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Neurol Res. 2020, 42:346-53. 10.1080\/01616412.2020.1726588","journal-title":"Neurol Res"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c00180","article-title":"Single molecule assay for ultrasensitive detection of cathepsin B in human blood","volume":"6","author":"Thangavelu B","year":"2021","unstructured":"Thangavelu B, Boutt\u00e9 AM. Single molecule assay for ultrasensitive detection of cathepsin B in human blood. ACS Omega. 2021, 6:9609-16. 10.1021\/acsomega.1c00180","journal-title":"ACS Omega"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2021.113033","article-title":"\u03bcDrop: multi-analyte portable electrochemical-sensing device for blood-based detection of cleaved tau and neuron filament light in traumatic brain injury patients","volume":"178","author":"Khetani S","year":"2021","unstructured":"Khetani S, Singh A, Besler B, et al.. \u03bcDrop: multi-analyte portable electrochemical-sensing device for blood-based detection of cleaved tau and neuron filament light in traumatic brain injury patients. Biosens Bioelectron. 2021, 178:113033. 10.1016\/j.bios.2021.113033","journal-title":"Biosens Bioelectron"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S125620","article-title":"Biomarkers in traumatic brain injury (TBI): a review","volume":"14","author":"Dadas A","year":"2018","unstructured":"Dadas A, Washington J, Diaz-Arrastia R, Janigro D. 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Assist Technol. 2021, 10.1080\/10400435.2021.1923087","journal-title":"Assist Technol"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.2196\/24455","article-title":"The Geriatric Acute and Post-Acute Fall Prevention Intervention (GAPcare) II to assess the use of the Apple Watch in older emergency department patients with falls: protocol for a mixed methods study","volume":"10","author":"Strauss DH","year":"2021","unstructured":"Strauss DH, Davoodi NM, Healy M, Metts CL, Merchant RC, Banskota S, Goldberg EM. The Geriatric Acute and Post-Acute Fall Prevention Intervention (GAPcare) II to assess the use of the Apple Watch in older emergency department patients with falls: protocol for a mixed methods study. JMIR Res Protoc. 2021, 10:e24455. 10.2196\/24455","journal-title":"JMIR Res Protoc"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2018.1428089","article-title":"An update on diagnostic and prognostic biomarkers for traumatic brain injury","volume":"18","author":"Wang KK","year":"2018","unstructured":"Wang KK, Yang Z, Zhu T, Shi Y, Rubenstein R, Tyndall JA, Manley GT. An update on diagnostic and prognostic biomarkers for traumatic brain injury. Expert Rev Mol Diagn. 2018, 18:165-80. 10.1080\/14737159.2018.1428089","journal-title":"Expert Rev Mol Diagn"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.3171\/2015.8.FOCUS15329","article-title":"Role of apolipoprotein E polymorphism as a prognostic marker in traumatic brain injury and neurodegenerative disease: a critical review","volume":"39","author":"Maiti TK","year":"2015","unstructured":"Maiti TK, Konar S, Bir S, Kalakoti P, Bollam P, Nanda A. 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Neurocrit Care. 2022, 36:180-91. 10.1007\/s12028-021-01280-7","journal-title":"Neurocrit Care"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.2043","article-title":"Functional outcomes over the first year after moderate to severe traumatic brain injury in the prospective, longitudinal TRACK-TBI study","volume":"78","author":"McCrea MA","year":"2021","unstructured":"McCrea MA, Giacino JT, Barber J, et al.. Functional outcomes over the first year after moderate to severe traumatic brain injury in the prospective, longitudinal TRACK-TBI study. 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