{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T03:29:53Z","timestamp":1766719793062},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,17]]},"DOI":"10.7759\/cureus.28097","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T11:29:23Z","timestamp":1660735763000},"source":"Crossref","is-referenced-by-count":1,"title":["Morphological and Skeletal Abnormalities Induced by Rolapitant: An Antiemetic Agent"],"prefix":"10.7759","author":[{"given":"Sohel","family":"Solanki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogesh","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaktibala","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha  V","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Belodu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hareesh RS","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S97543","article-title":"Differential pharmacology and clinical utility of rolapitant in chemotherapy-induced nausea and vomiting","volume":"9","author":"Rapoport BL","year":"2017","unstructured":"Rapoport BL. Differential pharmacology and clinical utility of rolapitant in chemotherapy-induced nausea and vomiting. Cancer Manag Res. 2017, 9:41-50. 10.2147\/CMAR.S97543","journal-title":"Cancer Manag Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1066","article-title":"Pharmacokinetics of rolapitant in patients with mild to moderate hepatic impairment","volume":"58","author":"Wang J","year":"2018","unstructured":"Wang J, Wang X, Zhang ZY, Arora S, Lu S, Kansra V. Pharmacokinetics of rolapitant in patients with mild to moderate hepatic impairment. J Clin Pharmacol. 2018, 58:686-93. 10.1002\/jcph.1066","journal-title":"J Clin Pharmacol"},{"key":"ref3","article-title":"Antiemetic Neurokinin-1 Receptor Blockers","author":"Ibrahim MA","year":"2021","unstructured":"Ibrahim MA, Preuss CV. Antiemetic Neurokinin-1 Receptor Blockers. StatPearls Publishing, Treasure Island, FL; 2021."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S108872","article-title":"Differential clinical pharmacology of rolapitant in delayed chemotherapy-induced nausea and vomiting (CINV)","volume":"11","author":"Rashad N","year":"2017","unstructured":"Rashad N, Abdel-Rahman O. Differential clinical pharmacology of rolapitant in delayed chemotherapy-induced nausea and vomiting (CINV). Drug Des Devel Ther. 2017, 11:947-54. 10.2147\/DDDT.S108872","journal-title":"Drug Des Devel Ther"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.065342","article-title":"HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP\/ABCG2)","volume":"310","author":"Gupta A","year":"2004","unstructured":"Gupta A, Zhang Y, Unadkat JD, Mao Q. HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP\/ABCG2). J Pharmacol Exp Ther. 2004, 310:334-41. 10.1124\/jpet.104.065342","journal-title":"J Pharmacol Exp Ther"},{"key":"ref6","article-title":"Use of chick embryo in screening for teratogenicity","volume":"42","author":"Kotwani A","year":"1998","unstructured":"Kotwani A. Use of chick embryo in screening for teratogenicity. Indian J Physiol Pharmacol. 1998, 42:189-204.","journal-title":"Indian J Physiol Pharmacol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/09709274.2007.11905976","article-title":"Methotrexate induced gross malformations in chick embryos","volume":"21","author":"Natekar PE","year":"2007","unstructured":"Natekar PE. Methotrexate induced gross malformations in chick embryos. J. Hum. Ecol. 2007, 21:223-226. 10.1080\/09709274.2007.11905976","journal-title":"J. Hum. Ecol"},{"key":"ref8","article-title":"Effect of gentamicin on kidneys in developing chicks","volume":"16","author":"Singroha R","year":"2012","unstructured":"Singroha R, Srivastava SK, Chhikara P. Effect of gentamicin on kidneys in developing chicks. Eur J Anat. 2012, 16:119-126.","journal-title":"Eur J Anat"},{"key":"ref9","article-title":"The effects of Alphacypermethrin pesticide on the development of in Ovo Gallus domesticus, the 29th National Graduate Research Conference","author":"Thongphanich S","year":"2013","unstructured":"Thongphanich S, Roongruangchai J. The effects of Alphacypermethrin pesticide on the development of in Ovo Gallus domesticus, the 29th National Graduate Research Conference. Mae Fah Luang University. 2013,","journal-title":"Mae Fah Luang University"},{"key":"ref10","article-title":"Developmental and biochemical effects of imidacloprid on developing chick embryos","volume":"12","author":"Hussein M","year":"2014","unstructured":"Hussein M, Singh V, Gupta P, Yadav B, Singh AK. Developmental and biochemical effects of imidacloprid on developing chick embryos. J Anat Sciences. 