{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:42:00Z","timestamp":1782258120977,"version":"3.54.5"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,7]]},"DOI":"10.7759\/cureus.14883","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T10:07:58Z","timestamp":1620382078000},"source":"Crossref","is-referenced-by-count":6,"title":["Study of Single Nucleotide Polymorphisms in Endosomal Toll-Like Receptors-3, 7, and 9 Genes in Patients With Dengue: A Case-Control Study"],"prefix":"10.7759","author":[{"given":"Arvind K","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanu","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra Kumar","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268811002500","article-title":"Dengue: a newly emerging viral infection in Andaman and Nicobar Islands, India","volume":"140","author":"Chaaithanya IK","year":"2012","unstructured":"Chaaithanya IK, Bhattacharya D, Muruganandam N, et al.. Dengue: a newly emerging viral infection in Andaman and Nicobar Islands, India. Epidemiol Infect. 2012, 140:1920-4. 10.1017\/S0950268811002500","journal-title":"Epidemiol Infect"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02288-0","article-title":"Epidemic dengue\/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century","volume":"10","author":"Gubler DJ","year":"2002","unstructured":"Gubler DJ. Epidemic dengue\/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002, 10:100-3. 10.1016\/S0966-842X(01)02288-0","journal-title":"Trends Microbiol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2011.02.001","article-title":"Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses","volume":"22","author":"Yu M","year":"2011","unstructured":"Yu M, Levine SJ. Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses. Cytokine Growth Factor Rev. 2011, 22:63-72. 10.1016\/j.cytogfr.2011.02.001","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2010.090122","article-title":"A real-time PCR assay for the simultaneous detection of functional N284I and L412F polymorphisms in the human Toll-like receptor 3 gene","volume":"12","author":"Brown RA","year":"2010","unstructured":"Brown RA, Razonable RR. A real-time PCR assay for the simultaneous detection of functional N284I and L412F polymorphisms in the human Toll-like receptor 3 gene. J Mol Diagn. 2010, 12:493-7. 10.2353\/jmoldx.2010.090122","journal-title":"J Mol Diagn"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001680","article-title":"Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants","volume":"32","author":"Beima-Sofie K","year":"2018","unstructured":"Beima-Sofie K, Wamalwa D, Maleche-Obimbo E, et al.. Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants. AIDS. 2018, 32:267-70. 10.1097\/QAD.0000000000001680","journal-title":"AIDS"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0644","article-title":"Association of toll-like receptor 3 and toll-like receptor 9 single nucleotide polymorphisms with hepatitis C virus infection and hepatic fibrosis in egyptian patients","volume":"96","author":"Zayed RA","year":"2017","unstructured":"Zayed RA, Omran D, Mokhtar DA, et al.. Association of toll-like receptor 3 and toll-like receptor 9 single nucleotide polymorphisms with hepatitis C virus infection and hepatic fibrosis in egyptian patients. Am J Trop Med Hyg. 2017, 96:720-6. 10.4269\/ajtmh.16-0644","journal-title":"Am J Trop Med Hyg"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283629117","article-title":"Toll-like receptor variants are associated with infant HIV-1 acquisition and peak plasma HIV-1 RNA level","volume":"27","author":"Beima-Sofie KM","year":"2013","unstructured":"Beima-Sofie KM, Bigham AW, Lingappa JR, et al.. Toll-like receptor variants are associated with infant HIV-1 acquisition and peak plasma HIV-1 RNA level. AIDS. 2013, 27:2431-9. 10.1097\/QAD.0b013e3283629117","journal-title":"AIDS"},{"key":"ref8","unstructured":"World Health Organization, Special Programme for Research, Training in Tropical Diseases, World Health Organization. Department of Control of Neglected Tropical Diseases, World Health Organization. Epidemic and Pandemic Alert, 2009. Dengue. guidelines for diagnosis, treatment, prevention and control. World Health Organization. (2013). Accessed: 01.03.2013: https:\/\/www.who.int\/tdr\/publications\/documents\/dengue-diagnosis.pdf."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2147\/BSAM.S46573","article-title":"Methods for extracting genomic DNA from whole blood samples: current perspectives","volume":"2","author":"Chacon-Cortes D","year":"2014","unstructured":"Chacon-Cortes D, Griffiths L. Methods for extracting genomic DNA from whole blood samples: current perspectives. J Biorepository Sci Appl Med. 2014, 2:1-9. 