{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T05:53:37Z","timestamp":1746770017674},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,6]]},"DOI":"10.7759\/cureus.22887","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T15:36:35Z","timestamp":1646580995000},"source":"Crossref","is-referenced-by-count":6,"title":["Intratympanic Versus Systemic Steroid Therapy for Idiopathic Sudden Hearing Loss: A Systematic Review and Meta-Analysis"],"prefix":"10.7759","author":[{"given":"Christos","family":"Sialakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Iliadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikaterini","family":"Frantzana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros","family":"Ouzounakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lambrini","family":"Kourkouta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0b013e3181f7aba3","article-title":"Intratympanic steroid therapy for sudden hearing loss: a review of the literature","volume":"32","author":"Seggas I","year":"2011","unstructured":"Seggas I, Koltsidopoulos P, Bibas A, Tzonou A, Sismanis A. Intratympanic steroid therapy for sudden hearing loss: a review of the literature. Otol Neurotol. 2011, 32:29-35. 10.1097\/mao.0b013e3181f7aba3","journal-title":"Otol Neurotol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-021-00498-x","article-title":"Management of sudden sensorineural hearing loss among primary care physicians in Canada: a survey study","volume":"50","author":"Ng B","year":"2021","unstructured":"Ng B, Crowson MG, Lin V. Management of sudden sensorineural hearing loss among primary care physicians in Canada: a survey study. J Otolaryngol Head Neck Surg. 2021, 50:22. 10.1186\/s40463-021-00498-x","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811418169","article-title":"Simultaneous versus subsequent intratympanic dexamethasone for idiopathic sudden sensorineural hearing loss","volume":"145","author":"Park MK","year":"2011","unstructured":"Park MK, Lee CK, Park KH, Lee JD, Lee CG, Lee BD. Simultaneous versus subsequent intratympanic dexamethasone for idiopathic sudden sensorineural hearing loss. Otolaryngol Head Neck Surg. 2011, 145:1016-21. 10.1177\/0194599811418169","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811419466","article-title":"Intratympanic steroids for sudden sensorineural hearing loss: a systematic review","volume":"145","author":"Spear SA","year":"2011","unstructured":"Spear SA, Schwartz SR. Intratympanic steroids for sudden sensorineural hearing loss: a systematic review. Otolaryngol Head Neck Surg. 2011, 145:534-43. 10.1177\/0194599811419466","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref5","doi-asserted-by":"crossref","DOI":"10.1177\/014556139607500806","article-title":"Intratympanic steroid treatment of inner ear disease and tinnitus (preliminary report)","volume":"75","author":"Silverstein H","year":"1996","unstructured":"Silverstein H, Choo D, Rosenberg SI, Kuhn J, Seidman M, Stein I. Intratympanic steroid treatment of inner ear disease and tinnitus (preliminary report). Ear Nose Throat J. 1996, 75:468-71, 474, 476 passim.","journal-title":"Ear Nose Throat J"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins JP","year":"2011","unstructured":"Higgins JP, Altman DG, G\u00f8tzsche PC, et al.. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011, 343:d5928. 10.1136\/bmj.d5928","journal-title":"BMJ"},{"key":"ref8","unstructured":"Review Manager (RevMan) version 5.4. (2020). Accessed. 10\/02\/22: https:\/\/training.cochrane.org\/online-learning\/core-software-cochrane-reviews\/revman\/revman-non-cochrane-reviews."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher D","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009, 6:e1000097. 10.1371\/journal.pmed.1000097","journal-title":"PLoS Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1523-0","article-title":"Treatment of sudden sensorineural hearing loss with transtympanic injection of steroids as single therapy: a randomized clinical study","volume":"268","author":"Dispenza F","year":"2011","unstructured":"Dispenza F, Amodio E, De Stefano A, Gallina S, Marchese D, Mathur N, Riggio F. Treatment of sudden sensorineural hearing loss with transtympanic injection of steroids as single therapy: a randomized clinical study. Eur Arch Otorhinolaryngol. 2011, 268:1273-8. 10.1007\/s00405-011-1523-0","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4691-8","article-title":"Sudden hearing loss: an effectivity comparison of intratympanic and systemic steroid treatments","volume":"274","author":"Ermutlu G","year":"2017","unstructured":"Ermutlu G, S\u00fcsl\u00fc N, Y\u0131lmaz T, Sara\u00e7 S. Sudden hearing loss: an effectivity comparison of intratympanic and systemic steroid treatments. Eur Arch Otorhinolaryngol. 2017, 274:3585-91. 