{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:54:58Z","timestamp":1792180498547,"version":"4.4.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,5]]},"DOI":"10.7759\/cureus.29964","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:45:01Z","timestamp":1665017101000},"source":"Crossref","is-referenced-by-count":23,"title":["Factors Contributing to Anastomotic Leakage Following Colorectal Surgery: Why, When, and Who Leaks?"],"prefix":"10.7759","author":[{"given":"Shravani","family":"Sripathi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashal I","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roja T","family":"Meda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya P","family":"Nuguru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriker","family":"Rachakonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13534","article-title":"A collaborative review of the current concepts and challenges of anastomotic leaks in colorectal surgery","volume":"19","author":"Vallance A","year":"2017","unstructured":"Vallance A, Wexner S, Berho M, et al.. A collaborative review of the current concepts and challenges of anastomotic leaks in colorectal surgery. Colorectal Dis. 2017, 19:O1-O12. 10.1111\/codi.13534","journal-title":"Colorectal Dis"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1177\/145749691210100403","article-title":"The art of bowel anastomosis","volume":"101","author":"Chen C","year":"2012","unstructured":"Chen C. The art of bowel anastomosis. Scand J Surg. 2012, 101:238-40. 10.1177\/145749691210100403","journal-title":"Scand J Surg"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.10.012","article-title":"Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer","volume":"147","author":"Rahbari NN","year":"2010","unstructured":"Rahbari NN, Weitz J, Hohenberger W, et al.. Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer. Surgery. 2010, 147:339-51. 10.1016\/j.surg.2009.10.012","journal-title":"Surgery"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4314\/ejhs.v29i6.14","article-title":"Colorectal anastomosis leak: rate, risk factors and outcome in a tertiary teaching hospital, Addis Ababa Ethiopia, a five year retrospective study","volume":"29","author":"Wako G","year":"2019","unstructured":"Wako G, Teshome H, Abebe E. Colorectal anastomosis leak: rate, risk factors and outcome in a tertiary teaching hospital, Addis Ababa Ethiopia, a five year retrospective study. Ethiop J Health Sci. 2019, 29:767-74. 10.4314\/ejhs.v29i6.14","journal-title":"Ethiop J Health Sci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000225083.27182.85","article-title":"Anastomotic leaks after intestinal anastomosis: it's later than you think","volume":"245","author":"Hyman N","year":"2007","unstructured":"Hyman N, Manchester TL, Osler T, Burns B, Cataldo PA. Anastomotic leaks after intestinal anastomosis: it's later than you think. Ann Surg. 2007, 245:254-8. 10.1097\/01.sla.0000225083.27182.85","journal-title":"Ann Surg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0869-4","article-title":"Prognosis after anastomotic leakage in colorectal surgery","volume":"48","author":"Branagan G","year":"2005","unstructured":"Branagan G, Finnis D. Prognosis after anastomotic leakage in colorectal surgery. Dis Colon Rectum. 2005, 48:1021-6. 10.1007\/s10350-004-0869-4","journal-title":"Dis Colon Rectum"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/bjs5.50302","article-title":"Meta-analysis of the impact of postoperative infective complications on oncological outcomes in colorectal cancer surgery","volume":"4","author":"Lawler J","year":"2020","unstructured":"Lawler J, Choynowski M, Bailey K, Bucholc M, Johnston A, Sugrue M. Meta-analysis of the impact of postoperative infective complications on oncological outcomes in colorectal cancer surgery. BJS Open. 2020, 4:737-47. 10.1002\/bjs5.50302","journal-title":"BJS Open"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-5881-8","article-title":"Oncologic impact of anastomotic leakage following colorectal cancer surgery: a systematic review and meta-analysis","volume":"24","author":"Ha GW","year":"2017","unstructured":"Ha GW, Kim JH, Lee MR. Oncologic impact of anastomotic leakage following colorectal cancer surgery: a systematic review and meta-analysis. Ann Surg Oncol. 2017, 24:3289-99. 10.1245\/s10434-017-5881-8","journal-title":"Ann Surg Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i25.5718","article-title":"Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis","volume":"22","author":"Kawada K","year":"2016","unstructured":"Kawada K, Sakai Y. Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis. World J Gastroenterol. 2016, 22:5718-27. 10.3748\/wjg.v22.i25.5718","journal-title":"World J Gastroenterol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03079.x","article-title":"A nationwide study on anastomotic leakage after colonic cancer surgery","volume":"14","author":"Krarup PM","year":"2012","unstructured":"Krarup PM, Jorgensen LN, Andreasen AH, Harling H. A nationwide study on anastomotic leakage after colonic cancer surgery. Colorectal Dis. 2012, 14:e661-7. 