{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:37:00Z","timestamp":1769906220965,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,19]]},"DOI":"10.7759\/cureus.27029","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T19:23:34Z","timestamp":1658258614000},"source":"Crossref","is-referenced-by-count":3,"title":["The Alien Limb Phenomenon in Creutzfeldt-Jakob Disease: A Systematic Review of Case Reports"],"prefix":"10.7759","author":[{"given":"Meghdeep","family":"Sen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A","family":"Moncayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deydie","family":"Suarez Salazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Gabriela","family":"Tenemaza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikaela","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gashaw","family":"Hassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo E","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Monteros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Garofalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayush","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Fernando","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"[Disorders of interhemispheric transfer (callosal disonnection). 3 cases of tumor of the corpus callosum. The strange hand sign]","volume":"126","author":"Brion S","year":"1972","unstructured":"Brion S, Jedynak CP. [Disorders of interhemispheric transfer (callosal disonnection). 3 cases of tumor of the corpus callosum. The strange hand sign]. Rev Neurol (Paris). 1972, 126:257-66.","journal-title":"Rev Neurol (Paris)"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6898-y","article-title":"The alien limb phenomenon","volume":"260","author":"Graff-Radford J","year":"2013","unstructured":"Graff-Radford J, Rubin MN, Jones DT, et al.. The alien limb phenomenon. J Neurol. 2013, 260:1880-8. 10.1007\/s00415-013-6898-y","journal-title":"J Neurol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2020.130","article-title":"Alien limb phenomenon as a heralding manifestation of toxic leukoencephalopathy","volume":"47","author":"Gupta P","year":"2020","unstructured":"Gupta P, Dash D, Singh RK, Sebastian LJ, Tripathi M. Alien limb phenomenon as a heralding manifestation of toxic leukoencephalopathy. Can J Neurol Sci. 2020, 47:861-3. 10.1017\/cjn.2020.130","journal-title":"Can J Neurol Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.9.806","article-title":"The alien hand and related signs","volume":"55","author":"Doody RS","year":"1992","unstructured":"Doody RS, Jankovic J. The alien hand and related signs. J Neurol Neurosurg Psychiatry. 1992, 55:806-10. 10.1136\/jnnp.55.9.806","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-7766.2004.06-189.x","article-title":"The alien limb","volume":"4","author":"Josephs KA","year":"2004","unstructured":"Josephs KA, Rossor MN. The alien limb. J Neurol Neurosurg Psychiatry\r\n. 2004, 4:44-5. 10.1111\/j.1474-7766.2004.06-189.x","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1017\/s0317167100000834","article-title":"Alien hand phenomena: a review with the addition of six personal cases","volume":"27","author":"Fisher CM","year":"2000","unstructured":"Fisher CM. Alien hand phenomena: a review with the addition of six personal cases. Can J Neurol Sci. 2000, 27:192-203. 10.1017\/s0317167100000834","journal-title":"Can J Neurol Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.08.009","article-title":"The alien limb phenomenon and Creutzfeldt-Jakob disease","volume":"19","author":"Rubin MN","year":"2013","unstructured":"Rubin MN. The alien limb phenomenon and Creutzfeldt-Jakob disease. Parkinsonism Relat Disord. 2013, 19:378. 10.1016\/j.parkreldis.2012.08.009","journal-title":"Parkinsonism Relat Disord"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/13554794.2010.497154","article-title":"Sequelae of a left-sided parietal stroke: posterior alien hand syndrome","volume":"16","author":"Kloesel B","year":"2010","unstructured":"Kloesel B, Czarnecki K, Muir JJ, Keller AS. Sequelae of a left-sided parietal stroke: posterior alien hand syndrome. Neurocase. 2010, 16:488-93. 10.1080\/13554794.2010.497154","journal-title":"Neurocase"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.661130","article-title":"A critical review of alien limb-related phenomena and implications for functional magnetic resonance imaging studies","volume":"12","author":"Di Pietro M","year":"2021","unstructured":"Di Pietro M, Russo M, Dono F, et al.. A critical review of alien limb-related phenomena and implications for functional magnetic resonance imaging studies. Front Neurol. 2021, 12:661130. 10.3389\/fneur.2021.661130","journal-title":"Front Neurol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2013.01.004","article-title":"Exaggerated object affordance and absent automatic inhibition in alien hand syndrome","volume":"49","author":"McBride J","year":"2013","unstructured":"McBride J, Sumner P, Jackson SR, Bajaj N, Husain M. Exaggerated object affordance and absent automatic inhibition in alien hand syndrome. Cortex. 2013, 49:2040-54. 