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J Clin Sleep Med. 2011, 7:41-8.","journal-title":"J Clin Sleep Med"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.4088\/pcc.v09n0502","article-title":"Morbidity associated with sleep disorders in primary care: a longitudinal cohort study","volume":"9","author":"Wallander MA","year":"2007","unstructured":"Wallander MA, Johansson S, Ruig\u00f3mez A, Garc\u00eda Rodr\u00edguez LA, Jones R. Morbidity associated with sleep disorders in primary care: a longitudinal cohort study. Prim Care Companion J Clin Psychiatry. 2007, 9:338-45. 10.4088\/pcc.v09n0502","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"ref58","article-title":"Clinical update on epidemiology, pathogenesis and nonpharmacological treatment of insomnia [Article in Turkish]","volume":"12","author":"Kahraman M","year":"2006","unstructured":"Kahraman M. Clinical update on epidemiology, pathogenesis and nonpharmacological treatment of insomnia [Article in Turkish]. Turk Noroloji Derg. 2006, 12:87-97.","journal-title":"Turk Noroloji Derg"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1468S","article-title":"Iron deficiency alters brain development and functioning","volume":"133","author":"Beard J","year":"2003","unstructured":"Beard J. Iron deficiency alters brain development and functioning. J Nutr. 2003, 133:1468S-72S. 10.1093\/jn\/133.5.1468S","journal-title":"J Nutr"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1989.tb01408.x","article-title":"Iron deficiency: definition and diagnosis","volume":"226","author":"Cook JD","year":"1989","unstructured":"Cook JD, Skikne BS. Iron deficiency: definition and diagnosis. J Intern Med. 1989, 226:349-55. 10.1111\/j.1365-2796.1989.tb01408.x","journal-title":"J Intern Med"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181586aef","article-title":"Iron deficiency anemia in infancy is associated with altered temporal organization of sleep states in childhood","volume":"62","author":"Peirano PD","year":"2007","unstructured":"Peirano PD, Algar\u00edn CR, Garrido MI, Lozoff B. Iron deficiency anemia in infancy is associated with altered temporal organization of sleep states in childhood. Pediatr Res. 2007, 62:715-9. 10.1203\/PDR.0b013e3181586aef","journal-title":"Pediatr Res"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1767-06.2006","article-title":"Dopaminergic control of sleep-wake states","volume":"26","author":"Dzirasa K","year":"2006","unstructured":"Dzirasa K, Ribeiro S, Costa R, et al.. Dopaminergic control of sleep-wake states. J Neurosci. 2006, 26:10577-89. 10.1523\/JNEUROSCI.1767-06.2006","journal-title":"J Neurosci"},{"key":"ref63","article-title":"Where you least expect it: dopamine in the pons and modulation of sleep and REM-sleep","volume":"26","author":"Keating GL","year":"2003","unstructured":"Keating GL, Rye DB. Where you least expect it: dopamine in the pons and modulation of sleep and REM-sleep. Sleep. 2003, 26:788-9.","journal-title":"Sleep"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4128-13.2014","article-title":"Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans","volume":"34","author":"Holst SC","year":"2014","unstructured":"Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. 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