{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:12:18Z","timestamp":1790385138821,"version":"4.1.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,7]]},"DOI":"10.7759\/cureus.28900","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T18:41:43Z","timestamp":1662576103000},"source":"Crossref","is-referenced-by-count":4,"title":["A Novel Agnostic Respiratory Stimulant as a Treatment for Apnea of Prematurity: A Proof-of-Concept Study"],"prefix":"10.7759","author":[{"given":"Thomas L","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M","family":"Raab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Schweikert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Diana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Fort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana S","family":"Frum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Pergolizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B","family":"Raffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(94)90149-x","article-title":"The epidemiology of neonatal respiratory disease","volume":"37","author":"Bohin S","year":"1994","unstructured":"Bohin S, Field DJ. The epidemiology of neonatal respiratory disease. Early Hum Dev. 1994, 37:73-90. 10.1016\/0378-3782(94)90149-x","journal-title":"Early Hum Dev"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1409-6","article-title":"Apnea of prematurity: from cause to treatment","volume":"170","author":"Zhao J","year":"2011","unstructured":"Zhao J, Gonzalez F, Mu D. Apnea of prematurity: from cause to treatment. Eur J Pediatr. 2011, 170:1097-105. 10.1007\/s00431-011-1409-6","journal-title":"Eur J Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3757","article-title":"Apnea of prematurity","volume":"137","author":"Eichenwald EC","year":"2016","unstructured":"Eichenwald EC. Apnea of prematurity. Pediatrics. 2016, 137:10.1542\/peds.2015-3757","journal-title":"Pediatrics"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s1526-0542(04)90067-x","article-title":"Apnoea of prematurity","volume":"5","author":"Martin RJ","year":"2004","unstructured":"Martin RJ, Abu-Shaweesh JM, Baird TM. Apnoea of prematurity. Paediatr Respir Rev. 2004, 5:S377-82. 10.1016\/s1526-0542(04)90067-x","journal-title":"Paediatr Respir Rev"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.09.017","article-title":"Outcomes for the extremely premature infant: what is new? And where are we going?","volume":"40","author":"Robertson CM","year":"2009","unstructured":"Robertson CM, Watt MJ, Dinu IA. Outcomes for the extremely premature infant: what is new? And where are we going?. Pediatr Neurol. 2009, 40:189-96. 10.1016\/j.pediatrneurol.2008.09.017","journal-title":"Pediatr Neurol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000442813","article-title":"The real-world routine use of caffeine citrate in preterm infants: a European postauthorization safety study","volume":"109","author":"Lista G","year":"2016","unstructured":"Lista G, Fabbri L, Polackova R, et al.. The real-world routine use of caffeine citrate in preterm infants: a European postauthorization safety study. Neonatology. 2016, 109:221-7. 10.1159\/000442813","journal-title":"Neonatology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054065","article-title":"Caffeine therapy for apnea of prematurity","volume":"354","author":"Schmidt B","year":"2006","unstructured":"Schmidt B, Roberts RS, Davis P, et al.. Caffeine therapy for apnea of prematurity. N Engl J Med. 2006, 354:2112-21. 10.1056\/NEJMoa054065","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu182","article-title":"GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers","volume":"113","author":"McLeod JF","year":"2014","unstructured":"McLeod JF, Leempoels JM, Peng SX, Dax SL, Myers LJ, Golder FJ. GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers. Br J Anaesth. 2014, 113:875-83. 10.1093\/bja\/aeu182","journal-title":"Br J Anaesth"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000844","article-title":"Identification and characterization of GAL-021 as a novel breathing control modulator","volume":"123","author":"Golder FJ","year":"2015","unstructured":"Golder FJ, Dax S, Baby SM, et al.. Identification and characterization of GAL-021 as a novel breathing control modulator. Anesthesiology. 