{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:31:49Z","timestamp":1788888709094,"version":"build-2803163510"},"reference-count":246,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,27]]},"DOI":"10.7759\/cureus.30770","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T16:34:08Z","timestamp":1666888448000},"source":"Crossref","is-referenced-by-count":13,"title":["Obesity: A Doorway to a Molecular Path Leading to Infertility"],"prefix":"10.7759","author":[{"given":"Rahnuma","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mainul","family":"Haque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"Obesity and Overweight. (2022). Accessed. May 17, 2022: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0893","article-title":"European Society of Endocrinology Clinical Practice Guideline: endocrine work-up in obesity","volume":"182","author":"Pasqual R","year":"2020","unstructured":"Pasqual R, Casanueva F, Haluzik M, et al.. European Society of Endocrinology Clinical Practice Guideline: endocrine work-up in obesity. Eur J Endocrinol. 2020, 182:1-32. 10.1530\/EJE-19-0893","journal-title":"Eur J Endocrinol"},{"key":"ref3","article-title":"Obesity","author":"Panuganti KK","year":"2022","unstructured":"Panuganti KK, Nguyen M, Kshirsagar RK. Obesity. StatPearls, Treasure Island; 2022."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1919-y","article-title":"Why primary obesity is a disease?","volume":"17","author":"De Lorenzo A","year":"2019","unstructured":"De Lorenzo A, Gratteri S, Gualtieri P, Cammarano A, Bertucci P, Di Renzo L. Why primary obesity is a disease?. J Transl Med. 2019, 17:169. 10.1186\/s12967-019-1919-y","journal-title":"J Transl Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.02.022","article-title":"Obesity and cancer: existing and new hypotheses for a causal connection","volume":"30","author":"Stone TW","year":"2018","unstructured":"Stone TW, McPherson M, Gail Darlington L. Obesity and cancer: existing and new hypotheses for a causal connection. EBioMedicine. 2018, 30:14-28. 10.1016\/j.ebiom.2018.02.022","journal-title":"EBioMedicine"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.747822","article-title":"The contribution of physiological and accelerated aging to cancer progression through senescence-induced inflammation","volume":"11","author":"Morales-Valencia J","year":"2021","unstructured":"Morales-Valencia J, David G. The contribution of physiological and accelerated aging to cancer progression through senescence-induced inflammation. Front Oncol. 2021, 11:747822. 10.3389\/fonc.2021.747822","journal-title":"Front Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-022-01311-2","article-title":"Do cancer and cancer treatments accelerate aging?","volume":"24","author":"Bhatia R","year":"2022","unstructured":"Bhatia R, Holtan S, Jurdi NE, Prizment A, Blaes A. Do cancer and cancer treatments accelerate aging?. Curr Oncol Rep. 2022, 24:1401-12. 10.1007\/s11912-022-01311-2","journal-title":"Curr Oncol Rep"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22378","article-title":"Obesity as a disease: the Obesity Society 2018 position statement","volume":"27","author":"Jastreboff AM","year":"2019","unstructured":"Jastreboff AM, Kotz CM, Kahan S, Kelly AS, Heymsfield SB. Obesity as a disease: the Obesity Society 2018 position statement. Obesity (Silver Spring). 2019, 27:7-9. 10.1002\/oby.22378","journal-title":"Obesity (Silver Spring)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11120840","article-title":"Molecular mechanisms underlying the relationship between obesity and male infertility","volume":"11","author":"Barbagallo F","year":"2021","unstructured":"Barbagallo F, Condorelli RA, Mongio\u00ec LM, et al.. Molecular mechanisms underlying the relationship between obesity and male infertility. Metabolites. 2021, 11:10.3390\/metabo11120840","journal-title":"Metabolites"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2020","article-title":"Impact of body mass index and metabolic syndrome on sperm DNA fragmentation in males from infertile couples: a cross-sectional study from Vietnam","volume":"7","author":"Le MT","year":"2020","unstructured":"Le MT, Nguyen DN, Le DD, Tran NQ. Impact of body mass index and metabolic syndrome on sperm DNA fragmentation in males from infertile couples: a cross-sectional study from Vietnam. Metabol Open. 2020, 7:100054. 10.1016\/j.metop.2020","journal-title":"Metabol Open"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/and.13625","article-title":"Diagnostic value of advanced semen analysis in evaluation of male infertility","volume":"53","author":"Barb\u0103ro\u0219ie C","year":"2021","unstructured":"Barb\u0103ro\u0219ie C, Agarwal A, Henkel R. Diagnostic value of advanced semen analysis in evaluation of male infertility. Andrologia. 2021, 53:13625. 10.1111\/and.13625","journal-title":"Andrologia"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000549","article-title":"Impact of obesity on male and female reproductive outcomes","volume":"31","author":"Glenn T","year":"2019","unstructured":"Glenn T, Harris AL, Lindheim SR. Impact of obesity on male and female reproductive outcomes. Curr Opin Obstet Gynecol. 2019, 31:201-206. 10.1097\/GCO.0000000000000549","journal-title":"Curr Opin Obstet Gynecol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181da8f09","article-title":"Extreme obesity in pregnancy in the United Kingdom","volume":"115","author":"Knight M","year":"2010","unstructured":"Knight M, Kurinczuk JJ, Spark P, Brocklehurst P; UK Obstetric Surveillance System. Extreme obesity in pregnancy in the United Kingdom. Obstet Gynecol. 2010, 115:989-997. 10.1097\/AOG.0b013e3181da8f09","journal-title":"Obstet Gynecol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2015.07.012","article-title":"Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis","volume":"31","author":"Campbell JM","year":"2015","unstructured":"Campbell JM, Lane M, Owens JA, Bakos HW. Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis. Reprod Biomed Online. 2015, 31:593-604. 