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Heart Lung Circ. 2015, 24:686-95. 10.1016\/j.hlc.2014.12.161","journal-title":"Heart Lung Circ"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027497","article-title":"Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency","volume":"136","author":"van Veldhuisen DJ","year":"2017","unstructured":"van Veldhuisen DJ, Ponikowski P, van der Meer P, et al.. Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency. Circulation. 2017, 136:1374-83. 10.1161\/CIRCULATIONAHA.117.027497","journal-title":"Circulation"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.025","article-title":"2017 ACC\/AHA\/HFSA focused update of the 2013 ACCF\/AHA guideline for the\u00a0management of heart failure: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America","volume":"70","author":"Yancy CW","year":"2017","unstructured":"Yancy CW, Jessup M, Bozkurt B, et al.. 2017 ACC\/AHA\/HFSA focused update of the 2013 ACCF\/AHA guideline for the\u00a0management of heart failure: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. J Am Coll Cardiol. 2017, 70:776-803. 10.1016\/j.jacc.2017.04.025","journal-title":"J Am Coll Cardiol"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21154","article-title":"Intravenous iron: from anathema to standard of care","volume":"83","author":"Auerbach M","year":"2008","unstructured":"Auerbach M, Coyne D, Ballard H. Intravenous iron: from anathema to standard of care. Am J Hematol. 2008, 83:580-8. 10.1002\/ajh.21154","journal-title":"Am J Hematol"},{"key":"ref61","article-title":"Intravenous iron-dextran: therapeutic and experimental possibilities [Article in German]","volume":"100","author":"Ganzoni AM","year":"1970","unstructured":"Ganzoni AM. Intravenous iron-dextran: therapeutic and experimental possibilities [Article in German]. Schweiz Med Wochenschr. 1970, 100:301-3.","journal-title":"Schweiz Med Wochenschr"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.5427","article-title":"Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency. The IRONOUT HF Randomized Clinical Trial","volume":"317","author":"Lewis GD","year":"2017","unstructured":"Lewis GD, Malhotra R, Hernandez AF, et al.. Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency. The IRONOUT HF Randomized Clinical Trial. JAMA. 2017, 317:1958-66. 10.1001\/jama.2017.5427","journal-title":"JAMA"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000736","article-title":"Identifying responders to oral iron supplementation in heart failure with a reduced ejection fraction: a post-hoc analysis of the IRONOUT-HF trial","volume":"20","author":"Ambrosy AP","year":"2019","unstructured":"Ambrosy AP, Lewis GD, Malhotra R, et al.. Identifying responders to oral iron supplementation in heart failure with a reduced ejection fraction: a post-hoc analysis of the IRONOUT-HF trial. J Cardiovasc Med (Hagerstown). 2019, 20:223-5. 10.2459\/JCM.0000000000000736","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12250","article-title":"Single-dose intravenous iron in Southeast Asian heart failure patients: a pilot randomized placebo-controlled study (PRACTICE-ASIA-HF)","volume":"5","author":"Yeo TJ","year":"2018","unstructured":"Yeo TJ, Yeo PS, Hadi FA, et al.. Single-dose intravenous iron in Southeast Asian heart failure patients: a pilot randomized placebo-controlled study (PRACTICE-ASIA-HF). ESC Heart Fail. 2018, 5:344-53. 10.1002\/ehf2.12250","journal-title":"ESC Heart Fail"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038516","article-title":"Effect of iron isomaltoside on skeletal muscle energetics in patients with chronic heart failure and iron deficiency","volume":"139","author":"Charles-Edwards G","year":"2019","unstructured":"Charles-Edwards G, Amaral N, Sleigh A, et al.. Effect of iron isomaltoside on skeletal muscle energetics in patients with chronic heart failure and iron deficiency. Circulation. 2019, 139:2386-98. 10.1161\/CIRCULATIONAHA.118.038516","journal-title":"Circulation"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014254","article-title":"Noninvasive imaging estimation of myocardial iron repletion following administration of intravenous iron: the Myocardial-IRON Trial","volume":"9","author":"N\u00fa\u00f1ez J","year":"2020","unstructured":"N\u00fa\u00f1ez J, Mi\u00f1ana G, Cardells I, et al.. Noninvasive imaging estimation of myocardial iron repletion following administration of intravenous iron: the Myocardial-IRON Trial. J Am Heart Assoc. 2020, 9:e014254. 10.1161\/JAHA.119.014254","journal-title":"J Am Heart Assoc"},{"key":"ref67","unstructured":"Intravenous iron in patients with systolic heart failure and iron deficiency to improve morbidity &amp; mortality. (2021). Accessed. July 9, 2021: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03036462."},{"key":"ref68","unstructured":"Randomized placebo-controlled trial of FCM as treatment for heart failure with iron deficiency. (2021). Accessed. July 9, 2021: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03037931."},{"key":"ref69","unstructured":"Study to compare ferric carboxymaltose with placebo in patients with acute heart failure and iron deficiency. (2021). Accessed. July 9, 2021: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02937454."},{"key":"ref70","unstructured":"Effect of IV iron in patients with heart failure with preserved ejection fraction. (2020). Accessed. July 9, 2021: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03074591."},{"key":"ref71","unstructured":"Effects of iron therapy in heart failure with preserved ejection fraction and iron deficiency (PREFER-HF). (2019). Accessed. July 9, 2021: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03833336."},{"key":"ref72","unstructured":"Ferric carboxymaltose to improve skeletal muscle metabolism in heart failure patients with functional iron deficiency. (2021). Accessed. July 9, 2021: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03218384."},{"key":"ref73","unstructured":"Effects of iron therapy and exercise training in patients with heart failure and iron deficiency. (2021). Accessed. July 9, 2021: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03803111."},{"key":"ref74","unstructured":"Iron deficiency in heart failure patients. (2019). Accessed. July 7, 2020: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03883854."},{"key":"ref75","unstructured":"Study of the prevalence of iron deficiency in patients with heart failure (CARENFER IC). (2019). Accessed. July 7, 2020: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03924258."},{"key":"ref76","unstructured":"IV iron in acute decompensated heart failure. (2019). Accessed. July 7, 2020: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04063033."},{"key":"ref77","unstructured":"Iron in patients with cardiovascular disease (iCHF-2). (2019). Accessed. 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