{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:45:01Z","timestamp":1790009101823,"version":"4.0.1"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,15]]},"DOI":"10.7759\/cureus.17185","type":"journal-article","created":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T08:00:32Z","timestamp":1629014432000},"source":"Crossref","is-referenced-by-count":12,"title":["Factor V Leiden G1691A and Prothrombin Gene G20210A Mutations on Pregnancy Outcome"],"prefix":"10.7759","author":[{"given":"Jaskamal","family":"Padda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khizer","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayushi","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhu","family":"Pokhriyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitya","family":"Batra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gazala","family":"Hitawala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayden Charlene","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gutteridge","family":"Jean-Charles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s1521-6926(03)00021-5","article-title":"Haemostatic changes in pregnancy","volume":"16","author":"Bremme KA","year":"2003","unstructured":"Bremme KA. Haemostatic changes in pregnancy. Best Pract Res Clin Haematol. 2003, 16:153-68. 10.1016\/s1521-6926(03)00021-5","journal-title":"Best Pract Res Clin Haematol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.5.4.753","article-title":"Pregnancy and thrombophilia","volume":"5","author":"Patnaik MM","year":"2007","unstructured":"Patnaik MM, Haddad T, Morton CT. Pregnancy and thrombophilia. Expert Rev Cardiovasc Ther. 2007, 5:753-65. 10.1586\/14779072.5.4.753","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(82)90028-4","article-title":"The coagulation and fibrinolytic enzyme system in pregnancy and in the puerperium","volume":"13","author":"Beller FK","year":"1982","unstructured":"Beller FK, Ebert C. The coagulation and fibrinolytic enzyme system in pregnancy and in the puerperium. Eur J Obstet Gynecol Reprod Biol. 1982, 13:177-97. 10.1016\/0028-2243(82)90028-4","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref4","article-title":"Haemostasis in normal pregnancy","volume":"52","author":"Stirling Y","year":"1984","unstructured":"Stirling Y, Woolf L, North WR, Seghatchian MJ, Meade TW. Haemostasis in normal pregnancy. Thromb Haemost. 1984, 52:176-82.","journal-title":"Thromb Haemost"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/ob.1996.v175.a73866","article-title":"Comparison of protein S functional and antigenic assays in normal pregnancy","volume":"175","author":"Lefkowitz JB","year":"1996","unstructured":"Lefkowitz JB, Clarke SH, Barbour LA. Comparison of protein S functional and antigenic assays in normal pregnancy. Am J Obstet Gynecol. 1996, 175:657-60. 10.1053\/ob.1996.v175.a73866","journal-title":"Am J Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V68.4.881.881","article-title":"Functional and immunologic protein S levels are decreased during pregnancy","volume":"68","author":"Comp PC","year":"1986","unstructured":"Comp PC, Thurnau GR, Welsh J, Esmon CT. Functional and immunologic protein S levels are decreased during pregnancy. Blood. 1986, 68:881-5. 10.1182\/blood.V68.4.881.881","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90104-3","article-title":"Changes in protein C and protein S levels in normal pregnancy","volume":"172","author":"Faught W","year":"1995","unstructured":"Faught W, Garner P, Jones G, Ivey B. Changes in protein C and protein S levels in normal pregnancy. Am J Obstet Gynecol. 1995, 172:147-50. 10.1016\/0002-9378(95)90104-3","journal-title":"Am J Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05610.x","article-title":"Development of resistance to activated protein C during pregnancy","volume":"90","author":"Cumming AM","year":"1995","unstructured":"Cumming AM, Tait RC, Fildes S, Yoong A, Keeney S, Hay CR. Development of resistance to activated protein C during pregnancy. Br J Haematol. 1995, 90:725-7. 10.1111\/j.1365-2141.1995.tb05610.x","journal-title":"Br J Haematol"},{"key":"ref9","article-title":"Specific plasminogen activator inhibitor of placental type PAI 2 occurring in amniotic fluid and cord blood","volume":"110","author":"Lecander I","year":"1987","unstructured":"Lecander I, Astedt B. Specific plasminogen activator inhibitor of placental type PAI 2 occurring in amniotic fluid and cord blood. J Lab Clin Med. 1987, 110:602-5.","journal-title":"J Lab Clin Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/516420","article-title":"The role of thrombophilia in pregnancy","volume":"2013","author":"Battinelli EM","year":"2013","unstructured":"Battinelli EM, Marshall A, Connors JM. The role of thrombophilia in pregnancy. Thrombosis. 2013, 2013:516420. 