10.1016\/j.rbmo.2015.07.012","journal-title":"Reprod Biomed Online"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det428","article-title":"The relationship between male BMI and waist circumference on semen quality: data from the LIFE study","volume":"29","author":"Eisenberg ML","year":"2014","unstructured":"Eisenberg ML, Kim S, Chen Z, Sundaram R, Schisterman EF, Buck Louis GM. The relationship between male BMI and waist circumference on semen quality: data from the LIFE study. Hum Reprod. 2014, 29:193-200. 10.1093\/humrep\/det428","journal-title":"Hum Reprod"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/and.12461","article-title":"Effect of male body mass index on clinical outcomes following assisted reproductive technology: a meta-analysis","volume":"48","author":"Le W","year":"2016","unstructured":"Le W, Su SH, Shi LH, Zhang JF, Wu DL. Effect of male body mass index on clinical outcomes following assisted reproductive technology: a meta-analysis. Andrologia. 2016, 48:406-24. 10.1111\/and.12461","journal-title":"Andrologia"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.01.002","article-title":"Effect of male body mass index on assisted reproduction treatment outcome: an updated systematic review and meta-analysis","volume":"36","author":"Mushtaq R","year":"2018","unstructured":"Mushtaq R, Pundir J, Achilli C, Naji O, Khalaf Y, El-Toukhy T. Effect of male body mass index on assisted reproduction treatment outcome: an updated systematic review and meta-analysis. Reprod Biomed Online. 2018, 36:459-471. 10.1016\/j.rbmo.2018.01.002","journal-title":"Reprod Biomed Online"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4161\/spmg.21362","article-title":"Impact of obesity on male fertility, sperm function and molecular composition. Spermatogenesis","volume":"2","author":"Palmer NO","year":"2012","unstructured":"Palmer NO, Bakos HW, Fullston T, Lane M. Impact of obesity on male fertility, sperm function and molecular composition. Spermatogenesis. 2012, 2:253-263. 10.4161\/spmg.21362"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12536-4","article-title":"Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis","volume":"10","author":"Gallagher CS","year":"2019","unstructured":"Gallagher CS, M\u00e4kinen N, Harris HR, et al.. Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis. Nat Commun. 2019, 10:4857. 10.1038\/s41467-019-12536-4","journal-title":"Nat Commun"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.11.001","article-title":"Association of body mass index with severity of endometriosis in Korean women","volume":"105","author":"Yi KW","year":"2009","unstructured":"Yi KW, Shin JH, Park MS, Kim T, Kim SH, Hur JY. Association of body mass index with severity of endometriosis in Korean women. Int J Gynaecol Obstet. 2009, 105:39-42. 10.1016\/j.ijgo.2008.11.001","journal-title":"Int J Gynaecol Obstet"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.641","article-title":"Obesity and menstrual irregularity: associations with SHBG, testosterone, and insulin","volume":"17","author":"Wei S","year":"2009","unstructured":"Wei S, Schmidt MD, Dwyer T, Norman RJ, Venn AJ. Obesity and menstrual irregularity: associations with SHBG, testosterone, and insulin. Obesity (Silver Spring. 2009, 17:1070-6. 10.1038\/oby.2008.641","journal-title":"Obesity (Silver Spring"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.002","article-title":"Characteristics of obesity in polycystic ovary syndrome: etiology, treatment, and genetics","volume":"92","author":"Glueck CJ","year":"2019","unstructured":"Glueck CJ, Goldenberg N. Characteristics of obesity in polycystic ovary syndrome: etiology, treatment, and genetics. Metabolism. 2019, 92:108-20. 10.1016\/j.metabol.2018.11.002","journal-title":"Metabolism"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00440.2016","article-title":"Metabolic abnormalities and obesity's impact on the risk for developing preeclampsia","volume":"312","author":"Spradley FT","year":"2017","unstructured":"Spradley FT. Metabolic abnormalities and obesity's impact on the risk for developing preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2017, 312:5-12. 10.1152\/ajpregu.00440.2016","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S349874","article-title":"Association between body mass index and female infertility in the United States: data from National Health and Nutrition Examination Survey 2013-2018","volume":"15","author":"Zhu L","year":"2022","unstructured":"Zhu L, Zhou B, Zhu X, et al.. Association between body mass index and female infertility in the United States: data from National Health and Nutrition Examination Survey 2013-2018. Int J Gen Med. 2022, 15:1821-31. 10.2147\/IJGM.S349874","journal-title":"Int J Gen Med"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.03.021","article-title":"Body mass index and risk of miscarriage in women with recurrent miscarriage","volume":"94","author":"Metwally M","year":"2010","unstructured":"Metwally M, Saravelos SH, Ledger WL, Li TC. Body mass index and risk of miscarriage in women with recurrent miscarriage. Fertil Steril. 2010, 94:290-5. 10.1016\/j.fertnstert.2009.03.021","journal-title":"Fertil Steril"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00878-y","article-title":"Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation","volume":"20","author":"Dumesic DA","year":"2022","unstructured":"Dumesic DA, Padmanabhan V, Chazenbalk GD, Abbott DH. Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation. Reprod Biol Endocrinol. 2022, 20:12. 10.1186\/s12958-021-00878-y","journal-title":"Reprod Biol Endocrinol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh277","article-title":"Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study","volume":"19","author":"Lashen H","year":"2004","unstructured":"Lashen H, Fear K, Sturdee DW. Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study. Hum Reprod. 2004, 19:1644-6. 10.1093\/humrep\/deh277","journal-title":"Hum Reprod"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7575","article-title":"A case-control study of the relationship between visceral fat and development of uterine fibroids","volume":"18","author":"Sun K","year":"2019","unstructured":"Sun K, Xie Y, Zhao N, Li Z. A case-control study of the relationship between visceral fat and development of uterine fibroids. Exp Ther Med. 2019, 18:404-10. 