10.1016\/j.cortex.2013.01.004","journal-title":"Cortex"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00105","article-title":"A case of right alien hand syndrome coexisting with right-sided tactile extinction","volume":"10","author":"Schaefer M","year":"2016","unstructured":"Schaefer M, Denke C, Apostolova I, Heinze HJ, Galazky I. A case of right alien hand syndrome coexisting with right-sided tactile extinction. Front Hum Neurosci. 2016, 10:105. 10.3389\/fnhum.2016.00105","journal-title":"Front Hum Neurosci"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015010","article-title":"Alien hand syndrome: neural correlates of movements without conscious will","volume":"5","author":"Schaefer M","year":"2010","unstructured":"Schaefer M, Heinze HJ, Galazky I. Alien hand syndrome: neural correlates of movements without conscious will. PLoS One. 2010, 5:e15010. 10.1371\/journal.pone.0015010","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2005.10.004","article-title":"Movement disorders and Creutzfeldt-Jakob disease: a review","volume":"12","author":"Malt\u00eate D","year":"2006","unstructured":"Malt\u00eate D, Guyant-Mar\u00e9chal L, Mihout B, Hannequin D. Movement disorders and Creutzfeldt-Jakob disease: a review. Parkinsonism Relat Disord. 2006, 12:65-71. 10.1016\/j.parkreldis.2005.10.004","journal-title":"Parkinsonism Relat Disord"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-228305","article-title":"Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration","volume":"12","author":"Tilley BS","year":"2019","unstructured":"Tilley BS, Smith C, Pavese N, Attems J. Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration. BMJ Case Rep. 2019, 12:228305. 10.1136\/bcr-2018-228305","journal-title":"BMJ Case Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.10.001","article-title":"Unilateral spatial neglect and alien limb phenomenon may be early features of Creutzfeldt-Jakob disease","volume":"19","author":"Zannino S","year":"2013","unstructured":"Zannino S, Liguori C, Albanese M, et al.. Unilateral spatial neglect and alien limb phenomenon may be early features of Creutzfeldt-Jakob disease. Parkinsonism Relat Disord. 2013, 19:379-81. 10.1016\/j.parkreldis.2012.10.001","journal-title":"Parkinsonism Relat Disord"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm-2017-110853","article-title":"Methodological quality and synthesis of case series and case reports","volume":"23","author":"Murad MH","year":"2018","unstructured":"Murad MH, Sultan S, Haffar S, Bazerbachi F. Methodological quality and synthesis of case series and case reports. BMJ Evid Based Med. 2018, 23:60-3. 10.1136\/bmjebm-2017-110853","journal-title":"BMJ Evid Based Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.7916\/D80C6CGX","article-title":"Arm levitation as initial manifestation of Creutzfeldt-Jakob disease: case report and review of the literature","volume":"8","author":"Ciarlariello VB","year":"2018","unstructured":"Ciarlariello VB, Barsottini OG, Espay AJ, Pedroso JL. Arm levitation as initial manifestation of Creutzfeldt-Jakob disease: case report and review of the literature. Tremor Other Hyperkinet Mov (N Y). 2018, 8:572. 10.7916\/D80C6CGX","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14624","article-title":"Sporadic Creutzfeldt-Jakob disease with tau pathology mimicking new-onset refractory non-convulsive status epilepticus: case report and review of the literature","volume":"28","author":"Gonzalez-Martinez A","year":"2021","unstructured":"Gonzalez-Martinez A, Quintas S, Redondo N, Casado-Fern\u00e1ndez L, Vivancos J. Sporadic Creutzfeldt-Jakob disease with tau pathology mimicking new-onset refractory non-convulsive status epilepticus: case report and review of the literature. Eur J Neurol. 2021, 28:1385-91. 10.1111\/ene.14624","journal-title":"Eur J Neurol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20858","article-title":"Creutzfeldt-Jakob disease presenting with alien limb sign","volume":"21","author":"Fogel B","year":"2006","unstructured":"Fogel B, Wu M, Kremen S, Murthy K, Jackson G, Vanek Z. Creutzfeldt-Jakob disease presenting with alien limb sign. Mov Disord. 2006, 21:1040-2. 10.1002\/mds.20858","journal-title":"Mov Disord"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s004150200077","article-title":"Familial Creutzfeldt-Jakob disease initially presenting with alien hand syndrome","volume":"249","author":"Oberndorfer S","year":"2002","unstructured":"Oberndorfer S, Urbanits S, Lahrmann H, Jarius C, Albrecht G, Grisold W. Familial Creutzfeldt-Jakob disease initially presenting with alien hand syndrome. J Neurol. 2002, 249:631-2. 10.1007\/s004150200077","journal-title":"J Neurol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.4.637","article-title":"Abnormal diffusion-weighted magnetic resonance imaging in Creutzfeldt-Jakob disease following corneal transplantations","volume":"59","author":"Rabinstein AA","year":"2002","unstructured":"Rabinstein AA, Whiteman ML, Shebert RT. Abnormal diffusion-weighted magnetic resonance imaging in Creutzfeldt-Jakob disease following corneal transplantations. Arch Neurol. 2002, 59:637-9. 10.1001\/archneur.59.4.637","journal-title":"Arch Neurol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.1.103","article-title":"Alien hand sign in Creutzfeldt-Jakob disease","volume":"68","author":"Inzelberg R","year":"2000","unstructured":"Inzelberg R, Nisipeanu P, Blumen SC, Carasso RL. Alien hand sign in Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry. 2000, 68:103-4. 