10.1155\/2013\/516420","journal-title":"Thrombosis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0","article-title":"Mutation in blood coagulation factor V associated with resistance to activated protein C","volume":"369","author":"Bertina RM","year":"1994","unstructured":"Bertina RM, Koeleman BP, Koster T, et al.. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994, 369:64-7. 10.1038\/369064a0","journal-title":"Nature"},{"key":"ref12","article-title":"Molecular diagnosis of inherited bleeding disorders and thrombophilia","volume":"36","author":"Lillicrap D","year":"1999","unstructured":"Lillicrap D. Molecular diagnosis of inherited bleeding disorders and thrombophilia. Semin Hematol. 1999, 36:340-51.","journal-title":"Semin Hematol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","article-title":"A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis","volume":"88","author":"Poort SR","year":"1996","unstructured":"Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996, 88:3698-703. 10.1182\/blood.V88.10.3698.bloodjournal88103698","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2003.00493.x","article-title":"G20210A is a functional mutation in the prothrombin gene; effect on protein levels and 3'-end formation","volume":"2","author":"Ceelie H","year":"2004","unstructured":"Ceelie H, Spaargaren-van Riel CC, Bertina RM, Vos HL. G20210A is a functional mutation in the prothrombin gene; effect on protein levels and 3'-end formation. J Thromb Haemost. 2004, 2:119-27. 10.1111\/j.1538-7836.2003.00493.x","journal-title":"J Thromb Haemost"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-267740","article-title":"Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1","volume":"116","author":"Meltzer ME","year":"2010","unstructured":"Meltzer ME, Lisman T, de Groot PG, Meijers JC, le Cessie S, Doggen CJ, Rosendaal FR. Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1. Blood. 2010, 116:113-21. 10.1182\/blood-2010-02-267740","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073670","article-title":"Thrombin activatable fibrinolysis inhibitor (TAFI): an updated narrative review","volume":"22","author":"Sillen M","year":"2021","unstructured":"Sillen M, Declerck PJ. Thrombin activatable fibrinolysis inhibitor (TAFI): an updated narrative review. Int J Mol Sci. 2021, 22:3670. 10.3390\/ijms22073670","journal-title":"Int J Mol Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000173986.32528.ca","article-title":"The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus","volume":"106","author":"Dizon-Townson D","year":"2005","unstructured":"Dizon-Townson D, Miller C, Sibai B, et al.. The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus. Obstet Gynecol. 2005, 106:517-24. 10.1097\/01.AOG.0000173986.32528.ca","journal-title":"Obstet Gynecol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(96)90064-1","article-title":"World distribution of factor V Leiden","volume":"347","author":"Dzimiri N","year":"1996","unstructured":"Dzimiri N, Meyer B. World distribution of factor V Leiden. Lancet. 1996, 347:481-2. 10.1016\/s0140-6736(96)90064-1","journal-title":"Lancet"},{"key":"ref19","article-title":"Geographic distribution of the 20210 G to A prothrombin variant","volume":"79","author":"Rosendaal FR","year":"1998","unstructured":"Rosendaal FR, Doggen CJ, Zivelin A, et al.. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost. 1998, 79:706-8.","journal-title":"Thromb Haemost"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000562","article-title":"Global prevalence of prothrombin gene mutation G20210A and implications in women's health: a systematic review","volume":"27","author":"Dziadosz M","year":"2016","unstructured":"Dziadosz M, Baxi LV. Global prevalence of prothrombin gene mutation G20210A and implications in women's health: a systematic review. Blood Coagul Fibrinolysis. 2016, 27:481-9. 10.1097\/MBC.0000000000000562","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref21","article-title":"The effect of factor V Leiden carriage on maternal and fetal health","volume":"167","author":"Bloomenthal D","year":"2002","unstructured":"Bloomenthal D, von Dadelszen P, Liston R, Magee L, Tsang P. The effect of factor V Leiden carriage on maternal and fetal health. CMAJ. 2002, 167:48-54.","journal-title":"CMAJ"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.3.1004","article-title":"Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C","volume":"90","author":"Dahlb\u00e4ck B","year":"1993","unstructured":"Dahlb\u00e4ck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A. 1993, 90:1004-8. 10.1073\/pnas.90.3.1004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01832.x","article-title":"Abnormalities of prothrombin: a review of the pathophysiology, diagnosis, and treatment","volume":"14","author":"Meeks SL","year":"2008","unstructured":"Meeks SL, Abshire TC. Abnormalities of prothrombin: a review of the pathophysiology, diagnosis, and treatment. Haemophilia. 2008, 14:1159-63. 