{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:37:40Z","timestamp":1782963460182,"version":"3.54.5"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,3]]},"DOI":"10.7759\/cureus.20128","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T12:39:48Z","timestamp":1638535188000},"source":"Crossref","is-referenced-by-count":3,"title":["The Role of Gene Variants in the Iron Metabolism of Anemic Adolescent Girls"],"prefix":"10.7759","author":[{"given":"Sudarshan Reddy","family":"Varikuti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devaraj  J","family":"Parasannavar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemalatha","family":"Rajkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulja","family":"Bhukya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uppala","family":"Satyanarayana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(19)30273-1","article-title":"The burden of child and maternal malnutrition and trends in its indicators in the states of India: the Global Burden of Disease Study 1990-2017","volume":"3","author":"Swaminathan S","year":"2019","unstructured":"Swaminathan S, Hemalatha R, Pandey A, et al.. The burden of child and maternal malnutrition and trends in its indicators in the states of India: the Global Burden of Disease Study 1990-2017. Lancet Child Adolesc Health. 2019, 3:855-70. 10.1016\/S2352-4642(19)30273-1","journal-title":"Lancet Child Adolesc Health"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-019-1550-2","article-title":"Ironing out the iron requirements of children and adolescents","volume":"56","author":"Pullakhandam R","year":"2019","unstructured":"Pullakhandam R, Kulkarni B, Rajkumar H. Ironing out the iron requirements of children and adolescents. Indian Pediatr. 2019, 56:547-8. 10.1007\/s13312-019-1550-2","journal-title":"Indian Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15034077","article-title":"Influence of diet, menstruation and genetic factors on iron status: a cross-sectional study in Spanish women of childbearing age","volume":"15","author":"Blanco-Rojo R","year":"2014","unstructured":"Blanco-Rojo R, Toxqui L, L\u00f3pez-Parra AM, Baeza-Richer C, P\u00e9rez-Granados AM, Arroyo-Pardo E, Vaquero MP. Influence of diet, menstruation and genetic factors on iron status: a cross-sectional study in Spanish women of childbearing age. Int J Mol Sci. 2014, 15:4077-87. 10.3390\/ijms15034077","journal-title":"Int J Mol Sci"},{"key":"ref4","article-title":"Anemia prophylaxis in adolescent school girls by weekly or daily iron-folate supplementation","volume":"40","author":"Agarwal KN","year":"2003","unstructured":"Agarwal KN, Gomber S, Bisht H, Som M. Anemia prophylaxis in adolescent school girls by weekly or daily iron-folate supplementation. Indian Pediatr. 2003, 40:296-301.","journal-title":"Indian Pediatr"},{"key":"ref5","article-title":"Combatting anemia in adolescent girls: a report from India","volume":"13","author":"Kanani S","year":"1994","unstructured":"Kanani S. Combatting anemia in adolescent girls: a report from India. Mothers Child. 1994, 13:1-3.","journal-title":"Mothers Child"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02723584","article-title":"Prevalence of iron, vitamin A, and iodine deficiencies amongst adolescent pregnant mothers","volume":"70","author":"Pathak P","year":"2003","unstructured":"Pathak P, Singh P, Kapil U, Raghuvanshi RS. Prevalence of iron, vitamin A, and iodine deficiencies amongst adolescent pregnant mothers. Indian J Pediatr. 2003, 70:299-301. 10.1007\/BF02723584","journal-title":"Indian J Pediatr"},{"key":"ref7","article-title":"Prevalence of anaemia and hookworm infestation among adolescent girls in one rural block of TamilNadu","volume":"8","author":"Sampathkumar V","year":"1997","unstructured":"Sampathkumar V, Rajaratnam A. Prevalence of anaemia and hookworm infestation among adolescent girls in one rural block of TamilNadu. Indian J Matern Child Health. 1997, 8:73-5.","journal-title":"Indian J Matern Child Health"},{"key":"ref8","article-title":"Review on iron and its importance for human health","volume":"19","author":"Abbaspour N","year":"2014","unstructured":"Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014, 19:164-74.","journal-title":"J Res Med Sci"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ng.466","article-title":"Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium","volume":"41","author":"Ganesh SK","year":"2009","unstructured":"Ganesh SK, Zakai NA, van Rooij FJ, et al.. