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Tranexamic acid versus \u025b-aminocaproic acid: efficacy and safety in paediatric cardiac surgery. Eur J Cardiothorac Surg. 2011, 39:892-7. 10.1016\/j.ejcts.2010.09.041","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31817bd889","article-title":"The role of Amicar in same-day anterior and posterior spinal fusion for idiopathic scoliosis","volume":"33","author":"Thompson GH","year":"2008","unstructured":"Thompson GH, Florentino-Pineda I, Poe-Kochert C, Armstrong DG, Son-Hing JP. The role of Amicar in same-day anterior and posterior spinal fusion for idiopathic scoliosis. Spine (Phila Pa 1976). 2008, 33:2237-42. 10.1097\/BRS.0b013e31817bd889","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318187c046","article-title":"Role of Amicar in surgery for neuromuscular scoliosis","volume":"33","author":"Thompson GH","year":"2008","unstructured":"Thompson GH, Florentino-Pineda I, Poe-Kochert C, Armstrong DG, Son-Hing J. Role of Amicar in surgery for neuromuscular scoliosis. Spine (Phila Pa 1976). 2008, 33:2623-9. 10.1097\/BRS.0b013e318187c046","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000253962.24179.bc","article-title":"Fibrinogen levels following Amicar in surgery for idiopathic scoliosis","volume":"32","author":"Thompson GH","year":"2007","unstructured":"Thompson GH, Florentino-Pineda I, Armstrong DG, Poe-Kochert C. Fibrinogen levels following Amicar in surgery for idiopathic scoliosis. Spine (Phila Pa 1976). 2007, 32:368-72. 10.1097\/01.brs.0000253962.24179.bc","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000109883.18015.b9","article-title":"The effect of amicar on perioperative blood loss in idiopathic scoliosis: the results of a prospective, randomized double-blind study","volume":"29","author":"Florentino-Pineda I","year":"2004","unstructured":"Florentino-Pineda I, Thompson GH, Poe-Kochert C, Huang RP, Haber LL, Blakemore LC. The effect of amicar on perioperative blood loss in idiopathic scoliosis: the results of a prospective, randomized double-blind study. Spine (Phila Pa 1976). 2004, 29:233-8. 10.1097\/01.brs.0000109883.18015.b9","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2004.01.016","article-title":"Comparison of epsilon aminocaproic acid and tranexamic acid in pediatric cardiac surgery","volume":"18","author":"Chauhan S","year":"2004","unstructured":"Chauhan S, Das SN, Bisoi A, Kale S, Kiran U. Comparison of epsilon aminocaproic acid and tranexamic acid in pediatric cardiac surgery. J Cardiothorac Vasc Anesth. 2004, 18:141-3. 10.1053\/j.jvca.2004.01.016","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref56","article-title":"Epsilon aminocaproic acid in paediatric cardiac surgery to reduce postoperative blood loss","volume":"111","author":"Rao BH","year":"2000","unstructured":"Rao BH, Saxena N, Chauhan S, Bisoi AK, Venugopal P. Epsilon aminocaproic acid in paediatric cardiac surgery to reduce postoperative blood loss. 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