10.1111\/j.1365-2516.2008.01832.x","journal-title":"Haemophilia"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-010-0691-5","article-title":"Platelet receptor signaling in thrombus formation","volume":"89","author":"Stegner D","year":"2011","unstructured":"Stegner D, Nieswandt B. Platelet receptor signaling in thrombus formation. J Mol Med (Berl). 2011, 89:109-21. 10.1007\/s00109-010-0691-5","journal-title":"J Mol Med (Berl)"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830160312","article-title":"Factor VIII: structure and function in blood clotting","volume":"16","author":"Chavin SI","year":"1984","unstructured":"Chavin SI. Factor VIII: structure and function in blood clotting. Am J Hematol. 1984, 16:297-306. 10.1002\/ajh.2830160312","journal-title":"Am J Hematol"},{"key":"ref26","article-title":"Physiology, factor V","author":"Lam W","year":"2021","unstructured":"Lam W, Moosavi L. Physiology, factor V. StatPearls Publishing, Treasure Island, FL; 2021."},{"key":"ref27","article-title":"","author":"Malkhassian D","year":"2021","unstructured":"Malkhassian D, Sabir S, Sharma S. Physiology, factor XIII. StatPearls Publishing, Treasure Island, FL; 2021. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538271\/."},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600852898","article-title":"Thrombin activatable fibrinolysis inhibitor (TAFI)--how does thrombin regulate fibrinolysis?","volume":"38","author":"Bouma BN","year":"2006","unstructured":"Bouma BN, Mosnier LO. Thrombin activatable fibrinolysis inhibitor (TAFI)--how does thrombin regulate fibrinolysis?. Ann Med. 2006, 38:378-88. 10.1080\/07853890600852898","journal-title":"Ann Med"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-02-0141","article-title":"Classic thrombophilic gene variants","volume":"114","author":"Mannucci PM","year":"2015","unstructured":"Mannucci PM, Franchini M. Classic thrombophilic gene variants. Thromb Haemost. 2015, 114:885-9. 10.1160\/TH15-02-0141","journal-title":"Thromb Haemost"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.20.12.2511","article-title":"Thrombin activatable fibrinolysis inhibitor and an antifibrinolytic pathway","volume":"20","author":"Bajzar L","year":"2000","unstructured":"Bajzar L. Thrombin activatable fibrinolysis inhibitor and an antifibrinolytic pathway. Arterioscler Thromb Vasc Biol. 2000, 20:2511-8. 10.1161\/01.atv.20.12.2511","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.048","article-title":"Evaluation and treatment of recurrent pregnancy loss: a committee opinion","volume":"98","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2012","unstructured":"Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril. 2012, 98:1103-11. 10.1016\/j.fertnstert.2012.06.048","journal-title":"Fertil Steril"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.11.025","article-title":"Definitions of infertility and recurrent pregnancy loss: a committee opinion","volume":"113","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2020","unstructured":"Practice Committee of the American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril. 2020, 113:533-5. 10.1016\/j.fertnstert.2019.11.025","journal-title":"Fertil Steril"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del150","article-title":"Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage","volume":"21","author":"Jauniaux E","year":"2006","unstructured":"Jauniaux E, Farquharson RG, Christiansen OB, Exalto N. Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Hum Reprod. 2006, 21:2216-22. 10.1093\/humrep\/del150","journal-title":"Hum Reprod"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92159-f","article-title":"Recurrent miscarriage I: definition and epidemiology","volume":"336","author":"Stirrat GM","year":"1990","unstructured":"Stirrat GM. Recurrent miscarriage I: definition and epidemiology. Lancet. 1990, 336:673-5. 10.1016\/0140-6736(90)92159-f","journal-title":"Lancet"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.10.002","article-title":"Recurrent pregnancy loss: evaluation and treatment","volume":"42","author":"Shahine L","year":"2015","unstructured":"Shahine L, Lathi R. Recurrent pregnancy loss: evaluation and treatment. Obstet Gynecol Clin North Am. 2015, 42:117-34. 10.1016\/j.ogc.2014.10.002","journal-title":"Obstet Gynecol Clin North Am"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000226","article-title":"Hereditary thrombophilia and recurrent pregnancy loss","volume":"59","author":"Pritchard AM","year":"2016","unstructured":"Pritchard AM, Hendrix PW, Paidas MJ. Hereditary thrombophilia and recurrent pregnancy loss. Clin Obstet Gynecol. 2016, 59:487-97. 10.1097\/GRF.0000000000000226","journal-title":"Clin Obstet Gynecol"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab010","article-title":"Hereditary thrombophilia and recurrent pregnancy loss: a systematic review and meta-analysis","volume":"36","author":"Liu X","year":"2021","unstructured":"Liu X, Chen Y, Ye C, et al.. Hereditary thrombophilia and recurrent pregnancy loss: a systematic review and meta-analysis. Hum Reprod. 