{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:49:13Z","timestamp":1782773353772,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,3]]},"DOI":"10.7759\/cureus.27656","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T01:16:40Z","timestamp":1659575800000},"source":"Crossref","is-referenced-by-count":2,"title":["Outcomes of Inflammatory Bowel Disease in Hospitalized Patients With Generalized Anxiety Disorder"],"prefix":"10.7759","author":[{"given":"Alexander J","family":"Kaye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani J","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah R","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil","family":"Ahlawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: pathogenesis","volume":"20","author":"Zhang YZ","year":"2014","unstructured":"Zhang YZ, Li YY. Inflammatory bowel disease: pathogenesis. World J Gastroenterol. 2014, 20:91-9. 10.3748\/wjg.v20.i1.91","journal-title":"World J Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30358-9","article-title":"Global burden of inflammatory bowel disease","volume":"5","author":"Jairath V","year":"2020","unstructured":"Jairath V, Feagan BG. Global burden of inflammatory bowel disease. Lancet Gastroenterol Hepatol. 2020, 5:2-3. 10.1016\/S2468-1253(19)30358-9","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: from 2015 to 2025","volume":"12","author":"Kaplan GG","year":"2015","unstructured":"Kaplan GG. The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol. 2015, 12:720-7. 10.1038\/nrgastro.2015.150","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21623","article-title":"Mood and nonmood components of perceived stress and exacerbation of Crohn's disease","volume":"17","author":"C\u00e1mara RJ","year":"2011","unstructured":"C\u00e1mara RJ, Schoepfer AM, Pittet V, Begr\u00e9 S, von K\u00e4nel R. Mood and nonmood components of perceived stress and exacerbation of Crohn's disease. Inflamm Bowel Dis. 2011, 17:2358-65. 10.1002\/ibd.21623","journal-title":"Inflamm Bowel Dis"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21346","article-title":"Anxiety and depression in patients with inflammatory bowel disease: comparisons with chronic liver disease patients and the general population","volume":"17","author":"H\u00e4user W","year":"2011","unstructured":"H\u00e4user W, Janke KH, Klump B, Hinz A. Anxiety and depression in patients with inflammatory bowel disease: comparisons with chronic liver disease patients and the general population. Inflamm Bowel Dis. 2011, 17:621-32. 10.1002\/ibd.21346","journal-title":"Inflamm Bowel Dis"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.134817","article-title":"Predicting relapse in Crohn's disease: a biopsychosocial model","volume":"57","author":"Bitton A","year":"2008","unstructured":"Bitton A, Dobkin PL, Edwardes MD, et al.. Predicting relapse in Crohn's disease: a biopsychosocial model. Gut. 2008, 57:1386-92. 10.1136\/gut.2007.134817","journal-title":"Gut"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2015.17.3\/bbandelow","article-title":"Epidemiology of anxiety disorders in the 21st century","volume":"17","author":"Bandelow B","year":"2015","unstructured":"Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues Clin Neurosci. 2015, 17:327-35. 10.31887\/DCNS.2015.17.3\/bbandelow","journal-title":"Dialogues Clin Neurosci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.1359","article-title":"Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States","volume":"21","author":"Kessler RC","year":"2012","unstructured":"Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen HU. Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int J Methods Psychiatr Res. 2012, 21:169-84. 10.1002\/mpr.1359","journal-title":"Int J Methods Psychiatr Res"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000518","article-title":"Robust association between inflammatory bowel disease and generalized anxiety disorder: findings from a Nationally Representative Canadian Study","volume":"21","author":"Fuller-Thomson E","year":"2015","unstructured":"Fuller-Thomson E, Lateef R, Sulman J. Robust association between inflammatory bowel disease and generalized anxiety disorder: findings from a Nationally Representative Canadian Study. Inflamm Bowel Dis. 2015, 21:2341-8. 10.1097\/MIB.0000000000000518","journal-title":"Inflamm Bowel Dis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/01612840.2020.1867675","article-title":"Pandemic-specific factors related to generalized anxiety disorder during the initial COVID-19 protocols in the United States","volume":"42","author":"Cordaro M","year":"2021","unstructured":"Cordaro M, Grigsby TJ, Howard JT, Deason RG, Haskard-Zolnierek K, Howard K. Pandemic-specific factors related to generalized anxiety disorder during the initial COVID-19 protocols in the United States. Issues Ment Health Nurs. 2021, 42:747-57. 