10.1136\/jnnp.68.1.103","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.3.404","article-title":"Isolated myoclonic alien hand as the sole presentation of pathologically established Creutzfeldt-Jakob disease: a report of two patients","volume":"63","author":"MacGowan DJ","year":"1997","unstructured":"MacGowan DJ, Delanty N, Petito F, Edgar M, Mastrianni J, DeArmond SJ. Isolated myoclonic alien hand as the sole presentation of pathologically established Creutzfeldt-Jakob disease: a report of two patients. J Neurol Neurosurg Psychiatry. 1997, 63:404-7. 10.1136\/jnnp.63.3.404","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-006-0611-1","article-title":"Creutzfeldt-Jakob disease presenting as corticobasal degeneration: a neurophysiological study","volume":"27","author":"Avanzino L","year":"2006","unstructured":"Avanzino L, Marinelli L, Buccolieri A, Trompetto C, Abbruzzese G. Creutzfeldt-Jakob disease presenting as corticobasal degeneration: a neurophysiological study. Neurol Sci. 2006, 27:118-21. 10.1007\/s10072-006-0611-1","journal-title":"Neurol Sci"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20140","article-title":"Presentation of Creutzfeldt-Jakob disease as acute corticobasal degeneration syndrome","volume":"19","author":"Kleiner-Fisman G","year":"2004","unstructured":"Kleiner-Fisman G, Bergeron C, Lang AE. Presentation of Creutzfeldt-Jakob disease as acute corticobasal degeneration syndrome. Mov Disord. 2004, 19:948-9. 10.1002\/mds.20140","journal-title":"Mov Disord"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2009.05.006","article-title":"Dominant posterior-variant alien hand syndrome after acute left parietal infarction","volume":"111","author":"Kessler J","year":"2009","unstructured":"Kessler J, Hathout G. Dominant posterior-variant alien hand syndrome after acute left parietal infarction. Clin Neurol Neurosurg. 2009, 111:633-5. 10.1016\/j.clineuro.2009.05.006","journal-title":"Clin Neurol Neurosurg"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.36.8.1094","article-title":"Opticosensory ataxia and alien hand syndrome after posterior cerebral artery territory infarction","volume":"36","author":"Levine DN","year":"1986","unstructured":"Levine DN, Rinn WE. Opticosensory ataxia and alien hand syndrome after posterior cerebral artery territory infarction. Neurology. 1986, 36:1094-7. 10.1212\/wnl.36.8.1094","journal-title":"Neurology"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.7916\/D8VX0F48","article-title":"Pathophysiology and treatment of alien hand syndrome","volume":"4","author":"Sarva H","year":"2014","unstructured":"Sarva H, Deik A, Severt WL. Pathophysiology and treatment of alien hand syndrome. Tremor Other Hyperkinet Mov (N Y). 2014, 4:241. 10.7916\/D8VX0F48","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-016-0676-z","article-title":"Alien hand syndrome","volume":"16","author":"Hassan A","year":"2016","unstructured":"Hassan A, Josephs KA. Alien hand syndrome. Curr Neurol Neurosci Rep. 2016, 16:73. 10.1007\/s11910-016-0676-z","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2021.02.013","article-title":"Dr. Strangelove demystified: disconnection of hand and language dominance explains alien-hand syndrome after corpus callosotomy","volume":"86","author":"Helmstaedter C","year":"2021","unstructured":"Helmstaedter C, Solymosi L, Kurthen M, Momjian S, Schaller K. Dr. Strangelove demystified: disconnection of hand and language dominance explains alien-hand syndrome after corpus callosotomy. Seizure. 2021, 86:147-51. 10.1016\/j.seizure.2021.02.013","journal-title":"Seizure"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000001401","article-title":"Rehabilitation of alien hand syndrome complicated by contralateral limb apraxia","volume":"99","author":"Alvarez A","year":"2020","unstructured":"Alvarez A, Weaver M, Alvarez G. Rehabilitation of alien hand syndrome complicated by contralateral limb apraxia. Am J Phys Med Rehabil. 2020, 99:e122-4. 10.1097\/PHM.0000000000001401","journal-title":"Am J Phys Med Rehabil"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2004.06.017","article-title":"Reduced endogenous control in alien hand syndrome: evidence from naturalistic action","volume":"43","author":"Giovannetti T","year":"2005","unstructured":"Giovannetti T, Buxbaum LJ, Biran I, Chatterjee A. Reduced endogenous control in alien hand syndrome: evidence from naturalistic action. Neuropsychologia. 2005, 43:75-88. 10.1016\/j.neuropsychologia.2004.06.017","journal-title":"Neuropsychologia"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/101908-the-alien-limb-phenomenon-in-creutzfeldt-jakob-disease-a-systematic-review-of-case-reports","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:45:46Z","timestamp":1707507946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/101908-the-alien-limb-phenomenon-in-creutzfeldt-jakob-disease-a-systematic-review-of-case-reports"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,19]]},"references-count":32,"URL":"https:\/\/doi.org\/10.7759\/cureus.27029","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,19]]}}}