10.3892\/etm.2019.7575","journal-title":"Exp Ther Med"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.5152\/jtgga.2015.15232","article-title":"Impact of obesity on infertility in women","volume":"16","author":"Da\u011f Z\u00d6","year":"2015","unstructured":"Da\u011f Z\u00d6, Dilbaz B. Impact of obesity on infertility in women. J Turk Ger Gynecol Assoc. 2015, 16:111-7. 10.5152\/jtgga.2015.15232","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/and.13617","article-title":"Obesity and male infertility: mechanisms and management","volume":"53","author":"Leisegang K","year":"2021","unstructured":"Leisegang K, Sengupta P, Agarwal A, Henkel R. Obesity and male infertility: mechanisms and management. Andrologia. 2021, 53:e13617. 10.1111\/and.13617","journal-title":"Andrologia"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020973","article-title":"Obesity and male reproduction: do sirtuins play a role?","volume":"23","author":"Barbagallo F","year":"2022","unstructured":"Barbagallo F, La Vignera S, Cannarella R, et al.. Obesity and male reproduction: do sirtuins play a role?. Int J Mol Sci. 2022, 23:10.3390\/ijms23020973","journal-title":"Int J Mol Sci"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.09.026","article-title":"Ovarian function and obesity--interrelationship, impact on women's reproductive lifespan and treatment options","volume":"316","author":"Racho\u0144 D","year":"2010","unstructured":"Racho\u0144 D, Teede H. Ovarian function and obesity--interrelationship, impact on women's reproductive lifespan and treatment options. Mol Cell Endocrinol. 2010, 316:172-9. 10.1016\/j.mce.2009.09.026","journal-title":"Mol Cell Endocrinol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.043","article-title":"Current knowledge of obesity's effects in the pre-and periconceptional periods and avenues for future research","volume":"203","author":"Jungheim ES","year":"2010","unstructured":"Jungheim ES, Moley KH. Current knowledge of obesity's effects in the pre-and periconceptional periods and avenues for future research. Am J Obstet Gynecol. 2010, 203:525-30. 10.1016\/j.ajog.2010.06.043","journal-title":"Am J Obstet Gynecol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.12.003","article-title":"Metabolic risk in PCOS: phenotype and adiposity impact","volume":"26","author":"Moran LJ","year":"2015","unstructured":"Moran LJ, Norman RJ, Teede HJ. Metabolic risk in PCOS: phenotype and adiposity impact. Trends Endocrinol Metab. 2015, 26:136-43. 10.1016\/j.tem.2014.12.003","journal-title":"Trends Endocrinol Metab"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2011.12.004","article-title":"Surgical management of metabolic dysfunction in PCOS","volume":"77","author":"Escobar-Morreale HF","year":"2012","unstructured":"Escobar-Morreale HF. Surgical management of metabolic dysfunction in PCOS. Steroids. 2012, 77:312-6. 10.1016\/j.steroids.2011.12.004","journal-title":"Steroids"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep360","article-title":"An internet-based prospective study of body size and time-to-pregnancy","volume":"25","author":"Wise LA","year":"2010","unstructured":"Wise LA, Rothman KJ, Mikkelsen EM, S\u00f8rensen HT, Riis A, Hatch EE. An internet-based prospective study of body size and time-to-pregnancy. Hum Reprod. 2010, 25:253-64. 10.1093\/humrep\/dep360","journal-title":"Hum Reprod"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem035","article-title":"Subfecundity in overweight and obese couples","volume":"22","author":"Ramlau-Hansen CH","year":"2007","unstructured":"Ramlau-Hansen CH, Thulstrup AM, Nohr EA, Bonde JP, S\u00f8rensen TI, Olsen J. Subfecundity in overweight and obese couples. Hum Reprod. 2007, 22:1634-7. 10.1093\/humrep\/dem035","journal-title":"Hum Reprod"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem371","article-title":"Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women","volume":"23","author":"van der Steeg JW","year":"2008","unstructured":"van der Steeg JW, Steures P, Eijkemans MJ, et al.. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum Reprod. 2008, 23:324-8. 10.1093\/humrep\/dem371","journal-title":"Hum Reprod"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del400","article-title":"Obesity and time to pregnancy","volume":"22","author":"Gesink Law DC","year":"2007","unstructured":"Gesink Law DC, Maclehose RF, Longnecker MP. Obesity and time to pregnancy. Hum Reprod. 2007, 22:414-20. 10.1093\/humrep\/del400","journal-title":"Hum Reprod"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62975-z","article-title":"Metabolomic alternations of follicular fluid of obese women undergoing in-vitro fertilization treatment","volume":"10","author":"Song J","year":"2020","unstructured":"Song J, Xiang S, Pang C, Guo J, Sun Z. Metabolomic alternations of follicular fluid of obese women undergoing in-vitro fertilization treatment. Sci Rep. 2020, 10:5968. 10.1038\/s41598-020-62975-z","journal-title":"Sci Rep"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.735783","article-title":"The combined impact of female and male body mass index on cumulative pregnancy outcomes after the first ovarian stimulation","volume":"12","author":"Zhao Z","year":"2021","unstructured":"Zhao Z, Jiang X, Li J, et al.. The combined impact of female and male body mass index on cumulative pregnancy outcomes after the first ovarian stimulation. Front Endocrinol (Lausanne). 2021, 12:735783. 10.3389\/fendo.2021.735783","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00809-x","article-title":"Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis","volume":"19","author":"Yang J","year":"2021","unstructured":"Yang J, He Y, Wu Y, Zhang D, Huang H. Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2021, 19:140. 