10.1080\/01612840.2020.1867675","journal-title":"Issues Ment Health Nurs"},{"key":"ref11","article-title":"","author":"Munir S","year":"2022","unstructured":"Munir S, Takov V. Generalized Anxiety Disorder. StatPearls Publishing, Treasure Island, FL; 2022. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK441870\/."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1491966","article-title":"Pharmacotherapy for generalized anxiety disorder in adult and pediatric patients: an evidence-based treatment review","volume":"19","author":"Strawn JR","year":"2018","unstructured":"Strawn JR, Geracioti L, Rajdev N, Clemenza K, Levine A. Pharmacotherapy for generalized anxiety disorder in adult and pediatric patients: an evidence-based treatment review. Expert Opin Pharmacother. 2018, 19:1057-70. 10.1080\/14656566.2018.1491966","journal-title":"Expert Opin Pharmacother"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2020.06.025","article-title":"Prevalence of mental disorder and impact on quality of life in inflammatory bowel disease","volume":"44","author":"Garc\u00eda-Alan\u00eds M","year":"2021","unstructured":"Garc\u00eda-Alan\u00eds M, Quiroz-Casian L, Casta\u00f1eda-Gonz\u00e1lez H, et al.. Prevalence of mental disorder and impact on quality of life in inflammatory bowel disease. Gastroenterol Hepatol. 2021, 44:206-13. 10.1016\/j.gastrohep.2020.06.025","journal-title":"Gastroenterol Hepatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaa310","article-title":"The impact of psychiatric comorbidity on health care utilization in inflammatory bowel disease: a population-based study","volume":"27","author":"Bernstein CN","year":"2021","unstructured":"Bernstein CN, Hitchon CA, Walld R, et al.. The impact of psychiatric comorbidity on health care utilization in inflammatory bowel disease: a population-based study. Inflamm Bowel Dis. 2021, 27:1462-74. 10.1093\/ibd\/izaa310","journal-title":"Inflamm Bowel Dis"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-021-04056-9","article-title":"Burden of depression and anxiety among patients with inflammatory bowel disease: results of a nationwide analysis","volume":"37","author":"Tarar ZI","year":"2022","unstructured":"Tarar ZI, Zafar MU, Farooq U, Ghous G, Aslam A, Inayat F, Ghouri YA. Burden of depression and anxiety among patients with inflammatory bowel disease: results of a nationwide analysis. Int J Colorectal Dis. 2022, 37:313-21. 10.1007\/s00384-021-04056-9","journal-title":"Int J Colorectal Dis"},{"key":"ref16","unstructured":"Overview of the National (Nationwide) Inpatient Sample (NIS). (2014). Accessed. May 11, 2021: http:\/\/www.hcup-us.ahrq.gov\/nisoverview.jsp."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e318297429c","article-title":"Why summary comorbidity measures such as the Charlson comorbidity index and Elixhauser score work","volume":"53","author":"Austin SR","year":"2015","unstructured":"Austin SR, Wong YN, Uzzo RG, Beck JR, Egleston BL. Why summary comorbidity measures such as the Charlson comorbidity index and Elixhauser score work. Med Care. 2015, 53:65-72. 10.1097\/MLR.0b013e318297429c","journal-title":"Med Care"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7139.1236","article-title":"What's wrong with Bonferroni adjustments","volume":"316","author":"Perneger TV","year":"1998","unstructured":"Perneger TV. What's wrong with Bonferroni adjustments. BMJ. 1998, 316:1236-8. 10.1136\/bmj.316.7139.1236","journal-title":"BMJ"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22888","article-title":"Risk factors of anxiety and depression in inflammatory bowel disease","volume":"18","author":"Nahon S","year":"2012","unstructured":"Nahon S, Lahmek P, Durance C, Olympie A, Lesgourgues B, Colombel JF, Gendre JP. Risk factors of anxiety and depression in inflammatory bowel disease. Inflamm Bowel Dis. 2012, 18:2086-91. 10.1002\/ibd.22888","journal-title":"Inflamm Bowel Dis"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.218","article-title":"Serious infection and mortality in patients with Crohn's disease: more than 5 years of follow-up in the TREAT\u2122 registry","volume":"107","author":"Lichtenstein GR","year":"2012","unstructured":"Lichtenstein GR, Feagan BG, Cohen RD, et al.. Serious infection and mortality in patients with Crohn's disease: more than 5 years of follow-up in the TREAT\u2122 registry. Am J Gastroenterol. 2012, 107:1409-22. 