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet. 2009, 41:1191-8. 10.1038\/ng.466","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038339","article-title":"Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations","volume":"7","author":"McLaren CE","year":"2012","unstructured":"McLaren CE, McLachlan S, Garner CP, et al.. Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. PLoS One. 2012, 7:e38339. 10.1371\/journal.pone.0038339","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-224808","article-title":"Down-regulation of Bmp\/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis","volume":"115","author":"Finberg KE","year":"2010","unstructured":"Finberg KE, Whittlesey RL, Fleming MD, Andrews NC. Down-regulation of Bmp\/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. Blood. 2010, 115:3817-26. 10.1182\/blood-2009-05-224808","journal-title":"Blood"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-8-69","article-title":"Four variants in transferrin and HFE genes as potential markers of iron deficiency anaemia risk: an association study in menstruating women","volume":"8","author":"Blanco-Rojo R","year":"2011","unstructured":"Blanco-Rojo R, Baeza-Richer C, L\u00f3pez-Parra AM, et al.. Four variants in transferrin and HFE genes as potential markers of iron deficiency anaemia risk: an association study in menstruating women. Nutr Metab (Lond). 2011, 8:69. 10.1186\/1743-7075-8-69","journal-title":"Nutr Metab (Lond)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/ng.462","article-title":"Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels","volume":"41","author":"Chambers JC","year":"2009","unstructured":"Chambers JC, Zhang W, Li Y, et al.. Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nat Genet. 2009, 41:1170-2. 10.1038\/ng.462","journal-title":"Nat Genet"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.11.011","article-title":"Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels","volume":"84","author":"Benyamin B","year":"2009","unstructured":"Benyamin B, McRae AF, Zhu G, et al.. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. Am J Hum Genet. 2009, 84:60-5. 10.1016\/j.ajhg.2008.11.011","journal-title":"Am J Hum Genet"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-232496","article-title":"A genome-wide association analysis of serum iron concentrations","volume":"115","author":"Tanaka T","year":"2010","unstructured":"Tanaka T, Roy CN, Yao W, et al.. A genome-wide association analysis of serum iron concentrations. Blood. 2010, 115:94-6. 10.1182\/blood-2009-07-232496","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03096.x","article-title":"Human transferrin G277S mutation: a risk factor for iron deficiency anaemia","volume":"115","author":"Lee PL","year":"2001","unstructured":"Lee PL, Halloran C, Trevino R, Felitti V, Beutler E. Human transferrin G277S mutation: a risk factor for iron deficiency anaemia. Br J Haematol. 2001, 115:329-33. 10.1046\/j.1365-2141.2001.03096.x","journal-title":"Br J Haematol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000154156","article-title":"Transferrin types, iron-binding capacity and body iron stores","volume":"43","author":"Sikstr\u00f6m C","year":"1993","unstructured":"Sikstr\u00f6m C, Beckman L, Hallmans G, Asplund K. Transferrin types, iron-binding capacity and body iron stores. Hum Hered. 1993, 43:337-41. 10.1159\/000154156","journal-title":"Hum Hered"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1119(97)00356-9","article-title":"Exon\/intron structure of the human transferrin receptor gene","volume":"199","author":"Evans P","year":"1997","unstructured":"Evans P, Kemp J. Exon\/intron structure of the human transferrin receptor gene. Gene. 1997, 199:123-31. 10.1016\/s0378-1119(97)00356-9","journal-title":"Gene"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.03.054","article-title":"Is the 1254T > C polymorphism in the DMT1 gene associated with Parkinson's disease?","volume":"594","author":"Saadat SM","year":"2015","unstructured":"Saadat SM, De\u011firmenci \u0130, \u00d6zkan S, Saydam F, \u00d6zdemir K\u00f6ro\u011flu Z, \u00c7olak E, G\u00fcne\u015f HV. Is the 1254T &gt; C polymorphism in the DMT1 gene associated with Parkinson's disease?. Neurosci Lett. 2015, 594:51-4. 