{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:37:00Z","timestamp":1764571020545},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,20]]},"DOI":"10.7759\/cureus.25163","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T13:11:16Z","timestamp":1653052276000},"source":"Crossref","is-referenced-by-count":3,"title":["Does the Same Hyperlactatemia Cut-Off in the Context of Acute Diseases Hold the Same Meaning in Diabetes Mellitus?"],"prefix":"10.7759","author":[{"given":"In\u00eas H","family":"Vieira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Petrova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 P","family":"Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Causes of lactic acidosis","author":"Emmett M","year":"2022","unstructured":"Emmett M, Szerlip H. Causes of lactic acidosis. UpToDate. Sterns RH (ed): Wolters Kluwer, Philadelphia, PA; 2022."},{"key":"ref2","article-title":"Lactic acidosis","author":"Foucher CD","year":"2020","unstructured":"Foucher CD, Tubben RE. Lactic acidosis. StatPearls Publishing, Treasure Island, FL; 2020."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1309483","article-title":"Lactic acidosis","volume":"371","author":"Kraut JA","year":"2014","unstructured":"Kraut JA, Madias NE. Lactic acidosis. N Engl J Med. 2014, 371:2309-19. 10.1056\/NEJMra1309483","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2017.07.008","article-title":"Low sensitivity of anion gap to detect clinically significant lactic acidosis in the emergency department","volume":"50","author":"Xu Q","year":"2017","unstructured":"Xu Q, HowlettClyne S, Fuezery A, Cembrowski GS. Low sensitivity of anion gap to detect clinically significant lactic acidosis in the emergency department. Clin Biochem. 2017, 50:1164-7. 10.1016\/j.clinbiochem.2017.07.008","journal-title":"Clin Biochem"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0438","article-title":"Lactic acidosis: an update","volume":"55","author":"Seheult J","year":"2017","unstructured":"Seheult J, Fitzpatrick G, Boran G. Lactic acidosis: an update. Clin Chem Lab Med. 2017, 55:322-33. 10.1515\/cclm-2016-0438","journal-title":"Clin Chem Lab Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2016.11.002","article-title":"A quick reference on high anion gap metabolic acidosis","volume":"47","author":"Funes S","year":"2017","unstructured":"Funes S, de Morais HA. A quick reference on high anion gap metabolic acidosis. Vet Clin North Am Small Anim Pract. 2017, 47:205-7. 10.1016\/j.cvsm.2016.11.002","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.82a.14098","article-title":"Lactic acidosis: clinical implications and management strategies","volume":"82","author":"Reddy AJ","year":"2015","unstructured":"Reddy AJ, Lam SW, Bauer SR, Guzman JA. Lactic acidosis: clinical implications and management strategies. Cleve Clin J Med. 2015, 82:615-24. 10.3949\/ccjm.82a.14098","journal-title":"Cleve Clin J Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.10.027","article-title":"Hyperlactatemia is an independent predictor of mortality and denotes distinct subtypes of severe sepsis and septic shock","volume":"30","author":"Thomas-Rueddel DO","year":"2015","unstructured":"Thomas-Rueddel DO, Poidinger B, Weiss M, et al.. Hyperlactatemia is an independent predictor of mortality and denotes distinct subtypes of severe sepsis and septic shock. J Crit Care. 2015, 30:439.e1-6. 10.1016\/j.jcrc.2014.10.027","journal-title":"J Crit Care"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5085-0","article-title":"The Surviving Sepsis Campaign Bundle: 2018 update","volume":"44","author":"Levy MM","year":"2018","unstructured":"Levy MM, Evans LE, Rhodes A. The Surviving Sepsis Campaign Bundle: 2018 update. Intensive Care Med. 2018, 44:925-8. 10.1007\/s00134-018-5085-0","journal-title":"Intensive Care Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-017-0415-8","article-title":"Serum lactate is an independent predictor of hospital mortality in critically ill patients in the emergency department: a retrospective study","volume":"25","author":"Bou Chebl R","year":"2017","unstructured":"Bou Chebl R, El Khuri C, Shami A, Rajha E, Faris N, Bachir R, Abou Dagher G. Serum lactate is an independent predictor of hospital mortality in critically ill patients in the emergency department: a retrospective study. Scand J Trauma Resusc Emerg Med. 2017, 25:69. 