{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:53:16Z","timestamp":1783119196152,"version":"3.54.6"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,14]]},"DOI":"10.7759\/cureus.18777","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T16:10:07Z","timestamp":1634227807000},"source":"Crossref","is-referenced-by-count":9,"title":["The Risk of Iatrogenic Hypercalcemia in Patients Undergoing Calcium Sulphate Beads Implantation in Prosthetic Joint Surgery: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Muhammad Yasir","family":"Tarar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko Ko Zayar","family":"Toe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Javed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Numan","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizaz","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195707000-00007","article-title":"The use of plaster of paris to fill defects in bone","volume":"146","author":"Peltier LF","year":"1957","unstructured":"Peltier LF, Bickel EY, Lillo R, Thein MS. The use of plaster of paris to fill defects in bone. Ann Surg. 1957, 146:61-9. 10.1097\/00000658-195707000-00007","journal-title":"Ann Surg"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000073345.50837.84","article-title":"Detection of biomaterial-associated infections in orthopaedic joint implants","volume":"413","author":"Neut D","year":"2003","unstructured":"Neut D, van Horn JR, van Kooten TG, van der Mei HC, Busscher HJ. Detection of biomaterial-associated infections in orthopaedic joint implants. Clin Orthop Relat Res. 2003, 413:261-8. 10.1097\/01.blo.0000073345.50837.84","journal-title":"Clin Orthop Relat Res"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20090501-03","article-title":"Antibiotic-impregnated calcium sulfate use in combat-related open fractures","volume":"32","author":"Helgeson MD","year":"2009","unstructured":"Helgeson MD, Potter BK, Tucker CJ, Frisch HM, Shawen SB. Antibiotic-impregnated calcium sulfate use in combat-related open fractures. Orthopedics. 2009, 32:323. 10.3928\/01477447-20090501-03","journal-title":"Orthopedics"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e3181df91d9","article-title":"A prospective, randomized clinical trial comparing an antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion","volume":"24","author":"McKee MD","year":"2010","unstructured":"McKee MD, Li-Bland EA, Wild LM, Schemitsch EH. A prospective, randomized clinical trial comparing an antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion. J Orthop Trauma. 2010, 24:483-90. 10.1097\/BOT.0b013e3181df91d9","journal-title":"J Orthop Trauma"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.15438\/rr.v3i1.27","article-title":"Dissolvable antibiotic beads in treatment of periprosthetic joint infection and revision arthroplasty - the use of synthetic pure calcium sulfate (Stimulan\u00ae) impregnated with vancomycin & tobramycin","volume":"3","author":"McPherson EJ","year":"2013","unstructured":"McPherson EJ, Dipane MV, Sherif M. Dissolvable antibiotic beads in treatment of periprosthetic joint infection and revision arthroplasty - the use of synthetic pure calcium sulfate (Stimulan\u00ae) impregnated with vancomycin &amp; tobramycin. Reconstructive Review. 2013, 3:10.15438\/rr.v3i1.27","journal-title":"Reconstructive Review"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.97B9.34532","article-title":"Hypercalcaemia following the use of antibiotic-eluting absorbable calcium sulphate beads in revision arthroplasty for infection","volume":"97-B","author":"Kallala R","year":"2015","unstructured":"Kallala R, Haddad FS. Hypercalcaemia following the use of antibiotic-eluting absorbable calcium sulphate beads in revision arthroplasty for infection. Bone Joint J. 2015, 97-B:1237-41. 10.1302\/0301-620X.97B9.34532","journal-title":"Bone Joint J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.710.BJR-2017-0319.R1","article-title":"Use of Stimulan absorbable calcium sulphate beads in revision lower limb arthroplasty: safety profile and complication rates","volume":"7","author":"Kallala R","year":"2018","unstructured":"Kallala R, Harris WE, Ibrahim M, Dipane M, McPherson E. Use of Stimulan absorbable calcium sulphate beads in revision lower limb arthroplasty: safety profile and complication rates. Bone Joint Res. 2018, 7:570-9. 