{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:18:15Z","timestamp":1793870295190,"version":"4.6.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,8]]},"DOI":"10.7759\/cureus.22016","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T13:42:58Z","timestamp":1644327778000},"source":"Crossref","is-referenced-by-count":5,"title":["A Cross-Sectional Study of Serum Glutathione Peroxidase: An Antioxidative Marker in Chronic Periodontitis and Chronic Kidney Disease"],"prefix":"10.7759","author":[{"given":"Plato","family":"Palathingal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaideep","family":"Mahendra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandapulaykal T","family":"Annamalai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam S","family":"Varma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Little","family":"Mahendra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libby","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Baby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil","family":"Jose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sruthi","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambily","family":"R","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00744.x","article-title":"The investigation of glutathione peroxidase, lactoferrin, myeloperoxidase and interleukin-1beta in gingival crevicular fluid: implications for oxidative stress in human periodontal diseases","volume":"39","author":"Wei PF","year":"2004","unstructured":"Wei PF, Ho KY, Ho YP, Wu YM, Yang YH, Tsai CC. The investigation of glutathione peroxidase, lactoferrin, myeloperoxidase and interleukin-1beta in gingival crevicular fluid: implications for oxidative stress in human periodontal diseases. J Periodontal Res. 2004, 39:287-93. 10.1111\/j.1600-0765.2004.00744.x","journal-title":"J Periodontal Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2003.00282.x","article-title":"Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses","volume":"30","author":"Ide M","year":"2003","unstructured":"Ide M, McPartlin D, Coward PY, Crook M, Lumb P, Wilson RF. Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. J Clin Periodontol. 2003, 30:334-40. 10.1034\/j.1600-051x.2003.00282.x","journal-title":"J Clin Periodontol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.02.002","article-title":"Crevicular fluid levels of plasma glutathione peroxidase (eGPx) in periodontal health and disease","volume":"54","author":"Patel SP","year":"2009","unstructured":"Patel SP, Pradeep AR, Chowdhry S. Crevicular fluid levels of plasma glutathione peroxidase (eGPx) in periodontal health and disease. Arch Oral Biol. 2009, 54:543-8. 10.1016\/j.archoralbio.2009.02.002","journal-title":"Arch Oral Biol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106s51219","article-title":"The nature of antioxidant defense mechanisms: a lesson from transgenic studies","volume":"106","author":"Ho YS","year":"1998","unstructured":"Ho YS, Magnenat JL, Gargano M, Cao J. The nature of antioxidant defense mechanisms: a lesson from transgenic studies. Environ Health Perspect. 1998, 106:1219-28. 10.1289\/ehp.98106s51219","journal-title":"Environ Health Perspect"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00178.x","article-title":"The role of reactive oxygen and antioxidant species in periodontal tissue destruction","volume":"43","author":"Chapple IL","year":"2007","unstructured":"Chapple IL, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol. 2007, 43:160-232. 10.1111\/j.1600-0757.2006.00178.x","journal-title":"Periodontol"},{"key":"ref6","article-title":"Mechanisms involved in the generation of free radicals","volume":"44","author":"Halliwell B","year":"1996","unstructured":"Halliwell B. Mechanisms involved in the generation of free radicals. Pathol Biol (Paris). 1996, 44:6-13.","journal-title":"Pathol Biol (Paris)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go AS","year":"2004","unstructured":"Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004, 351:1296-305. 10.1056\/NEJMoa041031","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.516","article-title":"Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease","volume":"74","author":"Cachofeiro V","year":"2008","unstructured":"Cachofeiro V, Goicochea M, de Vinuesa SG, Oubi\u00f1a P, Lahera V, Lu\u00f1o J. Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease. Kidney Int Suppl. 2008, 74:4-9. 10.1038\/ki.2008.516","journal-title":"Kidney Int Suppl"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey AS","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, et al.. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009, 150:604-12. 10.7326\/0003-4819-150-9-200905050-00006","journal-title":"Ann Intern Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240","article-title":"Periodontal disease in pregnancy. I. prevalence and severity","volume":"21","author":"Loe H","year":"1963","unstructured":"Loe H, Silness J. Periodontal disease in pregnancy. I. prevalence and severity. Acta Odontol Scand. 