{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:01:14Z","timestamp":1787032874997,"version":"build-2736575974"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,15]]},"DOI":"10.7759\/cureus.22252","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T19:05:48Z","timestamp":1644951948000},"source":"Crossref","is-referenced-by-count":8,"title":["Inflammatory Biochemical Mediators and Their Role in Myofascial Pain and Osteopathic Manipulative Treatment: A Literature Review"],"prefix":"10.7759","author":[{"given":"Benjamin T","family":"Leicht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chante","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Fascia: a morphological description and classification system based on a literature review","volume":"56","author":"Kumka M","year":"2012","unstructured":"Kumka M, Bonar J. Fascia: a morphological description and classification system based on a literature review. J Can Chiropr Assoc. 2012, 56:179-91.","journal-title":"J Can Chiropr Assoc"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2014.01.011","article-title":"Diagnosis of myofascial pain syndrome","volume":"25","author":"Gerwin RD","year":"2014","unstructured":"Gerwin RD. Diagnosis of myofascial pain syndrome. Phys Med Rehabil Clin N Am. 2014, 25:341-55. 10.1016\/j.pmr.2014.01.011","journal-title":"Phys Med Rehabil Clin N Am"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050387","article-title":"Motor endplate-anatomical, functional, and molecular concepts in the historical perspective","volume":"8","author":"Rudolf R","year":"2019","unstructured":"Rudolf R, Khan MM, Witzemann V. Motor endplate-anatomical, functional, and molecular concepts in the historical perspective. Cells. 2019, 8:387. 10.3390\/cells8050387","journal-title":"Cells"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4081\/reumatismo.2014.767","article-title":"Pain in fibromyalgia and related conditions","volume":"66","author":"Cassisi G","year":"2014","unstructured":"Cassisi G, Sarzi-Puttini P, Casale R, Cazzola M, Boccassini L, Atzeni F, Stisi S. Pain in fibromyalgia and related conditions. Reumatismo. 2014, 66:72-86. 10.4081\/reumatismo.2014.767","journal-title":"Reumatismo"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1113\/JP273997","article-title":"Human skeletal muscle fibroblasts stimulate in vitro myogenesis and in vivo muscle regeneration","volume":"595","author":"Mackey AL","year":"2017","unstructured":"Mackey AL, Magnan M, Chazaud B, Kjaer M. Human skeletal muscle fibroblasts stimulate in vitro myogenesis and in vivo muscle regeneration. J Physiol. 2017, 595:5115-27. 10.1113\/JP273997","journal-title":"J Physiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7556\/jaoa.2015.103","article-title":"Modeled osteopathic manipulative treatments: a review of their in vitro effects on fibroblast tissue preparations","volume":"115","author":"Zein-Hammoud M","year":"2015","unstructured":"Zein-Hammoud M, Standley PR. Modeled osteopathic manipulative treatments: a review of their in vitro effects on fibroblast tissue preparations. J Am Osteopath Assoc. 2015, 115:490-502. 10.7556\/jaoa.2015.103","journal-title":"J Am Osteopath Assoc"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2174\/1389202920666190116094736","article-title":"An overview about the biology of skeletal muscle satellite cells","volume":"20","author":"Forcina L","year":"2019","unstructured":"Forcina L, Miano C, Pelosi L, Musar\u00f2 A. An overview about the biology of skeletal muscle satellite cells. Curr Genomics. 2019, 20:24-37. 10.2174\/1389202920666190116094736","journal-title":"Curr Genomics"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.10.018","article-title":"Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points","volume":"89","author":"Shah JP","year":"2008","unstructured":"Shah JP, Danoff JV, Desai MJ, Parikh S, Nakamura LY, Phillips TM, Gerber LH. Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points. Arch Phys Med Rehabil. 2008, 89:16-23. 10.1016\/j.apmr.2007.10.018","journal-title":"Arch Phys Med Rehabil"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2017.01.005","article-title":"Biological effects of direct and indirect manipulation of the fascial system. Narrative review","volume":"21","author":"Parravicini G","year":"2017","unstructured":"Parravicini G, Bergna A. Biological effects of direct and indirect manipulation of the fascial system. Narrative review. J Bodyw Mov Ther. 2017, 21:435-45. 