{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:06:55Z","timestamp":1769850415100,"version":"3.49.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,10]]},"DOI":"10.7759\/cureus.17067","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T17:09:17Z","timestamp":1628615357000},"source":"Crossref","is-referenced-by-count":5,"title":["Fracture Nonunions and Delayed Unions Treated With Low-Intensity Pulsed Ultrasound Therapy: A Clinical Series"],"prefix":"10.7759","author":[{"given":"Kavyansh","family":"Bhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronak","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamrul","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Pimpl\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sucheta","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varsha","family":"Nandwana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mhafrin","family":"Basta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2775","article-title":"Epidemiology of fracture nonunion in 18 human bones","volume":"151","author":"Zura R","year":"2016","unstructured":"Zura R, Xiong Z, Einhorn T, et al.. Epidemiology of fracture nonunion in 18 human bones. JAMA Surg. 2016, 151:e162775. 10.1001\/jamasurg.2016.2775","journal-title":"JAMA Surg"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-20-05-273","article-title":"Assessment of compromised fracture healing","volume":"20","author":"Bishop JA","year":"2012","unstructured":"Bishop JA, Palanca AA, Bellino MJ, Lowenberg DW. Assessment of compromised fracture healing. J Am Acad Orthop Surg. 2012, 20:273-82. 10.5435\/JAAOS-20-05-273","journal-title":"J Am Acad Orthop Surg"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000001114","article-title":"Diagnosis and management of polytraumatized patients with severe extremity trauma","volume":"32 Suppl 1","author":"McKinley TO","year":"2018","unstructured":"McKinley TO, Gaski GE, Vodovotz Y, Corona BT, Billiar TR. Diagnosis and management of polytraumatized patients with severe extremity trauma. J Orthop Trauma. 2018, 32 Suppl 1:S1-6. 10.1097\/BOT.0000000000001114","journal-title":"J Orthop Trauma"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s40477-020-00464-9","article-title":"Experience of an isolated use of low-intensity pulsed ultrasound therapy on fracture healing in established non-unions: a prospective case series","author":"Bawale R","year":"2020","unstructured":"Bawale R, Segmeister M, Sinha S, Shariff S, Singh B. Experience of an isolated use of low-intensity pulsed ultrasound therapy on fracture healing in established non-unions: a prospective case series. J Ultrasound. 2020, 10.1007\/s40477-020-00464-9","journal-title":"J Ultrasound"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-01904-2","article-title":"Prevalence and influencing factors of nonunion in patients with tibial fracture: systematic review and meta-analysis","volume":"15","author":"Tian R","year":"2020","unstructured":"Tian R, Zheng F, Zhao W, Zhang Y, Yuan J, Zhang B, Li L. Prevalence and influencing factors of nonunion in patients with tibial fracture: systematic review and meta-analysis. J Orthop Surg Res. 2020, 15:377. 10.1186\/s13018-020-01904-2","journal-title":"J Orthop Surg Res"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.87.BJR-2018-0215.R2","article-title":"What is the role of ultrasound in fracture management?: Diagnosis and therapeutic potential for fractures, delayed unions, and fracture-related infection","volume":"8","author":"Nicholson JA","year":"2019","unstructured":"Nicholson JA, Tsang ST, MacGillivray TJ, Perks F, Simpson AH. What is the role of ultrasound in fracture management?: Diagnosis and therapeutic potential for fractures, delayed unions, and fracture-related infection. Bone Joint Res. 2019, 8:304-12. 10.1302\/2046-3758.87.BJR-2018-0215.R2","journal-title":"Bone Joint Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/14786440908564348","article-title":"The physical and biological effects of high-frequency soundwaves of great intensity","volume":"4","author":"Wood RW","year":"1927","unstructured":"Wood RW, Loomis AL. The physical and biological effects of high-frequency soundwaves of great intensity. Lond Edinb Dublin Philos Mag J Sci. 1927, 4:417-36. 10.1080\/14786440908564348","journal-title":"Lond Edinb Dublin Philos Mag J Sci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-005-0034-2","article-title":"The effect of ultrasound on the healing of muscle-pediculated bone graft in scaphoid non-union","volume":"30","author":"Ricardo M","year":"2006","unstructured":"Ricardo M. The effect of ultrasound on the healing of muscle-pediculated bone graft in scaphoid non-union. Int Orthop. 2006, 30:123-7. 10.1007\/s00264-005-0034-2","journal-title":"Int Orthop"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultras.2016.03.016","article-title":"Mode & mechanism of low intensity pulsed ultrasound (LIPUS) in fracture repair","volume":"70","author":"Harrison A","year":"2016","unstructured":"Harrison A, Lin S, Pounder N, Mikuni-Takagaki Y. Mode & mechanism of low intensity pulsed ultrasound (LIPUS) in fracture repair. Ultrasonics. 2016, 70:45-52. 