1963, 21:533-51. 10.3109\/00016356309011240","journal-title":"Acta Odontol Scand"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968","article-title":"Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition","volume":"22","author":"Silness J","year":"1964","unstructured":"Silness J, Loe H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964, 22:121-35. 10.3109\/00016356408993968","journal-title":"Acta Odontol Scand"},{"key":"ref12","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","year":"2002","unstructured":"K\/DOQI clinical practice guidelines for chronic kidney disease. evaluation, classification, and stratification. Am J Kidney Dis. 2002, 39:1-266.","journal-title":"Am J Kidney Dis"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-008-0202-z","article-title":"Lipid peroxidation and antioxidant activity in saliva of periodontitis patients: effect of smoking and periodontal treatment","volume":"12","author":"Guentsch A","year":"2008","unstructured":"Guentsch A, Preshaw PM, Bremer-Streck S, Klinger G, Glockmann E, Sigusch BW. Lipid peroxidation and antioxidant activity in saliva of periodontitis patients: effect of smoking and periodontal treatment. Clin Oral Investig. 2008, 12:345-52. 10.1007\/s00784-008-0202-z","journal-title":"Clin Oral Investig"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515602693","article-title":"Oxidative stress and IgG antibody modify periodontitis-CRP association","volume":"94","author":"Singer RE","year":"2015","unstructured":"Singer RE, Moss K, Kim SJ, Beck JD, Offenbacher S. Oxidative stress and IgG antibody modify periodontitis-CRP association. J Dent Res. 2015, 94:1698-705. 10.1177\/0022034515602693","journal-title":"J Dent Res"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2591","article-title":"Association of systemic oxidative stress with suppressed serum IgG to commensal oral biofilm and modulation by periodontal infection","volume":"11","author":"Singer RE","year":"2009","unstructured":"Singer RE, Moss K, Beck JD, Offenbacher S. Association of systemic oxidative stress with suppressed serum IgG to commensal oral biofilm and modulation by periodontal infection. Antioxid Redox Signal. 2009, 11:2973-83. 10.1089\/ars.2009.2591","journal-title":"Antioxid Redox Signal"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1997.tb00760.x","article-title":"Reactive oxygen species and antioxidants in inflammatory diseases","volume":"24","author":"Chapple IL","year":"1997","unstructured":"Chapple IL. Reactive oxygen species and antioxidants in inflammatory diseases. J Clin Periodontol. 1997, 24:287-96. 10.1111\/j.1600-051x.1997.tb00760.x","journal-title":"J Clin Periodontol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(99)00075-2","article-title":"Antioxidant enzymes and human diseases","volume":"32","author":"Mat\u00e9s JM","year":"1999","unstructured":"Mat\u00e9s JM, P\u00e9rez-G\u00f3mez C, N\u00fa\u00f1ez de Castro I. Antioxidant enzymes and human diseases. Clin Biochem. 1999, 32:595-603. 10.1016\/S0009-9120(99)00075-2","journal-title":"Clin Biochem"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01098.x","article-title":"Analysis of the association of polymorphism in the osteoprotegerin gene with susceptibility to chronic kidney disease and periodontitis","volume":"43","author":"Baioni CS","year":"2008","unstructured":"Baioni CS, de Souza CM, Ribeiro AP, et al.. Analysis of the association of polymorphism in the osteoprotegerin gene with susceptibility to chronic kidney disease and periodontitis. J Periodontal Res. 2008, 43:578-84. 10.1111\/j.1600-0765.2008.01098.x","journal-title":"J Periodontal Res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10010050","article-title":"Isolated systolic blood pressure and red-complex bacteria - a risk for generalized periodontitis and chronic kidney disease","volume":"10","author":"Mahendra J","year":"2021","unstructured":"Mahendra J, Palathingal P, Mahendra L, et al.. Isolated systolic blood pressure and red-complex bacteria - a risk for generalized periodontitis and chronic kidney disease. Microorganisms. 2021, 10:10.3390\/microorganisms10010050","journal-title":"Microorganisms"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0101-x","article-title":"Periodontal disease, chronic kidney disease and mortality: results from the third National Health and Nutrition Examination Survey","volume":"16","author":"Ricardo AC","year":"2015","unstructured":"Ricardo AC, Athavale A, Chen J, Hampole H, Garside D, Marucha P, Lash JP. Periodontal disease, chronic kidney disease and mortality: results from the third National Health and Nutrition Examination Survey. BMC Nephrol. 2015, 16:10.1186\/s12882-015-0101-x","journal-title":"BMC Nephrol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01365.x","article-title":"Relationships among bone turnover, renal function and periodontal disease in elderly Japanese","volume":"46","author":"Yoshihara A","year":"2011","unstructured":"Yoshihara A, Hayashi Y, Miyazaki H. Relationships among bone turnover, renal function and periodontal disease in elderly Japanese. J Periodontal Res. 2011, 46:491-6. 