{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:40:52Z","timestamp":1772271652587,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,7]]},"DOI":"10.7759\/cureus.12565","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T01:35:35Z","timestamp":1610069735000},"source":"Crossref","is-referenced-by-count":3,"title":["The AndroCoV Clinical Scoring for COVID-19 Diagnosis: A Prompt, Feasible, Costless, and Highly Sensitive Diagnostic Tool for COVID-19 Based on a 1757-Patient Cohort"],"prefix":"10.7759","author":[{"given":"Flavio  A","family":"Cadegiani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo A","family":"Zimerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Campello de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rute Alves","family":"Pereira e Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Gustavo Wambier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy","family":"Goren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: immunity, inflammation and intervention","volume":"20","author":"Tay MZ","year":"2020","unstructured":"Tay MZ, Poh CM, R\u00e9nia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 2020, 20:363-374. 10.1038\/s41577-020-0311-8","journal-title":"Nat Rev Immunol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-88952\/v1","article-title":"Azithromycin with nitazoxanide, hydroxychloroquine or ivermectin, with or without dutasteride, for early stage COVID- 19: an open-label prospective observational study in males with mild-to-moderate COVID-19 (The Pre-AndroCoV Male Trial) [PREPRINT]","author":"Cadegiani FA","year":"2020","unstructured":"Cadegiani FA, Goren A, Wambier CG, McCoy J. Azithromycin with nitazoxanide, hydroxychloroquine or ivermectin, with or without dutasteride, for early stage COVID- 19: an open-label prospective observational study in males with mild-to-moderate COVID-19 (The Pre-AndroCoV Male Trial) [PREPRINT]. Research Square. 2020, 10.21203\/rs.3.rs-88952\/v1","journal-title":"Research Square"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1101\/2020.10.31.20223883","article-title":"Early COVID-19 therapy with azithromycin plus nitazoxanide, ivermectin or hydroxychloroquine in outpatient settings significantly reduced symptoms compared to known outcomes in untreated patients [PREPRINT]","author":"Cadegiani FA","year":"2020","unstructured":"Cadegiani FA, Goren A, Wambier CG, McCoy J. Early COVID-19 therapy with azithromycin plus nitazoxanide, ivermectin or hydroxychloroquine in outpatient settings significantly reduced symptoms compared to known outcomes in untreated patients [PREPRINT]. medRxiv. 2020, 10.1101\/2020.10.31.20223883","journal-title":"medRxiv"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1101\/2020.10.05.20206870","article-title":"An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV female trial [PREPRINT]","author":"Cadegiani FA","year":"2020","unstructured":"Cadegiani FA, Goren A, Wambier CG, McCoy J. An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV female trial [PREPRINT]. medRxiv. 2020, 10.1101\/2020.10.05.20206870","journal-title":"medRxiv"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-98106\/v1","article-title":"Hydroxychloroquine, nitazoxanide and ivermectin have similar effects in early COVID- 19: a head-to-head comparison of the Pre-AndroCoV trial","author":"Cadegiani FA","year":"2020","unstructured":"Cadegiani FA, Goren A, McCoy J, et al.. Hydroxychloroquine, nitazoxanide and ivermectin have similar effects in early COVID- 19: a head-to-head comparison of the Pre-AndroCoV trial. Research Square. 2020, 10.21203\/rs.3.rs-98106\/v1","journal-title":"Research Square"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-020-00626-0","article-title":"Repurposing existing drugs for COVID-19: an endocrinology perspective","volume":"29","author":"Cadegiani FA","year":"2020","unstructured":"Cadegiani FA. Repurposing existing drugs for COVID-19: an endocrinology perspective. BMC Endocr Disord. 2020, 29:149. 10.1186\/s12902-020-00626-0","journal-title":"BMC Endocr Disord"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00453","article-title":"Spironolactone: an anti-androgenic and anti-hypertensive drug that may provide protection against the novel coronavirus (SARS-CoV-2) induced acute respiratory distress syndrome (ARDS) in COVID-19","volume":"28","author":"Cadegiani FA","year":"2020","unstructured":"Cadegiani FA, Wambier CG, Goren A. Spironolactone: an anti-androgenic and anti-hypertensive drug that may provide protection against the novel coronavirus (SARS-CoV-2) induced acute respiratory distress syndrome (ARDS) in COVID-19. Front Med (Lausanne). 2020, 28:453. 