{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:00:32Z","timestamp":1791442832984,"version":"4.3.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,20]]},"DOI":"10.7759\/cureus.24321","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T22:59:22Z","timestamp":1650495562000},"source":"Crossref","is-referenced-by-count":5,"title":["A Retrospective Health Economic Analysis of a Stable Hypochlorous Acid Preserved Wound Cleanser Versus 0.9% Saline Solution as Instillation for Negative-Pressure Wound Therapy in Severe and Infected Wounds"],"prefix":"10.7759","author":[{"given":"Kathy E","family":"Gallagher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily  C","family":"Alberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Mallow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel  H","family":"Hermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Cardenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.12.017","article-title":"Vacuum assisted closure: a review of development and current applications","volume":"29","author":"Lambert KV","year":"2005","unstructured":"Lambert KV, Hayes P, McCarthy M. Vacuum assisted closure: a review of development and current applications. Eur J Vasc Endovasc Surg. 2005, 29:219-26. 10.1016\/j.ejvs.2004.12.017","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"ref2","article-title":"[Vacuum assisted closure. Wound healing by negative pressure]","volume":"41","author":"Voinchet V","year":"1996","unstructured":"Voinchet V, Magalon G. [Vacuum assisted closure. Wound healing by negative pressure]. Ann Chir Plast Esthet. 1996, 41:583-9.","journal-title":"Ann Chir Plast Esthet"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12176","article-title":"Negative pressure wound therapy with saline instillation: 131 patient case series","volume":"10 Suppl 1","author":"Brinkert D","year":"2013","unstructured":"Brinkert D, Ali M, Naud M, Maire N, Trial C, T\u00e9ot L. Negative pressure wound therapy with saline instillation: 131 patient case series. Int Wound J. 2013, 10 Suppl 1:56-60. 10.1111\/iwj.12176","journal-title":"Int Wound J"},{"key":"ref4","article-title":"International consensus panel recommendations for the optimization of traditional and single-use negative pressure wound therapy in the treatment of acute and chronic wounds","volume":"33","author":"Hurd T","year":"2021","unstructured":"Hurd T, Kirsner RS, Sancho-Insenser JJ, et al.. International consensus panel recommendations for the optimization of traditional and single-use negative pressure wound therapy in the treatment of acute and chronic wounds. Wounds. 2021, 33:S1-11.","journal-title":"Wounds"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742%2D481X.2011.00813.x","article-title":"Negative pressure wound therapy: an adjuvant to surgical reconstruction of large or difficult skin and soft tissue defects","volume":"8","author":"Lee DL","year":"2011","unstructured":"Lee DL, Ryu AY, Rhee SC. Negative pressure wound therapy: an adjuvant to surgical reconstruction of large or difficult skin and soft tissue defects. Int Wound J. 2011, 8:406-11. 10.1111\/j.1742%2D481X.2011.00813.x","journal-title":"Int Wound J"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12664","article-title":"A solution for complex wounds: the evidence for negative pressure wound therapy with instillation","volume":"13","author":"Anghel EL","year":"2016","unstructured":"Anghel EL, Kim PJ, Attinger CE. A solution for complex wounds: the evidence for negative pressure wound therapy with instillation. Int Wound J. 2016, 13:19-24. 10.1111\/iwj.12664","journal-title":"Int Wound J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009261.pub6","article-title":"Negative pressure wound therapy for surgical wounds healing by primary closure","volume":"6","author":"Norman G","year":"2020","unstructured":"Norman G, Goh EL, Dumville JC, et al.. Negative pressure wound therapy for surgical wounds healing by primary closure. Cochrane Database Syst Rev. 2020, 6:CD009261. 10.1002\/14651858.CD009261.pub6","journal-title":"Cochrane Database Syst Rev"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.1097\/00000637-199706000-00002","article-title":"Vacuum-assisted closure: a new method for wound control and treatment: clinical experience","volume":"38","author":"Argenta LC","year":"1997","unstructured":"Argenta LC, Morykwas MJ. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Ann Plast Surg. 1997, 38:563-76.","journal-title":"Ann Plast Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.920","article-title":"The use of NPWT-i technology in complex surgical wounds","volume":"8","author":"Rupert P","year":"2016","unstructured":"Rupert P, Ochoa RA, Punch L, Van Epps J, Gordon-Burroughs S, Martinez S. The use of NPWT-i technology in complex surgical wounds. Cureus. 2016, 8:e920. 