{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:21:19Z","timestamp":1767993679420,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,18]]},"DOI":"10.7759\/cureus.20503","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T18:02:53Z","timestamp":1639850573000},"source":"Crossref","is-referenced-by-count":1,"title":["Management of Cervical Kyphotic Deformity Associated With Loeys-Dietz Vasculopathy and Cardiac Transplantation: Case Report, Literature Review, and Strategies for Complex Skeletal Dysplasias"],"prefix":"10.7759","author":[{"given":"Daniel A","family":"Donoho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy G","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler","family":"Lazaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1511","article-title":"A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2","volume":"37","author":"Loeys BL","year":"2005","unstructured":"Loeys BL, Chen J, Neptune ER, et al.. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet. 2005, 37:275-81. 10.1038\/ng1511","journal-title":"Nat Genet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.11","article-title":"Loeys-Dietz syndrome: a primer for diagnosis and management","volume":"16","author":"MacCarrick G","year":"2014","unstructured":"MacCarrick G, Black JH 3rd, Bowdin S, et al.. Loeys-Dietz syndrome: a primer for diagnosis and management. Genet Med. 2014, 16:576-87. 10.1038\/gim.2014.11","journal-title":"Genet Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.N.00680","article-title":"High prevalence of cervical deformity and instability requires surveillance in Loeys-Dietz syndrome","volume":"97","author":"Fuhrhop SK","year":"2015","unstructured":"Fuhrhop SK, McElroy MJ, Dietz HC 3rd, MacCarrick GL, Sponseller PD. High prevalence of cervical deformity and instability requires surveillance in Loeys-Dietz syndrome. J Bone Joint Surg Am. 2015, 97:411-9. 10.2106\/JBJS.N.00680","journal-title":"J Bone Joint Surg Am"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-1105-7","article-title":"Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods: resequencing microarray technology and next-generation sequencing","volume":"131","author":"Sakai H","year":"2012","unstructured":"Sakai H, Suzuki S, Mizuguchi T, et al.. Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods: resequencing microarray technology and next-generation sequencing. Hum Genet. 2012, 131:591-9. 10.1007\/s00439-011-1105-7","journal-title":"Hum Genet"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3171\/2018.4.SPINE171389","article-title":"Thoracogenic spinal deformity: a rare cause of early-onset scoliosis","volume":"29","author":"Eby SF","year":"2018","unstructured":"Eby SF, Hilaire TS, Glotzbecker M, Smith J, White KK, Larson AN. Thoracogenic spinal deformity: a rare cause of early-onset scoliosis. J Neurosurg Spine. 2018, 29:674-9. 10.3171\/2018.4.SPINE171389","journal-title":"J Neurosurg Spine"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000158959.91925.43","article-title":"Scoliosis after median sternotomy in children with congenital heart disease","volume":"30","author":"Ruiz-Iban MA","year":"2005","unstructured":"Ruiz-Iban MA, Burgos J, Aguado HJ, Diaz-Heredia J, Roger I, Muriel A, Sanchez PA. Scoliosis after median sternotomy in children with congenital heart disease. Spine (Phila Pa 1976). 2005, 30:E214-8. 10.1097\/01.brs.0000158959.91925.43","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3171\/2015.2.PEDS14533","article-title":"The efficacy of routine use of recombinant human bone morphogenetic protein-2 in occipitocervical and atlantoaxial fusions of the pediatric spine: a minimum of 12 months' follow-up with computed tomography","volume":"16","author":"Sayama C","year":"2015","unstructured":"Sayama C, Hadley C, Monaco GN, et al.. The efficacy of routine use of recombinant human bone morphogenetic protein-2 in occipitocervical and atlantoaxial fusions of the pediatric spine: a minimum of 12 months' follow-up with computed tomography. J Neurosurg Pediatr. 2015, 16:14-20. 10.3171\/2015.2.PEDS14533","journal-title":"J Neurosurg Pediatr"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2011.04.023","article-title":"A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned","volume":"11","author":"Carragee EJ","year":"2011","unstructured":"Carragee EJ, Hurwitz EL, Weiner BK. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J. 2011, 11:471-91. 10.1016\/j.spinee.2011.04.023","journal-title":"Spine J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01483","article-title":"Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis","volume":"95","author":"Carragee EJ","year":"2013","unstructured":"Carragee EJ, Chu G, Rohatgi R, et al.. Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis. J Bone Joint Surg Am. 2013, 95:1537-45. 10.2106\/JBJS.L.01483","journal-title":"J Bone Joint Surg Am"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2018.08.010","article-title":"A pan-cancer analysis reveals high-frequency genetic alterations in mediators of signaling by the TGF-\u03b2 superfamily","volume":"7","author":"Korkut A","year":"2018","unstructured":"Korkut A, Zaidi S, Kanchi RS, et al.. A pan-cancer analysis reveals high-frequency genetic alterations in mediators of signaling by the TGF-\u03b2 superfamily. Cell Syst. 2018, 7:422-437.e7. 