10.1016\/j.neulet.2015.03.054","journal-title":"Neurosci Lett"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.02.037","article-title":"Serum ferritin concentration is affected by ferroportin Q248H mutation in Africans","volume":"444","author":"Kasvosve I","year":"2015","unstructured":"Kasvosve I, Tshwenyego U, Phuthego T, Koto G, Zachariah M, Nyepetsi NG, Motswaledi MS. Serum ferritin concentration is affected by ferroportin Q248H mutation in Africans. Clin Chim Acta. 2015, 444:257-9. 10.1016\/j.cca.2015.02.037","journal-title":"Clin Chim Acta"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0695-1","article-title":"Association study of the G258S transferrin gene polymorphism and Parkinson's disease in the Spanish population","volume":"252","author":"Ezquerra M","year":"2005","unstructured":"Ezquerra M, Campdelacreu J, Mu\u00f1oz E, Tolosa E. Association study of the G258S transferrin gene polymorphism and Parkinson's disease in the Spanish population. J Neurol. 2005, 252:1269-70. 10.1007\/s00415-005-0695-1","journal-title":"J Neurol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4103\/2224-3151.228423","article-title":"The burden of iron-deficiency anaemia among women in India: how have iron and folic acid interventions fared?","volume":"7","author":"Rai RK","year":"2018","unstructured":"Rai RK, Fawzi WW, Barik A, Chowdhury A. The burden of iron-deficiency anaemia among women in India: how have iron and folic acid interventions fared?. WHO South East Asia J Public Health. 2018, 7:18-23. 10.4103\/2224-3151.228423","journal-title":"WHO South East Asia J Public Health"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2008.08.001","article-title":"Ferritin for the clinician","volume":"23","author":"Knovich MA","year":"2009","unstructured":"Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev. 2009, 23:95-104. 10.1016\/j.blre.2008.08.001","journal-title":"Blood Rev"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2005.04.009","article-title":"The C2 variant of human serum transferrin retains the iron binding properties of the native protein","volume":"1741","author":"Zatta P","year":"2005","unstructured":"Zatta P, Messori L, Mauri P, van Rensburg SJ, van Zyl J, Gabrielli S, Gabbiani C. The C2 variant of human serum transferrin retains the iron binding properties of the native protein. Biochim Biophys Acta. 2005, 1741:264-70. 10.1016\/j.bbadis.2005.04.009","journal-title":"Biochim Biophys Acta"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199801260-00001","article-title":"Transferrin C2, metal binding and Alzheimer's disease","volume":"9","author":"Van Landeghem GF","year":"1998","unstructured":"Van Landeghem GF, Sikstr\u00f6m C, Beckman LE, Adolfsson R, Beckman L. Transferrin C2, metal binding and Alzheimer's disease. Neuroreport. 1998, 9:177-9. 10.1097\/00001756-199801260-00001","journal-title":"Neuroreport"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.1.1.75","article-title":"Iron metabolism: iron deficiency and iron overload","volume":"1","author":"Andrews NC","year":"2000","unstructured":"Andrews NC. Iron metabolism: iron deficiency and iron overload. Annu Rev Genomics Hum Genet. 2000, 1:75-98. 10.1146\/annurev.genom.1.1.75","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30528","article-title":"Molecular genetic studies of DMT1 on 12q in French-Canadian restless legs syndrome patients and families","volume":"144B","author":"Xiong L","year":"2007","unstructured":"Xiong L, Dion P, Montplaisir J, et al.. Molecular genetic studies of DMT1 on 12q in French-Canadian restless legs syndrome patients and families. Am J Med Genet B Neuropsychiatr Genet. 2007, 144B:911-7. 10.1002\/ajmg.b.30528","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.072207","article-title":"Clinical aspects and pathogenesis of congenital dyserythropoietic anemias: from morphology to molecular approach","volume":"97","author":"Iolascon A","year":"2012","unstructured":"Iolascon A, Esposito MR, Russo R. Clinical aspects and pathogenesis of congenital dyserythropoietic anemias: from morphology to molecular approach. Haematologica. 2012, 97:1786-94. 10.3324\/haematol.2012.072207","journal-title":"Haematologica"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/75829-the-role-of-gene-variants-in-the-iron-metabolism-of-anemic-adolescent-girls","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:32:30Z","timestamp":1707507150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/75829-the-role-of-gene-variants-in-the-iron-metabolism-of-anemic-adolescent-girls"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,3]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.20128","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,3]]}}}