{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:55:12Z","timestamp":1782456912339,"version":"3.54.5"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,3]]},"DOI":"10.7759\/cureus.23795","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T05:42:16Z","timestamp":1649050936000},"source":"Crossref","is-referenced-by-count":2,"title":["Where Are We Heading With Fluid Responsiveness and Septic Shock?"],"prefix":"10.7759","author":[{"given":"Mohammed","family":"Megri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Fridenmaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Disselkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.6.2000","article-title":"Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence","volume":"121","author":"Michard F","year":"2002","unstructured":"Michard F, Teboul JL. Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence. Chest. 2002, 121:2000-8. 10.1378\/chest.121.6.2000","journal-title":"Chest"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181feeb15","article-title":"Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality","volume":"39","author":"Boyd JH","year":"2011","unstructured":"Boyd JH, Forbes J, Nakada TA, Walley KR, Russell JA. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med. 2011, 39:259-65. 10.1097\/CCM.0b013e3181feeb15","journal-title":"Crit Care Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062200","article-title":"Comparison of two fluid-management strategies in acute lung injury","volume":"354","author":"Wiedemann HP","year":"2006","unstructured":"Wiedemann HP, Wheeler AP, Bernard GR, et al.. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006, 354:2564-75. 10.1056\/NEJMoa062200","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.04.29","article-title":"Heart-lung interactions during mechanical ventilation: the basics","volume":"6","author":"Mahmood SS","year":"2018","unstructured":"Mahmood SS, Pinsky MR. Heart-lung interactions during mechanical ventilation: the basics. Ann Transl Med. 2018, 6:349. 10.21037\/atm.2018.04.29","journal-title":"Ann Transl Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2017.14491","article-title":"Basic concepts of heart-lung interactions during mechanical ventilation","volume":"147","author":"Gr\u00fcbler MR","year":"2017","unstructured":"Gr\u00fcbler MR, Wigger O, Berger D, Bl\u00f6chlinger S. Basic concepts of heart-lung interactions during mechanical ventilation. Swiss Med Wkly. 2017, 147:w14491. 10.4414\/smw.2017.14491","journal-title":"Swiss Med Wkly"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1960.15.5.878","article-title":"Influence of state of inflation of the lung on pulmonary vascular resistance","volume":"15","author":"Whittenberger JL","year":"1960","unstructured":"Whittenberger JL, McGregor M, Berglund E, Borst HG. Influence of state of inflation of the lung on pulmonary vascular resistance. J Appl Physiol. 1960, 15:878-82. 10.1152\/jappl.1960.15.5.878","journal-title":"J Appl Physiol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200106000-00012","article-title":"Positive end-expiratory pressure titration in acute respiratory distress syndrome patients: impact on right ventricular outflow impedance evaluated by pulmonary artery Doppler flow velocity measurements","volume":"29","author":"Schmitt JM","year":"2001","unstructured":"Schmitt JM, Vieillard-Baron A, Augarde R, Prin S, Page B, Jardin F. Positive end-expiratory pressure titration in acute respiratory distress syndrome patients: impact on right ventricular outflow impedance evaluated by pulmonary artery Doppler flow velocity measurements. Crit Care Med. 2001, 29:1154-8. 10.1097\/00003246-200106000-00012","journal-title":"Crit Care Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00081.2017","article-title":"Right atrial pressure and venous return during cardiopulmonary bypass","volume":"313","author":"Moller PW","year":"2017","unstructured":"Moller PW, Winkler B, Hurni S, et al.. Right atrial pressure and venous return during cardiopulmonary bypass. Am J Physiol Heart Circ Physiol. 2017, 313:H408-20. 10.1152\/ajpheart.00081.2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90112-7","article-title":"Effects of negative pleural pressure on left ventricular hemodynamics","volume":"53","author":"Kerelakes DJ","year":"1984","unstructured":"Kerelakes DJ. Effects of negative pleural pressure on left ventricular hemodynamics. Am J Cardiol. 