{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:28:01Z","timestamp":1789342081115,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,21]]},"DOI":"10.7759\/cureus.22468","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T02:54:47Z","timestamp":1645498487000},"source":"Crossref","is-referenced-by-count":4,"title":["Serotonin Syndrome Triggered by Overuse of Caffeine and Complicated With Neuroleptic Malignant Syndrome: A Case Report"],"prefix":"10.7759","author":[{"given":"Ryuichi","family":"Ohta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Serotonin syndrome","volume":"13","author":"Volpi-Abadie J","year":"2013","unstructured":"Volpi-Abadie J, Kaye AM, Kaye AD. Serotonin syndrome. Ochsner J. 2013, 13:533-40.","journal-title":"Ochsner J"},{"key":"ref2","article-title":"Demystifying serotonin syndrome (or serotonin toxicity)","volume":"64","author":"Foong AL","year":"2018","unstructured":"Foong AL, Grindrod KA, Patel T, Kellar J. Demystifying serotonin syndrome (or serotonin toxicity). Can Fam Physician. 2018, 64:720-7.","journal-title":"Can Fam Physician"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01575.x","article-title":"Triptans, serotonin agonists, and serotonin syndrome (serotonin toxicity): a review","volume":"50","author":"Gillman PK","year":"2010","unstructured":"Gillman PK. Triptans, serotonin agonists, and serotonin syndrome (serotonin toxicity): a review. Headache. 2010, 50:264-72. 10.1111\/j.1526-4610.2009.01575.x","journal-title":"Headache"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2007.09.007","article-title":"Serotonin syndrome: a complex but easily avoidable condition","volume":"30","author":"Dvir Y","year":"2008","unstructured":"Dvir Y, Smallwood P. Serotonin syndrome: a complex but easily avoidable condition. Gen Hosp Psychiatry. 2008, 30:284-7. 10.1016\/j.genhosppsych.2007.09.007","journal-title":"Gen Hosp Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04739.x","article-title":"Serotonin catabolism in the central and enteric nervous systems of rats upon induction of serotonin syndrome","volume":"103","author":"Squires LN","year":"2007","unstructured":"Squires LN, Talbot KN, Rubakhin SS, Sweedler JV. Serotonin catabolism in the central and enteric nervous systems of rats upon induction of serotonin syndrome. J Neurochem. 2007, 103:174-80. 10.1111\/j.1471-4159.2007.04739.x","journal-title":"J Neurochem"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1515\/9783110854657-097","article-title":"Caffeoyltryptophan from green robusta coffee beans","author":"Morishita H","year":"2019","unstructured":"Morishita H, Takai T, Yamada H, Fukuda F, Sawada M, Iwahashi H, Kido R. Caffeoyltryptophan from green robusta coffee beans. Progress in Tryptophan and Serotonin Research 1986: Proceedings, Fifth Meeting of the International Study Group for Tryptophan Research ISTRY, Cardiff, Wales, UK, July 28-August 1, 1986. De Gruyter, Berlin, Boston; 2019. 409-12. 10.1515\/9783110854657-097"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/PAF.0000000000000058","article-title":"Fatal caffeine overdose: a case report and review of literature","volume":"34","author":"Jabbar SB","year":"2013","unstructured":"Jabbar SB, Hanly MG. Fatal caffeine overdose: a case report and review of literature. Am J Forensic Med Pathol. 2013, 34:321-4. 10.1097\/PAF.0000000000000058","journal-title":"Am J Forensic Med Pathol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2013.08.042","article-title":"Caffeine overdose resulting in severe rhabdomyolysis and acute renal failure","volume":"32","author":"Campana C","year":"2014","unstructured":"Campana C, Griffin PL, Simon EL. Caffeine overdose resulting in severe rhabdomyolysis and acute renal failure. Am J Emerg Med. 2014, 32:111.e3-4. 10.1016\/j.ajem.2013.08.042","journal-title":"Am J Emerg Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-224185","article-title":"Dangerous mistake: an accidental caffeine overdose","volume":"2018","author":"Andrade A","year":"2018","unstructured":"Andrade A, Sousa C, Pedro M, Fernandes M. Dangerous mistake: an accidental caffeine overdose. BMJ Case Rep. 2018, 2018:bcr2018224185. 