10.1111\/j.1463-1318.2012.03079.x","journal-title":"Colorectal Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9272-x","article-title":"Risk factors and oncologic impact of anastomotic leakage after rectal cancer surgery","volume":"51","author":"Jung SH","year":"2008","unstructured":"Jung SH, Yu CS, Choi PW, Kim DD, Park IJ, Kim HC, Kim JC. Risk factors and oncologic impact of anastomotic leakage after rectal cancer surgery. Dis Colon Rectum. 2008, 51:902-8. 10.1007\/s10350-008-9272-x","journal-title":"Dis Colon Rectum"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1721-5","article-title":"The influence of fecal diversion and anastomotic leakage on survival after resection of rectal cancer","volume":"15","author":"Lin JK","year":"2011","unstructured":"Lin JK, Yueh TC, Chang SC, et al.. The influence of fecal diversion and anastomotic leakage on survival after resection of rectal cancer. J Gastrointest Surg. 2011, 15:2251-61. 10.1007\/s11605-011-1721-5","journal-title":"J Gastrointest Surg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2005.10.019","article-title":"Risk factors for anastomotic leakage after surgery for colorectal cancer: results of prospective surveillance","volume":"202","author":"Konishi T","year":"2006","unstructured":"Konishi T, Watanabe T, Kishimoto J, Nagawa H. Risk factors for anastomotic leakage after surgery for colorectal cancer: results of prospective surveillance. J Am Coll Surg. 2006, 202:439-44. 10.1016\/j.jamcollsurg.2005.10.019","journal-title":"J Am Coll Surg"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.40","article-title":"Risk factors for anastomotic leak following colorectal surgery: a case-control study","volume":"145","author":"Telem DA","year":"2010","unstructured":"Telem DA, Chin EH, Nguyen SQ, Divino CM. Risk factors for anastomotic leak following colorectal surgery: a case-control study. Arch Surg. 2010, 145:371-6; discussion 376. 10.1001\/archsurg.2010.40","journal-title":"Arch Surg"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-007-0399-3","article-title":"Incidence, consequences, and risk factors for anastomotic dehiscence after colorectal surgery: a prospective monocentric study","volume":"23","author":"Buchs NC","year":"2008","unstructured":"Buchs NC, Gervaz P, Secic M, Bucher P, Mugnier-Konrad B, Morel P. Incidence, consequences, and risk factors for anastomotic dehiscence after colorectal surgery: a prospective monocentric study. Int J Colorectal Dis. 2008, 23:265-70. 10.1007\/s00384-007-0399-3","journal-title":"Int J Colorectal Dis"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2006.03780.x","article-title":"Anastomotic leakage after lower gastrointestinal anastomosis: men are at a higher risk","volume":"76","author":"Lipska MA","year":"2006","unstructured":"Lipska MA, Bissett IP, Parry BR, Merrie AE. Anastomotic leakage after lower gastrointestinal anastomosis: men are at a higher risk. ANZ J Surg. 2006, 76:579-85. 10.1111\/j.1445-2197.2006.03780.x","journal-title":"ANZ J Surg"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5170","article-title":"Risk factors, short and long term outcome of anastomotic leaks in rectal cancer","volume":"6","author":"Jannasch O","year":"2015","unstructured":"Jannasch O, Klinge T, Otto R, et al.. Risk factors, short and long term outcome of anastomotic leaks in rectal cancer. Oncotarget. 2015, 6:36884-93. 10.18632\/oncotarget.5170","journal-title":"Oncotarget"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9395","article-title":"Risk factors for anastomotic leakage and leak-related mortality after colonic cancer surgery in a nationwide audit","volume":"101","author":"Bakker IS","year":"2014","unstructured":"Bakker IS, Grossmann I, Henneman D, Havenga K, Wiggers T. Risk factors for anastomotic leakage and leak-related mortality after colonic cancer surgery in a nationwide audit. Br J Surg. 2014, 101:424-32; discussion 432. 10.1002\/bjs.9395","journal-title":"Br J Surg"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12618","article-title":"Preoperative risk factors for anastomotic leakage after resection for colorectal cancer: a systematic review and meta-analysis","volume":"16","author":"Pommergaard HC","year":"2014","unstructured":"Pommergaard HC, Gessler B, Burcharth J, Angenete E, Haglind E, Rosenberg J. Preoperative risk factors for anastomotic leakage after resection for colorectal cancer: a systematic review and meta-analysis. Colorectal Dis. 2014, 16:662-71. 10.1111\/codi.12618","journal-title":"Colorectal Dis"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31827b8ed9","article-title":"Multicenter analysis of risk factors for anastomotic leakage after laparoscopic rectal cancer excision: the Korean laparoscopic colorectal surgery study group","volume":"257","author":"Park JS","year":"2013","unstructured":"Park JS, Choi GS, Kim SH, et al.. Multicenter analysis of risk factors for anastomotic leakage after laparoscopic rectal cancer excision: the Korean laparoscopic colorectal surgery study group. Ann Surg. 2013, 257:665-71. 