10.1016\/j.jbmt.2017.01.005","journal-title":"J Bodyw Mov Ther"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R600021-JLR200","article-title":"The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk","volume":"48","author":"Popa C","year":"2007","unstructured":"Popa C, Netea MG, van Riel PL, van der Meer JW, Stalenhoef AF. The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res. 2007, 48:751-62. 10.1194\/jlr.R600021-JLR200","journal-title":"J Lipid Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12696891","article-title":"Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-alpha and beta and tumor necrosis factor-alpha and beta","volume":"92","author":"Duncan MR","year":"1989","unstructured":"Duncan MR, Berman B. Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-alpha and beta and tumor necrosis factor-alpha and beta. J Invest Dermatol. 1989, 92:699-706. 10.1111\/1523-1747.ep12696891","journal-title":"J Invest Dermatol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2018.627-635","article-title":"The crucial roles of inflammatory mediators in inflammation: a review","volume":"11","author":"Abdulkhaleq LA","year":"2018","unstructured":"Abdulkhaleq LA, Assi MA, Abdullah R, Zamri-Saad M, Taufiq-Yap YH, Hezmee MN. The crucial roles of inflammatory mediators in inflammation: a review. Vet World. 2018, 11:627-35. 10.14202\/vetworld.2018.627-635","journal-title":"Vet World"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/342165","article-title":"Dry needling at myofascial trigger spots of rabbit skeletal muscles modulates the biochemicals associated with pain, inflammation, and hypoxia","volume":"2012","author":"Hsieh YL","year":"2012","unstructured":"Hsieh YL, Yang SA, Yang CC, Chou LW. Dry needling at myofascial trigger spots of rabbit skeletal muscles modulates the biochemicals associated with pain, inflammation, and hypoxia. Evid Based Complement Alternat Med. 2012, 2012:342165. 10.1155\/2012\/342165","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10725","article-title":"The role of TGF-\u03b21 during skeletal muscle regeneration","volume":"41","author":"Delaney K","year":"2017","unstructured":"Delaney K, Kasprzycka P, Ciemerych MA, Zimowska M. The role of TGF-\u03b21 during skeletal muscle regeneration. Cell Biol Int. 2017, 41:706-15. 10.1002\/cbin.10725","journal-title":"Cell Biol Int"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.04.006","article-title":"Interleukin-17 and innate immunity in infections and chronic inflammation","volume":"60","author":"Isailovic N","year":"2015","unstructured":"Isailovic N, Daigo K, Mantovani A, Selmi C. Interleukin-17 and innate immunity in infections and chronic inflammation. J Autoimmun. 2015, 60:1-11. 10.1016\/j.jaut.2015.04.006","journal-title":"J Autoimmun"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2014.01.012","article-title":"Myofascial pain syndrome treatments","volume":"25","author":"Borg-Stein J","year":"2014","unstructured":"Borg-Stein J, Iaccarino MA. Myofascial pain syndrome treatments. Phys Med Rehabil Clin N Am. 2014, 25:357-74. 10.1016\/j.pmr.2014.01.012","journal-title":"Phys Med Rehabil Clin N Am"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1654-9","article-title":"Fluence-dependent effects of low-level laser therapy in myofascial trigger spots on modulation of biochemicals associated with pain in a rabbit model","volume":"30","author":"Hsieh YL","year":"2015","unstructured":"Hsieh YL, Hong CZ, Chou LW, Yang SA, Yang CC. Fluence-dependent effects of low-level laser therapy in myofascial trigger spots on modulation of biochemicals associated with pain in a rabbit model. Lasers Med Sci. 2015, 30:209-16. 10.1007\/s10103-014-1654-9","journal-title":"Lasers Med Sci"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/66757-inflammatory-biochemical-mediators-and-their-role-in-myofascial-pain-and-osteopathic-manipulative-treatment-a-literature-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T14:37:45Z","timestamp":1707489465000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/66757-inflammatory-biochemical-mediators-and-their-role-in-myofascial-pain-and-osteopathic-manipulative-treatment-a-literature-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.22252","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,15]]}}}