10.1136\/bcr-2018-224185","journal-title":"BMJ Case Rep"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2015.03.040","article-title":"Emergency department visits and overdose deaths from combined use of opioids and benzodiazepines","volume":"49","author":"Jones CM","year":"2015","unstructured":"Jones CM, McAninch JK. Emergency department visits and overdose deaths from combined use of opioids and benzodiazepines. Am J Prev Med. 2015, 49:493-501. 10.1016\/j.amepre.2015.03.040","journal-title":"Am J Prev Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01045","article-title":"Antipsychotic treatment of behavioral and psychological symptoms of dementia (BPSD): management of extrapyramidal side effects","volume":"10","author":"Ohno Y","year":"2019","unstructured":"Ohno Y, Kunisawa N, Shimizu S. Antipsychotic treatment of behavioral and psychological symptoms of dementia (BPSD): management of extrapyramidal side effects. Front Pharmacol. 2019, 10:1045. 10.3389\/fphar.2019.01045","journal-title":"Front Pharmacol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000801","article-title":"Extrapyramidal symptoms and antidepressant drugs: neuropharmacological aspects of a frequent interaction in the elderly","volume":"6","author":"Govoni S","year":"2001","unstructured":"Govoni S, Racchi M, Masoero E, Zamboni M, Ferini-Strambi L. Extrapyramidal symptoms and antidepressant drugs: neuropharmacological aspects of a frequent interaction in the elderly. Mol Psychiatry. 2001, 6:134-42. 10.1038\/sj.mp.4000801","journal-title":"Mol Psychiatry"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.7.5.587","article-title":"Drug-induced serotonin syndrome: a review","volume":"7","author":"Sun-Edelstein C","year":"2008","unstructured":"Sun-Edelstein C, Tepper SJ, Shapiro RE. Drug-induced serotonin syndrome: a review. Expert Opin Drug Saf. 2008, 7:587-96. 10.1517\/14740338.7.5.587","journal-title":"Expert Opin Drug Saf"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.21137","article-title":"The persistent approach to diagnose infectious hepatic cysts in a patient with recurrent fever: a case report","volume":"14","author":"Ikeda H","year":"2022","unstructured":"Ikeda H, Ohta R, Nishikura N, Ryu Y, Sano C. The persistent approach to diagnose infectious hepatic cysts in a patient with recurrent fever: a case report. Cureus. 2022, 14:e21137. 10.7759\/cureus.21137","journal-title":"Cureus"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.21523","article-title":"Pericarditis with cardiac tamponade mimicking yellow nail syndrome in a patient with rheumatoid arthritis and a paucity of joint symptoms","volume":"14","author":"Tokonami A","year":"2022","unstructured":"Tokonami A, Ohta R, Tanaka Y, Amano S, Sano C. Pericarditis with cardiac tamponade mimicking yellow nail syndrome in a patient with rheumatoid arthritis and a paucity of joint symptoms. Cureus. 2022, 14:e21523. 10.7759\/cureus.21523","journal-title":"Cureus"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2007.05.003","article-title":"Bacteremia and sepsis in older adults","volume":"23","author":"Girard TD","year":"2007","unstructured":"Girard TD, Ely EW. Bacteremia and sepsis in older adults. Clin Geriatr Med. 2007, 23:633-47, viii. 10.1016\/j.cger.2007.05.003","journal-title":"Clin Geriatr Med"},{"key":"ref17","article-title":"Diseases with extremely elevated erythrocyte sedimentation rates in a secondary healthcare facility: retrospective cohort study","volume":"34","author":"Ohta R","year":"2017","unstructured":"Ohta R, Kaneko M, Hattori S. Diseases with extremely elevated erythrocyte sedimentation rates in a secondary healthcare facility: retrospective cohort study. Simane J Med Sci. 2017, 34:27-33.","journal-title":"Simane J Med Sci"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-reactive protein at sites of inflammation and infection","volume":"9","author":"Sproston NR","year":"2018","unstructured":"Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front Immunol. 2018, 9:754. 10.3389\/fimmu.2018.00754","journal-title":"Front Immunol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/85965-serotonin-syndrome-triggered-by-overuse-of-caffeine-and-complicated-with-neuroleptic-malignant-syndrome-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:46:09Z","timestamp":1707507969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/85965-serotonin-syndrome-triggered-by-overuse-of-caffeine-and-complicated-with-neuroleptic-malignant-syndrome-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.22468","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,21]]}}}