10.1111\/j.1600-0765.2011.01365.x","journal-title":"J Periodontal Res"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12502","article-title":"Association between periodontitis and mortality in stages 3-5 chronic kidney disease: NHANES III and linked mortality study","volume":"43","author":"Sharma P","year":"2016","unstructured":"Sharma P, Dietrich T, Ferro CJ, Cockwell P, Chapple IL. Association between periodontitis and mortality in stages 3-5 chronic kidney disease: NHANES III and linked mortality study. J Clin Periodontol. 2016, 43:104-13. 10.1111\/jcpe.12502","journal-title":"J Clin Periodontol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/370314","article-title":"Identification of subgingival periodontal pathogens and association with the severity of periodontitis in patients with chronic kidney diseases: a cross-sectional study","volume":"2015","author":"Ismail FB","year":"2015","unstructured":"Ismail FB, Ismail G, Dumitriu AS, et al.. Identification of subgingival periodontal pathogens and association with the severity of periodontitis in patients with chronic kidney diseases: a cross-sectional study. Biomed Res Int. 2015, 2015:10.1155\/2015\/370314","journal-title":"Biomed Res Int"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140338","article-title":"Effect of initial periodontal therapy on oxidative stress markers in gingival crevicular fluid, saliva, and serum in smokers and non-smokers with chronic periodontitis","volume":"86","author":"Hendek MK","year":"2015","unstructured":"Hendek MK, Erdemir EO, Kisa U, Ozcan G. Effect of initial periodontal therapy on oxidative stress markers in gingival crevicular fluid, saliva, and serum in smokers and non-smokers with chronic periodontitis. J Periodontol. 2015, 86:273-82. 10.1902\/jop.2014.140338","journal-title":"J Periodontol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4812613","article-title":"Grapefruit consumption improves vitamin C status in periodontitis patients","volume":"199","author":"Staudte H","year":"2005","unstructured":"Staudte H, Sigusch BW, Glockmann E. Grapefruit consumption improves vitamin C status in periodontitis patients. Br Dent J. 2005, 199:213-7. 10.1038\/sj.bdj.4812613","journal-title":"Br Dent J"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6665","article-title":"Oxidant mechanisms in renal injury and disease","volume":"25","author":"Ratliff BB","year":"2016","unstructured":"Ratliff BB, Abdulmahdi W, Pawar R, Wolin MS. Oxidant mechanisms in renal injury and disease. Antioxid Redox Signal. 2016, 25:119-46. 10.1089\/ars.2016.6665","journal-title":"Antioxid Redox Signal"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.2174\/1573403x10666140416094901","article-title":"Is there an association between periodontitis and hypertension?","volume":"10","author":"Paizan ML","year":"2014","unstructured":"Paizan ML, Vilela-Martin JF. Is there an association between periodontitis and hypertension?. Curr Cardiol Rev. 2014, 10:355-61. 10.2174\/1573403x10666140416094901","journal-title":"Curr Cardiol Rev"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12834","article-title":"Association between periodontitis and chronic kidney disease: systematic review and meta-analysis","volume":"25","author":"Deschamps-Lenhardt S","year":"2019","unstructured":"Deschamps-Lenhardt S, Martin-Cabezas R, Hannedouche T, Huck O. Association between periodontitis and chronic kidney disease: systematic review and meta-analysis. Oral Dis. 2019, 25:385-402. 10.1111\/odi.12834","journal-title":"Oral Dis"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1590\/s1806-83242012005000008","article-title":"Effect of non-surgical periodontal treatment on the subgingival microbiota of patients with chronic kidney disease","volume":"26","author":"Artese HP","year":"2012","unstructured":"Artese HP, de Sousa CO, Torres MC, Silva-Boghossian CM, Colombo AP. Effect of non-surgical periodontal treatment on the subgingival microbiota of patients with chronic kidney disease. Braz Oral Res. 2012, 26:366-72. 10.1590\/s1806-83242012005000008","journal-title":"Braz Oral Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/85316-a-cross-sectional-study-of-serum-glutathione-peroxidase-an-antioxidative-marker-in-chronic-periodontitis-and-chronic-kidney-disease","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:44:46Z","timestamp":1707507886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/85316-a-cross-sectional-study-of-serum-glutathione-peroxidase-an-antioxidative-marker-in-chronic-periodontitis-and-chronic-kidney-disease"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,8]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.22016","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,8]]}}}