10.1302\/2046-3758.710.BJR-2017-0319.R1","journal-title":"Bone Joint Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/1120700020925093","article-title":"Complication rates are low with the use of Stimulan calcium sulphate based antibiotic delivery system in the management of patients with hip-related PJI: early results of a consecutive case series","volume":"30","author":"Sandiford NA","year":"2020","unstructured":"Sandiford NA. Complication rates are low with the use of Stimulan calcium sulphate based antibiotic delivery system in the management of patients with hip-related PJI: early results of a consecutive case series. Hip Int. 2020, 30:3-6. 10.1177\/1120700020925093","journal-title":"Hip Int"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.5414\/CNCS110179","article-title":"Unique case of profound iatrogenic hypercalcemia in a patient with recent orthopedic prosthetic infection","volume":"8","author":"Jung Y","year":"2020","unstructured":"Jung Y, Moe K, Torres EA, Kalantar-Zadeh K, Hanna RM. Unique case of profound iatrogenic hypercalcemia in a patient with recent orthopedic prosthetic infection. Clin Nephrol Case Stud. 2020, 8:91-5. 10.5414\/CNCS110179","journal-title":"Clin Nephrol Case Stud"},{"key":"ref10","article-title":"Hypercalcemia","author":"Sadiq NM","year":"2021","unstructured":"Sadiq NM, Naganathan S, Badireddy M. Hypercalcemia. StatPearls Publishing, Treasure Island (FL); 2021."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"62","author":"Liberati A","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J, et al.. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009, 62:e1-34. 10.1016\/j.jclinepi.2009.06.006","journal-title":"J Clin Epidemiol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-017-0391-8","article-title":"Clarifying the distinction between case series and cohort studies in systematic reviews of comparative studies: potential impact on body of evidence and workload","volume":"17","author":"Mathes T","year":"2017","unstructured":"Mathes T, Pieper D. Clarifying the distinction between case series and cohort studies in systematic reviews of comparative studies: potential impact on body of evidence and workload. BMC Med Res Methodol. 2017, 17:107. 10.1186\/s12874-017-0391-8","journal-title":"BMC Med Res Methodol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.4.180092","article-title":"Periprosthetic joint infection: current concepts and outlook","volume":"4","author":"Izakovicova P","year":"2019","unstructured":"Izakovicova P, Borens O, Trampuz A. Periprosthetic joint infection: current concepts and outlook. EFORT Open Rev. 2019, 4:482-94. 10.1302\/2058-5241.4.180092","journal-title":"EFORT Open Rev"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-2102-9","article-title":"New definition for periprosthetic joint infection: from the workgroup of the Musculoskeletal Infection Society","volume":"469","author":"Parvizi J","year":"2011","unstructured":"Parvizi J, Zmistowski B, Berbari EF, et al.. New definition for periprosthetic joint infection: from the workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res. 2011, 469:2992-4. 10.1007\/s11999-011-2102-9","journal-title":"Clin Orthop Relat Res"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.17.01005","article-title":"Alpha defensin lateral flow test for diagnosis of periprosthetic joint infection: not a screening but a confirmatory test","volume":"100","author":"Renz N","year":"2018","unstructured":"Renz N, Yermak K, Perka C, Trampuz A. Alpha defensin lateral flow test for diagnosis of periprosthetic joint infection: not a screening but a confirmatory test. J Bone Joint Surg Am. 2018, 100:742-50. 10.2106\/JBJS.17.01005","journal-title":"J Bone Joint Surg Am"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.103B1.BJJ-2020-1381.R1","article-title":"The EBJIS definition of periprosthetic joint infection","author":"McNally M","year":"2021","unstructured":"The EBJIS definition of periprosthetic joint infection. 2021, 103-B.18-25. 10.1302\/0301-620X.103B1.BJJ-2020-1381.R1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5371\/hp.2018.30.3.138","article-title":"Management of periprosthetic joint infection","volume":"30","author":"Li C","year":"2018","unstructured":"Li C, Renz N, Trampuz A. Management of periprosthetic joint infection. Hip Pelvis. 2018, 30:138-46. 10.5371\/hp.2018.30.3.138","journal-title":"Hip Pelvis"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01803-7","article-title":"What are the inpatient and day case costs following primary total hip replacement of patients treated for prosthetic joint infection: a matched cohort study using linked data from the National Joint Registry and Hospital Episode Statistics","volume":"18","author":"Garfield K","year":"2020","unstructured":"Garfield K, Noble S, Lenguerrand E, Whitehouse MR, Sayers A, Reed MR, Blom AW. What are the inpatient and day case costs following primary total hip replacement of patients treated for prosthetic joint infection: a matched cohort study using linked data from the National Joint Registry and Hospital Episode Statistics. BMC Med. 2020, 18:335. 