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Two case-reports","volume":"66","author":"Attout H","year":"1999","unstructured":"Attout H, Toussirot E, Aug\u00e9 B, Chavot D, Wendling D. Rheumatoid arthritis and multiple sclerosis in the same patient. Two case-reports. Rev Rhum Engl Ed. 1999, 66:169-72.","journal-title":"Rev Rhum Engl Ed"},{"key":"ref111","article-title":"Ankylosing spondylitis and multiple sclerosis in an HLA-B27 negative patient","volume":"104","author":"Tan FU","year":"2004","unstructured":"Tan FU, Tellio\u011flu S, Aydin G, Erdemo\u011flu AK, Kele\u015f I. Ankylosing spondylitis and multiple sclerosis in an HLA-B27 negative patient. Acta Neurol Belg. 2004, 104:169-72.","journal-title":"Acta Neurol Belg"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0282-5","article-title":"Multiple sclerosis associated with systemic sclerosis","volume":"27","author":"Pelidou SH","year":"2007","unstructured":"Pelidou SH, Tsifetaki N, Giannopoulos S, Deretzi G, Voulgari P, Kyritsis A. 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