VG. Dysmetabolic iron overload in metabolic syndrome. Curr Pharm Des. 2020, 26:1019-1024. 10.2174\/1381612826666200130090703","journal-title":"Curr Pharm Des"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1190","article-title":"Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease","volume":"2","author":"Britton L","year":"2018","unstructured":"Britton L, Bridle K, Reiling J, et al.. Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease. Hepatol Commun. 2018, 2:644-653. 10.1002\/hep4.1190","journal-title":"Hepatol Commun"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.972","article-title":"Glucose abnormalities in non\u2010alcoholic fatty liver disease and chronic hepatitis C virus infection: the role of iron overload","volume":"25","author":"Lecube A","year":"2009","unstructured":"Lecube A, Hernandez C, Simo R. Glucose abnormalities in non\u2010alcoholic fatty liver disease and chronic hepatitis C virus infection: the role of iron overload. Diabetes Metab Res Rev. 2009, 25:403-410. 10.1002\/dmrr.972","journal-title":"Diabetes Metab Res Rev"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.14218%2FJCTH.2015.00051","article-title":"Hepatitis C virus, insulin resistance, and steatosis","volume":"4","author":"Kralj D","year":"2016","unstructured":"Kralj D, Juki\u0107 LV, Stojsavljevi\u0107 S, Duvnjak M, Smoli\u0107 M, \u010cur\u010di\u0107 IB. Hepatitis C virus, insulin resistance, and steatosis. J Clin Transl Hepatol. 2016, 4:66-75. 10.14218%2FJCTH.2015.00051","journal-title":"J Clin Transl Hepatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000441","article-title":"The peroxisome proliferator activated receptor-c pioglitazone improves vascular function and decreases disease activity in patients with rheumatoid arthritis","volume":"2","author":"Marder W","year":"2013","unstructured":"Marder W, Khalatbari S, Myles JD, et al.. The peroxisome proliferator activated receptor-c pioglitazone improves vascular function and decreases disease activity in patients with rheumatoid arthritis. J Am Heart Assoc. 2013, 2:e000441. 10.1161\/JAHA.113.000441","journal-title":"J Am Heart Assoc"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01474.x","article-title":"Use of HOMA\u2010IR in hepatitis C","volume":"18","author":"Eslam M","year":"2011","unstructured":"Eslam M, Kawaguchi T, Del Campo J, Sata M, Abo\u2010Elneen Khattab M, Romero\u2010Gomez M. Use of HOMA\u2010IR in hepatitis C. J Viral Hepat. 2011, 18:675-684. 10.1111\/j.1365-2893.2011.01474.x","journal-title":"J Viral Hepat"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1309\/6L34-V3AR-DW39-DH30","article-title":"Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status vs transferrin receptor concentration","volume":"115","author":"Wians Jr FH","year":"2001","unstructured":"Wians Jr FH, Urban JE, Keffer JH, Kroft SH. Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status vs transferrin receptor concentration. Am J Clin Pathol. 2001, 115:112-118. 10.1309\/6L34-V3AR-DW39-DH30","journal-title":"Am J Clin Pathol"},{"key":"ref17","article-title":"Hepcidin levels in Egyptian patients with chronic hepatitis C and the effect of anti-viral therapy","volume":"22","author":"Marzouk HA","year":"2013","unstructured":"Marzouk HA, Zayed NA, Al-Ansary M, et al.. Hepcidin levels in Egyptian patients with chronic hepatitis C and the effect of anti-viral therapy. World Appl Sci J. 2013, 22:1140-1145.","journal-title":"World Appl Sci J"},{"key":"ref18","article-title":"Study of serum hepcidin in patients with chronic hepatitis C","volume":"30","author":"El Lehleh AM","year":"2017","unstructured":"El Lehleh AM, El Shazly RA, Hamza RR. Study of serum hepcidin in patients with chronic hepatitis C. Menoufia Med J. 2017, 30:721.","journal-title":"Menoufia Med J"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13435","article-title":"Insulin regulation of gluconeogenesis","volume":"1411","author":"Hatting M","year":"2018","unstructured":"Hatting M, Tavares CD, Sharabi K, Rines AK, Puigserver P. Insulin regulation of gluconeogenesis. Ann N Y Acad Sci. 2018, 1411:21-35.  10.1111\/nyas.13435","journal-title":"Ann N Y Acad Sci"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i14.1642","article-title":"Relationship between hepatitis C virus infection and type 2 diabetes mellitus: meta-analysis","volume":"18","author":"Naing C","year":"2012","unstructured":"Naing C, Mak JW, Ahmed SI, Maung M. Relationship between hepatitis C virus infection and type 2 diabetes mellitus: meta-analysis. World J Gastroenterol. 2012, 18:1642-1651.  10.3748\/wjg.v18.i14.1642","journal-title":"World J Gastroenterol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.4103\/sjamf.sjamf_59_18","article-title":"Inadequate serum hepcidin levels in chronic hepatitis C infection-induced type 2 diabetes mellitus","volume":"3","author":"Ali ST","year":"2019","unstructured":"Ali ST, Mohamed NA. Inadequate serum hepcidin levels in chronic hepatitis C infection-induced type 2 diabetes mellitus. Sci J Al-Azhar Med Fac Girls. 2019, 3:91. 10.4103\/sjamf.sjamf_59_18","journal-title":"Sci J Al-Azhar Med Fac Girls"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2020.108441","article-title":"Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet","volume":"84","author":"Varghese J","year":"2020","unstructured":"Varghese J, James JV, Anand R, et al.. Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet. J Nutr Biochem. 2020, 84:108441. 10.1016\/j.jnutbio.2020.108441","journal-title":"J Nutr Biochem"},{"key":"ref23","article-title":"Insulin resistance and serum parameters of iron status in type 2 diabetics","volume":"7","author":"Zafar U","year":"2011","unstructured":"Zafar U, Qureshi HJ, Karim A. Insulin resistance and serum parameters of iron status in type 2 diabetics. PJP. 2011, 7:28-31.","journal-title":"PJP"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00152.x","article-title":"Hepatic iron accumulation may be associated with insulin resistance in patients with chronic hepatitis C","volume":"37","author":"Sumida Y","year":"2007","unstructured":"Sumida Y, Kanemasa K, Fukumoto K, Yoshida N, Sakai K. Hepatic iron accumulation may be associated with insulin resistance in patients with chronic hepatitis C. Hepatol Res. 2007, 37:932-940. 10.1111\/j.1872-034X.2007.00152.x","journal-title":"Hepatol Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/45145-insulin-resistance-and-chronic-hepatitis-c-relationship-with-serum-iron-and-hepcidin","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:22:00Z","timestamp":1707506520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/45145-insulin-resistance-and-chronic-hepatitis-c-relationship-with-serum-iron-and-hepcidin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,28]]},"references-count":24,"URL":"https:\/\/doi.org\/10.7759\/cureus.12349","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,28]]}}}