10.1007\/s00405-017-4691-8","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref12","article-title":"Intratympanic steroids for sudden sensorineural hearing loss","volume":"7","author":"Kosyakov S","year":"2011","unstructured":"Kosyakov S, Atanesyan A, Gunenkov A, Ashkhatunyan E, Kurlova A. Intratympanic steroids for sudden sensorineural hearing loss. Int Adv Otol. 2011, 7:323-32.","journal-title":"Int Adv Otol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4808-0","article-title":"Efficacy of systemic and intratympanic corticosteroid combination therapy versus intratympanic or systemic therapy in patients with idiopathic sudden sensorineural hearing loss: a randomized controlled trial","volume":"275","author":"Ashtiani MK","year":"2018","unstructured":"Ashtiani MK, Firouzi F, Bastaninejad S, et al.. Efficacy of systemic and intratympanic corticosteroid combination therapy versus intratympanic or systemic therapy in patients with idiopathic sudden sensorineural hearing loss: a randomized controlled trial. Eur Arch Otorhinolaryngol. 2018, 275:89-97. 10.1007\/s00405-017-4808-0","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318168da7a","article-title":"Combination therapy (intratympanic dexamethasone + high-dose prednisone taper) for the treatment of idiopathic sudden sensorineural hearing loss","volume":"29","author":"Battaglia A","year":"2008","unstructured":"Battaglia A, Burchette R, Cueva R. Combination therapy (intratympanic dexamethasone + high-dose prednisone taper) for the treatment of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2008, 29:453-60. 10.1097\/MAO.0b013e318168da7a","journal-title":"Otol Neurotol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1476-8","article-title":"The efficiency of intratympanic dexamethasone injection as a sequential treatment after initial systemic steroid therapy for sudden sensorineural hearing loss","volume":"268","author":"Lee JB","year":"2011","unstructured":"Lee JB, Choi SJ, Park K, Park HY, Choo OS, Choung YH. The efficiency of intratympanic dexamethasone injection as a sequential treatment after initial systemic steroid therapy for sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol. 2011, 268:833-9. 10.1007\/s00405-010-1476-8","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181585428","article-title":"Can intratympanic dexamethasone added to systemic steroids improve hearing outcome in patients with sudden deafness?","volume":"118","author":"Ahn JH","year":"2008","unstructured":"Ahn JH, Yoo MH, Yoon TH, Chung JW. Can intratympanic dexamethasone added to systemic steroids improve hearing outcome in patients with sudden deafness?. Laryngoscope. 2008, 118:279-82. 10.1097\/MLG.0b013e3181585428","journal-title":"Laryngoscope"},{"key":"ref17","article-title":"Combined intratympanic and systemic steroid therapy for poor prognosis sudden sensorineural hearing loss","volume":"25","author":"Arastou S","year":"2013","unstructured":"Arastou S, Tajedini A, Borghei P. Combined intratympanic and systemic steroid therapy for poor prognosis sudden sensorineural hearing loss. Iran J Otorhinolaryngol. 2013, 25:23-8.","journal-title":"Iran J Otorhinolaryngol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812464475","article-title":"Efficacy of 3 different steroid treatments for sudden sensorineural hearing loss: a prospective, randomized trial","volume":"148","author":"Lim HJ","year":"2013","unstructured":"Lim HJ, Kim YT, Choi SJ, Lee JB, Park HY, Park K, Choung YH. Efficacy of 3 different steroid treatments for sudden sensorineural hearing loss: a prospective, randomized trial. Otolaryngol Head Neck Surg. 2013, 148:121-7. 10.1177\/0194599812464475","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.679","article-title":"Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial","volume":"305","author":"Rauch SD","year":"2011","unstructured":"Rauch SD, Halpin CF, Antonelli PJ, et al.. Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial. JAMA. 2011, 305:2071-9. 10.1001\/jama.2011.679","journal-title":"JAMA"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4803-5","article-title":"Systemic, intratympanic and combined administration of steroids for sudden hearing loss. A prospective randomized multicenter trial","volume":"275","author":"Tsounis M","year":"2018","unstructured":"Tsounis M, Psillas G, Tsalighopoulos M, Vital V, Maroudias N, Markou K. Systemic, intratympanic and combined administration of steroids for sudden hearing loss. A prospective randomized multicenter trial. Eur Arch Otorhinolaryngol. 2018, 275:103-10. 10.1007\/s00405-017-4803-5","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.08.009","article-title":"Hearing outcomes of daily intratympanic dexamethasone alone as a primary treatment modality for ISSHL","volume":"141","author":"Hong SM","year":"2009","unstructured":"Hong SM, Park CH, Lee JH. Hearing outcomes of daily intratympanic dexamethasone alone as a primary treatment modality for ISSHL. Otolaryngol Head Neck Surg. 2009, 141:579-83. 