10.1097\/SLA.0b013e31827b8ed9","journal-title":"Ann Surg"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/ases.12439","article-title":"Preventive effect of diverting stoma on anastomotic leakage after laparoscopic low anterior resection with double stapling technique reconstruction applied based on risk stratification","volume":"11","author":"Hamabe A","year":"2018","unstructured":"Hamabe A, Ito M, Nishigori H, Nishizawa Y, Sasaki T. Preventive effect of diverting stoma on anastomotic leakage after laparoscopic low anterior resection with double stapling technique reconstruction applied based on risk stratification. Asian J Endosc Surg. 2018, 11:220-6. 10.1111\/ases.12439","journal-title":"Asian J Endosc Surg"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15911","article-title":"Trends in risk factors of anastomotic leakage after colorectal cancer surgery (2011-2019): A Dutch population-based study","volume":"23","author":"Arron MN","year":"2021","unstructured":"Arron MN, Greijdanus NG, Ten Broek RP, et al.. Trends in risk factors of anastomotic leakage after colorectal cancer surgery (2011-2019): A Dutch population-based study. Colorectal Dis. 2021, 23:3251-61. 10.1111\/codi.15911","journal-title":"Colorectal Dis"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00357.2003","article-title":"Gender differences in small intestinal endothelial function: inhibitory role of androgens","volume":"286","author":"Ba ZF","year":"2004","unstructured":"Ba ZF, Yokoyama Y, Toth B, Rue LW 3rd, Bland KI, Chaudry IH. Gender differences in small intestinal endothelial function: inhibitory role of androgens. Am J Physiol Gastrointest Liver Physiol. 2004, 286:G452-7. 10.1152\/ajpgi.00357.2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000973","article-title":"Risk factors for anastomotic leak after colon resection for cancer: multivariate analysis and nomogram from a multicentric, prospective, national study with 3193 patients","volume":"262","author":"Frasson M","year":"2015","unstructured":"Frasson M, Flor-Lorente B, Rodr\u00edguez JL, et al.. Risk factors for anastomotic leak after colon resection for cancer: multivariate analysis and nomogram from a multicentric, prospective, national study with 3193 patients. Ann Surg. 2015, 262:321-30. 10.1097\/SLA.0000000000000973","journal-title":"Ann Surg"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00615.x","article-title":"Risk factors for anastomotic leakage after resection of rectal cancer","volume":"85","author":"Rullier E","year":"1998","unstructured":"Rullier E, Laurent C, Garrelon JL, Michel P, Saric J, Parneix M. Risk factors for anastomotic leakage after resection of rectal cancer. Br J Surg. 1998, 85:355-8. 10.1046\/j.1365-2168.1998.00615.x","journal-title":"Br J Surg"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/s1091-255x(02)00124-5","article-title":"Laparoscopic colectomy in obese and nonobese patients","volume":"7","author":"Senagore AJ","year":"2003","unstructured":"Senagore AJ, Delaney CP, Madboulay K, Brady KM, Fazio VW. Laparoscopic colectomy in obese and nonobese patients. J Gastrointest Surg. 2003, 7:558-61. 10.1016\/s1091-255x(02)00124-5","journal-title":"J Gastrointest Surg"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0159-9","article-title":"Anastomotic dehiscence after resection and primary anastomosis in left-sided colonic emergencies","volume":"48","author":"Biondo S","year":"2005","unstructured":"Biondo S, Par\u00e9s D, Kreisler E, Ragu\u00e9 JM, Fraccalvieri D, Ruiz AG, Jaurrieta E. Anastomotic dehiscence after resection and primary anastomosis in left-sided colonic emergencies. Dis Colon Rectum. 2005, 48:2272-80. 10.1007\/s10350-005-0159-9","journal-title":"Dis Colon Rectum"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-013-1803-9","article-title":"The impact of visceral obesity on surgical outcomes of laparoscopic surgery for colon cancer","volume":"29","author":"Watanabe J","year":"2014","unstructured":"Watanabe J, Tatsumi K, Ota M, et al.. The impact of visceral obesity on surgical outcomes of laparoscopic surgery for colon cancer. Int J Colorectal Dis. 2014, 29:343-51. 10.1007\/s00384-013-1803-9","journal-title":"Int J Colorectal Dis"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/ans.13132","article-title":"Impact of visceral obesity on outcomes of laparoscopic colorectal surgery: a meta-analysis","volume":"85","author":"Yang T","year":"2015","unstructured":"Yang T, Wei M, He Y, Deng X, Wang Z. Impact of visceral obesity on outcomes of laparoscopic colorectal surgery: a meta-analysis. ANZ J Surg. 2015, 85:507-13. 10.1111\/ans.13132","journal-title":"ANZ J Surg"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6627-9","article-title":"Risk factors for anastomotic leakage after left-sided colorectal resection with rectal anastomosis","volume":"46","author":"M\u00e4kel\u00e4 JT","year":"2003","unstructured":"M\u00e4kel\u00e4 JT, Kiviniemi H, Laitinen S. Risk factors for anastomotic leakage after left-sided colorectal resection with rectal anastomosis. Dis Colon Rectum. 2003, 46:653-60. 