{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:14:27Z","timestamp":1774714467225,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,13]]},"DOI":"10.7759\/cureus.21187","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T08:33:17Z","timestamp":1642062797000},"source":"Crossref","is-referenced-by-count":5,"title":["Acute Calculous Cholecystitis With Sinus Bradycardia: Cope's Sign Encountered"],"prefix":"10.7759","author":[{"given":"Haris","family":"Iftikhar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feroze Salahuddin","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nood Dhafi R","family":"Al-Marri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany  A","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarij","family":"Masood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1515\/jom-1989-890510","article-title":"Electrocardiographic changes in acute cholecystitis","volume":"89","author":"Dickerman JL","year":"1989","unstructured":"Dickerman JL. Electrocardiographic changes in acute cholecystitis. J Am Osteopath Assoc. 1989, 89:630-5. 10.1515\/jom-1989-890510","journal-title":"J Am Osteopath Assoc"},{"key":"ref2","article-title":"Electrocardiographic changes in cardiac patients with acute gallbladder disease","volume":"52","author":"Krasna MJ","year":"1986","unstructured":"Krasna MJ, Flancbaum L. Electrocardiographic changes in cardiac patients with acute gallbladder disease. Am Surg. 1986, 52:541-3.","journal-title":"Am Surg"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5754.146","article-title":"\"Cope's sign\" and reflex bradycardia in two patients with cholecystitis","volume":"2","author":"O'Reilly MV","year":"1971","unstructured":"O'Reilly MV, Krauthamer MJ. \"Cope's sign\" and reflex bradycardia in two patients with cholecystitis. Br Med J. 1971, 2:146. 10.1136\/bmj.2.5754.146","journal-title":"Br Med J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.6.625","article-title":"Neurally mediated syncope in 2 patients with extracardiac disease","volume":"159","author":"Vloka ME","year":"1999","unstructured":"Vloka ME, Tamis JE, Steinberg JS. Neurally mediated syncope in 2 patients with extracardiac disease. Arch Intern Med. 1999, 159:625-7. 10.1001\/archinte.159.6.625","journal-title":"Arch Intern Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0b013e32832baed8","article-title":"Complete atrioventricular block in a patient with acute cholecystitis: a case of cardio-biliary reflex?","volume":"16","author":"Franzen D","year":"2009","unstructured":"Franzen D, Jung S, Fatio R, Brunckhorst CB. Complete atrioventricular block in a patient with acute cholecystitis: a case of cardio-biliary reflex?. Eur J Emerg Med. 2009, 16:346-7. 10.1097\/MEJ.0b013e32832baed8","journal-title":"Eur J Emerg Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.07.014","article-title":"Idioventricular rhythm in a patient with acute cholecystitis","volume":"35","author":"Akyel A","year":"2011","unstructured":"Akyel A, Yayla C, Kunak T, Yaman B, Tavil Y, Boyaci B. Idioventricular rhythm in a patient with acute cholecystitis. Clin Res Hepatol Gastroenterol. 2011, 35:774-6. 10.1016\/j.clinre.2011.07.014","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.12.153","article-title":"Asystole complicating acalculous cholecystitis, the \"Cope's sign\" revisited","volume":"182","author":"Lau YM","year":"2015","unstructured":"Lau YM, Hui WM, Lau CP. Asystole complicating acalculous cholecystitis, the \"Cope's sign\" revisited. Int J Cardiol. 2015, 182:447-8. 10.1016\/j.ijcard.2014.12.153","journal-title":"Int J Cardiol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.22514\/sv101.062015.14","article-title":"Intermittent complete heart block in acute calculous cholecystitis","volume":"10","author":"Sori\u0107 M","year":"2015","unstructured":"Sori\u0107 M, Mileti\u0107 W, \u017diga S, Grabovac V. Intermittent complete heart block in acute calculous cholecystitis. Signa Vitae. 2015, 10:53-4. 10.22514\/sv101.062015.14","journal-title":"Signa Vitae"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ienj.2017.10.002","article-title":"Cope's sign and complete heart block in a 78-year-old patient with biliary colic","volume":"37","author":"Papakonstantinou PE","year":"2018","unstructured":"Papakonstantinou PE, Asimakopoulou NI, Kanoupakis E, Maragkoudakis S, Panagiotakis S, Gikas A. Cope's sign and complete heart block in a 78-year-old patient with biliary colic. Int Emerg Nurs. 2018, 37:3-5. 10.1016\/j.ienj.2017.10.002","journal-title":"Int Emerg Nurs"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/2221-6189.288597","article-title":"Cope\u2019s sign and complete heart block secondary to acute cholecystitis: a case report","volume":"9","author":"Kumar N","year":"2020","unstructured":"Kumar N, Kumar P, Dubey P, Kumar A, Kumar A. Cope\u2019s sign and complete heart block secondary to acute cholecystitis: a case report. J Acute Dis. 2020, 9:176. 10.4103\/2221-6189.288597","journal-title":"J Acute Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/ans.16110","article-title":"Bradycardia and syncope: the case of the torted gallbladder","volume":"91","author":"Scott B","year":"2021","unstructured":"Scott B, Hameed A, Knox R. Bradycardia and syncope: the case of the torted gallbladder. ANZ J Surg. 2021, 91:E50-1. 10.1111\/ans.16110","journal-title":"ANZ J Surg"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/82591-acute-calculous-cholecystitis-with-sinus-bradycardia-copes-sign-encountered","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:42:17Z","timestamp":1707507737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/82591-acute-calculous-cholecystitis-with-sinus-bradycardia-copes-sign-encountered"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,13]]},"references-count":11,"URL":"https:\/\/doi.org\/10.7759\/cureus.21187","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,13]]}}}