10.2147\/BSAM.S46573","journal-title":"J Biorepository Sci Appl Med"},{"key":"ref10","unstructured":"BioEdit. (2015). Accessed. 15.03.2015: http:\/\/available at: http:\/\/www.mbio.ncsu.edu\/ BioEdit\/."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/13550280802298120","article-title":"Association of toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis","volume":"14","author":"Ishizaki Y","year":"2008","unstructured":"Ishizaki Y, Takemoto M, Kira R, et al.. Association of toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis. J Neurovirol. 2008, 14:486-91. 10.1080\/13550280802298120","journal-title":"J Neurovirol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023346","article-title":"Activation of toll-like receptor 3 impairs the dengue virus serotype 2 replication through induction of IFN-\u03b2 in cultured hepatoma cells","volume":"6","author":"Liang Z","year":"2011","unstructured":"Liang Z, Wu S, Li Y, et al.. Activation of toll-like receptor 3 impairs the dengue virus serotype 2 replication through induction of IFN-\u03b2 in cultured hepatoma cells. PLoS One. 2011, 6:e23346. 10.1371\/journal.pone.0023346","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019323","article-title":"Decreased dengue replication and an increased anti-viral humoral response with the use of combined Toll-like receptor 3 and 7\/8 agonists in macaques","volume":"6","author":"Sariol CA","year":"2011","unstructured":"Sariol CA, Mart\u00ednez MI, Rivera F, et al.. Decreased dengue replication and an increased anti-viral humoral response with the use of combined Toll-like receptor 3 and 7\/8 agonists in macaques. PLoS One. 2011, 6:e19323. 10.1371\/journal.pone.0019323","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2014.09.020","article-title":"Polymorphisms in RNA sensing toll like receptor genes and its association with clinical outcomes of dengue virus infection","volume":"220","author":"Alagarasu K","year":"2015","unstructured":"Alagarasu K, Bachal RV, Memane RS, et al.. Polymorphisms in RNA sensing toll like receptor genes and its association with clinical outcomes of dengue virus infection. Immunobiology. 2015, 220:164-8. 10.1016\/j.imbio.2014.09.020","journal-title":"Immunobiology"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.07.010","article-title":"Toll-like receptor-3 gene polymorphism in patients with Japanese encephalitis","volume":"286","author":"Biyani S","year":"2015","unstructured":"Biyani S, Garg RK, Jain A, et al.. Toll-like receptor-3 gene polymorphism in patients with Japanese encephalitis. J Neuroimmunol. 2015, 286:71-6. 10.1016\/j.jneuroim.2015.07.010","journal-title":"J Neuroimmunol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq082","article-title":"A functional toll-like receptor 3 gene (TLR3) may be a risk factor for tick-borne encephalitis virus (TBEV) infection","volume":"203","author":"Kindberg E","year":"2011","unstructured":"Kindberg E, Vene S, Mickiene A, et al.. A functional toll-like receptor 3 gene (TLR3) may be a risk factor for tick-borne encephalitis virus (TBEV) infection. J Infect Dis. 2011, 203:523-8. 10.1093\/infdis\/jiq082","journal-title":"J Infect Dis"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03270.x","article-title":"A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages","volume":"131","author":"Zhou Y","year":"2010","unstructured":"Zhou Y, Wang X, Liu M, et al.. A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages. Immunology. 2010, 131:40-9. 10.1111\/j.1365-2567.2010.03270.x","journal-title":"Immunology"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.042572-0","article-title":"Polymorphisms in Toll-like receptor 3 confer natural resistance to human herpes simplex virus type 2 infection","volume":"93","author":"Svensson A","year":"2012","unstructured":"Svensson A, Tunb\u00e4ck P, Nordstr\u00f6m I, et al.. Polymorphisms in Toll-like receptor 3 confer natural resistance to human herpes simplex virus type 2 infection. J Gen Virol. 2012, 93:1717-24. 10.1099\/vir.0.042572-0","journal-title":"J Gen Virol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/57983-study-of-single-nucleotide-polymorphisms-in-endosomal-toll-like-receptors-3-7-and-9-genes-in-patients-with-dengue-a-case-control-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:33:11Z","timestamp":1707507191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/57983-study-of-single-nucleotide-polymorphisms-in-endosomal-toll-like-receptors-3-7-and-9-genes-in-patients-with-dengue-a-case-control-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,7]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.14883","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,7]]}}}