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Diabetes Obes Metab. 2022, 24:44-54. 10.1111\/dom.14569","journal-title":"Diabetes Obes Metab"},{"key":"ref84","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2015.04.005","article-title":"Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis","volume":"149","author":"Vilar-Gomez E","year":"2015","unstructured":"Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, et al.. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015, 149:367-78.","journal-title":"Gastroenterology"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-022-01081-x","article-title":"Effects of a low free sugar diet on the management of nonalcoholic fatty liver disease: a randomized clinical trial","author":"Khodami B","year":"2022","unstructured":"Khodami B, Hatami B, Yari Z, et al.. 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Case Rep Gastroenterol. 2022, 16:240-6. 10.1159\/000523964","journal-title":"Case Rep Gastroenterol"},{"key":"ref89","article-title":"Managing nonalcoholic fatty liver disease: recommendations for family physicians","volume":"53","author":"Grattagliano I","year":"2007","unstructured":"Grattagliano I, Portincasa P, Palmieri VO, Palasciano G. Managing nonalcoholic fatty liver disease: recommendations for family physicians. Can Fam Physician. 2007, 53:857-63.","journal-title":"Can Fam Physician"},{"key":"ref90","article-title":"Non-alcoholic fatty liver disease: a patient guideline","volume":"3","author":"Francque SM","year":"2021","unstructured":"Francque SM, Marchesini G, Kautz A, et al.. Non-alcoholic fatty liver disease: a patient guideline. JHEP Rep. 2021, 3:100322.","journal-title":"JHEP Rep"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2740-8","article-title":"Identifying practice gaps to optimize medical care for patients with nonalcoholic fatty liver disease","volume":"58","author":"Wieland AC","year":"2013","unstructured":"Wieland AC, Quallick M, Truesdale A, Mettler P, Bambha KM. Identifying practice gaps to optimize medical care for patients with nonalcoholic fatty liver disease. Dig Dis Sci. 2013, 58:2809-16. 10.1007\/s10620-013-2740-8","journal-title":"Dig Dis Sci"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v13.i2.233","article-title":"Awareness of non-alcoholic steatohepatitis and treatment guidelines: what are physicians telling us?","volume":"13","author":"Wessels DH","year":"2021","unstructured":"Wessels DH, Rosenberg Z. Awareness of non-alcoholic steatohepatitis and treatment guidelines: what are physicians telling us?. World J Hepatol. 2021, 13:233-41. 10.4254\/wjh.v13.i2.233","journal-title":"World J Hepatol"},{"key":"ref93","article-title":"Screening for nonalcoholic fatty liver disease in the primary care clinic","volume":"15","author":"Pandyarajan V","year":"2019","unstructured":"Pandyarajan V, Gish RG, Alkhouri N, Noureddin M. Screening for nonalcoholic fatty liver disease in the primary care clinic. Gastroenterol Hepatol. 2019, 15:357-65.","journal-title":"Gastroenterol Hepatol"},{"key":"ref94","unstructured":"Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. (2012). Accessed. April 19, 2022: https:\/\/www.worldgastroenterology.org\/guidelines\/nafld-nash\/nafld-nash-english."},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi Z","year":"2018","unstructured":"Younossi Z, Anstee QM, Marietti M, et al.. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2018, 15:11-20. 10.1038\/nrgastro.2017.109","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref96","article-title":"Case-finding strategies in non-alcoholic fatty liver disease","volume":"3","author":"Boursier J","year":"2021","unstructured":"Boursier J, Tsochatzis EA. Case-finding strategies in non-alcoholic fatty liver disease. JHEP Rep. 2021, 3:100219.","journal-title":"JHEP Rep"},{"key":"ref97","article-title":"The challenging ethical landscape of non-alcoholic fatty liver disease","author":"Berry P","year":"2022","unstructured":"Berry P, Kotha S. The challenging ethical landscape of non-alcoholic fatty liver disease. Eur Med J. 2022, 1-9.","journal-title":"Eur Med J"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00523-4","article-title":"Advancing the global public health agenda for NAFLD: a consensus statement","volume":"19","author":"Lazarus JV","year":"2022","unstructured":"Lazarus JV, Mark HE, Anstee QM, et al.. Advancing the global public health agenda for NAFLD: a consensus statement. Nat Rev Gastroenterol Hepatol. 2022, 19:60-78. 10.1038\/s41575-021-00523-4","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22429","article-title":"Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes","volume":"48","author":"Fracanzani AL","year":"2008","unstructured":"Fracanzani AL, Valenti L, Bugianesi E, et al.. Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology. 2008, 48:792-8. 10.1002\/hep.22429","journal-title":"Hepatology"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1068","article-title":"Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study","volume":"34","author":"Lewis JD","year":"2011","unstructured":"Lewis JD, Ferrara A, Peng T, et al.. Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study. Diabetes Care. 2011, 34:916-22. 10.2337\/dc10-1068","journal-title":"Diabetes Care"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2017.1293523","article-title":"Current and future treatment options in non-alcoholic steatohepatitis (NASH)","volume":"11","author":"Lazaridis N","year":"2017","unstructured":"Lazaridis N, Tsochatzis E. Current and future treatment options in non-alcoholic steatohepatitis (NASH). Expert Rev Gastroenterol Hepatol. 2017, 11:357-69. 10.1080\/17474124.2017.1293523","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1143","article-title":"Lean NAFLD: a not so benign condition?","volume":"2","author":"VanWagner LB","year":"2018","unstructured":"VanWagner LB, Armstrong MJ. Lean NAFLD: a not so benign condition?. Hepatol Commun. 2018, 2:5-8. 10.1002\/hep4.1143","journal-title":"Hepatol Commun"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27678","article-title":"Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases - U.S. Food and Drug Administration joint workshop","volume":"61","author":"Sanyal AJ","year":"2015","unstructured":"Sanyal AJ, Friedman SL, McCullough AJ, Dimick L. Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases - U.S. Food and Drug Administration joint workshop. Hepatology. 2015, 61:1392-405. 10.1002\/hep.27678","journal-title":"Hepatology"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2017.11929552","article-title":"Improving health outcomes through patient education and partnerships with patients","volume":"30","author":"Paterick TE","year":"2017","unstructured":"Paterick TE, Patel N, Tajik AJ, Chandrasekaran K. Improving health outcomes through patient education and partnerships with patients. Proc (Bayl Univ Med Cent). 2017, 30:112-3. 10.1080\/08998280.2017.11929552","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"ref105","unstructured":"Nonalcoholic fatty liver disease (NAFLD) &amp; NASH. ( 2022). Accessed. 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