10.1016\/j.otohns.2009.08.009","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref22","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel N","year":"1959","unstructured":"Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959, 22:719-48.","journal-title":"J Natl Cancer Inst"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.joto.2021.02.001","article-title":"Intratympanic vs systemic use of steroids as first-line treatment for sudden hearing loss: a meta-analysis of randomized, controlled trials","volume":"16","author":"Yang T","year":"2021","unstructured":"Yang T, Liu H, Chen F, et al.. Intratympanic vs systemic use of steroids as first-line treatment for sudden hearing loss: a meta-analysis of randomized, controlled trials. J Otol. 2021, 16:165-77. 10.1016\/j.joto.2021.02.001","journal-title":"J Otol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.joto.2016.02.002","article-title":"A comparison of effects of systemic and intratympanic steroid therapies for sudden sensorineural hearing loss: a meta-analysis","volume":"11","author":"Zhao D","year":"2016","unstructured":"Zhao D, Tong B, Wang Q, Hellstrom S, Duan M. A comparison of effects of systemic and intratympanic steroid therapies for sudden sensorineural hearing loss: a meta-analysis. J Otol. 2016, 11:18-23. 10.1016\/j.joto.2016.02.002","journal-title":"J Otol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1260157","article-title":"A comparison between systemic and intratympanic steroid therapies as initial therapy for idiopathic sudden sensorineural hearing loss: a meta-analysis","volume":"137","author":"Qiang Q","year":"2017","unstructured":"Qiang Q, Wu X, Yang T, Yang C, Sun H. A comparison between systemic and intratympanic steroid therapies as initial therapy for idiopathic sudden sensorineural hearing loss: a meta-analysis. Acta Otolaryngol. 2017, 137:598-605. 10.1080\/00016489.2016.1260157","journal-title":"Acta Otolaryngol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020908067","article-title":"Effectiveness of steroid treatment for sudden sensorineural hearing loss: a meta-analysis of randomized controlled trials","volume":"54","author":"Li J","year":"2020","unstructured":"Li J, Ding L. Effectiveness of steroid treatment for sudden sensorineural hearing loss: a meta-analysis of randomized controlled trials. Ann Pharmacother. 2020, 54:949-57. 10.1177\/1060028020908067","journal-title":"Ann Pharmacother"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318254ee04","article-title":"Intratympanic steroid treatment for sudden deafness: a meta-analysis of randomized controlled trials","volume":"33","author":"Garavello W","year":"2012","unstructured":"Garavello W, Galluzzi F, Gaini RM, Zanetti D. Intratympanic steroid treatment for sudden deafness: a meta-analysis of randomized controlled trials. Otol Neurotol. 2012, 33:724-9. 10.1097\/MAO.0b013e318254ee04","journal-title":"Otol Neurotol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.0047","article-title":"Intratympanic vs systemic corticosteroids in first-line treatment of idiopathic sudden sensorineural hearing loss: a systematic review and meta-analysis","volume":"146","author":"Mirian C","year":"2020","unstructured":"Mirian C, Ovesen T. Intratympanic vs systemic corticosteroids in first-line treatment of idiopathic sudden sensorineural hearing loss: a systematic review and meta-analysis. JAMA Otolaryngol Head Neck Surg. 2020, 146:421-8. 10.1001\/jamaoto.2020.0047","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3288-8","article-title":"Intratympanic steroids as a salvage treatment for sudden sensorineural hearing loss? A meta-analysis","volume":"272","author":"Ng JH","year":"2015","unstructured":"Ng JH, Ho RC, Cheong CS, Ng A, Yuen HW, Ngo RY. Intratympanic steroids as a salvage treatment for sudden sensorineural hearing loss? A meta-analysis. Eur Arch Otorhinolaryngol. 2015, 272:2777-82. 10.1007\/s00405-014-3288-8","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26394","article-title":"Intratympanic dexamethasone in sudden sensorineural hearing loss: a systematic review and meta-analysis","volume":"127","author":"El Sabbagh NG","year":"2017","unstructured":"El Sabbagh NG, Sewitch MJ, Bezdjian A, Daniel SJ. Intratympanic dexamethasone in sudden sensorineural hearing loss: a systematic review and meta-analysis. Laryngoscope. 2017, 127:1897-908. 10.1002\/lary.26394","journal-title":"Laryngoscope"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/85262-intratympanic-versus-systemic-steroid-therapy-for-idiopathic-sudden-hearing-loss-a-systematic-review-and-meta-analysis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:40:52Z","timestamp":1707507652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/85262-intratympanic-versus-systemic-steroid-therapy-for-idiopathic-sudden-hearing-loss-a-systematic-review-and-meta-analysis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,6]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.22887","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,6]]}}}