2021, 36:1213-29. 10.1093\/humrep\/deab010","journal-title":"Hum Reprod"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-020-05610-6","article-title":"Association between factor V Leiden mutation and recurrent pregnancy loss in the middle east countries: a Newcastle-Ottawa meta-analysis","volume":"302","author":"Hamedi B","year":"2020","unstructured":"Hamedi B, Feulefack J, Khan A, Sergi C. Association between factor V Leiden mutation and recurrent pregnancy loss in the middle east countries: a Newcastle-Ottawa meta-analysis. Arch Gynecol Obstet. 2020, 302:345-54. 10.1007\/s00404-020-05610-6","journal-title":"Arch Gynecol Obstet"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3443-x","article-title":"Factor V Leiden mutation in women with early recurrent pregnancy loss: a meta-analysis and systematic review of the causal association","volume":"291","author":"Sergi C","year":"2015","unstructured":"Sergi C, Al Jishi T, Walker M. Factor V Leiden mutation in women with early recurrent pregnancy loss: a meta-analysis and systematic review of the causal association. Arch Gynecol Obstet. 2015, 291:671-9. 10.1007\/s00404-014-3443-x","journal-title":"Arch Gynecol Obstet"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.12.001","article-title":"Prothrombin G20210A mutation is associated with recurrent pregnancy loss: a systematic review and meta-analysis update","volume":"135","author":"Gao H","year":"2015","unstructured":"Gao H, Tao FB. Prothrombin G20210A mutation is associated with recurrent pregnancy loss: a systematic review and meta-analysis update. Thromb Res. 2015, 135:339-46. 10.1016\/j.thromres.2014.12.001","journal-title":"Thromb Res"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1038\/gim.0b013e31822e575b","article-title":"Can Factor V Leiden and prothrombin G20210A testing in women with recurrent pregnancy loss result in improved pregnancy outcomes?: results from a targeted evidence-based review","volume":"14","author":"Bradley LA","year":"2012","unstructured":"Bradley LA, Palomaki GE, Bienstock J, Varga E, Scott JA. Can Factor V Leiden and prothrombin G20210A testing in women with recurrent pregnancy loss result in improved pregnancy outcomes?: results from a targeted evidence-based review. Genet Med. 2012, 14:39-50. 10.1038\/gim.0b013e31822e575b","journal-title":"Genet Med"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05847.x","article-title":"Thrombophilia in pregnancy: a systematic review","volume":"132","author":"Robertson L","year":"2006","unstructured":"Robertson L, Wu O, Langhorne P, et al.. Thrombophilia in pregnancy: a systematic review. Br J Haematol. 2006, 132:171-96. 10.1111\/j.1365-2141.2005.05847.x","journal-title":"Br J Haematol"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-2115(01)00496-1","article-title":"How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review","volume":"101","author":"Alfirevic Z","year":"2002","unstructured":"Alfirevic Z, Roberts D, Martlew V. How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review. Eur J Obstet Gynecol Reprod Biol. 2002, 101:6-14. 10.1016\/s0301-2115(01)00496-1","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000292","article-title":"The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies","volume":"7","author":"Rodger MA","year":"2010","unstructured":"Rodger MA, Betancourt MT, Clark P, et al.. The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. PLoS Med. 2010, 7:e1000292. 10.1371\/journal.pmed.1000292","journal-title":"PLoS Med"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181c88918","article-title":"Prothrombin gene G20210A mutation and obstetric complications","volume":"115","author":"Silver RM","year":"2010","unstructured":"Silver RM, Zhao Y, Spong CY, et al.. Prothrombin gene G20210A mutation and obstetric complications. Obstet Gynecol. 2010, 115:14-20. 10.1097\/AOG.0b013e3181c88918","journal-title":"Obstet Gynecol"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(96)04125-6","article-title":"Increased fetal loss in women with heritable thrombophilia","volume":"348","author":"Preston FE","year":"1996","unstructured":"Preston FE, Rosendaal FR, Walker ID, et al.. Increased fetal loss in women with heritable thrombophilia. Lancet. 1996, 348:913-6. 10.1016\/s0140-6736(96)04125-6","journal-title":"Lancet"},{"key":"ref47","unstructured":"Preeclampsia. (2018). Accessed. June 24, 2021: https:\/\/emedicine.medscape.com\/article\/1476919-overview."},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.03.043","article-title":"Prevalence of preeclampsia and eclampsia in adolescent pregnancy: a systematic review and meta-analysis of 291,247 adolescents worldwide since 1969","volume":"248","author":"Macedo TC","year":"2020","unstructured":"Macedo TC, Montagna E, Trevisan CM, et al.. Prevalence of preeclampsia and eclampsia in adolescent pregnancy: a systematic review and meta-analysis of 291,247 adolescents worldwide since 1969. Eur J Obstet Gynecol Reprod Biol. 2020, 248:177-86. 