{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:39:40Z","timestamp":1761514780298},"reference-count":22,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,27]]},"DOI":"10.7759\/cureus.15950","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T07:01:05Z","timestamp":1624777265000},"source":"Crossref","is-referenced-by-count":2,"title":["Complicated Brucellosis With Multisystem Involvement: Two Case Reports"],"prefix":"10.7759","author":[{"given":"Irfan","family":"Varikkodan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vamanjore A","family":"Naushad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishan K","family":"Purayil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Mathew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farooq M","family":"Alrawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70382-6","article-title":"The new global map of human brucellosis","volume":"6","author":"Pappas G","year":"2006","unstructured":"Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis. 2006, 6:91-9. 10.1016\/S1473-3099(06)70382-6","journal-title":"Lancet Infect Dis"},{"key":"ref2","article-title":"Natural history of brucellosis in an endemic region in different time periods","volume":"48","author":"Bosilkovski M","year":"2009","unstructured":"Bosilkovski M, Dimzova M, Grozdanovski K. Natural history of brucellosis in an endemic region in different time periods. Acta Clin Croat. 2009, 48:41-6.","journal-title":"Acta Clin Croat"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2003.44.1.33","article-title":"Complications of brucellosis in different age groups: a study of 283 cases in southeastern Anatolia of Turkey","volume":"44","author":"G\u00fcr A","year":"2003","unstructured":"G\u00fcr A, Geyik MF, Dikici B, Nas K, Cevik R, Sarac J, Hosoglu S. Complications of brucellosis in different age groups: a study of 283 cases in southeastern Anatolia of Turkey. Yonsei Med J. 2003, 44:33-44. 10.3349\/ymj.2003.44.1.33","journal-title":"Yonsei Med J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2005.10.011","article-title":"Acute brucellosis: presentation, diagnosis, and treatment of 144 cases","volume":"11","author":"Andriopoulos P","year":"2007","unstructured":"Andriopoulos P, Tsironi M, Deftereos S, Aessopos A, Assimakopoulos G. Acute brucellosis: presentation, diagnosis, and treatment of 144 cases. Int J Infect Dis. 2007, 11:52-7. 10.1016\/j.ijid.2005.10.011","journal-title":"Int J Infect Dis"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2010.51.327","article-title":"Human brucellosis in Macedonia - 10 years of clinical experience in endemic region","volume":"51","author":"Bosilkovski M","year":"2010","unstructured":"Bosilkovski M, Krteva L, Dimzova M, Vidinic I, Sopova Z, Spasovska K. Human brucellosis in Macedonia - 10 years of clinical experience in endemic region. Croat Med J. 2010, 51:327-36. 10.3325\/cmj.2010.51.327","journal-title":"Croat Med J"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199607000-00003","article-title":"Complications associated with Brucella melitensis infection: a study of 530 cases","volume":"75","author":"Colmenero JD","year":"1996","unstructured":"Colmenero JD, Reguera JM, Martos F, et al.. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine. 1996, 75:195-211. 10.1097\/00005792-199607000-00003","journal-title":"Medicine"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.04.002","article-title":"A comparative analysis of tuberculous, brucellar and pyogenic spontaneous spondylodiscitis patients","volume":"55","author":"Turunc T","year":"2007","unstructured":"Turunc T, Demiroglu YZ, Uncu H, Colakoglu S, Arslan H. A comparative analysis of tuberculous, brucellar and pyogenic spontaneous spondylodiscitis patients. J Infect. 2007, 55:158-63. 10.1016\/j.jinf.2007.04.002","journal-title":"J Infect"},{"key":"ref8","article-title":"Osteoarticular involvement in brucellosis: study of 196 cases in the Republic of Macedonia","volume":"45","author":"Bosilkovski M","year":"2004","unstructured":"Bosilkovski M, Krteva L, Caparoska S, Dimzova M. Osteoarticular involvement in brucellosis: study of 196 cases in the Republic of Macedonia. Croat Med J. 2004, 45:727-33.","journal-title":"Croat Med J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12351","article-title":"Update on treatment options for spinal brucellosis","volume":"20","author":"Ulu-Kilic A","year":"2014","unstructured":"Ulu-Kilic A, Karakas A, Erdem H, et al.. Update on treatment options for spinal brucellosis. Clin Microbiol Infect. 2014, 20:O75-82. 10.1111\/1469-0691.12351","journal-title":"Clin Microbiol Infect"},{"key":"ref10","article-title":"Osteoarticular complications of brucellosis in an Atlantic area of Spain","volume":"26","author":"Gonz\u00e1lez-Gay MA","year":"1999","unstructured":"Gonz\u00e1lez-Gay MA, Garc\u00eda-Porr\u00faa C, Iba\u00f1ez D, Garc\u00eda-Pa\u00eds MJ. Osteoarticular complications of brucellosis in an Atlantic area of Spain. J Rheumatol. 1999, 26:141-5.","journal-title":"J Rheumatol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/ard.49.12.994","article-title":"Brucella arthritis: a study of 96 cases in Kuwait","volume":"49","author":"Khateeb MI","year":"1990","unstructured":"Khateeb MI, Araj GF, Majeed SA, Lulu AR. Brucella arthritis: a study of 96 cases in Kuwait. Ann Rheum Dis. 1990, 49:994-8. 