10.1007\/s10350-004-6627-9","journal-title":"Dis Colon Rectum"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamasurg.2","article-title":"Risk factors for anastomotic leakage after anterior resection for rectal cancer","volume":"148","author":"Kang CY","year":"2013","unstructured":"Kang CY, Halabi WJ, Chaudhry OO, et al.. Risk factors for anastomotic leakage after anterior resection for rectal cancer. JAMA Surg. 2013, 148:65-71. 10.1001\/2013.jamasurg.2","journal-title":"JAMA Surg"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i36.4605","article-title":"Laparoscopic low anterior resection for rectal carcinoma: complications and management in 132 consecutive patients","volume":"16","author":"Zhu QL","year":"2010","unstructured":"Zhu QL, Feng B, Lu AG, et al.. Laparoscopic low anterior resection for rectal carcinoma: complications and management in 132 consecutive patients. World J Gastroenterol. 2010, 16:4605-10. 10.3748\/wjg.v16.i36.4605","journal-title":"World J Gastroenterol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1999.01165.x","article-title":"Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery","volume":"86","author":"S\u00f8rensen LT","year":"1999","unstructured":"S\u00f8rensen LT, J\u00f8rgensen T, Kirkeby LT, Skovdal J, Vennits B, Wille-J\u00f8rgensen P. Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery. Br J Surg. 1999, 86:927-31. 10.1046\/j.1365-2168.1999.01165.x","journal-title":"Br J Surg"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000157131.84130.12","article-title":"Risk factors for tissue and wound complications in gastrointestinal surgery","volume":"241","author":"S\u00f8rensen LT","year":"2005","unstructured":"S\u00f8rensen LT, Hemmingsen U, Kallehave F, Wille-J\u00f8rgensen P, Kjaergaard J, M\u00f8ller LN, J\u00f8rgensen T. Risk factors for tissue and wound complications in gastrointestinal surgery. Ann Surg. 2005, 241:654-8. 10.1097\/01.sla.0000157131.84130.12","journal-title":"Ann Surg"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0000000000000471","article-title":"Risk factors and oncologic outcomes of anastomosis leakage after laparoscopic right colectomy","volume":"27","author":"Kwak HD","year":"2017","unstructured":"Kwak HD, Kim SH, Kang DW, Baek SJ, Kwak JM, Kim J. Risk factors and oncologic outcomes of anastomosis leakage after laparoscopic right colectomy. Surg Laparosc Endosc Percutan Tech. 2017, 27:440-4. 10.1097\/SLE.0000000000000471","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"ref36","article-title":"American Society of Anesthesiologists Classification","author":"Doyle DJ","year":"2022","unstructured":"Doyle DJ, Goyal A, Garmon EH. American Society of Anesthesiologists Classification. StatPearls, Treasure Island, FL; 2022."},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0703-2","article-title":"Leakage after resection and intraperitoneal anastomosis for colorectal malignancy: analysis of risk factors","volume":"49","author":"Choi HK","year":"2006","unstructured":"Choi HK, Law WL, Ho JW. Leakage after resection and intraperitoneal anastomosis for colorectal malignancy: analysis of risk factors. Dis Colon Rectum. 2006, 49:1719-25. 10.1007\/s10350-006-0703-2","journal-title":"Dis Colon Rectum"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-004-0150-9","article-title":"Effects of steroid on the healing of colonic anastomoses in the rat","volume":"8 Suppl 1","author":"Mantzoros I","year":"2004","unstructured":"Mantzoros I, Kanellos I, Demetriades H, et al.. Effects of steroid on the healing of colonic anastomoses in the rat. Tech Coloproctol. 2004, 8 Suppl 1:s180-3. 10.1007\/s10151-004-0150-9","journal-title":"Tech Coloproctol"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.1690","article-title":"Long-term and perioperative corticosteroids in anastomotic leakage: a prospective study of 259 left-sided colorectal anastomoses","volume":"147","author":"Slieker JC","year":"2012","unstructured":"Slieker JC, Komen N, Mannaerts GH, et al.. Long-term and perioperative corticosteroids in anastomotic leakage: a prospective study of 259 left-sided colorectal anastomoses. Arch Surg. 2012, 147:447-52. 10.1001\/archsurg.2011.1690","journal-title":"Arch Surg"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-984870","article-title":"Management of locally advanced primary and recurrent rectal cancer","volume":"20","author":"de Wilt JH","year":"2007","unstructured":"de Wilt JH, Vermaas M, Ferenschild FT, Verhoef C. Management of locally advanced primary and recurrent rectal cancer. Clin Colon Rectal Surg. 2007, 20:255-63. 10.1055\/s-2007-984870","journal-title":"Clin Colon Rectal Surg"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-015-4117-x","article-title":"Clinical risk factors for anastomotic leakage after laparoscopic anterior resection for rectal cancer: a systematic review and meta-analysis","volume":"29","author":"Qu H","year":"2015","unstructured":"Qu H, Liu Y, Bi DS. Clinical risk factors for anastomotic leakage after laparoscopic anterior resection for rectal cancer: a systematic review and meta-analysis. Surg Endosc. 2015, 29:3608-17. 