10.1016\/j.ejogrb.2020.03.043","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.09.011","article-title":"A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restriction","volume":"192","author":"Howley HE","year":"2005","unstructured":"Howley HE, Walker M, Rodger MA. A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restriction. Am J Obstet Gynecol. 2005, 192:694-708. 10.1016\/j.ajog.2004.09.011","journal-title":"Am J Obstet Gynecol"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.001","article-title":"Thrombophilia and pregnancy complications","volume":"191","author":"Kujovich JL","year":"2004","unstructured":"Kujovich JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol. 2004, 191:412-24. 10.1016\/j.ajog.2004.03.001","journal-title":"Am J Obstet Gynecol"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.126849","article-title":"Acquired and inherited thrombophilia in women with unexplained fetal losses","volume":"187","author":"Alonso A","year":"2002","unstructured":"Alonso A, Soto I, Urgell\u00e9s MF, Corte JR, Rodr\u00edguez MJ, Pinto CR. Acquired and inherited thrombophilia in women with unexplained fetal losses. Am J Obstet Gynecol. 2002, 187:1337-42. 10.1067\/mob.2002.126849","journal-title":"Am J Obstet Gynecol"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000146250.85561.e9","article-title":"Genetic thrombophilias and preeclampsia: a meta-analysis","volume":"105","author":"Lin J","year":"2005","unstructured":"Lin J, August P. Genetic thrombophilias and preeclampsia: a meta-analysis. Obstet Gynecol. 2005, 105:182-92. 10.1097\/01.AOG.0000146250.85561.e9","journal-title":"Obstet Gynecol"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-07-0411","article-title":"The polymorphism of platelet membrane integrin alpha2beta1 (alpha2807TT) is associated with premature onset of fetal loss","volume":"93","author":"Gerhardt A","year":"2005","unstructured":"Gerhardt A, Scharf RE, Mikat-Drozdzynski B, Kr\u00fcssel JS, Bender HG, Zotz RB. The polymorphism of platelet membrane integrin alpha2beta1 (alpha2807TT) is associated with premature onset of fetal loss. Thromb Haemost. 2005, 93:124-9. 10.1160\/TH04-07-0411","journal-title":"Thromb Haemost"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.07.053","article-title":"The common prothrombotic factors in nulliparous women do not compromise blood flow in the feto-maternal circulation and are not associated with preeclampsia or intrauterine growth restriction","volume":"191","author":"Salomon O","year":"2004","unstructured":"Salomon O, Seligsohn U, Steinberg DM, et al.. The common prothrombotic factors in nulliparous women do not compromise blood flow in the feto-maternal circulation and are not associated with preeclampsia or intrauterine growth restriction. Am J Obstet Gynecol. 2004, 191:2002-9. 10.1016\/j.ajog.2004.07.053","journal-title":"Am J Obstet Gynecol"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-872430","article-title":"MTHFR C677T Polymorphism and factor V Leiden mutation are not associated with recurrent spontaneous abortion of unexplained etiology in Japanese women","volume":"31","author":"Kobashi G","year":"2005","unstructured":"Kobashi G, Kato EH, Morikawa M, et al.. MTHFR C677T Polymorphism and factor V Leiden mutation are not associated with recurrent spontaneous abortion of unexplained etiology in Japanese women. Semin Thromb Hemost. 2005, 31:266-71. 10.1055\/s-2005-872430","journal-title":"Semin Thromb Hemost"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2004.11.001","article-title":"Fetal genotype for specific inherited thrombophilias is not associated with severe preeclampsia","volume":"12","author":"Stanley-Christian H","year":"2005","unstructured":"Stanley-Christian H, Ghidini A, Sacher R, Shemirani M. Fetal genotype for specific inherited thrombophilias is not associated with severe preeclampsia. J Soc Gynecol Investig. 2005, 12:198-201. 10.1016\/j.jsgi.2004.11.001","journal-title":"J Soc Gynecol Investig"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.050","article-title":"Absence of association of inherited thrombophilia with unexplained third-trimester intrauterine fetal death","volume":"192","author":"Gonen R","year":"2005","unstructured":"Gonen R, Lavi N, Attias D, Schliamser L, Borochowitz Z, Toubi E, Ohel G. Absence of association of inherited thrombophilia with unexplained third-trimester intrauterine fetal death. Am J Obstet Gynecol. 2005, 192:742-6. 10.1016\/j.ajog.2004.12.050","journal-title":"Am J Obstet Gynecol"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.114691","article-title":"Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia","volume":"185","author":"Livingston JC","year":"2001","unstructured":"Livingston JC, Barton JR, Park V, Haddad B, Phillips O, Sibai BM. Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia. Am J Obstet Gynecol. 2001, 185:153-7. 10.1067\/mob.2001.114691","journal-title":"Am J Obstet Gynecol"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.06.082","article-title":"Prevalence of factor V Leiden, prothrombin and methylene tetrahydrofolate reductase mutations in women with adverse pregnancy outcomes in Lebanon","volume":"195","author":"Zahed LF","year":"2006","unstructured":"Zahed LF, Rayes RF, Mahfouz RA, Taher AT, Maarouf HH, Nassar AH. Prevalence of factor V Leiden, prothrombin and methylene tetrahydrofolate reductase mutations in women with adverse pregnancy outcomes in Lebanon. Am J Obstet Gynecol. 2006, 195:1114-8. 10.1016\/j.ajog.2006.06.082","journal-title":"Am J Obstet Gynecol"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.retram.2019.08.002","article-title":"Evaluation of Factor V Leiden and prothrombin G20210A mutations in Sudanese women with severe preeclampsia","volume":"68","author":"Elzein HO","year":"2020","unstructured":"Elzein HO, Saad AA, Yousif AA, Elamin E, Abdalhabib EK, Elzaki SG. Evaluation of Factor V Leiden and prothrombin G20210A mutations in Sudanese women with severe preeclampsia. Curr Res Transl Med. 2020, 68:77-80. 10.1016\/j.retram.2019.08.002","journal-title":"Curr Res Transl Med"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(00)00861-9","article-title":"Severe preeclampsia and high frequency of genetic thrombophilic mutations","volume":"96","author":"Kupferminc MJ","year":"2000","unstructured":"Kupferminc MJ, Fait G, Many A, Gordon D, Eldor A, Lessing JB. Severe preeclampsia and high frequency of genetic thrombophilic mutations. Obstet Gynecol. 2000, 96:45-9. 10.1016\/s0029-7844(00)00861-9","journal-title":"Obstet Gynecol"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.811201.x","article-title":"Factor V Leiden and factor II G20210A in preeclampsia and HELLP syndrome","volume":"81","author":"Benedetto C","year":"2002","unstructured":"Benedetto C, Marozio L, Salton L, Maul\u00e0 V, Chieppa G, Massobrio M. Factor V Leiden and factor II G20210A in preeclampsia and HELLP syndrome. Acta Obstet Gynecol Scand. 2002, 81:1095-100. 10.1034\/j.1600-0412.2002.811201.x","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1081\/prg-100100132","article-title":"Maternal and neonatal outcome of preeclamptic pregnancies: the potential roles of factor V Leiden mutation and 5,10 methylenetetrahydrofolate reductase","volume":"19","author":"Rig\u00f3 J Jr","year":"2000","unstructured":"Rig\u00f3 J Jr, Nagy B, Fintor L, Tanyi J, Beke A, Kar\u00e1di I, Papp Z. Maternal and neonatal outcome of preeclamptic pregnancies: the potential roles of factor V Leiden mutation and 5,10 methylenetetrahydrofolate reductase. Hypertens Pregnancy. 2000, 19:163-72. 10.1081\/prg-100100132","journal-title":"Hypertens Pregnancy"},{"key":"ref64","article-title":"Impact of intrauterine growth retardation and body proportionality on fetal and neonatal outcome","volume":"86","author":"Kramer MS","year":"1990","unstructured":"Kramer MS, Olivier M, McLean FH, Willis DM, Usher RH. Impact of intrauterine growth retardation and body proportionality on fetal and neonatal outcome. Pediatrics. 1990, 86:707-13.","journal-title":"Pediatrics"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(98)70180-5","article-title":"Growth and development of term children born with low birth weight: effects of genetic and environmental factors","volume":"133","author":"Strauss RS","year":"1998","unstructured":"Strauss RS, Dietz WH. Growth and development of term children born with low birth weight: effects of genetic and environmental factors. J Pediatr. 1998, 133:67-72. 10.1016\/s0022-3476(98)70180-5","journal-title":"J Pediatr"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.5.625","article-title":"Adult functional outcome of those born small for gestational age: twenty-six-year follow-up of the 1970 British Birth Cohort","volume":"283","author":"Strauss RS","year":"2000","unstructured":"Strauss RS. Adult functional outcome of those born small for gestational age: twenty-six-year follow-up of the 1970 British Birth Cohort. JAMA. 2000, 283:625-32. 10.1001\/jama.283.5.625","journal-title":"JAMA"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.4137\/CMPed.S40070","article-title":"Intrauterine growth restriction: antenatal and postnatal aspects","volume":"10","author":"Sharma D","year":"2016","unstructured":"Sharma D, Shastri S, Sharma P. Intrauterine growth restriction: antenatal and postnatal aspects. Clin Med Insights Pediatr. 2016, 10:67-83. 10.4137\/CMPed.S40070","journal-title":"Clin Med Insights Pediatr"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994947","article-title":"Uteroplacental hemostasis in intrauterine fetal growth retardation","volume":"25","author":"Sheppard BL","year":"1999","unstructured":"Sheppard BL, Bonnar J. Uteroplacental hemostasis in intrauterine fetal growth retardation. Semin Thromb Hemost. 