2014, 12:12-17.","journal-title":"J Anat Sciences"},{"key":"ref11","article-title":"Adverse effects of antimalarial drug - alpha\/beta artether on growth of developing chick embryo","volume":"2","author":"Mittal LK","year":"2015","unstructured":"Mittal LK, Ashoka RK, Singh V, Tomar S, Mishra A. Adverse effects of antimalarial drug - alpha\/beta artether on growth of developing chick embryo. Int J Multidiscip Res. 2015, 2:407-410.","journal-title":"Int J Multidiscip Res"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasi.2017.12.005","article-title":"Effects of \u03b1\/\u03b2 artether\u2014an antimalarial drug on cerebral cortex in developing chick embryo - a histopathological and immunohistochemical study","volume":"66","author":"Singh V","year":"2017","unstructured":"Singh V, Mittal LK, Ashoka RK. Effects of \u03b1\/\u03b2 artether\u2014an antimalarial drug on cerebral cortex in developing chick embryo - a histopathological and immunohistochemical study. J Anat Soc India. 2017, 66:97-104. 10.1016\/j.jasi.2017.12.005","journal-title":"J Anat Soc India"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-2850-6","article-title":"General principles and etiology","author":"Wilson JG","year":"1977","unstructured":"Wilson JG, Andfraser FC. General principles and etiology. Handbook of Teratology. Wilson JG, Andfraser FC (ed): Springer, New York, NY; 1977. 1:357\u201185. 10.1007\/978-1-4684-2850-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-230x(08)60725-3","article-title":"Inductive tissue interaction in development","volume":"4","author":"Grobstein C","year":"1956","unstructured":"Grobstein C. Inductive tissue interaction in development. Adv Cancer Res. 1956, 4:187-236. 10.1016\/s0065-230x(08)60725-3","journal-title":"Adv Cancer Res"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(72)90100-5","article-title":"Reconstruction of brain tissue from cell suspensions: II. specific enhancement of aggregation of embryonic cerebral cells by supernatant from homologous cell cultures","volume":"27","author":"Garber BB","year":"1972","unstructured":"Garber BB, Moscona AA. Reconstruction of brain tissue from cell suspensions: II. specific enhancement of aggregation of embryonic cerebral cells by supernatant from homologous cell cultures. Developmental Biology. 1972, 27:235-243. 10.1016\/0012-1606(72)90100-5","journal-title":"Developmental Biology"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(72)90232-4","article-title":"The effect of cortisone on collagen synthesis in the secondary palate of mice","volume":"17","author":"Shapira Y","year":"1972","unstructured":"Shapira Y, Shoshan S. The effect of cortisone on collagen synthesis in the secondary palate of mice. Arch Oral Biol. 1972, 17:1699-703. 10.1016\/0003-9969(72)90232-4","journal-title":"Arch Oral Biol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/00220345710500055201","article-title":"Preliminary studies of the lipids of normal and cleft palates of the rat","volume":"50","author":"Stefanovich V","year":"1971","unstructured":"Stefanovich V, Gianelly A. Preliminary studies of the lipids of normal and cleft palates of the rat. J Dent Res. 1971, 50:1360. 10.1177\/00220345710500055201","journal-title":"J Dent Res"},{"key":"ref18","article-title":"Congenital anomalies in rat fetuses induced by amniocentesis","volume":"62","author":"Singh S","year":"1974","unstructured":"Singh S, Mathur MM, Singh G. Congenital anomalies in rat fetuses induced by amniocentesis. Indian J Med Res. 1974, 62:394-401.","journal-title":"Indian J Med Res"},{"key":"ref19","article-title":"Teratogenic effects of chlorpromazine hydrochloride in rat foetuses","volume":"67","author":"Singh S","year":"1978","unstructured":"Singh S, Padmanabhan R. Teratogenic effects of chlorpromazine hydrochloride in rat foetuses. Indian J Med Res. 1978, 67:300-9.","journal-title":"Indian J Med Res"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8933-4_4","article-title":"Cell death and reduced proliferative rate","author":"Scott WJ","year":"1977","unstructured":"Scott WJ. Cell death and reduced proliferative rate. Handbook of Teratology. Wilson JG, Fraser FC (ed): Springer, Boston, MA; 1977. 2:81-98. 10.1007\/978-1-4615-8933-4_4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-017571-3.50036-X","article-title":"Biochemical aspects of teratology","volume":"6","author":"Neubert D","year":"1971","unstructured":"Neubert D, Merker HJ, Kohler E, Krowke R, Barrach HJ. Biochemical aspects of teratology. Adv Biosci. 