10.7759\/cureus.920","journal-title":"Cureus"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s001130050318","article-title":"[Vacuum sealing as carrier system for controlled local drug administration in wound infection]","volume":"101","author":"Fleischmann W","year":"1998","unstructured":"Fleischmann W, Russ M, Westhauser A, Stampehl M. [Vacuum sealing as carrier system for controlled local drug administration in wound infection]. Unfallchirurg. 1998, 101:649-54. 10.1007\/s001130050318","journal-title":"Unfallchirurg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000007610","article-title":"Management of acute and traumatic wounds with negative-pressure wound therapy with instillation and dwell time","volume":"147","author":"Diehm YF","year":"2021","unstructured":"Diehm YF, Fischer S, Wirth GA, et al.. Management of acute and traumatic wounds with negative-pressure wound therapy with instillation and dwell time. Plast Reconstr Surg. 2021, 147:43S-53S. 10.1097\/PRS.0000000000007610","journal-title":"Plast Reconstr Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.865","article-title":"A case review series of Christiana Care Health System's experience with negative pressure wound therapy instillation","volume":"8","author":"Felte R","year":"2016","unstructured":"Felte R, Gallagher KE, Tinkoff GH, Cipolle M. A case review series of Christiana Care Health System's experience with negative pressure wound therapy instillation. Cureus. 2016, 8:e865. 10.7759\/cureus.865","journal-title":"Cureus"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2015.24.Sup4b.4","article-title":"Prologue: transformational healing solutions","volume":"24","author":"Harding K","year":"2015","unstructured":"Harding K. Prologue: transformational healing solutions. J Wound Care. 2015, 24:4-5. 10.12968\/jowc.2015.24.Sup4b.4","journal-title":"J Wound Care"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000438060.46290.7a","article-title":"The impact of negative-pressure wound therapy with instillation compared with standard negative-pressure wound therapy: a retrospective, historical, cohort, controlled study","volume":"133","author":"Kim PJ","year":"2014","unstructured":"Kim PJ, Attinger CE, Steinberg JS, et al.. The impact of negative-pressure wound therapy with instillation compared with standard negative-pressure wound therapy: a retrospective, historical, cohort, controlled study. Plast Reconstr Surg. 2014, 133:709-16. 10.1097\/01.prs.0000438060.46290.7a","journal-title":"Plast Reconstr Surg"},{"key":"ref15","article-title":"Efficacy of negative pressure wound therapy with instillation and dwell time for the treatment of a complex chronic venous leg ulcer","volume":"32","author":"Scarpa C","year":"2020","unstructured":"Scarpa C, de Antoni E, Vindigni V, Bassetto F. Efficacy of negative pressure wound therapy with instillation and dwell time for the treatment of a complex chronic venous leg ulcer. Wounds. 2020, 32:372-4.","journal-title":"Wounds"},{"key":"ref16","article-title":"Negative pressure wound therapy with instillation and dwell time used to treat pyoderma gangrenosum: a case report","volume":"32","author":"Woelfel SL","year":"2020","unstructured":"Woelfel SL. Negative pressure wound therapy with instillation and dwell time used to treat pyoderma gangrenosum: a case report. Wounds. 2020, 32:E59-61.","journal-title":"Wounds"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccw.2014.02.001","article-title":"Negative pressure wound therapy with instillation (NPWTi) better reduces post-debridement bioburden in chronically infected lower extremity wounds than NPWT alone","volume":"4","author":"Goss SG","year":"2012","unstructured":"Goss SG, Schwartz JA, Facchin F, Avdagic E, Gendics C, Lantis JC 2nd. Negative pressure wound therapy with instillation (NPWTi) better reduces post-debridement bioburden in chronically infected lower extremity wounds than NPWT alone. J Am Coll Clin Wound Spec. 2012, 4:74-80. 10.1016\/j.jccw.2014.02.001","journal-title":"J Am Coll Clin Wound Spec"},{"key":"ref18","article-title":"Use of negative pressure wound therapy with automated, volumetric instillation for the treatment of extremity and trunk wounds: clinical outcomes and potential cost-effectiveness","volume":"14","author":"Gabriel A","year":"2014","unstructured":"Gabriel A, Kahn K, Karmy-Jones R. Use of negative pressure wound therapy with automated, volumetric instillation for the treatment of extremity and trunk wounds: clinical outcomes and potential cost-effectiveness. Eplasty. 2014, 14:e41.","journal-title":"Eplasty"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.18535\/jmscr\/v8i6.79","article-title":"Level 1 Trauma center experience utilizing negative pressure wound therapy with instillation: hypochlorous acid versus normal saline solution in complex or infected wounds","volume":"8","author":"Alberto EC","year":"2020","unstructured":"Alberto EC, Cardenas L, Cipolle M, Gallagher KE. Level 1 Trauma center experience utilizing negative pressure wound therapy with instillation: hypochlorous acid versus normal saline solution in complex or infected wounds. J Med Sci Clin Res. 2020, 8:414-20. 