10.1186\/s12958-021-00809-x","journal-title":"Reprod Biol Endocrinol"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00149","article-title":"Cumulative live birth rates according to maternal body mass index after first ovarian stimulation for in vitro fertilization: a single center analysis of 14,782 patients","volume":"11","author":"Xue X","year":"2020","unstructured":"Xue X, Shi W, Zhou H, Tian L, Zhao Z, Zhou D, Shi J. Cumulative live birth rates according to maternal body mass index after first ovarian stimulation for in vitro fertilization: a single center analysis of 14,782 patients. Front Endocrinol (Lausanne. 2020, 11:149. 10.3389\/fendo.2020.00149","journal-title":"Front Endocrinol (Lausanne"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq306","article-title":"Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates","volume":"26","author":"Luke B","year":"2011","unstructured":"Luke B, Brown MB, Stern JE, Missmer SA, Fujimoto VY, Leach R. SART Writing Group: Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates. Hum Reprod. 2011, 26:245-52. 10.1093\/humrep\/deq306","journal-title":"Hum Reprod"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.22074\/ijfs.2019.5433","article-title":"The effects of maternal and paternal body mass index on live birth rate after intracytoplasmic sperm injection cycles","volume":"13","author":"Arabipoor A","year":"2019","unstructured":"Arabipoor A, Ashrafi M, Hemat M, Zolfaghari Z. The effects of maternal and paternal body mass index on live birth rate after intracytoplasmic sperm injection cycles. Int J Fertil Steril. 2019, 13:24-31. 10.22074\/ijfs.2019.5433","journal-title":"Int J Fertil Steril"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der416","article-title":"Complications and outcome of assisted reproduction technologies in overweight and obese women","volume":"27","author":"Koning AM","year":"2012","unstructured":"Koning AM, Mutsaerts MA, Kuchenbecker WK, Broekmans FJ, Land JA, Mol BW, Hoek A. Complications and outcome of assisted reproduction technologies in overweight and obese women. Hum Reprod. 2012, 27:457-67. 10.1093\/humrep\/der416","journal-title":"Hum Reprod"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.08.012","article-title":"The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review","volume":"62","author":"Michalakis K","year":"2013","unstructured":"Michalakis K, Mintziori G, Kaprara A, Tarlatzis BC, Goulis DG. The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review. Metabolism. 2013, 62:457-78. 10.1016\/j.metabol.2012.08.012","journal-title":"Metabolism"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms004","article-title":"Balancing ovulation and anovulation: integration of the reproductive and energy balance axes by neuropeptides","volume":"18","author":"Evans JJ","year":"2012","unstructured":"Evans JJ, Anderson GM. Balancing ovulation and anovulation: integration of the reproductive and energy balance axes by neuropeptides. Hum Reprod Update. 2012, 18:313-32. 10.1093\/humupd\/dms004","journal-title":"Hum Reprod Update"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1415","article-title":"Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system","volume":"152","author":"Castellano JM","year":"2011","unstructured":"Castellano JM, Bentsen AH, S\u00e1nchez-Garrido MA, et al.. Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system. Endocrinology. 2011, 152:3396-408. 10.1210\/en.2010-1415","journal-title":"Endocrinology"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/s41367-019-0009-1","article-title":"Female infertility: which role for obesity?","volume":"9","author":"Gambineri A","year":"2019","unstructured":"Gambineri A, Laudisio D, Marocco C, Radellini S, Colao A, Savastano S. Female infertility: which role for obesity?. Int J Obes Suppl. 2019, 9:65-72. 10.1038\/s41367-019-0009-1","journal-title":"Int J Obes Suppl"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S275898","article-title":"Obesity, insulin resistance, and type 2 diabetes: associations and therapeutic implications","volume":"13","author":"Wondmkun YT","year":"2020","unstructured":"Wondmkun YT. Obesity, insulin resistance, and type 2 diabetes: associations and therapeutic implications. Diabetes Metab Syndr Obes. 2020, 13:3611-6. 10.2147\/DMSO.S275898","journal-title":"Diabetes Metab Syndr Obes"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5487.2122","article-title":"Role of brain insulin receptor in control of body weight and reproduction","volume":"289","author":"Br\u00fcning JC","year":"2000","unstructured":"Br\u00fcning JC, Gautam D, Burks DJ, et al.. Role of brain insulin receptor in control of body weight and reproduction. Science. 2000, 289:2122-5. 10.1126\/science.289.5487.2122","journal-title":"Science"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.08.088","article-title":"Evidence that obesity and androgens have independent and opposing effects on gonadotropin production from puberty to maturity","volume":"1364","author":"Rosenfield RL","year":"2010","unstructured":"Rosenfield RL, Bordini B. Evidence that obesity and androgens have independent and opposing effects on gonadotropin production from puberty to maturity. Brain Res. 2010, 1364:186-97. 10.1016\/j.brainres.2010.08.088","journal-title":"Brain Res"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1727","article-title":"Decreasing insulin sensitivity in women induces alterations in LH pulsatility","volume":"101","author":"van Leckwyck M","year":"2016","unstructured":"van Leckwyck M, Kong W, Burton KJ, Amati F, Vionnet N, Pralong FP. Decreasing insulin sensitivity in women induces alterations in LH pulsatility. J Clin Endocrinol Metab. 2016, 101:3240-9. 10.1210\/jc.2016-1727","journal-title":"J Clin Endocrinol Metab"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2274","article-title":"Pulsatile luteinizing hormone amplitude and progesterone metabolite excretion are reduced in obese women","volume":"92","author":"Jain A","year":"2007","unstructured":"Jain A, Polotsky AJ, Rochester D, et al.. Pulsatile luteinizing hormone amplitude and progesterone metabolite excretion are reduced in obese women. J Clin Endocrinol Metab. 2007, 92:2468-73. 