1971, 6:575-622. 10.1016\/B978-0-08-017571-3.50036-X","journal-title":"Adv Biosci"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550120405","article-title":"Toxicology of carbaryl and aldicarb on brain and limb cultures of chick embryos","volume":"12","author":"Farage-Elawar M","year":"1992","unstructured":"Farage-Elawar M, Rowles TK. Toxicology of carbaryl and aldicarb on brain and limb cultures of chick embryos. J Appl Toxicol. 1992, 12:239-44. 10.1002\/jat.2550120405","journal-title":"J Appl Toxicol"},{"key":"ref23","unstructured":"Tag archives. schering-plough. (2015). Accessed: December 3, 2018: https:\/\/newdrugapprovals.org\/tag\/schering-plough\/."},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.03.021","article-title":"Rolapitant (SCH 619734): a potent, selective and orally active neurokinin NK1 receptor antagonist with centrally-mediated antiemetic effects in ferrets","volume":"102","author":"Duffy RA","year":"2012","unstructured":"Duffy RA, Morgan C, Naylor R, Higgins GA, Varty GB, Lachowicz JE, Parker EM. Rolapitant (SCH 619734): a potent, selective and orally active neurokinin NK1 receptor antagonist with centrally-mediated antiemetic effects in ferrets. Pharmacol Biochem Behav. 2012, 102:95-100. 10.1016\/j.pbb.2012.03.021","journal-title":"Pharmacol Biochem Behav"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2165\/11203680-000000000-00000","article-title":"Aprepitant: a review of its use in the prevention of nausea and vomiting","volume":"69","author":"Curran MP","year":"2009","unstructured":"Curran MP, Robinson DM. Aprepitant: a review of its use in the prevention of nausea and vomiting. Drugs. 2009, 69:1853-78. 10.2165\/11203680-000000000-00000","journal-title":"Drugs"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep125","article-title":"Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting","volume":"103","author":"Diemunsch P","year":"2009","unstructured":"Diemunsch P, Joshi GP, Brichant JF. Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting. Br J Anaesth. 2009, 103:7-13. 10.1093\/bja\/aep125","journal-title":"Br J Anaesth"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.09.005","article-title":"Mechanisms and latest clinical studies of new NK1 receptor antagonists for chemotherapy-induced nausea and vomiting: rolapitant and NEPA (netupitant\/palonosetron)","volume":"41","author":"Rojas C","year":"2015","unstructured":"Rojas C, Slusher BS. Mechanisms and latest clinical studies of new NK1 receptor antagonists for chemotherapy-induced nausea and vomiting: rolapitant and NEPA (netupitant\/palonosetron). Cancer Treat Rev. 2015, 41:904-13. 10.1016\/j.ctrv.2015.09.005","journal-title":"Cancer Treat Rev"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.023","article-title":"Efficacy and safety of rolapitant for prevention of chemotherapy-induced nausea and vomiting over multiple cycles of moderately or highly emetogenic chemotherapy","volume":"57","author":"Rapoport B","year":"2016","unstructured":"Rapoport B, Schwartzberg L, Chasen M, Powers D, Arora S, Navari R, Schnadig I. Efficacy and safety of rolapitant for prevention of chemotherapy-induced nausea and vomiting over multiple cycles of moderately or highly emetogenic chemotherapy. Eur J Cancer. 2016, 57:23-30. 10.1016\/j.ejca.2015.12.023","journal-title":"Eur J Cancer"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00034-0","article-title":"Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of moderately emetogenic chemotherapy or anthracycline and cyclophosphamide regimens in patients with cancer: a randomised, active-controlled, double-blind, phase 3 trial","volume":"16","author":"Schwartzberg LS","year":"2015","unstructured":"Schwartzberg LS. Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of moderately emetogenic chemotherapy or anthracycline and cyclophosphamide regimens in patients with cancer: a randomised, active-controlled, double-blind, phase 3 trial. Lancet. 2015, 16:1071-78. 10.1016\/S1470-2045(15)00034-0","journal-title":"Lancet"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/81508-morphological-and-skeletal-abnormalities-induced-by-rolapitant-an-antiemetic-agent","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:39:15Z","timestamp":1707507555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/81508-morphological-and-skeletal-abnormalities-induced-by-rolapitant-an-antiemetic-agent"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,17]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.28097","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,17]]}}}