10.1007\/s00464-015-4117-x","journal-title":"Surg Endosc"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2004.00657.x","article-title":"Risk factors for anastomotic leakage after anterior resection of the rectum","volume":"6","author":"Matthiessen P","year":"2004","unstructured":"Matthiessen P, Hallb\u00f6\u00f6k O, Andersson M, Ruteg\u00e5rd J, Sj\u00f6dahl R. Risk factors for anastomotic leakage after anterior resection of the rectum. Colorectal Dis. 2004, 6:462-9. 10.1111\/j.1463-1318.2004.00657.x","journal-title":"Colorectal Dis"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31829068c5","article-title":"Preoperative chemoradiotherapy effects on anastomotic leakage after rectal cancer resection: a propensity score matching analysis","volume":"259","author":"Chang JS","year":"2014","unstructured":"Chang JS, Keum KC, Kim NK, et al.. Preoperative chemoradiotherapy effects on anastomotic leakage after rectal cancer resection: a propensity score matching analysis. Ann Surg. 2014, 259:516-21. 10.1097\/SLA.0b013e31829068c5","journal-title":"Ann Surg"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.3.817","article-title":"Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial","volume":"20","author":"Marijnen CA","year":"2002","unstructured":"Marijnen CA, Kapiteijn E, van de Velde CJ, et al.. Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol. 2002, 20:817-25. 10.1200\/JCO.2002.20.3.817","journal-title":"J Clin Oncol"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001041","article-title":"Combined mechanical and oral antibiotic bowel preparation reduces incisional surgical site infection and anastomotic leak rates after elective colorectal resection: an analysis of colectomy-targeted ACS NSQIP","volume":"262","author":"Scarborough JE","year":"2015","unstructured":"Scarborough JE, Mantyh CR, Sun Z, Migaly J. Combined mechanical and oral antibiotic bowel preparation reduces incisional surgical site infection and anastomotic leak rates after elective colorectal resection: an analysis of colectomy-targeted ACS NSQIP. Ann Surg. 2015, 262:331-7. 10.1097\/SLA.0000000000001041","journal-title":"Ann Surg"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i4.519","article-title":"Impact of mechanical bowel preparation in elective colorectal surgery: A meta-analysis","volume":"24","author":"Rollins KE","year":"2018","unstructured":"Rollins KE, Javanmard-Emamghissi H, Lobo DN. Impact of mechanical bowel preparation in elective colorectal surgery: A meta-analysis. World J Gastroenterol. 2018, 24:519-36. 10.3748\/wjg.v24.i4.519","journal-title":"World J Gastroenterol"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000851","article-title":"Is there a role for oral antibiotic preparation alone before colorectal surgery? ACS-NSQIP analysis by coarsened exact matching","volume":"60","author":"Garfinkle R","year":"2017","unstructured":"Garfinkle R, Abou-Khalil J, Morin N, et al.. Is there a role for oral antibiotic preparation alone before colorectal surgery? ACS-NSQIP analysis by coarsened exact matching. Dis Colon Rectum. 2017, 60:729-37. 10.1097\/DCR.0000000000000851","journal-title":"Dis Colon Rectum"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.3393\/jksc.2010.26.4.265","article-title":"Risk factors for anastomotic leakage after laparoscopic rectal resection","volume":"26","author":"Choi DH","year":"2010","unstructured":"Choi DH, Hwang JK, Ko YT, et al.. Risk factors for anastomotic leakage after laparoscopic rectal resection. J Korean Soc Coloproctol. 2010, 26:265-73. 10.3393\/jksc.2010.26.4.265","journal-title":"J Korean Soc Coloproctol"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01466.x","article-title":"Risk factors for anastomotic leakage after rectal cancer surgery: a case-control study","volume":"10","author":"Jestin P","year":"2008","unstructured":"Jestin P, P\u00e5hlman L, Gunnarsson U. Risk factors for anastomotic leakage after rectal cancer surgery: a case-control study. Colorectal Dis. 2008, 10:715-21. 10.1111\/j.1463-1318.2007.01466.x","journal-title":"Colorectal Dis"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181deb649","article-title":"The angiographic anatomy of the small arteries and their collaterals in colorectal resections: some insights into anastomotic perfusion","volume":"251","author":"Allison AS","year":"2010","unstructured":"Allison AS, Bloor C, Faux W, Arumugam P, Widdison A, Lloyd-Davies E, Maskell G. The angiographic anatomy of the small arteries and their collaterals in colorectal resections: some insights into anastomotic perfusion. Ann Surg. 2010, 251:1092-7. 10.1097\/SLA.0b013e3181deb649","journal-title":"Ann Surg"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.10.015","article-title":"Colonic anastomotic leak: risk factors, diagnosis, and treatment","volume":"208","author":"Kingham TP","year":"2009","unstructured":"Kingham TP, Pachter HL. Colonic anastomotic leak: risk factors, diagnosis, and treatment. J Am Coll Surg. 2009, 208:269-78. 10.1016\/j.jamcollsurg.2008.10.015","journal-title":"J Am Coll Surg"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-009-0658-6","article-title":"Surgeons lack predictive accuracy for anastomotic leakage in gastrointestinal surgery","volume":"24","author":"Karliczek A","year":"2009","unstructured":"Karliczek A, Harlaar NJ, Zeebregts CJ, Wiggers T, Baas PC, van Dam GM. Surgeons lack predictive accuracy for anastomotic leakage in gastrointestinal surgery. Int J Colorectal Dis. 2009, 24:569-76. 