1984, 53:1412. 10.1016\/0002-9149(84)90112-7","journal-title":"Am J Cardiol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1204000503","article-title":"Stroke volume variation as a predictor of fluid responsiveness in patients undergoing airway pressure release ventilation","volume":"40","author":"Suehiro K","year":"2012","unstructured":"Suehiro K, Rinka H, Ishikawa J, Fuke A, Arimoto H, Miyaichi T. Stroke volume variation as a predictor of fluid responsiveness in patients undergoing airway pressure release ventilation. Anaesth Intensive Care. 2012, 40:767-72. 10.1177\/0310057X1204000503","journal-title":"Anaesth Intensive Care"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-016-9951-4","article-title":"Applicability of stroke volume variation in patients of a general intensive care unit: a longitudinal observational study","volume":"31","author":"Mair S","year":"2017","unstructured":"Mair S, Tschirdewahn J, G\u00f6tz S, et al.. Applicability of stroke volume variation in patients of a general intensive care unit: a longitudinal observational study. J Clin Monit Comput. 2017, 31:1177-87. 10.1007\/s10877-016-9951-4","journal-title":"J Clin Monit Comput"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9903035","article-title":"Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure","volume":"162","author":"Michard F","year":"2000","unstructured":"Michard F, Boussat S, Chemla D, et al.. Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure. Am J Respir Crit Care Med. 2000, 162:134-8. 10.1164\/ajrccm.162.1.9903035","journal-title":"Am J Respir Crit Care Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen277","article-title":"Uncalibrated pulse contour-derived stroke volume variation predicts fluid responsiveness in mechanically ventilated patients undergoing liver transplantation","volume":"101","author":"Biais M","year":"2008","unstructured":"Biais M, Nouette-Gaulain K, Cottenceau V, Revel P, Sztark F. Uncalibrated pulse contour-derived stroke volume variation predicts fluid responsiveness in mechanically ventilated patients undergoing liver transplantation. Br J Anaesth. 2008, 101:761-8. 10.1093\/bja\/aen277","journal-title":"Br J Anaesth"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201801-0088CI","article-title":"Arterial pulse pressure variation with mechanical ventilation","volume":"199","author":"Teboul JL","year":"2019","unstructured":"Teboul JL, Monnet X, Chemla D, Michard F. Arterial pulse pressure variation with mechanical ventilation. Am J Respir Crit Care Med. 2019, 199:22-31. 10.1164\/rccm.201801-0088CI","journal-title":"Am J Respir Crit Care Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-015-9759-7","article-title":"Non-invasive measurements of pulse pressure variation and stroke volume variation in anesthetized patients using the Nexfin blood pressure monitor","volume":"30","author":"Stens J","year":"2016","unstructured":"Stens J, Oeben J, Van Dusseldorp AA, Boer C. Non-invasive measurements of pulse pressure variation and stroke volume variation in anesthetized patients using the Nexfin blood pressure monitor. J Clin Monit Comput. 2016, 30:587-94. 10.1007\/s10877-015-9759-7","journal-title":"J Clin Monit Comput"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0650-6","article-title":"Does pulse pressure variation predict fluid responsiveness in critically ill patients? A systematic review and meta-analysis","volume":"18","author":"Yang X","year":"2014","unstructured":"Yang X, Du B. Does pulse pressure variation predict fluid responsiveness in critically ill patients? A systematic review and meta-analysis. Crit Care. 2014, 18:650. 10.1186\/s13054-014-0650-6","journal-title":"Crit Care"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a590da","article-title":"Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature","volume":"37","author":"Marik PE","year":"2009","unstructured":"Marik PE, Cavallazzi R, Vasu T, Hirani A. Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature. Crit Care Med. 2009, 37:2642-7. 10.1097\/CCM.0b013e3181a590da","journal-title":"Crit Care Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0869-x","article-title":"Applicability of pulse pressure variation: how many shades of grey?","volume":"19","author":"Michard F","year":"2015","unstructured":"Michard F, Chemla D, Teboul JL. Applicability of pulse pressure variation: how many shades of grey?. Crit Care. 2015, 19:144. 