10.1038\/ajg.2012.218","journal-title":"Am J Gastroenterol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200101000-00015","article-title":"Psychiatric predictors of noncompliance in inflammatory bowel disease: psychiatry and compliance","volume":"32","author":"Nigro G","year":"2001","unstructured":"Nigro G, Angelini G, Grosso SB, Caula G, Sategna-Guidetti C. Psychiatric predictors of noncompliance in inflammatory bowel disease: psychiatry and compliance. J Clin Gastroenterol. 2001, 32:66-8. 10.1097\/00004836-200101000-00015","journal-title":"J Clin Gastroenterol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(02)01383-9","article-title":"Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis","volume":"114","author":"Kane S","year":"2003","unstructured":"Kane S, Huo D, Aikens J, Hanauer S. Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis. Am J Med. 2003, 114:39-43. 10.1016\/s0002-9343(02)01383-9","journal-title":"Am J Med"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.205","article-title":"Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior","volume":"37","author":"Haroon E","year":"2012","unstructured":"Haroon E, Raison CL, Miller AH. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology. 2012, 37:137-62. 10.1038\/npp.2011.205","journal-title":"Neuropsychopharmacology"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.146357","article-title":"C-reactive protein: a predictive factor and marker of inflammation in inflammatory bowel disease. Results from a prospective population-based study","volume":"57","author":"Henriksen M","year":"2008","unstructured":"Henriksen M, Jahnsen J, Lygren I, Stray N, Sauar J, Vatn MH, Moum B. C-reactive protein: a predictive factor and marker of inflammation in inflammatory bowel disease. Results from a prospective population-based study. Gut. 2008, 57:1518-23. 10.1136\/gut.2007.146357","journal-title":"Gut"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1163\/156856005774423773","article-title":"Intestinal dysmotility in inflammatory bowel disease: mechanisms of the reduced activity of smooth muscle contraction","volume":"13","author":"Ozaki H","year":"2005","unstructured":"Ozaki H, Hori M, Kinoshita K, Ohama T. Intestinal dysmotility in inflammatory bowel disease: mechanisms of the reduced activity of smooth muscle contraction. Inflammopharmacology. 2005, 13:103-11. 10.1163\/156856005774423773","journal-title":"Inflammopharmacology"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0585-0","article-title":"Anxiety, depression, and the microbiome: a role for gut peptides","volume":"15","author":"Lach G","year":"2018","unstructured":"Lach G, Schellekens H, Dinan TG, Cryan JF. Anxiety, depression, and the microbiome: a role for gut peptides. Neurotherapeutics. 2018, 15:36-59. 10.1007\/s13311-017-0585-0","journal-title":"Neurotherapeutics"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04351.x","article-title":"The influence of citalopram on interdigestive gastrointestinal motility in man","volume":"32","author":"Janssen P","year":"2010","unstructured":"Janssen P, Vos R, Tack J. The influence of citalopram on interdigestive gastrointestinal motility in man. Aliment Pharmacol Ther. 2010, 32:289-95. 10.1111\/j.1365-2036.2010.04351.x","journal-title":"Aliment Pharmacol Ther"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.2.140","article-title":"Microflora modulation of motility","volume":"17","author":"Quigley EM","year":"2011","unstructured":"Quigley EM. Microflora modulation of motility. J Neurogastroenterol Motil. 2011, 17:140-7. 10.5056\/jnm.2011.17.2.140","journal-title":"J Neurogastroenterol Motil"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92870-0","article-title":"Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis","volume":"11","author":"Nishihara Y","year":"2021","unstructured":"Nishihara Y, Ogino H, Tanaka M, et al.. Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis. Sci Rep. 2021, 11:13743. 10.1038\/s41598-021-92870-0","journal-title":"Sci Rep"},{"key":"ref30","article-title":"Impact of the DSM-IV to DSM-5 Changes on the National Survey on Drug Use and Health","author":"Glasheen C","year":"2016","unstructured":"Glasheen C, Batts K, Karg R, et al.. Impact of the DSM-IV to DSM-5 Changes on the National Survey on Drug Use and Health. Substance Abuse and Mental Health Services Administration, Rockville, MD; 2016."}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/103094-outcomes-of-inflammatory-bowel-disease-in-hospitalized-patients-with-generalized-anxiety-disorder","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:47:06Z","timestamp":1707508026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/103094-outcomes-of-inflammatory-bowel-disease-in-hospitalized-patients-with-generalized-anxiety-disorder"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,3]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.27656","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,3]]}}}