10.1210\/jc.2006-2274","journal-title":"J Clin Endocrinol Metab"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0366-6","article-title":"Role of hormonal and inflammatory alterations in obesity-related reproductive dysfunction at the level of the hypothalamic-pituitary-ovarian axis","volume":"16","author":"Goldsammler M","year":"2018","unstructured":"Goldsammler M, Merhi Z, Buyuk E. Role of hormonal and inflammatory alterations in obesity-related reproductive dysfunction at the level of the hypothalamic-pituitary-ovarian axis. Reprod Biol Endocrinol. 2018, 16:45. 10.1186\/s12958-018-0366-6","journal-title":"Reprod Biol Endocrinol"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1100","article-title":"Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice","volume":"152","author":"Quennell JH","year":"2011","unstructured":"Quennell JH, Howell CS, Roa J, Augustine RA, Grattan DR, Anderson GM. Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology. 2011, 152:1541-50. 10.1210\/en.2010-1100","journal-title":"Endocrinology"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1693","article-title":"Leptin indirectly regulates gonadotropin-releasing hormone neuronal function","volume":"150","author":"Quennell JH","year":"2009","unstructured":"Quennell JH, Mulligan AC, Tups A, et al.. Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology. 2009, 150:2805-12. 10.1210\/en.2008-1693","journal-title":"Endocrinology"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.10.013","article-title":"Roles of leptin in reproduction, pregnancy and polycystic ovary syndrome: consensus knowledge and recent developments","volume":"64","author":"V\u00e1zquez MJ","year":"2015","unstructured":"V\u00e1zquez MJ, Romero-Ruiz A, Tena-Sempere M. Roles of leptin in reproduction, pregnancy and polycystic ovary syndrome: consensus knowledge and recent developments. Metabolism. 2015, 64:79-91. 10.1016\/j.metabol.2014.10.013","journal-title":"Metabolism"},{"key":"ref60","article-title":"Leptin and female reproductive health","author":"Jaiswar SP","year":"2022","unstructured":"Jaiswar SP, Priyadarshini A. Leptin and female reproductive health. Weight Management - Challenges and Opportunities. Heshmati HM (ed): IntechOpen, London; 2022."},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6524","article-title":"Relationship of serum leptin and reproductive hormones in unexplained infertile and fertile females","volume":"11","author":"Baig M","year":"2019","unstructured":"Baig M, Azhar A, Rehman R, Syed H, Tariq S, Gazzaz ZJ. Relationship of serum leptin and reproductive hormones in unexplained infertile and fertile females. Cureus. 2019, 11:e6524. 10.7759\/cureus.6524","journal-title":"Cureus"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.585887","article-title":"Leptin and obesity: role and clinical implication","volume":"12","author":"Obradovic M","year":"2021","unstructured":"Obradovic M, Sudar-Milovanovic E, Soskic S, et al.. Leptin and obesity: role and clinical implication. Front Endocrinol (Lausanne). 2021, 12:585887. 10.3389\/fendo.2021.585887","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.069","article-title":"Leptin in leanness and obesity: JACC State-of-the-Art Review","volume":"77","author":"Perakakis N","year":"2021","unstructured":"Perakakis N, Farr OM, Mantzoros CS. Leptin in leanness and obesity: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021, 77:745-60. 10.1016\/j.jacc.2020.11.069","journal-title":"J Am Coll Cardiol"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(01)03010-2","article-title":"Leptin and reproduction: a review","volume":"77","author":"Moschos S","year":"2002","unstructured":"Moschos S, Chan JL, Mantzoros CS. Leptin and reproduction: a review. Fertil Steril. 2002, 77:433-44. 10.1016\/s0015-0282(01)03010-2","journal-title":"Fertil Steril"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.01.017","article-title":"Obesity and female infertility: potential mediators of obesity's impact","volume":"107","author":"Broughton DE","year":"2017","unstructured":"Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesity's impact. Fertil Steril. 2017, 107:840-7. 10.1016\/j.fertnstert.2017.01.017","journal-title":"Fertil Steril"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176039","article-title":"There and back again: leptin actions in white adipose tissue","volume":"21","author":"Mart\u00ednez-S\u00e1nchez N","year":"2020","unstructured":"Mart\u00ednez-S\u00e1nchez N. There and back again: leptin actions in white adipose tissue. Int J Mol Sci. 2020, 21:10.3390\/ijms21176039","journal-title":"Int J Mol Sci"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv057","article-title":"Leptin and its potential interest in assisted reproduction cycles","volume":"22","author":"Catteau A","year":"2016","unstructured":"Catteau A, Caillon H, Barri\u00e8re P, Denis MG, Masson D, Fr\u00e9our T. Leptin and its potential interest in assisted reproduction cycles. Hum Reprod Update. 2016, 22:320-41. 10.1093\/humupd\/dmv057","journal-title":"Hum Reprod Update"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.9.1819","article-title":"Baseline non-fasting serum leptin concentration to body mass index ratio is predictive of IVF outcomes","volume":"16","author":"Brannian JD","year":"2001","unstructured":"Brannian JD, Schmidt SM, Kreger DO, Hansen KA. Baseline non-fasting serum leptin concentration to body mass index ratio is predictive of IVF outcomes. Hum Reprod. 2001, 16:1819-26. 10.1093\/humrep\/16.9.1819","journal-title":"Hum Reprod"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det072","article-title":"Leptin suppresses anti-Mullerian hormone gene expression through the JAK2\/STAT3 pathway in luteinized granulosa cells of women undergoing IVF","volume":"28","author":"Merhi Z","year":"2013","unstructured":"Merhi Z, Buyuk E, Berger DS, Zapantis A, Israel DD, Chua S Jr, Jindal S. Leptin suppresses anti-Mullerian hormone gene expression through the JAK2\/STAT3 pathway in luteinized granulosa cells of women undergoing IVF. Hum Reprod. 2013, 28:1661-9. 