10.1007\/s00384-009-0658-6","journal-title":"Int J Colorectal Dis"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(80)90232-9","article-title":"Evaluation of ischemic intestine by Doppler ultrasound","volume":"139","author":"Cooperman M","year":"1980","unstructured":"Cooperman M, Martin EW Jr, Carey LC. Evaluation of ischemic intestine by Doppler ultrasound. Am J Surg. 1980, 139:73-7. 10.1016\/0002-9610(80)90232-9","journal-title":"Am J Surg"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199108000-00008","article-title":"Intraoperative evaluation of intestinal ischemia: a comparison of methods","volume":"84","author":"Dyess DL","year":"1991","unstructured":"Dyess DL, Bruner BW, Donnell CA, Ferrara JJ, Powell RW. Intraoperative evaluation of intestinal ischemia: a comparison of methods. South Med J. 1991, 84:966-9, 974. 10.1097\/00007611-199108000-00008","journal-title":"South Med J"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-010-0699-x","article-title":"Intraoperative laser fluorescence angiography in colorectal surgery: a noninvasive analysis to reduce the rate of anastomotic leakage","volume":"395","author":"Kudszus S","year":"2010","unstructured":"Kudszus S, Roesel C, Schachtrupp A, H\u00f6er JJ. Intraoperative laser fluorescence angiography in colorectal surgery: a noninvasive analysis to reduce the rate of anastomotic leakage. Langenbecks Arch Surg. 2010, 395:1025-30. 10.1007\/s00423-010-0699-x","journal-title":"Langenbecks Arch Surg"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.09.015","article-title":"Perfusion assessment in laparoscopic left-sided\/anterior resection (PILLAR II): a multi-institutional study","volume":"220","author":"Jafari MD","year":"2015","unstructured":"Jafari MD, Wexner SD, Martz JE, et al.. Perfusion assessment in laparoscopic left-sided\/anterior resection (PILLAR II): a multi-institutional study. J Am Coll Surg. 2015, 220:82-92.e1. 10.1016\/j.jamcollsurg.2014.09.015","journal-title":"J Am Coll Surg"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1186\/1754-9493-4-5","article-title":"Complications in colorectal surgery: risk factors and preventive strategies","volume":"4","author":"Kirchhoff P","year":"2010","unstructured":"Kirchhoff P, Clavien PA, Hahnloser D. Complications in colorectal surgery: risk factors and preventive strategies. Patient Saf Surg. 2010, 4:5. 10.1186\/1754-9493-4-5","journal-title":"Patient Saf Surg"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000249","article-title":"Risk factors and consequences of anastomotic leak after colectomy: a national analysis","volume":"58","author":"Midura EF","year":"2015","unstructured":"Midura EF, Hanseman D, Davis BR, Atkinson SJ, Abbott DE, Shah SA, Paquette IM. Risk factors and consequences of anastomotic leak after colectomy: a national analysis. Dis Colon Rectum. 2015, 58:333-8. 10.1097\/DCR.0000000000000249","journal-title":"Dis Colon Rectum"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800721019","article-title":"Hypovolaemia and healing in colonic anastomoses","volume":"72","author":"Foster ME","year":"1985","unstructured":"Foster ME, Laycock JR, Silver IA, Leaper DJ. Hypovolaemia and healing in colonic anastomoses. Br J Surg. 1985, 72:831-4. 10.1002\/bjs.1800721019","journal-title":"Br J Surg"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e3182423c0d","article-title":"Risk factors for anastomotic leakage after colectomy","volume":"55","author":"Leichtle SW","year":"2012","unstructured":"Leichtle SW, Mouawad NJ, Welch KB, Lampman RM, Cleary RK. Risk factors for anastomotic leakage after colectomy. Dis Colon Rectum. 2012, 55:569-75. 10.1097\/DCR.0b013e3182423c0d","journal-title":"Dis Colon Rectum"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199203000-00013","article-title":"Blood transfusion impairs the healing of experimental intestinal anastomoses","volume":"215","author":"Tadros T","year":"1992","unstructured":"Tadros T, Wobbes T, Hendriks T. Blood transfusion impairs the healing of experimental intestinal anastomoses. Ann Surg. 1992, 215:276-81. 10.1097\/00000658-199203000-00013","journal-title":"Ann Surg"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-013-0685-3","article-title":"Risk factors and predictive factors for anastomotic leakage after resection for colorectal cancer: reappraisal of the literature","volume":"44","author":"Fujita F","year":"2014","unstructured":"Fujita F, Torashima Y, Kuroki T, Eguchi S. Risk factors and predictive factors for anastomotic leakage after resection for colorectal cancer: reappraisal of the literature. Surg Today. 2014, 44:1595-602. 10.1007\/s00595-013-0685-3","journal-title":"Surg Today"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3180603024","article-title":"Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial","volume":"246","author":"Matthiessen P","year":"2007","unstructured":"Matthiessen P, Hallb\u00f6\u00f6k O, Ruteg\u00e5rd J, Simert G, Sj\u00f6dahl R. Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial. Ann Surg. 2007, 246:207-14. 10.1097\/SLA.0b013e3180603024","journal-title":"Ann Surg"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318176bf65","article-title":"Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery","volume":"248","author":"H\u00fcser N","year":"2008","unstructured":"H\u00fcser N, Michalski CW, Erkan M, Schuster T, Rosenberg R, Kleeff J, Friess H. Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery. Ann Surg. 2008, 248:52-60. 10.1097\/SLA.0b013e318176bf65","journal-title":"Ann Surg"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5045","article-title":"Protective defunctioning stoma in low anterior resection for rectal carcinoma","volume":"92","author":"Gastinger I","year":"2005","unstructured":"Gastinger I, Marusch F, Steinert R, Wolff S, Koeckerling F, Lippert H. Protective defunctioning stoma in low anterior resection for rectal carcinoma. Br J Surg. 2005, 92:1137-42. 10.1002\/bjs.5045","journal-title":"Br J Surg"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.11.014","article-title":"Incidence of and risk factors for anastomotic leakage after laparoscopic anterior resection with intracorporeal rectal transection and double-stapling technique anastomosis for rectal cancer","volume":"202","author":"Akiyoshi T","year":"2011","unstructured":"Akiyoshi T, Ueno M, Fukunaga Y, et al.. Incidence of and risk factors for anastomotic leakage after laparoscopic anterior resection with intracorporeal rectal transection and double-stapling technique anastomosis for rectal cancer. Am J Surg. 2011, 202:259-64. 10.1016\/j.amjsurg.2010.11.014","journal-title":"Am J Surg"},{"key":"ref67","article-title":"Anastomotic leakage after anterior resection for rectal cancer with mesorectal excision: incidence, risk factors, and management","volume":"81","author":"Tortorelli AP","year":"2015","unstructured":"Tortorelli AP, Alfieri S, Sanchez AM, et al.. Anastomotic leakage after anterior resection for rectal cancer with mesorectal excision: incidence, risk factors, and management. Am Surg. 2015, 81:41-7.","journal-title":"Am Surg"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2017.07.044","article-title":"Defunctioning stoma- a prognosticator for leaks in low rectal restorative cancer resection: A retrospective analysis of stoma database","volume":"21","author":"Abudeeb H","year":"2017","unstructured":"Abudeeb H, Hammad A, Ugwu A, et al.. Defunctioning stoma- a prognosticator for leaks in low rectal restorative cancer resection: A retrospective analysis of stoma database. Ann Med Surg (Lond). 2017, 21:114-7. 10.1016\/j.amsu.2017.07.044","journal-title":"Ann Med Surg (Lond)"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.10.017","article-title":"Effects of a diverting stoma on symptomatic anastomotic leakage after low anterior resection for rectal cancer: a propensity score matching analysis of 1,014 consecutive patients","volume":"220","author":"Shiomi A","year":"2015","unstructured":"Shiomi A, Ito M, Maeda K, et al.. Effects of a diverting stoma on symptomatic anastomotic leakage after low anterior resection for rectal cancer: a propensity score matching analysis of 1,014 consecutive patients. J Am Coll Surg. 2015, 220:186-94. 10.1016\/j.jamcollsurg.2014.10.017","journal-title":"J Am Coll Surg"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-016-2509-6","article-title":"To drain or not to drain in colorectal anastomosis: a meta-analysis","volume":"31","author":"Zhang HY","year":"2016","unstructured":"Zhang HY, Zhao CL, Xie J, et al.. To drain or not to drain in colorectal anastomosis: a meta-analysis. Int J Colorectal Dis. 2016, 31:951-60. 10.1007\/s00384-016-2509-6","journal-title":"Int J Colorectal Dis"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2008.04535.x","article-title":"Pelvic drainage for anterior resection revisited: use of drains in anastomotic leaks","volume":"78","author":"Tsujinaka S","year":"2008","unstructured":"Tsujinaka S, Kawamura YJ, Konishi F, Maeda T, Mizokami K. Pelvic drainage for anterior resection revisited: use of drains in anastomotic leaks. ANZ J Surg. 2008, 78:461-5. 10.1111\/j.1445-2197.2008.04535.x","journal-title":"ANZ J Surg"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4806","article-title":"Risk factors for anastomotic failure after total mesorectal excision of rectal cancer","volume":"92","author":"Peeters KC","year":"2005","unstructured":"Peeters KC, Tollenaar RA, Marijnen CA, et al.. Risk factors for anastomotic failure after total mesorectal excision of rectal cancer. Br J Surg. 2005, 92:211-6. 10.1002\/bjs.4806","journal-title":"Br J Surg"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12491","article-title":"To drain or not to drain extraperitoneal colorectal anastomosis? A systematic review and meta-analysis","volume":"16","author":"Rondelli F","year":"2014","unstructured":"Rondelli F, Bugiantella W, Vedovati MC, et al.. To drain or not to drain extraperitoneal colorectal anastomosis? A systematic review and meta-analysis. Colorectal Dis. 2014, 16:O35-42. 