2015, 123:1093-104. 10.1097\/ALN.0000000000000844","journal-title":"Anesthesiology"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.96","article-title":"Lucinactant attenuates pulmonary inflammatory response, preserves lung structure, and improves physiologic outcomes in a preterm lamb model of RDS","volume":"72","author":"Wolfson MR","year":"2012","unstructured":"Wolfson MR, Wu J, Hubert TL, Gregory TJ, Mazela J, Shaffer TH. Lucinactant attenuates pulmonary inflammatory response, preserves lung structure, and improves physiologic outcomes in a preterm lamb model of RDS. Pediatr Res. 2012, 72:375-83. 10.1038\/pr.2012.96","journal-title":"Pediatr Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1090587","article-title":"Recombinant human Clara cell secretory protein treatment increases lung mRNA expression of surfactant proteins and vascular endothelial growth factor in a premature lamb model of respiratory distress syndrome","volume":"25","author":"Wolfson MR","year":"2008","unstructured":"Wolfson MR, Funanage VL, Kirwin SM, Pilon AL, Shashikant BN, Miller TL, Shaffer TH. Recombinant human Clara cell secretory protein treatment increases lung mRNA expression of surfactant proteins and vascular endothelial growth factor in a premature lamb model of respiratory distress syndrome. Am J Perinatol. 2008, 25:637-45. 10.1055\/s-0028-1090587","journal-title":"Am J Perinatol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00246.2005","article-title":"Dose response to rhCC10-augmented surfactant therapy in a lamb model of infant respiratory distress syndrome: physiological, inflammatory, and kinetic profiles","volume":"99","author":"Shashikant BN","year":"2005","unstructured":"Shashikant BN, Miller TL, Welch RW, Pilon AL, Shaffer TH, Wolfson MR. Dose response to rhCC10-augmented surfactant therapy in a lamb model of infant respiratory distress syndrome: physiological, inflammatory, and kinetic profiles. J Appl Physiol (1985). 2005, 99:2204-11. 10.1152\/japplphysiol.00246.2005","journal-title":"J Appl Physiol (1985)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/9780470752425.app1","article-title":"Appendix 1: normal physiological values","year":"2002","unstructured":"Appendix 1. normal physiological values. Clinical Examination of Farm Animals. Jackson PG, Cockcroft PD (ed): Blackwell Science Ltd, Oxford, UK; 2002. 301. 10.1002\/9780470752425.app1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000253022.10607.61","article-title":"Effects of recombinant Clara cell secretory protein (rhCC10) on inflammatory-related matrix metalloproteinase activity in a preterm lamb model of neonatal respiratory distress","volume":"8","author":"Miller TL","year":"2007","unstructured":"Miller TL, Shashikant BN, Pilon AL, Pierce RA, Shaffer TH, Wolfson MR. Effects of recombinant Clara cell secretory protein (rhCC10) on inflammatory-related matrix metalloproteinase activity in a preterm lamb model of neonatal respiratory distress. Pediatr Crit Care Med. 2007, 8:40-6. 10.1097\/01.PCC.0000253022.10607.61","journal-title":"Pediatr Crit Care Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000367","article-title":"Two studies on reversal of opioid-induced respiratory depression by BK-channel blocker GAL021 in human volunteers","volume":"121","author":"Roozekrans M","year":"2014","unstructured":"Roozekrans M, van der Schrier R, Okkerse P, Hay J, McLeod JF, Dahan A. Two studies on reversal of opioid-induced respiratory depression by BK-channel blocker GAL021 in human volunteers. Anesthesiology. 2014, 121:459-68. 10.1097\/ALN.0000000000000367","journal-title":"Anesthesiology"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/103824-a-novel-agnostic-respiratory-stimulant-as-a-treatment-for-apnea-of-prematurity-a-proof-of-concept-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:46:40Z","timestamp":1707508000000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/103824-a-novel-agnostic-respiratory-stimulant-as-a-treatment-for-apnea-of-prematurity-a-proof-of-concept-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.28900","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,7]]}}}