10.1093\/humrep\/det072","journal-title":"Hum Reprod"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084270","article-title":"Revisiting the impact of local leptin signaling in folliculogenesis and oocyte maturation in obese mothers","volume":"22","author":"Wo\u0142odko K","year":"2021","unstructured":"Wo\u0142odko K, Castillo-Fernandez J, Kelsey G, Galv\u00e3o A. Revisiting the impact of local leptin signaling in folliculogenesis and oocyte maturation in obese mothers. Int J Mol Sci. 2021, 22:10.3390\/ijms22084270","journal-title":"Int J Mol Sci"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.845165","article-title":"Elevated serum leptin levels as a predictive marker for polycystic ovary syndrome","volume":"13","author":"Peng Y","year":"2022","unstructured":"Peng Y, Yang H, Song J, et al.. Elevated serum leptin levels as a predictive marker for polycystic ovary syndrome. Front Endocrinol (Lausanne). 2022, 13:845165. 10.3389\/fendo.2022.845165","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-013-9283-3","article-title":"Adiponectin and energy homeostasis","volume":"15","author":"Lee B","year":"2014","unstructured":"Lee B, Shao J. Adiponectin and energy homeostasis. Rev Endocr Metab Disord. 2014, 15:149-56. 10.1007\/s11154-013-9283-3","journal-title":"Rev Endocr Metab Disord"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401534","article-title":"Adiponectin: regulation of its production and its role in human diseases","volume":"11","author":"Shehzad A","year":"2012","unstructured":"Shehzad A, Iqbal W, Shehzad O, Lee YS. Adiponectin: regulation of its production and its role in human diseases. Hormones (Athens). 2012, 11:8-20. 10.1007\/BF03401534","journal-title":"Hormones (Athens)"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon. 2021.e07851","article-title":"Adiponectin gene polymorphisms associated with diabetes mellitus: a descriptive review","volume":"7","author":"Howlader M","year":"2021","unstructured":"Howlader M, Sultana MI, Akter F, Hossain MM. Adiponectin gene polymorphisms associated with diabetes mellitus: a descriptive review. Heliyon. 2021, 7:07851. 10.1016\/j.heliyon. 2021.e07851","journal-title":"Heliyon"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0336","article-title":"Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up","volume":"151","author":"Thaler JP","year":"2010","unstructured":"Thaler JP, Schwartz MW. Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology. 2010, 151:4109-15. 10.1210\/en.2010-0336","journal-title":"Endocrinology"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.695623","article-title":"Neuropeptide y and metabolism syndrome: an update on perspectives of clinical therapeutic intervention strategies","volume":"9","author":"Huang Y","year":"2021","unstructured":"Huang Y, Lin X, Lin S. Neuropeptide y and metabolism syndrome: an update on perspectives of clinical therapeutic intervention strategies. Front Cell Dev Biol. 2021, 9:695623. 10.3389\/fcell.2021.695623","journal-title":"Front Cell Dev Biol"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1530\/REP-06-0244","article-title":"Regulation of adiponectin and its receptors in rat ovary by human chorionic gonadotrophin treatment and potential involvement of adiponectin in granulosa cell steroidogenesis","volume":"133","author":"Chabrolle C","year":"2007","unstructured":"Chabrolle C, Tosca L, Dupont J. Regulation of adiponectin and its receptors in rat ovary by human chorionic gonadotrophin treatment and potential involvement of adiponectin in granulosa cell steroidogenesis. Reproduction. 2007, 133:719-31. 10.1530\/REP-06-0244","journal-title":"Reproduction"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041219","article-title":"Multifaceted physiological roles of adiponectin in inflammation and diseases","volume":"21","author":"Choi HM","year":"2020","unstructured":"Choi HM, Doss HM, Kim KS. Multifaceted physiological roles of adiponectin in inflammation and diseases. Int J Mol Sci. 2020, 21:10.3390\/ijms21041219","journal-title":"Int J Mol Sci"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0679","article-title":"Adiponectin induces periovulatory changes in ovarian follicular cells","volume":"147","author":"Ledoux S","year":"2006","unstructured":"Ledoux S, Campos DB, Lopes FL, Dobias-Goff M, Palin MF, Murphy BD. Adiponectin induces periovulatory changes in ovarian follicular cells. Endocrinology. 2006, 147:5178-86. 10.1210\/en.2006-0679","journal-title":"Endocrinology"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-2080","article-title":"Adiponectin deficiency leads to female subfertility and ovarian dysfunctions in mice","volume":"157","author":"Cheng L","year":"2016","unstructured":"Cheng L, Shi H, Jin Y, et al.. Adiponectin deficiency leads to female subfertility and ovarian dysfunctions in mice. Endocrinology. 2016, 157:4875-87. 10.1210\/en.2015-2080","journal-title":"Endocrinology"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.3892\/br.2019.1213","article-title":"Role of adiponectin in ovarian follicular development and ovarian reserve","volume":"1","author":"Merhi Z","year":"2019","unstructured":"Merhi Z, Bazzi AA, Bonney EA, Buyuk E. Role of adiponectin in ovarian follicular development and ovarian reserve. Biomed Rep. 2019, 1:1-5. 10.3892\/br.2019.1213","journal-title":"Biomed Rep"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0336-z","article-title":"Obesity as disruptor of the female fertility","volume":"16","author":"Silvestris E","year":"2018","unstructured":"Silvestris E, de Pergola G, Rosania R, Loverro G. Obesity as disruptor of the female fertility. Reprod Biol Endocrinol. 2018, 16:22. 10.1186\/s12958-018-0336-z","journal-title":"Reprod Biol Endocrinol"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2011.03.005","article-title":"Human resistin: found in translation from mouse to man","volume":"22","author":"Schwartz DR","year":"2011","unstructured":"Schwartz DR, Lazar MA. Human resistin: found in translation from mouse to man. Trends Endocrinol Metab. 2011, 22:259-65. 10.1016\/j.tem.2011.03.005","journal-title":"Trends Endocrinol Metab"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2011.01.005","article-title":"Effect of resistin on granulosa and theca cell function in cattle","volume":"124","author":"Spicer LJ","year":"2011","unstructured":"Spicer LJ, Schreiber NB, Lagaly DV, Aad PY, Douthit LB, Grado-Ahuir JA. Effect of resistin on granulosa and theca cell function in cattle. Anim Reprod Sci. 2011, 124:19-27. 