{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:42:28Z","timestamp":1780504948728,"version":"3.54.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,29]]},"DOI":"10.7759\/cureus.20020","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T18:02:44Z","timestamp":1638295364000},"source":"Crossref","is-referenced-by-count":2,"title":["Persistent Pulmonary Hypertension of the Newborn: The Efficacy Comparison of Vasodilators Sildenafil Plus Bosentan Versus Sildenafil Plus Beraprost at a Tertiary Childcare Health Facility"],"prefix":"10.7759","author":[{"given":"Mudasser","family":"Adnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Sohail","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafiz Muhammad","family":"Anwar-ul-Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Afsheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashim","family":"Raza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.37.5.2218","article-title":"Postnatal causes and severity of persistent pulmonary hypertension of newborn","volume":"37","author":"Arshad MS","year":"2021","unstructured":"Arshad MS, Adnan M, Anwar-Ul-Haq HM, Zulqarnain A. Postnatal causes and severity of persistent pulmonary hypertension of newborn. Pak J Med Sci. 2021, 37:1387-91. 10.12669\/pjms.37.5.2218","journal-title":"Pak J Med Sci"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542\/neo.16-12-e680","article-title":"Persistent pulmonary hypertension of the newborn","volume":"16","author":"Lakshminrusimha S","year":"2015","unstructured":"Lakshminrusimha S, Keszler M. Persistent pulmonary hypertension of the newborn. Neoreviews. 2015, 16:e680-92. 10.1542\/neo.16-12-e680","journal-title":"Neoreviews"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.295.3728","article-title":"Risk factors and mortality among newborns with persistent pulmonary hypertension","volume":"29","author":"Razzaq A","year":"2013","unstructured":"Razzaq A, Iqbal Quddusi A, Nizami N. Risk factors and mortality among newborns with persistent pulmonary hypertension. Pak J Med Sci. 2013, 29:1099-104. 10.12669\/pjms.295.3728","journal-title":"Pak J Med Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1536740","article-title":"An Asian multicenter retrospective study on persistent pulmonary hypertension of the newborn: incidence, etiology, diagnosis, treatment and outcome","volume":"33","author":"Nakwan N","year":"2020","unstructured":"Nakwan N, Jain S, Kumar K, et al.. An Asian multicenter retrospective study on persistent pulmonary hypertension of the newborn: incidence, etiology, diagnosis, treatment and outcome. J Matern Fetal Neonatal Med. 2020, 33:2032-7. 10.1080\/14767058.2018.1536740","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13051","article-title":"Current and future treatments for persistent pulmonary hypertension in the newborn","volume":"123","author":"Pedersen J","year":"2018","unstructured":"Pedersen J, Hedegaard ER, Simonsen U, Kr\u00fcger M, Infanger M, Grimm D. Current and future treatments for persistent pulmonary hypertension in the newborn. Basic Clin Pharmacol Toxicol. 2018, 123:392-406. 10.1111\/bcpt.13051","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4021\/ijcp79w","article-title":"Persistent pulmonary hypertension of the newborn: recent advances in the management","volume":"2","author":"Agrawala A","year":"2013","unstructured":"Agrawala A, Agrawal R. Persistent pulmonary hypertension of the newborn: recent advances in the management. Int J Clin Pediatr. 2013, 2:1-11. 10.4021\/ijcp79w","journal-title":"Int J Clin Pediatr"},{"key":"ref7","article-title":"Comparison of the efficacy of sildenafil alone versus sildenafil plus bosentan in new-borns with persistent pulmonary hypertension","volume":"30","author":"Fatima N","year":"2018","unstructured":"Fatima N, Arshad S, Quddusi AI, Rehman A, Nadeem A, Iqbal I. Comparison of the efficacy of sildenafil alone versus sildenafil plus bosentan in new-borns with persistent pulmonary hypertension. J Ayub Med Coll Abbottabad. 2018, 30:333-6.","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000298137","article-title":"Persistent pulmonary hypertension of the newborn successfully treated with beraprost sodium: a retrospective chart review","volume":"99","author":"Nakwan N","year":"2011","unstructured":"Nakwan N, Nakwan N, Wannaro J. Persistent pulmonary hypertension of the newborn successfully treated with beraprost sodium: a retrospective chart review. Neonatology. 2011, 99:32-7. 10.1159\/000298137","journal-title":"Neonatology"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/6.10.744","article-title":"Persistent fetal circulation","volume":"6","author":"D'cunha C","year":"2001","unstructured":"D'cunha C, Sankaran K. Persistent fetal circulation. Paediatr Child Health. 2001, 6:744-50. 