{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:01:22Z","timestamp":1787032882623,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,18]]},"DOI":"10.7759\/cureus.26981","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T15:05:43Z","timestamp":1658156743000},"source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Levels in Patients With Multiple Sclerosis and Healthy Controls"],"prefix":"10.7759","author":[{"given":"Selma","family":"Tekin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent Sinan","family":"Bir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esin","family":"Avci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hande","family":"\u015eenol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u015f\u0131k","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"\u00c7\u0131nk\u0131r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2015.01.001","article-title":"Environmental factors in multiple sclerosis","volume":"44","author":"Pantazou V","year":"2015","unstructured":"Pantazou V, Schluep M, Du Pasquier R. Environmental factors in multiple sclerosis. Presse Med. 2015, 44:e113-20. 10.1016\/j.lpm.2015.01.001","journal-title":"Presse Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-017-0914-2","article-title":"Comorbidity and metabolic syndrome in patients with multiple sclerosis from Asturias and Catalonia, Spain","volume":"17","author":"Sicras-Mainar A","year":"2017","unstructured":"Sicras-Mainar A, Ru\u00edz-Beato E, Navarro-Artieda R, Maurino J. Comorbidity and metabolic syndrome in patients with multiple sclerosis from Asturias and Catalonia, Spain. BMC Neurol. 2017, 17:134. 10.1186\/s12883-017-0914-2","journal-title":"BMC Neurol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v42i1.32383","article-title":"Comorbidity in multiple sclerosis: past, present and future","volume":"42","author":"Marrie RA","year":"2019","unstructured":"Marrie RA. Comorbidity in multiple sclerosis: past, present and future. Clin Invest Med. 2019, 42:E5-E12. 10.25011\/cim.v42i1.32383","journal-title":"Clin Invest Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c0d6e0","article-title":"Body size and risk of MS in two cohorts of US women","volume":"73","author":"Munger KL","year":"2009","unstructured":"Munger KL, Chitnis T, Ascherio A. Body size and risk of MS in two cohorts of US women. Neurology. 2009, 73:1543-50. 10.1212\/WNL.0b013e3181c0d6e0","journal-title":"Neurology"},{"key":"ref5","article-title":"The effects of body mass index (BMI) on multiple sclerosis (MS) progression","volume":"1","author":"Ben-Zacharia AB","year":"2018","unstructured":"Ben-Zacharia AB. The effects of body mass index (BMI) on multiple sclerosis (MS) progression. Ann Mult Scler Res. 2018, 1:1-7.","journal-title":"Ann Mult Scler Res"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nri3871","article-title":"Immunopathology of multiple sclerosis","volume":"15","author":"Dendrou CA","year":"2015","unstructured":"Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015, 15:545-58. 10.1038\/nri3871","journal-title":"Nat Rev Immunol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.08.017","article-title":"Insulin resistance, inflammation, and cognition in Alzheimer's disease: lessons for multiple sclerosis","volume":"245","author":"Watson GS","year":"2006","unstructured":"Watson GS, Craft S. Insulin resistance, inflammation, and cognition in Alzheimer's disease: lessons for multiple sclerosis. J Neurol Sci. 2006, 245:21-33. 10.1016\/j.jns.2005.08.017","journal-title":"J Neurol Sci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.441","article-title":"Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?","volume":"52","author":"Styskal J","year":"2012","unstructured":"Styskal J, Van Remmen H, Richardson A, Salmon AB. Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?. Free Radic Biol Med. 2012, 52:46-58. 10.1016\/j.freeradbiomed.2011.10.441","journal-title":"Free Radic Biol Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.08.001","article-title":"Disability in patients with multiple sclerosis: influence of insulin resistance, adiposity, and oxidative stress","volume":"30","author":"Oliveira SR","year":"2014","unstructured":"Oliveira SR, Sim\u00e3o AN, Kallaur AP, et al.. Disability in patients with multiple sclerosis: influence of insulin resistance, adiposity, and oxidative stress. Nutrition. 2014, 30:268-73. 10.1016\/j.nut.2013.08.001","journal-title":"Nutrition"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.02.009","article-title":"The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance","volume":"21","author":"Lee C","year":"2015","unstructured":"Lee C, Zeng J, Drew BG, et al.. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015, 21:443-54. 10.1016\/j.cmet.2015.02.009","journal-title":"Cell Metab"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12685","article-title":"Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance","volume":"19","author":"Du C","year":"2018","unstructured":"Du C, Zhang C, Wu W, et al.. Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance. Pediatr Diabetes. 2018, 19:1058-64. 10.1111\/pedi.12685","journal-title":"Pediatr Diabetes"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-020-02273-0","article-title":"Relationship between the mitochondria-derived peptide MOTS-c and insulin resistance in obstructive sleep apnea","volume":"25","author":"Baylan FA","year":"2021","unstructured":"Baylan FA, Yarar E. Relationship between the mitochondria-derived peptide MOTS-c and insulin resistance in obstructive sleep apnea. Sleep Breath. 