10.1186\/s12916-020-01803-7","journal-title":"BMC Med"},{"key":"ref19","doi-asserted-by":"crossref","DOI":"10.1097\/00003086-200210000-00003","article-title":"Periprosthetic total hip infection: outcomes using a staging system","volume":"403","author":"McPherson EJ","year":"2002","unstructured":"McPherson EJ. Periprosthetic total hip infection: outcomes using a staging system. Clin Orthop Relat Res. 2002, 403:8-15.","journal-title":"Clin Orthop Relat Res"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.05.074","article-title":"Preoperative risk factor screening protocols in total joint arthroplasty: a systematic review","volume":"35","author":"Johns WL","year":"2020","unstructured":"Johns WL, Layon D, Golladay GJ, Kates SL, Scott M, Patel NK. Preoperative risk factor screening protocols in total joint arthroplasty: a systematic review. J Arthroplasty. 2020, 35:3353-63. 10.1016\/j.arth.2020.05.074","journal-title":"J Arthroplasty"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilms: a common cause of persistent infections","volume":"284","author":"Costerton JW","year":"1999","unstructured":"Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science. 1999, 284:1318-22. 10.1126\/science.284.5418.1318","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-020-00622-8","article-title":"Elution profiles of synthetic CaSO4 hemihydrate beads loaded with vancomycin and tobramycin","volume":"45","author":"Maale GE","year":"2020","unstructured":"Maale GE, Eager JJ, Mohammadi DK, Calderon FA 2nd. Elution profiles of synthetic CaSO4 hemihydrate beads loaded with vancomycin and tobramycin. Eur J Drug Metab Pharmacokinet. 2020, 45:547-55. 10.1007\/s13318-020-00622-8","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(05)70114-0","article-title":"Calcium sulfate- and calcium phosphate-based bone substitutes. mimicry of the mineral phase of bone","volume":"30","author":"Tay BK","year":"1999","unstructured":"Tay BK, Patel VV, Bradford DS. Calcium sulfate- and calcium phosphate-based bone substitutes. mimicry of the mineral phase of bone. Orthop Clin North Am. 1999, 30:615-23. 10.1016\/S0030-5898(05)70114-0","journal-title":"Orthop Clin North Am"},{"key":"ref24","article-title":"","author":"Dreesmann H","year":"1892","unstructured":"Dreesmann H. Ueber Knochenplombierung bei Hohlenformigen Defekten des Knochens. 1892. https:\/\/www.scirp.org\/(S(351jmbntvnsjt1aadkozje))\/reference\/ReferencesPapers.aspx?ReferenceID=2366877."},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.17140\/NPOJ-1-103","article-title":"A novel case of hypercalcemia following the use of calcium sulfate beads","volume":"1","author":"Carlson Jr CR","year":"2015","unstructured":"Carlson Jr CR, Markulis E, Thompson E, Havill J. A novel case of hypercalcemia following the use of calcium sulfate beads. Nephrol Open J. 2015, 1:17-9. 10.17140\/NPOJ-1-103","journal-title":"Nephrol Open J"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4158\/ACCR-2019-0194","article-title":"Prolonged hypercalcemia from antibiotic-eluting calcium sulfate beads","volume":"5","author":"Vora A","year":"2019","unstructured":"Vora A, Ali S. Prolonged hypercalcemia from antibiotic-eluting calcium sulfate beads. AACE Clin Case Rep. 2019, 5:e349-51. 10.4158\/ACCR-2019-0194","journal-title":"AACE Clin Case Rep"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4158\/ACCR-2019-0216","article-title":"Severe hypercalcemia after joint arthroscopy: calcium sulfate beads to blame","volume":"5","author":"Magdaleno A","year":"2019","unstructured":"Magdaleno A, McCauley RA. Severe hypercalcemia after joint arthroscopy: calcium sulfate beads to blame. AACE Clin Case Rep. 2019, 5:e372-4. 10.4158\/ACCR-2019-0216","journal-title":"AACE Clin Case Rep"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/73480-the-risk-of-iatrogenic-hypercalcemia-in-patients-undergoing-calcium-sulphate-beads-implantation-in-prosthetic-joint-surgery-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:35:28Z","timestamp":1707507328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/73480-the-risk-of-iatrogenic-hypercalcemia-in-patients-undergoing-calcium-sulphate-beads-implantation-in-prosthetic-joint-surgery-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,14]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.18777","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10,14]]}}}