10.1186\/s13054-015-0869-x","journal-title":"Crit Care"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2233-5","article-title":"The respiratory variation in inferior vena cava diameter as a guide to fluid therapy","volume":"30","author":"Feissel M","year":"2004","unstructured":"Feissel M, Michard F, Faller JP, Teboul JL. The respiratory variation in inferior vena cava diameter as a guide to fluid therapy. Intensive Care Med. 2004, 30:1834-7. 10.1007\/s00134-004-2233-5","journal-title":"Intensive Care Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2259-8","article-title":"Respiratory changes in inferior vena cava diameter are helpful in predicting fluid responsiveness in ventilated septic patients","volume":"30","author":"Barbier C","year":"2004","unstructured":"Barbier C, Loubi\u00e8res Y, Schmit C, Hayon J, Ric\u00f4me JL, Jardin F, Vieillard-Baron A. Respiratory changes in inferior vena cava diameter are helpful in predicting fluid responsiveness in ventilated septic patients. Intensive Care Med. 2004, 30:1740-6. 10.1007\/s00134-004-2259-8","journal-title":"Intensive Care Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000801","article-title":"Does respiratory variation in inferior vena cava diameter predict fluid responsiveness: a systematic review and meta-analysis","volume":"47","author":"Long E","year":"2017","unstructured":"Long E, Oakley E, Duke T, Babl FE. Does respiratory variation in inferior vena cava diameter predict fluid responsiveness: a systematic review and meta-analysis. Shock. 2017, 47:550-9. 10.1097\/SHK.0000000000000801","journal-title":"Shock"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0647-1","article-title":"Jugular vein distensibility predicts fluid responsiveness in septic patients","volume":"18","author":"Guarracino F","year":"2014","unstructured":"Guarracino F, Ferro B, Forfori F, Bertini P, Magliacano L, Pinsky MR. Jugular vein distensibility predicts fluid responsiveness in septic patients. Crit Care. 2014, 18:647. 10.1186\/s13054-014-0647-1","journal-title":"Crit Care"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-011-1200-x","article-title":"Influence of tidal volume for stroke volume variation to predict fluid responsiveness in patients undergoing one-lung ventilation","volume":"25","author":"Suehiro K","year":"2011","unstructured":"Suehiro K, Okutani R. Influence of tidal volume for stroke volume variation to predict fluid responsiveness in patients undergoing one-lung ventilation. J Anesth. 2011, 25:777-80. 10.1007\/s00540-011-1200-x","journal-title":"J Anesth"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","volume":"342","author":"Brower RG","year":"2000","unstructured":"Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000, 342:1301-8. 10.1056\/NEJM200005043421801","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002183","article-title":"The changes in pulse pressure variation or stroke volume variation after a \u201ctidal volume challenge\u201d reliably predict fluid responsiveness during low tidal volume ventilation","volume":"45","author":"Myatra SN","year":"2017","unstructured":"Myatra SN, Prabu NR, Divatia JV, Monnet X, Kulkarni AP, Teboul JL. The changes in pulse pressure variation or stroke volume variation after a \u201ctidal volume challenge\u201d reliably predict fluid responsiveness during low tidal volume ventilation. Crit Care Med. 2017, 45:415-21. 10.1097\/CCM.0000000000002183","journal-title":"Crit Care Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1686-y","article-title":"The influence of the airway driving pressure on pulsed pressure variation as a predictor of fluid responsiveness","volume":"36","author":"Muller L","year":"2010","unstructured":"Muller L, Louart G, Bousquet PJ, et al.. The influence of the airway driving pressure on pulsed pressure variation as a predictor of fluid responsiveness. Intensive Care Med. 2010, 36:496-503. 10.1007\/s00134-009-1686-y","journal-title":"Intensive Care Med"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet582","article-title":"End-expiratory occlusion manoeuvre does not accurately predict fluid responsiveness in the operating theatre","volume":"112","author":"Guinot PG","year":"2014","unstructured":"Guinot PG, Godart J, de Broca B, Bernard E, Lorne E, Dupont H. End-expiratory occlusion manoeuvre does not accurately predict fluid responsiveness in the operating theatre. Br J Anaesth. 