{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:07:53Z","timestamp":1789459673002,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,5]]},"DOI":"10.7759\/cureus.14306","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T15:13:38Z","timestamp":1617635618000},"source":"Crossref","is-referenced-by-count":8,"title":["Role of Prucalopride in Treating Functional Constipation and Gastroparesis: A Systemic Review"],"prefix":"10.7759","author":[{"given":"Hassam","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Pamarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiza","family":"Sarfraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.423","article-title":"Inpatient burden of constipation in the United States: an analysis of national trends in the United States from 1997 to 2010","volume":"109","author":"Sethi S","year":"2014","unstructured":"Sethi S, Mikami S, Leclair J, et al.. Inpatient burden of constipation in the United States: an analysis of national trends in the United States from 1997 to 2010. Am J Gastroenterol. 2014, 109:250-6. 10.1038\/ajg.2013.423","journal-title":"Am J Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"Longstreth GF","year":"2006","unstructured":"Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology. 2006, 130:1480-91. 10.1053\/j.gastro.2005.11.061","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel disorders","volume":"150","author":"Mearin F","year":"2016","unstructured":"Mearin F, Lacy BE, Chang L, Chey WD, Lembo AJ, Simren M, Spiller R. Bowel disorders. Gastroenterology. 2016, 150:P1393-1407.E5. 10.1053\/j.gastro.2016.02.031","journal-title":"Gastroenterology"},{"key":"ref4","article-title":"Constipation in an elderly community: a study of prevalence and potential risk factors","volume":"91","author":"Talley NJ","year":"1996","unstructured":"Talley NJ, Fleming KC, Evans JM, O'Keefe EA, Weaver AL, Zinsmeister AR, Melton LJ 3rd. Constipation in an elderly community: a study of prevalence and potential risk factors. Am J Gastroenterol. 1996, 91:19-25.","journal-title":"Am J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.80.2.185","article-title":"Demographic and dietary determinants of constipation in the US population","volume":"80","author":"Sandler RS","year":"1990","unstructured":"Sandler RS, Jordan MC, Shelton BJ. Demographic and dietary determinants of constipation in the US population. Am J Public Health. 1990, 80:185-9. 10.2105\/ajph.80.2.185","journal-title":"Am J Public Health"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90175-x","article-title":"Prevalence of gastrointestinal symptoms in the elderly: a population-based study","volume":"102","author":"Talley NJ","year":"1992","unstructured":"Talley NJ, O'Keefe EA, Zinsmeister AR, Melton LJ III. Prevalence of gastrointestinal symptoms in the elderly: a population-based study. Gastroenterology. 1992, 102:895-901. 10.1016\/0016-5085(92)90175-x","journal-title":"Gastroenterology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.187","article-title":"American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation","volume":"109","author":"Ford AC","year":"2014","unstructured":"Ford AC, Moayyedi P, Lacy BE, et al.. American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol. 2014, 109:S2-26. 10.1038\/ajg.2014.187","journal-title":"Am J Gastroenterol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13958","article-title":"Prucalopride in diabetic and connective tissue disease-related gastroparesis: randomized placebo-controlled crossover pilot trial","volume":"33","author":"Andrews CN","year":"2021","unstructured":"Andrews CN, Woo M, Buresi M, et al.. Prucalopride in diabetic and connective tissue disease-related gastroparesis: randomized placebo-controlled crossover pilot trial. Neurogastroenterol Motil. 2021, 33:e13958. 10.1111\/nmo.13958","journal-title":"Neurogastroenterol Motil"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01059.x","article-title":"5-HT4 receptor agonists: similar but not the same","volume":"20","author":"De Maeyer JH","year":"2008","unstructured":"De Maeyer JH, Lefebvre RA, Schuurkes JA. 5-HT4 receptor agonists: similar but not the same. Neurogastroenterol Motil. 2008, 20:99-112. 10.1111\/j.1365-2982.2007.01059.x","journal-title":"Neurogastroenterol Motil"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(01)01087-1","article-title":"The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound","volume":"423","author":"Briejer MR","year":"2001","unstructured":"Briejer MR, Bosmans JP, Van Daele P, et al.. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001, 423:71-83. 10.1016\/s0014-2999(01)01087-1","journal-title":"Eur J Pharmacol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.12.020","article-title":"The facilitating effect of prucalopride on cholinergic neurotransmission in pig gastric circular muscle is regulated by phosphodiesterase 4","volume":"62","author":"Priem E","year":"2012","unstructured":"Priem E, Van Colen I, De Maeyer JH, Lefebvre RA. The facilitating effect of prucalopride on cholinergic neurotransmission in pig gastric circular muscle is regulated by phosphodiesterase 4. Neuropharmacology. 2012, 62:2126-35. 10.1016\/j.neuropharm.2011.12.020","journal-title":"Neuropharmacology"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2001.00280.x","article-title":"Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs","volume":"13","author":"Briejer MR","year":"2001","unstructured":"Briejer MR, Prins NH, Schuurkes JA. Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs. Neurogastroenterol Motil. 2001, 13:465-72. 10.1046\/j.1365-2982.2001.00280.x","journal-title":"Neurogastroenterol Motil"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088064","article-title":"Anorectal manometric abnormalities and colonic propulsive impairment in patients with severe chronic idiopathic constipation","volume":"39","author":"Bassotti G","year":"1994","unstructured":"Bassotti G, Chiarioni G, Vantini I, Betti C, Fusaro C, Pelli MA, Morelli A. Anorectal manometric abnormalities and colonic propulsive impairment in patients with severe chronic idiopathic constipation. Dig Dis Sci. 1994, 39:1558-64. 10.1007\/BF02088064","journal-title":"Dig Dis Sci"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.682","article-title":"Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans","volume":"44","author":"Bouras EP","year":"1999","unstructured":"Bouras EP, Camilleri M, Burton DD, McKinzie S. Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans. Gut. 1999, 44:682-6. 10.1136\/gut.44.5.682","journal-title":"Gut"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21166","article-title":"Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder","volume":"120","author":"Bouras EP","year":"2001","unstructured":"Bouras EP, Camilleri M, Burton DD, Thomforde G, McKinzie S, Zinsmeister AR. Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder. Gastroenterology. 2001, 120:354-60. 10.1053\/gast.2001.21166","journal-title":"Gastroenterology"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.076869","article-title":"Electrophysiological effects of prucalopride, a novel enterokinetic agent, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists","volume":"313","author":"Pau D","year":"2005","unstructured":"Pau D, Workman AJ, Kane KA, Rankin AC. Electrophysiological effects of prucalopride, a novel enterokinetic agent, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists. J Pharmacol Exp Ther. 2005, 313:146-53. 10.1124\/jpet.104.076869","journal-title":"J Pharmacol Exp Ther"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01533.x","article-title":"A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation","volume":"22","author":"M\u00fcller-Lissner S","year":"2010","unstructured":"M\u00fcller-Lissner S, Rykx A, Kerstens R, Vandeplassche L. A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation. Neurogastroenterol Motil. 2010, 22:991-8, e255. 10.1111\/j.1365-2982.2010.01533.x","journal-title":"Neurogastroenterol Motil"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01983.x","article-title":"Prucalopride in the treatment of chronic constipation in patients from the Asia-Pacific region: a randomized, double-blind, placebo-controlled study","volume":"24","author":"Ke M","year":"2012","unstructured":"Ke M, Zou D, Yuan Y, et al.. Prucalopride in the treatment of chronic constipation in patients from the Asia-Pacific region: a randomized, double-blind, placebo-controlled study. Neurogastroenterol Motil. 2012, 24:999-e541. 10.1111\/j.1365-2982.2012.01983.x","journal-title":"Neurogastroenterol Motil"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.115","article-title":"A randomized, double-blind, placebo-controlled, phase 3 trial to evaluate the efficacy, safety, and tolerability of prucalopride in men with chronic constipation","volume":"110","author":"Yiannakou Y","year":"2015","unstructured":"Yiannakou Y, Piessevaux H, Bouchoucha M, et al.. A randomized, double-blind, placebo-controlled, phase 3 trial to evaluate the efficacy, safety, and tolerability of prucalopride in men with chronic constipation. Am J Gastroenterol. 2015, 110:741-8. 10.1038\/ajg.2015.115","journal-title":"Am J Gastroenterol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03884.x","article-title":"Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study","volume":"29","author":"Quigley EM","year":"2009","unstructured":"Quigley EM, Vandeplassche L, Kerstens R, Ausma J. Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2009, 29:315-28. 10.1111\/j.1365-2036.2008.03884.x","journal-title":"Aliment Pharmacol Ther"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800670","article-title":"A placebo-controlled trial of prucalopride for severe chronic constipation","volume":"358","author":"Camilleri M","year":"2008","unstructured":"Camilleri M, Kerstens R, Rykx A, Vandeplassche L. A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med. 2008, 358:2344-54. 10.1056\/NEJMoa0800670","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.162404","article-title":"Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives","volume":"58","author":"Tack J","year":"2009","unstructured":"Tack J, van Outryve M, Beyens G, Kerstens R, Vandeplassche L. Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives. Gut. 2009, 58:357-65. 10.1136\/gut.2008.162404","journal-title":"Gut"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12217","article-title":"Effect of prucalopride on symptoms of chronic constipation","volume":"26","author":"Tack J","year":"2014","unstructured":"Tack J, Stanghellini V, Dubois D, Joseph A, Vandeplassche L, Kerstens R. Effect of prucalopride on symptoms of chronic constipation. Neurogastroenterol Motil. 2014, 26:21-7. 10.1111\/nmo.12217","journal-title":"Neurogastroenterol Motil"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12553","article-title":"A randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of long-term treatment with prucalopride","volume":"27","author":"Piessevaux H","year":"2015","unstructured":"Piessevaux H, Corazziari E, Rey E, et al.. A randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of long-term treatment with prucalopride. Neurogastroenterol Motil. 2015, 27:805-15. 10.1111\/nmo.12553","journal-title":"Neurogastroenterol Motil"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000304","article-title":"Prucalopride in gastroparesis: a randomized placebo-controlled crossover study","volume":"114","author":"Carbone F","year":"2019","unstructured":"Carbone F, Van den Houte K, Clevers E, et al.. Prucalopride in gastroparesis: a randomized placebo-controlled crossover study. Am J Gastroenterol. 2019, 114:1265-1274. 10.14309\/ajg.0000000000000304","journal-title":"Am J Gastroenterol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4147-9","article-title":"Efficacy and safety of prucalopride in chronic constipation: an integrated analysis of six randomized, controlled clinical trials","volume":"61","author":"Camilleri M","year":"2016","unstructured":"Camilleri M, Piessevaux H, Yiannakou Y, et al.. Efficacy and safety of prucalopride in chronic constipation: an integrated analysis of six randomized, controlled clinical trials. Dig Dis Sci. 2016, 61:2357-2372. 10.1007\/s10620-016-4147-9","journal-title":"Dig Dis Sci"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/55806-role-of-prucalopride-in-treating-functional-constipation-and-gastroparesis-a-systemic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:31:22Z","timestamp":1707507082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/55806-role-of-prucalopride-in-treating-functional-constipation-and-gastroparesis-a-systemic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,5]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.14306","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4,5]]}}}