{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:39:24Z","timestamp":1779115164367,"version":"3.51.4"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,4]]},"DOI":"10.7759\/cureus.17713","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T13:54:21Z","timestamp":1630763661000},"source":"Crossref","is-referenced-by-count":1,"title":["Spironolactone-Induced Lichenoid Drug Reaction and Subsequent Diffuse Eruptive Squamous Cell Carcinomas Successfully Treated With Systemic Methotrexate"],"prefix":"10.7759","author":[{"given":"Anuj","family":"Kunadia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Shulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveed","family":"Sami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03290110036005","article-title":"Spironolactone-induced lichen planus","volume":"240","author":"Downham TF","year":"1978","unstructured":"Downham TF. Spironolactone-induced lichen planus. JAMA. 1978, 240:1138. 10.1001\/jama.1978.03290110036005","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14503","article-title":"Eruptive keratoacanthomas arising in the setting of lichenoid toxicity after programmed cell death 1 inhibition with nivolumab","volume":"32","author":"Feldstein SI","year":"2018","unstructured":"Feldstein SI, Patel F, Larsen L, Kim E, Hwang S, Fung MA. Eruptive keratoacanthomas arising in the setting of lichenoid toxicity after programmed cell death 1 inhibition with nivolumab. J Eur Acad Dermatol Venereol. 2018, 32:e58-9. 10.1111\/jdv.14503","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1097\/00125480-199809000-00001","article-title":"Keratoacanthoma: a clinically distinct variant of well differentiated squamous cell carcinoma","volume":"5","author":"Beham A","year":"1998","unstructured":"Beham A, Regauer S, Soyer HP, Beham-Schmid C. Keratoacanthoma: a clinically distinct variant of well differentiated squamous cell carcinoma. Adv Anat Pathol. 1998, 5:269-80.","journal-title":"Adv Anat Pathol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199805000-00004","article-title":"Keratoacanthoma: is it a real entity?","volume":"40","author":"Manstein CH","year":"1998","unstructured":"Manstein CH, Frauenhoffer CJ, Besden JE. Keratoacanthoma: is it a real entity?. Ann Plast Surg. 1998, 40:469-72. 10.1097\/00000637-199805000-00004","journal-title":"Ann Plast Surg"},{"key":"ref5","article-title":"Spironolactone","author":"Patibandla S","year":"2021","unstructured":"Patibandla S, Heaton J, Kyaw H. Spironolactone. StatPearls Publishing, Treasure Island, FL; 2021."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000246889","article-title":"Spironolactone-associated cutaneous effects: a case report and a review of the literature","volume":"189","author":"Gupta AK","year":"1994","unstructured":"Gupta AK, Knowles SR, Shear NH. Spironolactone-associated cutaneous effects: a case report and a review of the literature. Dermatology. 1994, 189:402-5. 10.1159\/000246889","journal-title":"Dermatology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1998.00281.x","article-title":"Lichenoid drug eruption induced by spironolactone","volume":"23","author":"Clark C","year":"1998","unstructured":"Clark C, Douglas WS. Lichenoid drug eruption induced by spironolactone. Clin Exp Dermatol. 1998, 23:43-4. 10.1046\/j.1365-2230.1998.00281.x","journal-title":"Clin Exp Dermatol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2340\/0001555574476","article-title":"Lichenoid drug eruption induced by spironolactone","volume":"74","author":"Sch\u00f6n MP","year":"1994","unstructured":"Sch\u00f6n MP, Tebbe B, Trautmann C, Orfanos CE. Lichenoid drug eruption induced by spironolactone. Acta Derm Venereol. 1994, 74:476. 10.2340\/0001555574476","journal-title":"Acta Derm Venereol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(90)90116-a","article-title":"Grinspan's syndrome: a drug-induced phenomenon?","volume":"70","author":"Lamey PJ","year":"1990","unstructured":"Lamey PJ, Gibson J, Barclay SC, Miller S. Grinspan's syndrome: a drug-induced phenomenon?. Oral Surg Oral Med Oral Pathol. 1990, 70:184-5. 10.1016\/0030-4220(90)90116-a","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0989","article-title":"Eruptive keratoacanthomas associated with pembrolizumab therapy","volume":"153","author":"Freites-Martinez A","year":"2017","unstructured":"Freites-Martinez A, Kwong BY, Rieger KE, Coit DG, Colevas AD, Lacouture ME. Eruptive keratoacanthomas associated with pembrolizumab therapy. JAMA Dermatol. 2017, 153:694-7. 10.1001\/jamadermatol.2017.0989","journal-title":"JAMA Dermatol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28980","article-title":"Clinico-morphological features of BRAF inhibition-induced proliferative skin lesions in cancer patients","volume":"121","author":"Belum VR","year":"2015","unstructured":"Belum VR, Rosen AC, Jaimes N, et al.. Clinico-morphological features of BRAF inhibition-induced proliferative skin lesions in cancer patients. Cancer. 2015, 121:60-8. 10.1002\/cncr.28980","journal-title":"Cancer"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002139","article-title":"Cutaneous ultrasound for tumor thickness measurement in squamous cell carcinoma: the effect of neoadjuvant intralesional methotrexate in 40 patients","volume":"46","author":"Berg\u00f3n-Send\u00edn M","year":"2020","unstructured":"Berg\u00f3n-Send\u00edn M, Pulido-P\u00e9rez A, Carretero L\u00f3pez F, D\u00edez-Sebasti\u00e1n J, Su\u00e1rez-Fern\u00e1ndez R. Cutaneous ultrasound for tumor thickness measurement in squamous cell carcinoma: the effect of neoadjuvant intralesional methotrexate in 40 patients. Dermatol Surg. 2020, 46:530-6. 10.1097\/DSS.0000000000002139","journal-title":"Dermatol Surg"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/65824-spironolactone-induced-lichenoid-drug-reaction-and-subsequent-diffuse-eruptive-squamous-cell-carcinomas-successfully-treated-with-systemic-methotrexate","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:29:08Z","timestamp":1707506948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/65824-spironolactone-induced-lichenoid-drug-reaction-and-subsequent-diffuse-eruptive-squamous-cell-carcinomas-successfully-treated-with-systemic-methotrexate"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,4]]},"references-count":12,"URL":"https:\/\/doi.org\/10.7759\/cureus.17713","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,4]]}}}