10.1111\/codi.12491","journal-title":"Colorectal Dis"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2006.00999.x","article-title":"Drainage or nondrainage in elective colorectal anastomosis: a systematic review and meta-analysis","volume":"8","author":"Karliczek A","year":"2006","unstructured":"Karliczek A, Jesus EC, Matos D, Castro AA, Atallah AN, Wiggers T. Drainage or nondrainage in elective colorectal anastomosis: a systematic review and meta-analysis. Colorectal Dis. 2006, 8:259-65. 10.1111\/j.1463-1318.2006.00999.x","journal-title":"Colorectal Dis"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001991","article-title":"To drain or not to drain infraperitoneal anastomosis after rectal excision for cancer: the GRECCAR 5 randomized trial","volume":"265","author":"Denost Q","year":"2017","unstructured":"Denost Q, Rouanet P, Faucheron JL, et al.. To drain or not to drain infraperitoneal anastomosis after rectal excision for cancer: the GRECCAR 5 randomized trial. Ann Surg. 2017, 265:474-80. 10.1097\/SLA.0000000000001991","journal-title":"Ann Surg"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-013-2227-0","article-title":"Do we really know why colorectal anastomoses leak?","volume":"17","author":"Shogan BD","year":"2013","unstructured":"Shogan BD, Carlisle EM, Alverdy JC, Umanskiy K. Do we really know why colorectal anastomoses leak?. J Gastrointest Surg. 2013, 17:1698-707. 10.1007\/s11605-013-2227-0","journal-title":"J Gastrointest Surg"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195505000-00016","article-title":"Antibiotic protection of colon anastomoses","volume":"141","author":"Cohn IJ","year":"1955","unstructured":"Cohn IJ, Rives JD. Antibiotic protection of colon anastomoses. Ann Surg. 1955, 141:707-17. 10.1097\/00000658-195505000-00016","journal-title":"Ann Surg"},{"key":"ref78","article-title":"Healing of ischemic colonic anastomoses in the rat: role of antibiotic preparation","volume":"97","author":"Cohen SR","year":"1985","unstructured":"Cohen SR, Cornell CN, Collins MH, Sell JE, Blanc WA, Altman RP. Healing of ischemic colonic anastomoses in the rat: role of antibiotic preparation. Surgery. 1985, 97:443-6.","journal-title":"Surgery"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010658","article-title":"Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak","volume":"7","author":"Shogan BD","year":"2015","unstructured":"Shogan BD, Belogortseva N, Luong PM, et al.. Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak. Sci Transl Med. 2015, 7:286ra68. 10.1126\/scitranslmed.3010658","journal-title":"Sci Transl Med"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2013.114","article-title":"Proceedings of the first international summit on intestinal anastomotic leak, Chicago, Illinois, October 4-5, 2012","volume":"15","author":"Shogan BD","year":"2014","unstructured":"Shogan BD, An GC, Schardey HM, et al.. Proceedings of the first international summit on intestinal anastomotic leak, Chicago, Illinois, October 4-5, 2012. Surg Infect (Larchmt). 2014, 15:479-89. 10.1089\/sur.2013.114","journal-title":"Surg Infect (Larchmt)"},{"key":"ref81","article-title":"Anastomotic leak after colorectal cancer surgery - risk factors in 21th century","volume":"25","author":"Jasarovic D","year":"2020","unstructured":"Jasarovic D, Stojanovic D, Mitrovic N, Stevanovic D. Anastomotic leak after colorectal cancer surgery - risk factors in 21th century. J BUON. 2020, 25:2199-204.","journal-title":"J BUON"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-019-0474-1","article-title":"The effect of diets delivered into the gastrointestinal tract on gut motility after colorectal surgery-a systematic review and meta-analysis of randomised controlled trials","volume":"73","author":"Hogan S","year":"2019","unstructured":"Hogan S, Steffens D, Rangan A, Solomon M, Carey S. The effect of diets delivered into the gastrointestinal tract on gut motility after colorectal surgery-a systematic review and meta-analysis of randomised controlled trials. Eur J Clin Nutr. 2019, 73:1331-42. 10.1038\/s41430-019-0474-1","journal-title":"Eur J Clin Nutr"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1590\/s1807-59322011001200001","article-title":"A randomized controlled trial evaluating early versus traditional oral feeding after colorectal surgery","volume":"66","author":"Dag A","year":"2011","unstructured":"Dag A, Colak T, Turkmenoglu O, Gundogdu R, Aydin S. A randomized controlled trial evaluating early versus traditional oral feeding after colorectal surgery. Clinics (Sao Paulo). 2011, 66:2001-5. 10.1590\/s1807-59322011001200001","journal-title":"Clinics (Sao Paulo)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/111135-factors-contributing-to-anastomotic-leakage-following-colorectal-surgery-why-when-and-who-leaks","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:40:30Z","timestamp":1707507630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/111135-factors-contributing-to-anastomotic-leakage-following-colorectal-surgery-why-when-and-who-leaks"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,5]]},"references-count":83,"URL":"https:\/\/doi.org\/10.7759\/cureus.29964","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,5]]}}}