1999, 25:443-6. 10.1055\/s-2007-994947","journal-title":"Semin Thromb Hemost"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(01)01621-0","article-title":"Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia","volume":"98","author":"Many A","year":"2001","unstructured":"Many A, Schreiber L, Rosner S, Lessing JB, Eldor A, Kupferminc MJ. Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia. Obstet Gynecol. 2001, 98:1041-4. 10.1016\/s0029-7844(01)01621-0","journal-title":"Obstet Gynecol"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2016.08.001","article-title":"Association between factor V Leiden mutation, small for gestational age, and preterm birth: a systematic review and meta-analysis","volume":"38","author":"Hemsworth EM","year":"2016","unstructured":"Hemsworth EM, O'Reilly AM, Allen VM, Kuhle S, Brock JK. Association between factor V Leiden mutation, small for gestational age, and preterm birth: a systematic review and meta-analysis. J Obstet Gynaecol Can. 2016, 38:897-908. 10.1016\/j.jogc.2016.08.001","journal-title":"J Obstet Gynaecol Can"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-05-0373","article-title":"Thrombophilias and adverse pregnancy outcome - a confounded problem!","volume":"99","author":"Kist WJ","year":"2008","unstructured":"Kist WJ, Janssen NG, Kalk JJ, Hague WM, Dekker GA, de Vries JI. Thrombophilias and adverse pregnancy outcome - a confounded problem!. Thromb Haemost. 2008, 99:77-85. 10.1160\/TH07-05-0373","journal-title":"Thromb Haemost"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-10-0637","article-title":"The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis","volume":"91","author":"Dudding TE","year":"2004","unstructured":"Dudding TE, Attia J. The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis. Thromb Haemost. 2004, 91:700-11. 10.1160\/TH03-10-0637","journal-title":"Thromb Haemost"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2002.02194.x","article-title":"Mid-trimester severe intrauterine growth restriction is associated with a high prevalence of thrombophilia","volume":"109","author":"Kupferminc MJ","year":"2002","unstructured":"Kupferminc MJ, Many A, Bar-Am A, Lessing JB, Ascher-Landsberg J. Mid-trimester severe intrauterine growth restriction is associated with a high prevalence of thrombophilia. BJOG. 2002, 109:1373-6. 10.1046\/j.1471-0528.2002.02194.x","journal-title":"BJOG"},{"key":"ref74","article-title":"Familial thrombophilia and the occurrence of fetal growth restriction","volume":"86","author":"Martinelli P","year":"2001","unstructured":"Martinelli P, Grandone E, Colaizzo D, Paladini D, Sciannam\u00e9 N, Margaglione M, Di Minno G. Familial thrombophilia and the occurrence of fetal growth restriction. Haematologica. 2001, 86:428-31.","journal-title":"Haematologica"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a6e96a","article-title":"Genetic thrombophilias and intrauterine growth restriction: a meta-analysis","volume":"113","author":"Facco F","year":"2009","unstructured":"Facco F, You W, Grobman W. Genetic thrombophilias and intrauterine growth restriction: a meta-analysis. Obstet Gynecol. 2009, 113:1206-16. 10.1097\/AOG.0b013e3181a6e96a","journal-title":"Obstet Gynecol"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06902.x","article-title":"The GOAL study: a prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes","volume":"140","author":"Clark P","year":"2008","unstructured":"Clark P, Walker ID, Govan L, Wu O, Greer IA. The GOAL study: a prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes. Br J Haematol. 2008, 140:236-40. 10.1111\/j.1365-2141.2007.06902.x","journal-title":"Br J Haematol"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200207043470105","article-title":"Absence of association of thrombophilia polymorphisms with intrauterine growth restriction","volume":"347","author":"Infante-Rivard C","year":"2002","unstructured":"Infante-Rivard C, Rivard GE, Yotov WV, et al.. Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. N Engl J Med. 2002, 347:19-25. 10.1056\/NEJM200207043470105","journal-title":"N Engl J Med"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39205.484572.55","article-title":"Inherited thrombophilia and pregnancy associated venous thromboembolism","volume":"334","author":"Lim W","year":"2007","unstructured":"Lim W, Eikelboom JW, Ginsberg JS. Inherited thrombophilia and pregnancy associated venous thromboembolism. BMJ. 2007, 334:1318-21. 10.1136\/bmj.39205.484572.55","journal-title":"BMJ"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12954","article-title":"Incidence and causes of maternal mortality in the USA","volume":"42","author":"Kuriya A","year":"2016","unstructured":"Kuriya A, Piedimonte S, Spence AR, Czuzoj-Shulman N, Kezouh A, Abenhaim HA. Incidence and causes of maternal mortality in the USA. J Obstet Gynaecol Res. 2016, 42:661-8. 