10.1093\/pch\/6.10.744","journal-title":"Paediatr Child Health"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2009.04.004","article-title":"Advances in the diagnosis and management of persistent pulmonary hypertension of the newborn","volume":"56","author":"Konduri GG","year":"2009","unstructured":"Konduri GG, Kim UO. Advances in the diagnosis and management of persistent pulmonary hypertension of the newborn. Pediatr Clin North Am. 2009, 56:579-600. 10.1016\/j.pcl.2009.04.004","journal-title":"Pediatr Clin North Am"},{"key":"ref11","article-title":"Sildenafil in the management of pulmonary hypertension in newborn","volume":"35","author":"Al Mamun MA","year":"2019","unstructured":"Al Mamun MA. Sildenafil in the management of pulmonary hypertension in newborn. DS (Child) H J. 2019, 35:94-9.","journal-title":"DS (Child) H J"},{"key":"ref12","article-title":"Oral sildenafil use in neonates with persistent pulmonary hypertension of newborn","volume":"29","author":"Hussain AS","year":"2017","unstructured":"Hussain AS, Ali R, Ahmed S, Naz F, Haroon A. Oral sildenafil use in neonates with persistent pulmonary hypertension of newborn. J Ayub Med Coll Abbottabad. 2017, 29:677-80.","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005698","article-title":"STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension","volume":"129","author":"Barst RJ","year":"2014","unstructured":"Barst RJ, Beghetti M, Pulido T, Layton G, Konourina I, Zhang M, Ivy DD. STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension. Circulation. 2014, 129:1914-23. 10.1161\/CIRCULATIONAHA.113.005698","journal-title":"Circulation"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005494.pub4","article-title":"Sildenafil for pulmonary hypertension in neonates","volume":"8","author":"Kelly LE","year":"2017","unstructured":"Kelly LE, Ohlsson A, Shah PS. Sildenafil for pulmonary hypertension in neonates. Cochrane Database Syst Rev. 2017, 8:CD005494. 10.1002\/14651858.CD005494.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.06.078","article-title":"Bosentan as adjunctive therapy for persistent pulmonary hypertension of the newborn: results of the randomized multicenter placebo-controlled exploratory trial","volume":"177","author":"Steinhorn RH","year":"2016","unstructured":"Steinhorn RH, Fineman J, Kusic-Pajic A, et al.. Bosentan as adjunctive therapy for persistent pulmonary hypertension of the newborn: results of the randomized multicenter placebo-controlled exploratory trial. J Pediatr. 2016, 177:90-96.e3. 10.1016\/j.jpeds.2016.06.078","journal-title":"J Pediatr"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0531-y","article-title":"Persistent pulmonary hypertension of the newborn with transposition of the great arteries: successful treatment with bosentan","volume":"167","author":"Goissen C","year":"2008","unstructured":"Goissen C, Ghyselen L, Tourneux P, Krim G, Storme L, Bou P, Maingourd Y. Persistent pulmonary hypertension of the newborn with transposition of the great arteries: successful treatment with bosentan. Eur J Pediatr. 2008, 167:437-40. 10.1007\/s00431-007-0531-y","journal-title":"Eur J Pediatr"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4103\/jcn.JCN_5_20","article-title":"Comparison of the effects of bosentan and sildenafil in the treatment of persistent pulmonary arterial hypertension in infants","volume":"9","author":"Farhangdoust S","year":"2020","unstructured":"Farhangdoust S, Mehralizadeh S, Bordbar A. Comparison of the effects of bosentan and sildenafil in the treatment of persistent pulmonary arterial hypertension in infants. J Clin Neonatol. 2020, 9:249-54. 10.4103\/jcn.JCN_5_20","journal-title":"J Clin Neonatol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/2045893217710639","article-title":"Combination therapy in pulmonary arterial hypertension: recent accomplishments and future challenges","volume":"7","author":"Lajoie AC","year":"2017","unstructured":"Lajoie AC, Bonnet S, Provencher S. Combination therapy in pulmonary arterial hypertension: recent accomplishments and future challenges. Pulm Circ. 2017, 7:312-25. 10.1177\/2045893217710639","journal-title":"Pulm Circ"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/78052-persistent-pulmonary-hypertension-of-the-newborn-the-efficacy-comparison-of-vasodilators-sildenafil-plus-bosentan-versus-sildenafil-plus-beraprost-at-a-tertiary-childcare-health-facility","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:32:24Z","timestamp":1707507144000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/78052-persistent-pulmonary-hypertension-of-the-newborn-the-efficacy-comparison-of-vasodilators-sildenafil-plus-bosentan-versus-sildenafil-plus-beraprost-at-a-tertiary-childcare-health-facility"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,29]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.20020","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,29]]}}}