10.1016\/j.anireprosci.2011.01.005","journal-title":"Anim Reprod Sci"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1126\/science.1097243","article-title":"Visfatin: a protein secreted by visceral fat that mimics the effects of insulin","volume":"307","author":"Fukuhara A","year":"2005","unstructured":"Fukuhara A, Matsuda M, Nishizawa M, et al.. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science. 2005, 307:426-30. 10.1126\/science.1097243","journal-title":"Science"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0936","article-title":"Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: parallel increase in plasma visfatin","volume":"91","author":"Tan BK","year":"2006","unstructured":"Tan BK, Chen J, Digby JE, Keay SD, Kennedy CR, Randeva HS. Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: parallel increase in plasma visfatin. J Clin Endocrinol Metab. 2006, 91:5022-8. 10.1210\/jc.2006-0936","journal-title":"J Clin Endocrinol Metab"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00450","article-title":"The role of growth hormone on ovarian functioning and ovarian angiogenesis","volume":"10","author":"Devesa J","year":"2019","unstructured":"Devesa J, Caicedo D. The role of growth hormone on ovarian functioning and ovarian angiogenesis. Front Endocrinol (Lausanne). 2019, 10:450. 10.3389\/fendo.2019.00450","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.64","article-title":"The GH\/IGF-1 axis in obesity: pathophysiology and therapeutic considerations","volume":"9","author":"Berryman DE","year":"2013","unstructured":"Berryman DE, Glad CA, List EO, Johannsson G. The GH\/IGF-1 axis in obesity: pathophysiology and therapeutic considerations. Nat Rev Endocrinol. 2013, 9:346-56. 10.1038\/nrendo.2013.64","journal-title":"Nat Rev Endocrinol"},{"key":"ref89","article-title":"Normal Physiology of Growth Hormone in Adults","author":"Olarescu NC","year":"2000","unstructured":"Olarescu NC, Gunawardane K, Hansen TK, M\u00f8ller N, J\u00f8rgensen JO. Normal Physiology of Growth Hormone in Adults. Feingold KR, Anawalt B, Boyce A, et al. (ed): Endotext, South Dartmouth; 2000."},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2014.09.002","article-title":"The complex relationship between obesity and the somatropic axis: the long and winding road","volume":"24","author":"Savastano S","year":"2014","unstructured":"Savastano S, Di Somma C, Barrea L, Colao A. The complex relationship between obesity and the somatropic axis: the long and winding road. Growth Horm IGF Res. 2014, 24:221-6. 10.1016\/j.ghir.2014.09.002","journal-title":"Growth Horm IGF Res"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew048","article-title":"Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy","volume":"31","author":"Rhee JS","year":"2016","unstructured":"Rhee JS, Saben JL, Mayer AL, et al.. Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy. Hum Reprod. 2016, 31:1315-26. 10.1093\/humrep\/dew048","journal-title":"Hum Reprod"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-007-9106-0","article-title":"The utility of serum leptin and follicular fluid leptin, estradiol, and progesterone levels during an in vitro fertilization cycle","volume":"24","author":"Hill MJ","year":"2007","unstructured":"Hill MJ, Uyehara CF, Hashiro GM, Frattarelli JL. The utility of serum leptin and follicular fluid leptin, estradiol, and progesterone levels during an in vitro fertilization cycle. J Assist Reprod Genet. 2007, 24:183-8. 10.1007\/s10815-007-9106-0","journal-title":"J Assist Reprod Genet"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv029","article-title":"Pregnancy complications in women with polycystic ovary syndrome","volume":"21","author":"Palomba S","year":"2015","unstructured":"Palomba S, de Wilde MA, Falbo A, Koster MP, La Sala GB, Fauser BC. Pregnancy complications in women with polycystic ovary syndrome. Hum Reprod Update. 2015, 21:575-92. 10.1093\/humupd\/dmv029","journal-title":"Hum Reprod Update"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-75","article-title":"A proteomic analysis of the endometrium in obese and overweight women with recurrent miscarriage: preliminary evidence for an endometrial defect","volume":"12","author":"Metwally M","year":"2014","unstructured":"Metwally M, Preece R, Thomas J, Ledger W, Li TC. A proteomic analysis of the endometrium in obese and overweight women with recurrent miscarriage: preliminary evidence for an endometrial defect. Reprod Biol Endocrinol. 2014, 12:75. 10.1186\/1477-7827-12-75","journal-title":"Reprod Biol Endocrinol"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah088","article-title":"Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migration","volume":"10","author":"Qiu Q","year":"2004","unstructured":"Qiu Q, Yang M, Tsang BK, Gruslin A. Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migration. Mol Hum Reprod. 2004, 10:677-84. 10.1093\/molehr\/gah088","journal-title":"Mol Hum Reprod"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm_00000073","article-title":"Leptin regulates the proliferation and apoptosis of human endometrial epithelial cells","volume":"22","author":"Tanaka T","year":"2008","unstructured":"Tanaka T, Umesaki N. Leptin regulates the proliferation and apoptosis of human endometrial epithelial cells. Int J Mol Med. 2008, 22:683-9. 10.3892\/ijmm_00000073","journal-title":"Int J Mol Med"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32832aee96","article-title":"The impact of body mass index on assisted reproduction","volume":"21","author":"Tamer Erel C","year":"2009","unstructured":"Tamer Erel C, Senturk LM. The impact of body mass index on assisted reproduction. Curr Opin Obstet Gynecol. 2009, 21:228-35. 10.1097\/GCO.0b013e32832aee96","journal-title":"Curr Opin Obstet Gynecol"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000194112.86051.26","article-title":"Recurrent miscarriage: pathophysiology and outcome","volume":"17","author":"Carrington B","year":"2005","unstructured":"Carrington B, Sacks G, Regan L. Recurrent miscarriage: pathophysiology and outcome. Curr Opin Obstet Gynecol. 