10.1016\/j.cels.2018.08.010","journal-title":"Cell Syst"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3171\/2014.10.PEDS14199","article-title":"Routine use of recombinant human bone morphogenetic protein-2 in posterior fusions of the pediatric spine and incidence of cancer","volume":"16","author":"Sayama C","year":"2015","unstructured":"Sayama C, Willsey M, Chintagumpala M, et al.. Routine use of recombinant human bone morphogenetic protein-2 in posterior fusions of the pediatric spine and incidence of cancer. J Neurosurg Pediatr. 2015, 16:4-13. 10.3171\/2014.10.PEDS14199","journal-title":"J Neurosurg Pediatr"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.10.058","article-title":"Successful heart transplantation in a patient with Loeys-Dietz syndrome","volume":"107","author":"Feroe AG","year":"2019","unstructured":"Feroe AG, Fiedler AG, D'Alessandro DA. Successful heart transplantation in a patient with Loeys-Dietz syndrome. Ann Thorac Surg. 2019, 107:e379-80. 10.1016\/j.athoracsur.2018.10.058","journal-title":"Ann Thorac Surg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000003230","article-title":"Solid organ transplant is associated with increased morbidity and mortality in patients undergoing one or two-level anterior cervical decompression and fusion","volume":"45","author":"Labaran LA","year":"2020","unstructured":"Labaran LA, Harris AB, Puvanesarajah V, Amin R, Raad M, Jain A, Hassanzadeh H. Solid organ transplant is associated with increased morbidity and mortality in patients undergoing one or two-level anterior cervical decompression and fusion. Spine (Phila Pa 1976). 2020, 45:158-62. 10.1097\/BRS.0000000000003230","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000002393","article-title":"Lumbar spine fusion surgery in solid organ transplant recipients is associated with increased medical complications and mortality","volume":"43","author":"Amin R","year":"2018","unstructured":"Amin R, Puvanesarajah V, Qureshi R, Jain A, Kebaish K, Shen FH, Hassanzadeh H. Lumbar spine fusion surgery in solid organ transplant recipients is associated with increased medical complications and mortality. Spine (Phila Pa 1976). 2018, 43:617-21. 10.1097\/BRS.0000000000002393","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000232809.04730.22","article-title":"Surgical correction of developmental scoliosis following cardiac transplantation: case report","volume":"31","author":"Tsirikos AI","year":"2006","unstructured":"Tsirikos AI, Baker AD, McMaster MJ, Rose M. Surgical correction of developmental scoliosis following cardiac transplantation: case report. Spine (Phila Pa 1976). 2006, 31:E713-7. 10.1097\/01.brs.0000232809.04730.22","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3171\/2011.2.SPINE10481","article-title":"Spinal surgery following organ transplantation","volume":"14","author":"Shaikh KA","year":"2011","unstructured":"Shaikh KA, Helbig GM, Shapiro SA, Shah MV, Khairi SA, Horn EM. Spinal surgery following organ transplantation. J Neurosurg Spine. 2011, 14:779-84. 10.3171\/2011.2.SPINE10481","journal-title":"J Neurosurg Spine"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1996.00170.x","article-title":"Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation","volume":"26","author":"Thi\u00e9baud D","year":"1996","unstructured":"Thi\u00e9baud D, Krieg MA, Gillard-Berguer D, Jacquet AF, Goy JJ, Burckhardt P. Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation. Eur J Clin Invest. 1996, 26:549-55. 10.1046\/j.1365-2362.1996.00170.x","journal-title":"Eur J Clin Invest"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.39.131","article-title":"Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in rats","volume":"39","author":"Kanda J","year":"2018","unstructured":"Kanda J, Izumo N, Furukawa M, et al.. Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in rats. Biomed Res. 2018, 39:131-9. 10.2220\/biomedres.39.131","journal-title":"Biomed Res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081900","article-title":"FK506 induces ligand-independent activation of the bone morphogenetic protein pathway and osteogenesis","volume":"20","author":"Sangadala S","year":"2019","unstructured":"Sangadala S, Devereaux EJ, Presciutti SM, Boden SD, Willet NJ. FK506 induces ligand-independent activation of the bone morphogenetic protein pathway and osteogenesis. Int J Mol Sci. 2019, 20:10.3390\/ijms20081900","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v040a10","article-title":"Effects of FK506 on the healing of diaphyseal, critical size defects in the rat femur","volume":"40","author":"De la Vega RE","year":"2020","unstructured":"De la Vega RE, Coenen MJ, M\u00fcller SA, Nagelli CV, Quirk NP, Lopez de Padilla C, Evans CH. Effects of FK506 on the healing of diaphyseal, critical size defects in the rat femur. Eur Cell Mater. 2020, 40:160-71. 10.22203\/eCM.v040a10","journal-title":"Eur Cell Mater"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/79272-management-of-cervical-kyphotic-deformity-associated-with-loeys-dietz-vasculopathy-and-cardiac-transplantation-case-report-literature-review-and-strategies-for-complex-skeletal-dysplasias","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:34:16Z","timestamp":1707507256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/79272-management-of-cervical-kyphotic-deformity-associated-with-loeys-dietz-vasculopathy-and-cardiac-transplantation-case-report-literature-review-and-strategies-for-complex-skeletal-dysplasias"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,18]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.20503","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,18]]}}}