2014, 112:1050-4. 10.1093\/bja\/aet582","journal-title":"Br J Anaesth"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002322","article-title":"End-expiratory occlusion test predicts fluid responsiveness in patients with protective ventilation in the operating room","volume":"125","author":"Biais M","year":"2017","unstructured":"Biais M, Larghi M, Henriot J, de Courson H, Sesay M, Nouette-Gaulain K. End-expiratory occlusion test predicts fluid responsiveness in patients with protective ventilation in the operating room. Anesth Analg. 2017, 125:1889-95. 10.1213\/ANE.0000000000002322","journal-title":"Anesth Analg"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181968fe1","article-title":"Predicting volume responsiveness by using the end-expiratory occlusion in mechanically ventilated intensive care unit patients","volume":"37","author":"Monnet X","year":"2009","unstructured":"Monnet X, Osman D, Ridel C, Lamia B, Richard C, Teboul JL. Predicting volume responsiveness by using the end-expiratory occlusion in mechanically ventilated intensive care unit patients. Crit Care Med. 2009, 37:951-6. 10.1097\/CCM.0b013e3181968fe1","journal-title":"Crit Care Med"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318229a500","article-title":"An increase in aortic blood flow after an infusion of 100 ml colloid over 1 minute can predict fluid responsiveness: the mini-fluid challenge study","volume":"115","author":"Muller L","year":"2011","unstructured":"Muller L, Toumi M, Bousquet PJ, et al.. An increase in aortic blood flow after an infusion of 100 ml colloid over 1 minute can predict fluid responsiveness: the mini-fluid challenge study. Anesthesiology. 2011, 115:541-7. 10.1097\/ALN.0b013e318229a500","journal-title":"Anesthesiology"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1186\/cc13891","article-title":"A 10-second fluid challenge guided by transthoracic echocardiography can predict fluid responsiveness","volume":"18","author":"Wu Y","year":"2014","unstructured":"Wu Y, Zhou S, Zhou Z, Liu B. A 10-second fluid challenge guided by transthoracic echocardiography can predict fluid responsiveness. Crit Care. 2014, 18:R108. 10.1186\/cc13891","journal-title":"Crit Care"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1293-3","article-title":"Passive leg raising for predicting fluid responsiveness: importance of the postural change","volume":"35","author":"Jabot J","year":"2009","unstructured":"Jabot J, Teboul JL, Richard C, Monnet X. Passive leg raising for predicting fluid responsiveness: importance of the postural change. Intensive Care Med. 2009, 35:85-90. 10.1007\/s00134-008-1293-3","journal-title":"Intensive Care Med"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.4.1245","article-title":"Changes in BP induced by passive leg raising predict response to fluid loading in critically ill patients","volume":"121","author":"Boulain T","year":"2002","unstructured":"Boulain T, Achard JM, Teboul JL, Richard C, Perrotin D, Ginies G. Changes in BP induced by passive leg raising predict response to fluid loading in critically ill patients. Chest. 2002, 121:1245-52. 10.1378\/chest.121.4.1245","journal-title":"Chest"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001556","article-title":"Predicting fluid responsiveness by passive leg raising: a systematic review and meta-analysis of 23 clinical trials","volume":"44","author":"Cherpanath TG","year":"2016","unstructured":"Cherpanath TG, Hirsch A, Geerts BF, Lagrand WK, Leeflang MM, Schultz MJ, Groeneveld AB. Predicting fluid responsiveness by passive leg raising: a systematic review and meta-analysis of 23 clinical trials. Crit Care Med. 2016, 44:981-91. 10.1097\/CCM.0000000000001556","journal-title":"Crit Care Med"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.05.019","article-title":"Changes in end-tidal CO2 could predict fluid responsiveness in the passive leg raising test but not in the mini-fluid challenge test: a prospective and observational study","volume":"30","author":"Xiao-ting W","year":"2015","unstructured":"Xiao-ting W, Hua Z, Da-wei L, Hong-min Z, Huai-wu H, Yun L, Wen-zhao C. Changes in end-tidal CO2 could predict fluid responsiveness in the passive leg raising test but not in the mini-fluid challenge test: a prospective and observational study. J Crit Care. 2015, 30:1061-6. 