10.3389\/fmed.2020.00453","journal-title":"Front Med (Lausanne)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.110112","article-title":"Spironolactone may provide protection from SARS-CoV-2: targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS)","volume":"16","author":"Cadegiani FA","year":"2020","unstructured":"Cadegiani FA, Goren A, Wambier CG. Spironolactone may provide protection from SARS-CoV-2: targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS). Med Hypotheses. 2020, 16:110112. 10.1016\/j.mehy.2020.110112","journal-title":"Med Hypotheses"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2020.07.011","article-title":"Systematic review with meta-analysis of the accuracy of diagnostic tests for COVID-19","volume":"49","author":"B\u00f6ger B","year":"2020","unstructured":"B\u00f6ger B, Fachi MM, Vilhena RO, Cobre AF, Tonin FS, Pontarolo R. Systematic review with meta-analysis of the accuracy of diagnostic tests for COVID-19. Am J Infect Control. 2020, 49:21-29. 10.1016\/j.ajic.2020.07.011","journal-title":"Am J Infect Control"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26211","article-title":"Diagnostic efficacy of anti-SARS-CoV-2 IgG\/IgM test for COVID- 19: a meta-analysis","volume":"93","author":"Zhang ZL","year":"2021","unstructured":"Zhang ZL, Hou YL, Li DT, Li FZ. Diagnostic efficacy of anti-SARS-CoV-2 IgG\/IgM test for COVID- 19: a meta-analysis. J Med Virol. 2021, 93:366-374. 10.1002\/jmv.26211","journal-title":"J Med Virol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.10.003","article-title":"Specificity and positive predictive value of SARS-CoV-2 nucleic acid amplification testing in a low-prevalence setting","volume":"743","author":"Skittrall JP","year":"2020","unstructured":"Skittrall JP, Wilson M, Smielewska AA, et al.. Specificity and positive predictive value of SARS-CoV-2 nucleic acid amplification testing in a low-prevalence setting. Clin Microbiol Infect. 2020, 743:30614-30615. 10.1016\/j.cmi.2020.10.003","journal-title":"Clin Microbiol Infect"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00324-2020","article-title":"False-negative RT-PCR in SARS-CoV-2 disease: experience from an Italian COVID-19 unit","volume":"6","author":"Di Paolo M","year":"2020","unstructured":"Di Paolo M, Iacovelli A, Olmati F, et al.. False-negative RT-PCR in SARS-CoV-2 disease: experience from an Italian COVID-19 unit. ERJ Open Res. 2020, 6:324. 10.1183\/23120541.00324-2020","journal-title":"ERJ Open Res"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.radi.2020.09.012","article-title":"Typical CT findings of COVID-19 pneumonia in patients presenting with repetitive negative RT-PCR","volume":"[Epub ahead of print]","author":"Brogna B","year":"2020","unstructured":"Brogna B, Bignardi E, Brogna C, et al.. Typical CT findings of COVID-19 pneumonia in patients presenting with repetitive negative RT-PCR. Radiography (Lond). 2020, [Epub ahead of print]:10.1016\/j.radi.2020.09.012","journal-title":"Radiography (Lond)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.3786","article-title":"Detection of SARS-CoV-2 in different types of clinical specimens","volume":"12","author":"Wang W","year":"2020","unstructured":"Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, Tan W. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020, 12:1843-1844. 10.1001\/jama.2020.3786","journal-title":"JAMA"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9942","article-title":"Positive chest CT features in patients with COVID-19 pneumonia and negative real-time polymerase chain reaction test","volume":"12","author":"Pakdemirli E","year":"2020","unstructured":"Pakdemirli E, Mandalia U, Monib S. Positive chest CT features in patients with COVID-19 pneumonia and negative real-time polymerase chain reaction test. Cureus. 2020, 12: e9942.  10.7759\/cureus.9942","journal-title":"Cureus"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2015897","article-title":"False negative tests for SARS-CoV-2 infection - challenges and implications","volume":"6","author":"Woloshin S","year":"2020","unstructured":"Woloshin S, Patel N, Kesselheim AS. False negative tests for SARS-CoV-2 infection - challenges and implications. N Engl J Med. 2020, 6:38. 10.1056\/NEJMp2015897","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1101\/2020.05.03.20089151","article-title":"Occurrence and timing of subsequent SARS-CoV-2 RT-PCR positivity among initially negative patients [PREPRINT]","author":"Long DR","year":"2020","unstructured":"Long DR, Gombar S, Hogan CA, et al.. Occurrence and timing of subsequent SARS-CoV-2 RT-PCR positivity among initially negative patients [PREPRINT]. medRxiv. 2020, 10.1101\/2020.05.03.20089151","journal-title":"medRxiv"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-020-00273-8","article-title":"Discrimination of false negative results in RT-PCR detection of SARS-CoV-2 RNAs in clinical specimens by using an internal reference","volume":"4","author":"Zhang Y","year":"2020","unstructured":"Zhang Y, Wang C, Han M, et al.. Discrimination of false negative results in RT-PCR detection of SARS-CoV-2 RNAs in clinical specimens by using an internal reference. Virol Sin. 2020, 4:1-10. 