{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:01:47Z","timestamp":1784710907451,"version":"3.55.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,5]]},"DOI":"10.7759\/cureus.25669","type":"journal-article","created":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T14:53:30Z","timestamp":1654440810000},"source":"Crossref","is-referenced-by-count":2,"title":["Low Serum Pyridoxine Levels Worsen Seizure Control in Adult Epilepsy Patients"],"prefix":"10.7759","author":[{"given":"Schweta","family":"Rane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sama","family":"Elrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Villarreal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haneef","family":"Zulfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Garza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeharika","family":"Thottempudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Masel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2014.01005","article-title":"Seizures caused by pyridoxine (vitamin B6) deficiency in adults: a case report and literature review","volume":"3","author":"Tong Y","year":"2014","unstructured":"Tong Y. Seizures caused by pyridoxine (vitamin B6) deficiency in adults: a case report and literature review. Intractable Rare Dis Res. 2014, 3:52-6. 10.5582\/irdr.2014.01005","journal-title":"Intractable Rare Dis Res"},{"key":"ref2","article-title":"Pyridoxine dependency: report of a case of intractable convulsions in an infant controlled by pyridoxine","volume":"13","author":"Hunt AD Jr","year":"1954","unstructured":"Hunt AD Jr, Stokes J Jr, McCrory WW, Stroud HH. Pyridoxine dependency: report of a case of intractable convulsions in an infant controlled by pyridoxine. Pediatrics. 1954, 13:140-5.","journal-title":"Pediatrics"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/510529","article-title":"Vitamin-responsive epileptic encephalopathies in children","volume":"2013","author":"Agadi S","year":"2013","unstructured":"Agadi S, Quach MM, Haneef Z. Vitamin-responsive epileptic encephalopathies in children. Epilepsy Res Treat. 2013, 2013:510529. 10.1155\/2013\/510529","journal-title":"Epilepsy Res Treat"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.180","article-title":"Epileptic status refractory to conventional treatment caused by vitamin B6 deficiency","volume":"29","author":"Valle-Morales L","year":"2009","unstructured":"Valle-Morales L, Cort\u00e9s-Cros E, Santana A, Barber M, Figueras T, Garc\u00eda-Hern\u00e1ndez JA. Epileptic status refractory to conventional treatment caused by vitamin B6 deficiency. J Perinatol. 2009, 29:252-3. 10.1038\/jp.2008.180","journal-title":"J Perinatol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.08.015","article-title":"Pyridoxine deficiency in adult patients with status epilepticus","volume":"52","author":"Dave HN","year":"2015","unstructured":"Dave HN, Eugene Ramsay R, Khan F, Sabharwal V, Irland M. Pyridoxine deficiency in adult patients with status epilepticus. Epilepsy Behav. 2015, 52:154-8. 10.1016\/j.yebeh.2015.08.015","journal-title":"Epilepsy Behav"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.14581\/jer.15006","article-title":"Seizures related to vitamin B6 deficiency in adults","volume":"5","author":"Lee DG","year":"2015","unstructured":"Lee DG, Lee Y, Shin H, et al.. Seizures related to vitamin B6 deficiency in adults. J Epilepsy Res. 2015, 5:23-4. 10.14581\/jer.15006","journal-title":"J Epilepsy Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb28058.x","article-title":"Vitamin B6 in clinical neurology","volume":"585","author":"Bernstein AL","year":"1990","unstructured":"Bernstein AL. Vitamin B6 in clinical neurology. Ann N Y Acad Sci. 1990, 585:250-60. 10.1111\/j.1749-6632.1990.tb28058.x","journal-title":"Ann N Y Acad Sci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.4.1043S","article-title":"Glutamate and epilepsy","volume":"130","author":"Chapman AG","year":"2000","unstructured":"Chapman AG. Glutamate and epilepsy. J Nutr. 2000, 130:1043S-5S. 10.1093\/jn\/130.4.1043S","journal-title":"J Nutr"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.042suppl.3008.x","article-title":"GABAergic mechanisms in epilepsy","volume":"42","author":"Treiman DM","year":"2001","unstructured":"Treiman DM. GABAergic mechanisms in epilepsy. Epilepsia. 2001, 42:8-12. 10.1046\/j.1528-1157.2001.042suppl.3008.x","journal-title":"Epilepsia"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5897\/AJPP11.024","article-title":"Effects of vitamin B6 on age associated changes of rat brain glutamate decarboxylase activity","volume":"5","author":"Messripour M","year":"2011","unstructured":"Messripour M, Mesripour A. Effects of vitamin B6 on age associated changes of rat brain glutamate decarboxylase activity. Afr J Pharm Pharmacol. 2011, 5:454-6. 10.5897\/AJPP11.024","journal-title":"Afr J Pharm Pharmacol"},{"key":"ref11","article-title":"Pyridoxine-dependent epilepsy - ALDH7A1","author":"Gospe SM Jr","year":"2021","unstructured":"Gospe SM Jr. Pyridoxine-dependent epilepsy - ALDH7A1. GeneReviews\u00ae. Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A (ed): University of Washington, Seattle, WA; 2021."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.10.1529","article-title":"Acute isoniazid toxicity and the need for adequate pyridoxine supplies","volume":"26","author":"Morrow LE","year":"2006","unstructured":"Morrow LE, Wear RE, Schuller D, Malesker M. Acute isoniazid toxicity and the need for adequate pyridoxine supplies. Pharmacotherapy. 2006, 26:1529-32. 10.1592\/phco.26.10.1529","journal-title":"Pharmacotherapy"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110384118","article-title":"Vitamin B6 deficiency: a potential cause of refractory seizures in adults","volume":"35","author":"Gerlach AT","year":"2011","unstructured":"Gerlach AT, Thomas S, Stawicki SP, Whitmill ML, Steinberg SM, Cook CH. Vitamin B6 deficiency: a potential cause of refractory seizures in adults. JPEN J Parenter Enteral Nutr. 2011, 35:272-5. 10.1177\/0148607110384118","journal-title":"JPEN J Parenter Enteral Nutr"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/99469-low-serum-pyridoxine-levels-worsen-seizure-control-in-adult-epilepsy-patients","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:44:25Z","timestamp":1707507865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/99469-low-serum-pyridoxine-levels-worsen-seizure-control-in-adult-epilepsy-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,5]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.25669","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,5]]}}}