2021, 25:861-6. 10.1007\/s11325-020-02273-0","journal-title":"Sleep Breath"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14007","article-title":"Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects","volume":"91","author":"Ramanjaneya M","year":"2019","unstructured":"Ramanjaneya M, Jerobin J, Bettahi I, et al.. Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects. Clin Endocrinol (Oxf). 2019, 91:278-87. 10.1111\/cen.14007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.12.001","article-title":"Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction","volume":"254","author":"Qin Q","year":"2018","unstructured":"Qin Q, Delrio S, Wan J, Jay Widmer R, Cohen P, Lerman LO, Lerman A. Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. Int J Cardiol. 2018, 254:23-7. 10.1016\/j.ijcard.2017.12.001","journal-title":"Int J Cardiol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2017-000681","article-title":"Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals","volume":"66","author":"Cataldo LR","year":"2018","unstructured":"Cataldo LR, Fern\u00e1ndez-Verdejo R, Santos JL, Galgani JE. Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals. J Investig Med. 2018, 66:1019-22. 10.1136\/jim-2017-000681","journal-title":"J Investig Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0129","article-title":"Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes","volume":"59","author":"Lu H","year":"2010","unstructured":"Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB. Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes. Diabetes. 2010, 59:448-59. 10.2337\/db09-0129","journal-title":"Diabetes"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00331","article-title":"Mitochondrial-derived peptides are down regulated in diabetes subjects","volume":"10","author":"Ramanjaneya M","year":"2019","unstructured":"Ramanjaneya M, Bettahi I, Jerobin J, et al.. Mitochondrial-derived peptides are down regulated in diabetes subjects. Front Endocrinol (Lausanne). 2019, 10:331. 10.3389\/fendo.2019.00331","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00274.2003","article-title":"Insulin stimulates interleukin-6 and tumor necrosis factor-alpha gene expression in human subcutaneous adipose tissue","volume":"286","author":"Krogh-Madsen R","year":"2004","unstructured":"Krogh-Madsen R, Plomgaard P, Keller P, Keller C, Pedersen BK. Insulin stimulates interleukin-6 and tumor necrosis factor-alpha gene expression in human subcutaneous adipose tissue. Am J Physiol Endocrinol Metab. 2004, 286:E234-8. 10.1152\/ajpendo.00274.2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14171","article-title":"The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity","volume":"7","author":"Kim SJ","year":"2019","unstructured":"Kim SJ, Miller B, Mehta HH, et al.. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiol Rep. 2019, 7:e14171. 10.14814\/phy2.14171","journal-title":"Physiol Rep"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00631.2005","article-title":"Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetic subjects","volume":"291","author":"Salinari S","year":"2006","unstructured":"Salinari S, Bertuzzi A, Gandolfi A, Greco AV, Scarfone A, Manco M, Mingrone G. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetic subjects. Am J Physiol Endocrinol Metab. 2006, 291:E1051-8. 10.1152\/ajpendo.00631.2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2018.1549464","article-title":"Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c","volume":"6","author":"Lee C","year":"2019","unstructured":"Lee C. Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c. Mol Cell Oncol. 2019, 6:1549464. 10.1080\/23723556.2018.1549464","journal-title":"Mol Cell Oncol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.05.049","article-title":"Treatment of multiple sclerosis: a review","volume":"133","author":"Hauser SL","year":"2020","unstructured":"Hauser SL, Cree BA. Treatment of multiple sclerosis: a review. Am J Med. 2020, 133:1380-90.e2. 10.1016\/j.amjmed.2020.05.049","journal-title":"Am J Med"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000503224","article-title":"Mitochondrial-derived peptide MOTS-c attenuates vascular calcification and secondary myocardial remodeling via adenosine monophosphate-activated protein kinase signaling pathway","volume":"10","author":"Wei M","year":"2020","unstructured":"Wei M, Gan L, Liu Z, et al.. Mitochondrial-derived peptide MOTS-c attenuates vascular calcification and secondary myocardial remodeling via adenosine monophosphate-activated protein kinase signaling pathway. Cardiorenal Med. 2020, 10:42-50. 10.1159\/000503224","journal-title":"Cardiorenal Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/105303-comparison-of-serum-mitochondrial-open-reading-frame-of-the-12s-rrna-c-mots-c-levels-in-patients-with-multiple-sclerosis-and-healthy-controls","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T14:45:20Z","timestamp":1707489920000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/105303-comparison-of-serum-mitochondrial-open-reading-frame-of-the-12s-rrna-c-mots-c-levels-in-patients-with-multiple-sclerosis-and-healthy-controls"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":23,"URL":"https:\/\/doi.org\/10.7759\/cureus.26981","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,18]]}}}