10.1186\/s13049-017-0415-8","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5151.141411","article-title":"Point of care blood gases with electrolytes and lactates in adult emergencies","volume":"4","author":"Kapoor D","year":"2014","unstructured":"Kapoor D, Srivastava M, Singh P. Point of care blood gases with electrolytes and lactates in adult emergencies. Int J Crit Illn Inj Sci. 2014, 4:216-22. 10.4103\/2229-5151.141411","journal-title":"Int J Crit Illn Inj Sci"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2013.09.005","article-title":"Plasma lactate and diabetes risk in 8045 participants of the atherosclerosis risk in communities study","volume":"23","author":"Juraschek SP","year":"2013","unstructured":"Juraschek SP, Selvin E, Miller ER, Brancati FL, Young JH. Plasma lactate and diabetes risk in 8045 participants of the atherosclerosis risk in communities study. Ann Epidemiol. 2013, 23:791-6.e4. 10.1016\/j.annepidem.2013.09.005","journal-title":"Ann Epidemiol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.05.018","article-title":"Hyperlactatemia in type 2 diabetes: can physical training help?","volume":"29","author":"Brinkmann C","year":"2015","unstructured":"Brinkmann C, Brixius K. Hyperlactatemia in type 2 diabetes: can physical training help?. J Diabetes Complications. 2015, 29:965-9. 10.1016\/j.jdiacomp.2015.05.018","journal-title":"J Diabetes Complications"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21488","article-title":"Metabolomic profiling to dissect the role of visceral fat in cardiometabolic health","volume":"24","author":"Menni C","year":"2016","unstructured":"Menni C, Migaud M, Glastonbury CA, et al.. Metabolomic profiling to dissect the role of visceral fat in cardiometabolic health. Obesity (Silver Spring). 2016, 24:1380-8. 10.1002\/oby.21488","journal-title":"Obesity (Silver Spring)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.06.014","article-title":"Elevated urinary D-lactate levels in patients with diabetes and microalbuminuria","volume":"116","author":"Chou CK","year":"2015","unstructured":"Chou CK, Lee YT, Chen SM, Hsieh CW, Huang TC, Li YC, Lee JA. Elevated urinary D-lactate levels in patients with diabetes and microalbuminuria. J Pharm Biomed Anal. 2015, 116:65-70. 10.1016\/j.jpba.2015.06.014","journal-title":"J Pharm Biomed Anal"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.01.028","article-title":"Serum lactate levels are associated with serum alanine aminotransferase and total bilirubin levels in patients with type 2 diabetes mellitus: a cross-sectional study","volume":"149","author":"Ishitobi M","year":"2019","unstructured":"Ishitobi M, Hosaka T, Morita N, et al.. Serum lactate levels are associated with serum alanine aminotransferase and total bilirubin levels in patients with type 2 diabetes mellitus: a cross-sectional study. Diabetes Res Clin Pract. 2019, 149:1-8. 10.1016\/j.diabres.2019.01.028","journal-title":"Diabetes Res Clin Pract"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA118.000690","article-title":"Metabolomic analysis identifies lactate as an important pathogenic factor in diabetes-associated cognitive decline rats","volume":"17","author":"Zhao L","year":"2018","unstructured":"Zhao L, Dong M, Ren M, Li C, Zheng H, Gao H. Metabolomic analysis identifies lactate as an important pathogenic factor in diabetes-associated cognitive decline rats. Mol Cell Proteomics. 2018, 17:2335-46. 10.1074\/mcp.RA118.000690","journal-title":"Mol Cell Proteomics"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6456018","article-title":"Lactate, a neglected factor for diabetes and cancer interaction","volume":"2016","author":"Wu Y","year":"2016","unstructured":"Wu Y, Dong Y, Atefi M, Liu Y, Elshimali Y, Vadgama JV. Lactate, a neglected factor for diabetes and cancer interaction. Mediators Inflamm. 2016, 2016:6456018. 10.1155\/2016\/6456018","journal-title":"Mediators Inflamm"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051237","article-title":"Diabetes medication use and blood lactate level among participants with type 2 diabetes: the atherosclerosis risk in communities carotid MRI study","volume":"7","author":"Mongraw-Chaffin ML","year":"2012","unstructured":"Mongraw-Chaffin ML, Matsushita K, Brancati FL, et al.. Diabetes medication use and blood lactate level among participants with type 2 diabetes: the atherosclerosis risk in communities carotid MRI study. PLoS One. 2012, 7:e51237. 10.1371\/journal.pone.0051237","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2011.07.071","article-title":"Prevalence and significance of lactic acidosis in diabetic ketoacidosis","volume":"27","author":"Cox K","year":"2012","unstructured":"Cox K, Cocchi MN, Salciccioli JD, Carney E, Howell M, Donnino MW. Prevalence and significance of lactic acidosis in diabetic ketoacidosis. J Crit Care. 2012, 27:132-7. 