10.1136\/ard.49.12.994","journal-title":"Ann Rheum Dis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.09.027","article-title":"Spinal brucellosis in South of Tunisia: review of 32 cases","volume":"14","author":"Koubaa M","year":"2014","unstructured":"Koubaa M, Maaloul I, Marrakchi C, et al.. Spinal brucellosis in South of Tunisia: review of 32 cases. Spine J. 2014, 14:1538-44. 10.1016\/j.spinee.2013.09.027","journal-title":"Spine J"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/BF01704893","article-title":"Clinical course and prognosis of Brucella spondylitis","volume":"20","author":"Colmenero JD","year":"1992","unstructured":"Colmenero JD, Cisneros JM, Orjuela DL, Pach\u00f3n J, Garcia-Portales R, Rodriguez-Sampedro F, Juarez C. Clinical course and prognosis of Brucella spondylitis. Infection. 1992, 20:38-42. 10.1007\/BF01704893","journal-title":"Infection"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcm100","article-title":"Spinal epidural abscess in clinical practice","volume":"101","author":"Sendi P","year":"2008","unstructured":"Sendi P, Bregenzer T, Zimmerli W. Spinal epidural abscess in clinical practice. QJM. 2008, 101:1-12. 10.1093\/qjmed\/hcm100","journal-title":"QJM"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3602","article-title":"Diagnosing pyogenic, brucella and tuberculous spondylitis using histopathology and MRI: a retrospective study","volume":"12","author":"Li T","year":"2016","unstructured":"Li T, Liu T, Jiang Z, Cui X, Sun J. Diagnosing pyogenic, brucella and tuberculous spondylitis using histopathology and MRI: a retrospective study. Exp Ther Med. 2016, 12:2069-77. 10.3892\/etm.2016.3602","journal-title":"Exp Ther Med"},{"key":"ref16","unstructured":"Joint Food and Agriculture Organization (FAO), World Health Organization (WHO). FAO-WHO expert committee on brucellosis (Sixth report). WHO technical report series, no 740. (1986).  https.\/\/apps.who.int\/iris\/handle\/10665\/40202."},{"key":"ref17","article-title":"Brucella species","author":"Young EJ","year":"2005","unstructured":"Young EJ. Brucella species. Principles and practice of infectious diseases, vol 2. Mandell, GL, Bennett, JE, Dolin R (ed): Churchill Livingstone, Philadelphia; 2005. 2669-2674."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2008.03.014","article-title":"Current therapeutic strategy in spinal brucellosis","volume":"12","author":"Alp E","year":"2008","unstructured":"Alp E, Doganay M. Current therapeutic strategy in spinal brucellosis. Int J Infect Dis. 2008, 12:573-7. 10.1016\/j.ijid.2008.03.014","journal-title":"Int J Infect Dis"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03841-14","article-title":"Administration of a triple versus a standard double antimicrobial regimen for human brucellosis more efficiently eliminates bacterial DNA load","volume":"58","author":"Vrioni G","year":"2014","unstructured":"Vrioni G, Bourdakis A, Pappas G, Pitiriga V, Mavrouli M, Pournaras S, Tsakris A. Administration of a triple versus a standard double antimicrobial regimen for human brucellosis more efficiently eliminates bacterial DNA load. Antimicrob Agents Chemother. 2014, 58:7541-4. 10.1128\/AAC.03841-14","journal-title":"Antimicrob Agents Chemother"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.9.2061","article-title":"Doxycycline-rifampin versus doxycycline-streptomycin in treatment of human brucellosis due to Brucella melitensis. The GECMEI Group. Grupo de Estudio de Castilla-la Mancha de Enfermedades Infecciosas","volume":"39","author":"Solera J","year":"1995","unstructured":"Solera J, Rodr\u00edguez-Zapata M, Geijo P, et al.. Doxycycline-rifampin versus doxycycline-streptomycin in treatment of human brucellosis due to Brucella melitensis. The GECMEI Group. Grupo de Estudio de Castilla-la Mancha de Enfermedades Infecciosas. Antimicrob Agents Chemother. 1995, 39:2061-7. 10.1128\/AAC.39.9.2061","journal-title":"Antimicrob Agents Chemother"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1086\/324489","article-title":"Epididymoorchitis due to Brucella mellitensis: a retrospective study of 59 patients","volume":"33","author":"Navarro-Mart\u00ednez A","year":"2001","unstructured":"Navarro-Mart\u00ednez A, Solera J, Corredoira J, Beato JL, Mart\u00ednez-Alfaro E, Ati\u00e9nzar M, Ariza J. Epididymoorchitis due to Brucella mellitensis: a retrospective study of 59 patients. Clin Infect Dis. 2001, 33:2017-22. 10.1086\/324489","journal-title":"Clin Infect Dis"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410x.1989.tb05131.x","article-title":"Epididymo-orchitis and Brucellosis","volume":"63","author":"Khan MS","year":"1989","unstructured":"Khan MS, Humayoon MS, Al Manee MS. Epididymo-orchitis and Brucellosis. Br J Urol. 1989, 63:87-9. 10.1111\/j.1464-410x.1989.tb05131.x","journal-title":"Br J Urol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/62795-complicated-brucellosis-with-multisystem-involvement-two-case-reports","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:25:00Z","timestamp":1707506700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/62795-complicated-brucellosis-with-multisystem-involvement-two-case-reports"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,27]]},"references-count":22,"URL":"https:\/\/doi.org\/10.7759\/cureus.15950","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,27]]}}}