10.1016\/j.jcrc.2015.05.019","journal-title":"J Crit Care"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000404","article-title":"Passive leg raising for assessment of volume responsiveness: a review","volume":"23","author":"Mesquida J","year":"2017","unstructured":"Mesquida J, Gruartmoner G, Ferrer R. Passive leg raising for assessment of volume responsiveness: a review. Curr Opin Crit Care. 2017, 23:237-43. 10.1097\/MCC.0000000000000404","journal-title":"Curr Opin Crit Care"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00195.2007","article-title":"Evaluation of a noninvasive continuous cardiac output monitoring system based on thoracic bioreactance","volume":"293","author":"Keren H","year":"2007","unstructured":"Keren H, Burkhoff D, Squara P. Evaluation of a noninvasive continuous cardiac output monitoring system based on thoracic bioreactance. Am J Physiol Heart Circ Physiol. 2007, 293:H583-9. 10.1152\/ajpheart.00195.2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0640-0","article-title":"Noninvasive cardiac output monitoring (NICOM): a clinical validation","volume":"33","author":"Squara P","year":"2007","unstructured":"Squara P, Denjean D, Estagnasie P, Brusset A, Dib JC, Dubois C. Noninvasive cardiac output monitoring (NICOM): a clinical validation. Intensive Care Med. 2007, 33:1191-4. 10.1007\/s00134-007-0640-0","journal-title":"Intensive Care Med"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1186\/cc7981","article-title":"Comparison of monitoring performance of Bioreactance vs. pulse contour during lung recruitment maneuvers","volume":"13","author":"Squara P","year":"2009","unstructured":"Squara P, Rotcajg D, Denjean D, Estagnasie P, Brusset A. Comparison of monitoring performance of Bioreactance vs. pulse contour during lung recruitment maneuvers. Crit Care. 2009, 13:R125. 10.1186\/cc7981","journal-title":"Crit Care"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.03.013","article-title":"Estimating the rapid haemodynamic effects of passive leg raising in critically ill patients using bioreactance","volume":"121","author":"Galarza L","year":"2018","unstructured":"Galarza L, Mercado P, Teboul JL, Girotto V, Beurton A, Richard C, Monnet X. Estimating the rapid haemodynamic effects of passive leg raising in critically ill patients using bioreactance. Br J Anaesth. 2018, 121:567-73. 10.1016\/j.bja.2018.03.013","journal-title":"Br J Anaesth"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-4134-1","article-title":"Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis","volume":"42","author":"Monnet X","year":"2016","unstructured":"Monnet X, Marik P, Teboul JL. Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis. Intensive Care Med. 2016, 42:1935-47. 10.1007\/s00134-015-4134-1","journal-title":"Intensive Care Med"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.04.025","article-title":"Fluid response evaluation in sepsis hypotension and shock: a randomized clinical trial","volume":"158","author":"Douglas IS","year":"2020","unstructured":"Douglas IS, Alapat PM, Corl KA, et al.. Fluid response evaluation in sepsis hypotension and shock: a randomized clinical trial. Chest. 2020, 158:1431-45. 10.1016\/j.chest.2020.04.025","journal-title":"Chest"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181eb3c21","article-title":"The passive leg-raising maneuver cannot accurately predict fluid responsiveness in patients with intra-abdominal hypertension","volume":"38","author":"Mahjoub Y","year":"2010","unstructured":"Mahjoub Y, Touzeau J, Airapetian N, et al.. The passive leg-raising maneuver cannot accurately predict fluid responsiveness in patients with intra-abdominal hypertension. Crit Care Med. 2010, 38:1824-9. 10.1097\/CCM.0b013e3181eb3c21","journal-title":"Crit Care Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/91255-where-are-we-heading-with-fluid-responsiveness-and-septic-shock","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:44:27Z","timestamp":1707507867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/91255-where-are-we-heading-with-fluid-responsiveness-and-septic-shock"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,3]]},"references-count":43,"URL":"https:\/\/doi.org\/10.7759\/cureus.23795","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,3]]}}}