10.1016\/j.jcrc.2011.07.071","journal-title":"J Crit Care"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2016.1216723","article-title":"Metformin-related lactic acidosis: is it a myth or an underestimated reality?","volume":"38","author":"Visconti L","year":"2016","unstructured":"Visconti L, Cernaro V, Ferrara D, et al.. Metformin-related lactic acidosis: is it a myth or an underestimated reality?. Ren Fail. 2016, 38:1560-5. 10.1080\/0886022X.2016.1216723","journal-title":"Ren Fail"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-016-0267-8","article-title":"Metformin associated lactic acidosis (MALA): clinical profiling and management","volume":"29","author":"Moioli A","year":"2016","unstructured":"Moioli A, Maresca B, Manzione A, et al.. Metformin associated lactic acidosis (MALA): clinical profiling and management. J Nephrol. 2016, 29:783-9. 10.1007\/s40620-016-0267-8","journal-title":"J Nephrol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2018.04.004","article-title":"Safe use of metformin in adults with type 2 diabetes and chronic kidney disease: lower dosages and sick-day education are essential","volume":"43","author":"MacCallum L","year":"2019","unstructured":"MacCallum L, Senior PA. Safe use of metformin in adults with type 2 diabetes and chronic kidney disease: lower dosages and sick-day education are essential. Can J Diabetes. 2019, 43:76-80. 10.1016\/j.jcjd.2018.04.004","journal-title":"Can J Diabetes"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1554","article-title":"Diabetes is associated with reduced stress hyperlactatemia in cardiac surgery","volume":"41","author":"Greco G","year":"2018","unstructured":"Greco G, Kirkwood KA, Gelijns AC, Moskowitz AJ, Lam DW. Diabetes is associated with reduced stress hyperlactatemia in cardiac surgery. Diabetes Care. 2018, 41:469-77. 10.2337\/dc17-1554","journal-title":"Diabetes Care"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6901345","article-title":"Hyperlactatemia and the outcome of type 2 diabetic patients suffering acute myocardial infarction","volume":"2016","author":"Aleksandar J","year":"2016","unstructured":"Aleksandar J, Vladan P, Markovic-Jovanovic S, Stolic R, Mitic J, Smilic T. Hyperlactatemia and the outcome of type 2 diabetic patients suffering acute myocardial infarction. J Diabetes Res. 2016, 2016:6901345. 10.1155\/2016\/6901345","journal-title":"J Diabetes Res"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.03060120024016","article-title":"Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function","volume":"185","author":"Katz S","year":"1963","unstructured":"Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA. 1963, 185:914-9. 10.1001\/jama.1963.03060120024016","journal-title":"JAMA"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.26497\/ao190038","article-title":"[Diabetes in aged in convalescence units: a sociodemographic and clinical characterization]","volume":"15","author":"Mendes R","year":"2020","unstructured":"Mendes R, Martins S, Fernandes L. [Diabetes in aged in convalescence units: a sociodemographic and clinical characterization]. Rev Port Endocrinol Diabetes Metab. 2020, 15:29-35. 10.26497\/ao190038","journal-title":"Rev Port Endocrinol Diabetes Metab"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03300-y","article-title":"Metformin use and early lactate levels in critically ill patients according to chronic and acute renal impairment","volume":"24","author":"Posma RA","year":"2020","unstructured":"Posma RA, Hulman A, Thomsen RW, Jespersen B, Nijsten MW, Christiansen CF. Metformin use and early lactate levels in critically ill patients according to chronic and acute renal impairment. Crit Care. 2020, 24:585. 10.1186\/s13054-020-03300-y","journal-title":"Crit Care"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/94301-does-the-same-hyperlactatemia-cut-off-in-the-context-of-acute-diseases-hold-the-same-meaning-in-diabetes-mellitus","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:42:17Z","timestamp":1707507737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/94301-does-the-same-hyperlactatemia-cut-off-in-the-context-of-acute-diseases-hold-the-same-meaning-in-diabetes-mellitus"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,20]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.25163","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,20]]}}}