10.1111\/jog.12954","journal-title":"J Obstet Gynaecol Res"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10265-9","article-title":"Thrombosis in pregnancy: maternal and fetal issues","volume":"353","author":"Greer IA","year":"1999","unstructured":"Greer IA. Thrombosis in pregnancy: maternal and fetal issues. Lancet. 1999, 353:1258-65. 10.1016\/S0140-6736(98)10265-9","journal-title":"Lancet"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-12-199612150-00003","article-title":"Frequency of pregnancy-related venous thromboembolism in anticoagulant factor-deficient women: implications for prophylaxis","volume":"125","author":"Friederich PW","year":"1996","unstructured":"Friederich PW, Sanson BJ, Simioni P, et al.. Frequency of pregnancy-related venous thromboembolism in anticoagulant factor-deficient women: implications for prophylaxis. Ann Intern Med. 1996, 125:955-60. 10.7326\/0003-4819-125-12-199612150-00003","journal-title":"Ann Intern Med"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(01)01190-5","article-title":"Postnatal screening for thrombophilia in women with severe pregnancy complications","volume":"97","author":"Alfirevic Z","year":"2001","unstructured":"Alfirevic Z, Mousa HA, Martlew V, Briscoe L, Perez-Casal M, Toh CH. Postnatal screening for thrombophilia in women with severe pregnancy complications. Obstet Gynecol. 2001, 97:753-9. 10.1016\/s0029-7844(01)01190-5","journal-title":"Obstet Gynecol"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0626","article-title":"Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy","volume":"106","author":"Greer IA","year":"2005","unstructured":"Greer IA, Nelson-Piercy C. Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood. 2005, 106:401-7. 10.1182\/blood-2005-02-0626","journal-title":"Blood"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4250","article-title":"Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder","volume":"103","author":"Gris JC","year":"2004","unstructured":"Gris JC, Mercier E, Qu\u00e9r\u00e9 I, et al.. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood. 2004, 103:3695-9. 10.1182\/blood-2003-12-4250","journal-title":"Blood"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.10.021","article-title":"Thromboprophylaxis and pregnancy outcomes in asymptomatic women with inherited thrombophilias","volume":"200","author":"Warren JE","year":"2009","unstructured":"Warren JE, Simonsen SE, Branch DW, Porter TF, Silver RM. Thromboprophylaxis and pregnancy outcomes in asymptomatic women with inherited thrombophilias. Am J Obstet Gynecol. 2009, 200:281.e1-5. 10.1016\/j.ajog.2008.10.021","journal-title":"Am J Obstet Gynecol"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-02-0163","article-title":"Location of venous thrombosis in patients with FVL or prothrombin G20210A mutations: systematic review and meta-analysis","volume":"110","author":"Dentali F","year":"2013","unstructured":"Dentali F, Pomero F, Borretta V, et al.. Location of venous thrombosis in patients with FVL or prothrombin G20210A mutations: systematic review and meta-analysis. Thromb Haemost. 2013, 110:191-4. 10.1160\/TH13-02-0163","journal-title":"Thromb Haemost"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04656.x","article-title":"Role of factor\u00a0V Leiden or G20210A prothrombin mutation in patients with symptomatic pulmonary embolism and deep vein thrombosis: a meta-analysis of the literature","volume":"10","author":"Dentali F","year":"2012","unstructured":"Dentali F, Ageno W, Bozzato S, Malato A, Gianni M, Squizzato A, Prisco D. Role of factor\u00a0V Leiden or G20210A prothrombin mutation in patients with symptomatic pulmonary embolism and deep vein thrombosis: a meta-analysis of the literature. J Thromb Haemost. 2012, 10:732-7. 10.1111\/j.1538-7836.2012.04656.x","journal-title":"J Thromb Haemost"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002703","article-title":"ACOG Practice Bulletin No. 197: inherited thrombophilias in pregnancy","volume":"132","author":"American College of Obstetricians and Gynecologists' Committee on Practice Bulletins-Obstetrics","year":"2018","unstructured":"American College of Obstetricians and Gynecologists' Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 197: inherited thrombophilias in pregnancy. Obstet Gynecol. 2018, 132:e18-34. 10.1097\/AOG.0000000000002703","journal-title":"Obstet Gynecol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/67636-factor-v-leiden-g1691a-and-prothrombin-gene-g20210a-mutations-on-pregnancy-outcome","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:34:12Z","timestamp":1707507252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/67636-factor-v-leiden-g1691a-and-prothrombin-gene-g20210a-mutations-on-pregnancy-outcome"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,15]]},"references-count":88,"URL":"https:\/\/doi.org\/10.7759\/cureus.17185","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,15]]}}}