{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:20:01Z","timestamp":1777623601197,"version":"3.51.4"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,3]]},"DOI":"10.7759\/cureus.25629","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T14:32:42Z","timestamp":1654266762000},"source":"Crossref","is-referenced-by-count":7,"title":["Incidental Detection of Human Herpesvirus-6 in Cerebrospinal Fluid Analysis: To Treat or Not to Treat?"],"prefix":"10.7759","author":[{"given":"Abdurrahman F","family":"Kharbat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithra","family":"Lakshmi-Narasimhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita","family":"Bhaskaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumesh","family":"Parat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/1179547620912952","article-title":"Human herpesvirus-6 meningitis in a premature infant with fevers: a case and literature review","volume":"13","author":"Kim F","year":"2020","unstructured":"Kim F, Reichman V, Hooven TA. Human herpesvirus-6 meningitis in a premature infant with fevers: a case and literature review. Clin Med Insights Case Rep. 2020, 13:1179547620912952. 10.1177\/1179547620912952","journal-title":"Clin Med Insights Case Rep"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00281","article-title":"Clinical utilization of the FilmArray meningitis\/encephalitis (ME) multiplex polymerase chain reaction (PCR) assay","volume":"10","author":"Radmard S","year":"2019","unstructured":"Radmard S, Reid S, Ciryam P, et al.. Clinical utilization of the FilmArray meningitis\/encephalitis (ME) multiplex polymerase chain reaction (PCR) assay. Front Neurol. 2019, 10:281. 10.3389\/fneur.2019.00281","journal-title":"Front Neurol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01692-07","article-title":"Detection and typing of human herpesvirus 6 by molecular methods in specimens from patients diagnosed with encephalitis or meningitis","volume":"45","author":"Tavakoli NP","year":"2007","unstructured":"Tavakoli NP, Nattanmai S, Hull R, Fusco H, Dzigua L, Wang H, Dupuis M. Detection and typing of human herpesvirus 6 by molecular methods in specimens from patients diagnosed with encephalitis or meningitis. J Clin Microbiol. 2007, 45:3972-3978. 10.1128\/JCM.01692-07","journal-title":"J Clin Microbiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002905","article-title":"Inherited chromosomally integrated human herpesvirus 6: an unexpected finding in a septic neonate","volume":"40","author":"Pugni L","year":"2021","unstructured":"Pugni L, Pietrasanta C, Ronchi A, et al.. Inherited chromosomally integrated human herpesvirus 6: an unexpected finding in a septic neonate. Pediatr Infect Dis J. 2021, 40:74-75. 10.1097\/INF.0000000000002905","journal-title":"Pediatr Infect Dis J"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.03.023","article-title":"Human herpesvirus 6 detection during the evaluation of sepsis in infants using the FilmArray meningitis\/encephalitis panel","volume":"223","author":"Dantuluri KL","year":"2020","unstructured":"Dantuluri KL, Konvinse KC, Crook J, Thomsen IP, Banerjee R. Human herpesvirus 6 detection during the evaluation of sepsis in infants using the FilmArray meningitis\/encephalitis panel. J Pediatr. 2020, 223:204-206. 10.1016\/j.jpeds.2020.03.023","journal-title":"J Pediatr"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-530","article-title":"Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways","volume":"8","author":"Gu B","year":"2011","unstructured":"Gu B, Zhang GF, Li LY, et al.. Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways. Virol J. 2011, 8:530. 10.1186\/1743-422X-8-530","journal-title":"Virol J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2001.tb00413.x","article-title":"The expanding spectrum of herpesvirus infections of the nervous system","volume":"11","author":"Kleinschmidt-DeMasters BK","year":"2001","unstructured":"Kleinschmidt-DeMasters BK, Gilden DH. The expanding spectrum of herpesvirus infections of the nervous system. Brain Pathol. 2001, 11:440-451. 10.1111\/j.1750-3639.2001.tb00413.x","journal-title":"Brain Pathol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0733-8619(02)00016-6","article-title":"Meningitis and encephalitis in children: an update","volume":"20","author":"Bonthius DJ","year":"2002","unstructured":"Bonthius DJ, Karacay B. Meningitis and encephalitis in children: an update. Neurol Clin. 2002, 20:1013-1038. 10.1016\/s0733-8619(02)00016-6","journal-title":"Neurol Clin"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3201\/eid1008.030788","article-title":"Human herpesviruses 6 and 7 and central nervous system infection in children","volume":"10","author":"Ansari A","year":"2004","unstructured":"Ansari A, Li S, Abzug MJ, Weinberg A. Human herpesviruses 6 and 7 and central nervous system infection in children. Emerg Infect Dis. 2004, 10:1450-1454. 10.3201\/eid1008.030788","journal-title":"Emerg Infect Dis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000942","article-title":"Human herpesvirus 6 encephalitis in immunocompetent and immunocompromised hosts","volume":"8","author":"Berzero G","year":"2021","unstructured":"Berzero G, Campanini G, Vegezzi E, et al.. Human herpesvirus 6 encephalitis in immunocompetent and immunocompromised hosts. Neurol Neuroimmunol Neuroinflamm. 2021, 8:942. 10.1212\/NXI.0000000000000942","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2838","article-title":"Chromosomal integration of human herpesvirus 6 is the major mode of congenital human herpesvirus 6 infection","volume":"122","author":"Hall CB","year":"2008","unstructured":"Hall CB, Caserta MT, Schnabel K, et al.. Chromosomal integration of human herpesvirus 6 is the major mode of congenital human herpesvirus 6 infection. Pediatrics. 2008, 122:513-520. 10.1542\/peds.2007-2838","journal-title":"Pediatrics"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.12.022","article-title":"Clinical and laboratory features of human herpesvirus 6 chromosomal integration","volume":"22","author":"Clark DA","year":"2016","unstructured":"Clark DA. Clinical and laboratory features of human herpesvirus 6 chromosomal integration. Clin Microbiol Infect. 2016, 22:333-339. 10.1016\/j.cmi.2015.12.022","journal-title":"Clin Microbiol Infect"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/99626-incidental-detection-of-human-herpesvirus-6-in-cerebrospinal-fluid-analysis-to-treat-or-not-to-treat","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:44:19Z","timestamp":1707507859000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/99626-incidental-detection-of-human-herpesvirus-6-in-cerebrospinal-fluid-analysis-to-treat-or-not-to-treat"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,3]]},"references-count":12,"URL":"https:\/\/doi.org\/10.7759\/cureus.25629","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,3]]}}}