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BMC Med. 2020, 18:235. 10.1186\/s12916-020-01678-8","journal-title":"BMC Med"},{"key":"ref222","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxab285","article-title":"Higher ultra-processed food consumption is associated with increased risk of incident coronary artery disease in the Atherosclerosis Risk in Communities study","volume":"151","author":"Du S","year":"2021","unstructured":"Du S, Kim H, Rebholz CM. Higher ultra-processed food consumption is associated with increased risk of incident coronary artery disease in the Atherosclerosis Risk in Communities study. 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Nutr J. 2019, 18:27. 10.1186\/s12937-019-0452-4","journal-title":"Nutr J"},{"key":"ref224","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-020-01142-4","article-title":"Comparing two methods for deriving dietary patterns associated with risk of metabolic syndrome among middle-aged and elderly Taiwanese adults with impaired kidney function","volume":"20","author":"Kurniawan AL","year":"2020","unstructured":"Kurniawan AL, Hsu CY, Lee HA, Rau HH, Paramastri R, Syauqy A, Chao JC. Comparing two methods for deriving dietary patterns associated with risk of metabolic syndrome among middle-aged and elderly Taiwanese adults with impaired kidney function. BMC Med Res Methodol. 2020, 20:255. 10.1186\/s12874-020-01142-4","journal-title":"BMC Med Res Methodol"},{"key":"ref225","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-020-0565-z","article-title":"Metabolic profiling of tissue-specific insulin resistance in human obesity: results from the Diogenes study and the Maastricht Study","volume":"44","author":"Vogelzangs N","year":"2020","unstructured":"Vogelzangs N, van der Kallen CJ, van Greevenbroek MM, et al.. Metabolic profiling of tissue-specific insulin resistance in human obesity: results from the Diogenes study and the Maastricht Study. 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