10.1007\/s12250-020-00273-8","journal-title":"Virol Sin"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16956","article-title":"Androgen receptor genetic variant predicts COVID-19 disease severity: a prospective longitudinal study of hospitalized COVID-19 male patients","volume":"[Epub ahead of print]","author":"McCoy J","year":"2020","unstructured":"McCoy J, Wambier CG, Herrera S, et al.. Androgen receptor genetic variant predicts COVID-19 disease severity: a prospective longitudinal study of hospitalized COVID-19 male patients. J Eur Acad Dermatol Venereol. 2020, [Epub ahead of print]:10.1111\/jdv.16956","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/der2.50","article-title":"COVID\u201019, androgens, and androgenic alopecia","volume":"[Epub ahead of print]","author":"Wambier CG","year":"2020","unstructured":"Wambier CG, Mehta N, Goren A, Cadegiani FA. COVID\u201019, androgens, and androgenic alopecia. Dermatological Reviews. 2020, [Epub ahead of print]:10.1002\/der2.50","journal-title":"Dermatological Reviews"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.07.099","article-title":"Androgenetic alopecia in COVID- 19: compared to age-matched epidemiologic studies and hospital outcomes with or without the Gabrin sign","volume":"83","author":"Wambier CG","year":"2020","unstructured":"Wambier CG, Van\u0303o-Galva\u0301n S, McCoy J, Pai S, Dhurat R, Goren A. Androgenetic alopecia in COVID- 19: compared to age-matched epidemiologic studies and hospital outcomes with or without the Gabrin sign. J Am Acad Dermatol. 2020, 83:453-454. 10.1016\/j.jaad.2020.07.099","journal-title":"J Am Acad Dermatol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17004","article-title":"Clinical symptoms of hyperandrogenic women diagnosed with COVID-19","volume":"[Epub ahead of print]","author":"Cadegiani FA","year":"2020","unstructured":"Cadegiani FA, Lim RK, Goren A, et al.. Clinical symptoms of hyperandrogenic women diagnosed with COVID-19. J Eur Acad Dermatol Venereol. 2020, [Epub ahead of print]:10.1111\/jdv.17004","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-135219\/v2","article-title":"Clinical diagnosis of COVID-19: a prompt, feasible, costless, and highly sensitive diagnostic tool for COVID-19 based on a 1,757-patient cohort (the AndroCoV clinical scoring for COVID-19 diagnosis) [PREPRINT]","author":"Cadegiani F","year":"2020","unstructured":"Cadegiani F, Alves Pereira R, Zimerman RA, de Souza BC, McCoy J, Wambier CG, Goren A. Clinical diagnosis of COVID-19: a prompt, feasible, costless, and highly sensitive diagnostic tool for COVID-19 based on a 1,757-patient cohort (the AndroCoV clinical scoring for COVID-19 diagnosis) [PREPRINT]. Research Square. 2020, 10.21203\/rs.3.rs-135219\/v2","journal-title":"Research Square"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2020.06.009","article-title":"A predictive score for COVID-19 diagnosis using clinical, laboratory and chest image data","volume":"24","author":"Vieceli T","year":"2020","unstructured":"Vieceli T, Oliveira Filho CM, Berger M, et al.. A predictive score for COVID-19 diagnosis using clinical, laboratory and chest image data. Braz J Infect Dis. 2020, 24:343-348. 10.1016\/j.bjid.2020.06.009","journal-title":"Braz J Infect Dis"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2174\/1874944502013010413","article-title":"Scoring system for the diagnosis of COVID-19","volume":"13","author":"Allam MF","year":"2020","unstructured":"Allam MF. Scoring system for the diagnosis of COVID-19. 2020, 13:413-414. 10.2174\/1874944502013010413"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2016.05.012","article-title":"Three-day regimen of oseltamivir for postexposure prophylaxis of influenza in wards","volume":"94","author":"Ishiguro N","year":"2016","unstructured":"Ishiguro N, Oyamada R, Nasuhara Y, et al.. Three-day regimen of oseltamivir for postexposure prophylaxis of influenza in wards. J Hosp Infect. 2016, 94:150-153. 10.1016\/j.jhin.2016.05.012","journal-title":"J Hosp Infect"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/49445-the-androcov-clinical-scoring-for-covid-19-diagnosis-a-prompt-feasible-costless-and-highly-sensitive-diagnostic-tool-for-covid-19-based-on-a-1757-patient-cohort","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T14:32:06Z","timestamp":1707489126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/49445-the-androcov-clinical-scoring-for-covid-19-diagnosis-a-prompt-feasible-costless-and-highly-sensitive-diagnostic-tool-for-covid-19-based-on-a-1757-patient-cohort"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,7]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.12565","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.12.23.20248803","asserted-by":"object"}]},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1,7]]}}}