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J Am Osteopath Assoc. 1994, 94:414-5.","journal-title":"J Am Osteopath Assoc"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(90)90059-o","article-title":"Functional asplenia in systemic lupus erythematosus","volume":"20","author":"Piliero P","year":"1990","unstructured":"Piliero P, Furie R. Functional asplenia in systemic lupus erythematosus. Semin Arthritis Rheum. 1990, 20:185-9. 10.1016\/0049-0172(90)90059-o","journal-title":"Semin Arthritis Rheum"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.11777","article-title":"Nonneoplastic, benign, and malignant splenic diseases: cross-sectional imaging findings and rare disease entities","volume":"203","author":"Thipphavong S","year":"2014","unstructured":"Thipphavong S, Duigenan S, Schindera ST, Gee MS, Philips S. Nonneoplastic, benign, and malignant splenic diseases: cross-sectional imaging findings and rare disease entities. 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