10.18535\/jmscr\/v8i6.79","journal-title":"J Med Sci Clin Res"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.6233","article-title":"Understanding costs of care in the operating room","volume":"153","author":"Childers CP","year":"2018","unstructured":"Childers CP, Maggard-Gibbons M. Understanding costs of care in the operating room. JAMA Surg. 2018, 153:e176233. 10.1001\/jamasurg.2017.6233","journal-title":"JAMA Surg"},{"key":"ref21","unstructured":"CPT codes 11042, 11043, 11044, 97597, 97602 - Debridement tissue wound care. (2020). Accessed. December 15, 2021: http:\/\/www.medicarepaymentandreimbursement.com\/2016\/10\/procedure-codes-11042-11043-11044-97597.html.."},{"key":"ref22","unstructured":"Orlando health. Pricing transparency guide. (2020). Accessed: December 15, 2021: https:\/\/www.orlandohealth.com\/patients-and-visitors\/patient-financial-resources\/pricing-transparency."},{"key":"ref23","unstructured":"Becker's Healthcare. Average hospital expenses per inpatient day across 50 states. (2019). Accessed: December 15, 2021: https:\/\/www.beckershospitalreview.com\/finance\/average-hospital-expenses-per-inpatient-day-across-50-states.html."},{"key":"ref24","unstructured":"Agency for Healthcare Research and Quality. Costs for hospital stays in the United States, 2012. (2014). Accessed: December 15, 2021: https:\/\/www.hcup-us.ahrq.gov\/reports\/statbriefs\/sb181-Hospital-Costs-United-States-2012.pdf."},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12939","article-title":"Influence of diabetes on tissue healing in orthopaedic injuries","volume":"45","author":"Stolarczyk A","year":"2018","unstructured":"Stolarczyk A, Sarzy\u0144ska S, Gondek A, Cudnoch-J\u0119drzejewska A. Influence of diabetes on tissue healing in orthopaedic injuries. Clin Exp Pharmacol Physiol. 2018, 45:619-27. 10.1111\/1440-1681.12939","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125","article-title":"Factors affecting wound healing","volume":"89","author":"Guo S","year":"2010","unstructured":"Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010, 89:219-29. 10.1177\/0022034509359125","journal-title":"J Dent Res"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3039","article-title":"Improved function of diabetic wound-site macrophages and accelerated wound closure in response to oral supplementation of a fermented papaya preparation","volume":"13","author":"Collard E","year":"2010","unstructured":"Collard E, Roy S. Improved function of diabetic wound-site macrophages and accelerated wound closure in response to oral supplementation of a fermented papaya preparation. Antioxid Redox Signal. 2010, 13:599-606. 10.1089\/ars.2009.3039","journal-title":"Antioxid Redox Signal"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2929","article-title":"Dysregulation of wound healing mechanisms in diabetes and the importance of negative pressure wound therapy (NPWT)","volume":"33","author":"Khamaisi M","year":"2017","unstructured":"Khamaisi M, Balanson S. Dysregulation of wound healing mechanisms in diabetes and the importance of negative pressure wound therapy (NPWT). Diabetes Metab Res Rev. 2017, 33:10.1002\/dmrr.2929","journal-title":"Diabetes Metab Res Rev"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2013.07.001","article-title":"Complications of general anesthesia","volume":"40","author":"Harris M","year":"2013","unstructured":"Harris M, Chung F. Complications of general anesthesia. Clin Plast Surg. 2013, 40:503-13. 10.1016\/j.cps.2013.07.001","journal-title":"Clin Plast Surg"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199909000-00022","article-title":"Which clinical anesthesia outcomes are important to avoid? The perspective of patients","volume":"89","author":"Macario A","year":"1999","unstructured":"Macario A, Weinger M, Carney S, Kim A. Which clinical anesthesia outcomes are important to avoid? The perspective of patients. Anesth Analg. 1999, 89:652-8. 10.1097\/00000539-199909000-00022","journal-title":"Anesth Analg"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/76351-a-retrospective-health-economic-analysis-of-a-stable-hypochlorous-acid-preserved-wound-cleanser-versus-09-saline-solution-as-instillation-for-negative-pressure-wound-therapy-in-severe-and-infected-wounds","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:36:56Z","timestamp":1707507416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/76351-a-retrospective-health-economic-analysis-of-a-stable-hypochlorous-acid-preserved-wound-cleanser-versus-09-saline-solution-as-instillation-for-negative-pressure-wound-therapy-in-severe-and-infected-wounds"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.24321","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,20]]}}}