10.1016\/j.ultras.2016.03.016","journal-title":"Ultrasonics"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2008.09.029","article-title":"Low-intensity pulsed ultrasound for the treatment of bone delayed union or nonunion: a review","volume":"35","author":"Romano CL","year":"2009","unstructured":"Romano CL, Romano D, Logoluso N. Low-intensity pulsed ultrasound for the treatment of bone delayed union or nonunion: a review. Ultrasound Med Biol. 2009, 35:529-36. 10.1016\/j.ultrasmedbio.2008.09.029","journal-title":"Ultrasound Med Biol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2017.05.016","article-title":"Healing of fracture nonunions treated with low-intensity pulsed ultrasound (LIPUS): a systematic review and meta-analysis","volume":"48","author":"Leighton R","year":"2017","unstructured":"Leighton R, Watson JT, Giannoudis P, Papakostidis C, Harrison A, Steen RG. Healing of fracture nonunions treated with low-intensity pulsed ultrasound (LIPUS): a systematic review and meta-analysis. Injury. 2017, 48:1339-47. 10.1016\/j.injury.2017.05.016","journal-title":"Injury"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.O.00027","article-title":"Enhancement of Bone-Healing by Low-Intensity Pulsed Ultrasound: A Systematic Review","volume":"4","author":"Rutten S","year":"2016","unstructured":"Rutten S, van den Bekerom MP, Sierevelt IN, Nolte PA. Enhancement of Bone-Healing by Low-Intensity Pulsed Ultrasound: A Systematic Review. JBJS Rev. 2016, 4:10.2106\/JBJS.RVW.O.00027","journal-title":"JBJS Rev"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2020.03.009","article-title":"Low intensity pulsed ultrasound therapy (LIPUS): a review of evidence and potential applications in diabetics","volume":"11","author":"Berber R","year":"2020","unstructured":"Berber R, Aziz S, Simkins J, Lin SS, Mangwani J. Low intensity pulsed ultrasound therapy (LIPUS): a review of evidence and potential applications in diabetics. J Clin Orthop Trauma. 2020, 11:S500-5. 10.1016\/j.jcot.2020.03.009","journal-title":"J Clin Orthop Trauma"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2018.2889669","article-title":"A review of low-intensity pulsed ultrasound for therapeutic applications","volume":"66","author":"Jiang X","year":"2019","unstructured":"Jiang X, Savchenko O, Li Y, Qi S, Yang T, Zhang W, Chen J. A review of low-intensity pulsed ultrasound for therapeutic applications. IEEE Trans Biomed Eng. 2019, 66:2704-18. 10.1109\/TBME.2018.2889669","journal-title":"IEEE Trans Biomed Eng"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2019.05.009","article-title":"Clinical and patient-reported outcomes following low intensity pulsed ultrasound (LIPUS, Exogen) for established post-traumatic and post-surgical nonunion in the foot and ankle","volume":"26","author":"Majeed H","year":"2020","unstructured":"Majeed H, Karim T, Davenport J, Karski M, Smith R, Clough TM. Clinical and patient-reported outcomes following low intensity pulsed ultrasound (LIPUS, Exogen) for established post-traumatic and post-surgical nonunion in the foot and ankle. Foot Ankle Surg. 2020, 26:405-11. 10.1016\/j.fas.2019.05.009","journal-title":"Foot Ankle Surg"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-229","article-title":"Improved healing response in delayed unions of the tibia with low-intensity pulsed ultrasound: results of a randomized sham-controlled trial","volume":"11","author":"Schofer MD","year":"2010","unstructured":"Schofer MD, Block JE, Aigner J, Schmelz A. Improved healing response in delayed unions of the tibia with low-intensity pulsed ultrasound: results of a randomized sham-controlled trial. BMC Musculoskelet Disord. 2010, 11:229. 10.1186\/1471-2474-11-229","journal-title":"BMC Musculoskelet Disord"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31822419ba","article-title":"Effects of low-intensity pulsed ultrasound therapy on fracture healing: a systematic review and meta-analysis","volume":"91","author":"Bashardoust Tajali S","year":"2012","unstructured":"Bashardoust Tajali S, Houghton P, MacDermid JC, Grewal R. Effects of low-intensity pulsed ultrasound therapy on fracture healing: a systematic review and meta-analysis. Am J Phys Med Rehabil. 2012, 91:349-67. 10.1097\/PHM.0b013e31822419ba","journal-title":"Am J Phys Med Rehabil"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-006-1080-3","article-title":"Low-intensity pulsed ultrasound treatment for postoperative delayed union or nonunion of long bone fractures","volume":"12","author":"Jingushi S","year":"2007","unstructured":"Jingushi S, Mizuno K, Matsushita T, Itoman M. Low-intensity pulsed ultrasound treatment for postoperative delayed union or nonunion of long bone fractures. J Orthop Sci. 2007, 12:35-41. 10.1007\/s00776-006-1080-3","journal-title":"J Orthop Sci"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/65852-fracture-nonunions-and-delayed-unions-treated-with-low-intensity-pulsed-ultrasound-therapy-a-clinical-series","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:32:27Z","timestamp":1707507147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/65852-fracture-nonunions-and-delayed-unions-treated-with-low-intensity-pulsed-ultrasound-therapy-a-clinical-series"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,10]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.17067","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,10]]}}}