2005, 17:591-7. 10.1097\/01.gco.0000194112.86051.26","journal-title":"Curr Opin Obstet Gynecol"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14785","article-title":"Female infertility in the era of obesity: the clash of two pandemics or inevitable consequence?","author":"Medenica S","year":"2022","unstructured":"Medenica S, Spoltore ME, Ormazabal P, et al.. Female infertility in the era of obesity: the clash of two pandemics or inevitable consequence?. Clin Endocrinol (Oxf). 2022, 10.1111\/cen.14785","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003679","article-title":"Obesity and risk of female reproductive conditions: a Mendelian randomisation study","volume":"19","author":"Venkatesh SS","year":"2022","unstructured":"Venkatesh SS, Ferreira T, Benonisdottir S, et al.. Obesity and risk of female reproductive conditions: a Mendelian randomisation study. PLoS Med. 2022, 19:e1003679. 10.1371\/journal.pmed.1003679","journal-title":"PLoS Med"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12540","article-title":"Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids","volume":"280","author":"Smith U","year":"2016","unstructured":"Smith U, Kahn BB. Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. J Intern Med. 2016, 280:465-75. 10.1111\/joim.12540","journal-title":"J Intern Med"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1514","article-title":"Obesity-induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell","volume":"63","author":"Wu S","year":"2014","unstructured":"Wu S, Divall S, Nwaopara A, Radovick S, Wondisford F, Ko C, Wolfe A. Obesity-induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell. Diabetes. 2014, 63:1270-82. 10.2337\/db13-1514","journal-title":"Diabetes"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i5.616","article-title":"Role of insulin and insulin resistance in androgen excess disorders","volume":"12","author":"Unluhizarci K","year":"2021","unstructured":"Unluhizarci K, Karaca Z, Kelestimur F. Role of insulin and insulin resistance in androgen excess disorders. World J Diabetes. 2021, 12:616-29. 10.4239\/wjd.v12.i5.616","journal-title":"World J Diabetes"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1159\/000448076","article-title":"The cross-link between adipokines, insulin resistance and obesity in offspring of diabetic pregnancies","volume":"86","author":"Bozkurt L","year":"2016","unstructured":"Bozkurt L, G\u00f6bl CS, Rami-Merhar B, Winhofer Y, Baumgartner-Parzer S, Schober E, Kautzky-Willer A. The cross-link between adipokines, insulin resistance and obesity in offspring of diabetic pregnancies. Horm Res Paediatr. 2016, 86:300-8. 10.1159\/000448076","journal-title":"Horm Res Paediatr"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.741764","article-title":"Resistance to the insulin and elevated level of androgen: a major cause of polycystic ovary syndrome","volume":"12","author":"Ding H","year":"2021","unstructured":"Ding H, Zhang J, Zhang F, Zhang S, Chen X, Liang W, Xie Q. Resistance to the insulin and elevated level of androgen: a major cause of polycystic ovary syndrome. Front Endocrinol (Lausanne). 2021, 12:741764. 10.3389\/fendo.2021.741764","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.06.010","article-title":"Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor","volume":"12","author":"Brothers KJ","year":"2010","unstructured":"Brothers KJ, Wu S, DiVall SA, et al.. Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. Cell Metab. 2010, 12:295-305. 10.1016\/j.cmet.2010.06.010","journal-title":"Cell Metab"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.107.060152","article-title":"Insulin signaling in mouse oocytes","volume":"77","author":"Acevedo N","year":"2007","unstructured":"Acevedo N, Ding J, Smith GD. Insulin signaling in mouse oocytes. Biol Reprod. 2007, 77:872-9. 10.1095\/biolreprod.107.060152","journal-title":"Biol Reprod"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des137","article-title":"Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes","volume":"27","author":"Ou XH","year":"2012","unstructured":"Ou XH, Li S, Wang ZB, et al.. Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes. Hum Reprod. 2012, 27:2130-45. 10.1093\/humrep\/des137","journal-title":"Hum Reprod"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines7010005","article-title":"Hypothalamic-pituitary-ovarian axis disorders impacting female fertility","volume":"7","author":"Mikhael S","year":"2019","unstructured":"Mikhael S, Punjala-Patel A, Gavrilova-Jordan L. Hypothalamic-pituitary-ovarian axis disorders impacting female fertility. Biomedicines. 2019, 7:10.3390\/biomedicines7010005","journal-title":"Biomedicines"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"352","author":"Ehrmann DA","year":"2005","unstructured":"Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. 2005, 352:1223-36. 10.1056\/NEJMra041536","journal-title":"N Engl J Med"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1097\/j.pbj.0000000000000116","article-title":"Infertility management in women with polycystic ovary syndrome: a review","volume":"6","author":"Cunha A","year":"2021","unstructured":"Cunha A, P\u00f3voa AM. Infertility management in women with polycystic ovary syndrome: a review. Porto Biomed J. 2021, 6:e116. 10.1097\/j.pbj.0000000000000116","journal-title":"Porto Biomed J"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00990.x","article-title":"The impact of obesity on reproduction in women with polycystic ovary syndrome","volume":"113","author":"Pasquali R","year":"2006","unstructured":"Pasquali R, Gambineri A, Pagotto U. The impact of obesity on reproduction in women with polycystic ovary syndrome. BJOG. 2006, 113:1148-59. 10.1111\/j.1471-0528.2006.00990.x","journal-title":"BJOG"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa285","article-title":"Obesity, polycystic ovary syndrome, and infertility: a new avenue for glp-1 receptor agonists","volume":"105","author":"Cena H","year":"2020","unstructured":"Cena H, Chiovato L, Nappi RE. Obesity, polycystic ovary syndrome, and infertility: a new avenue for glp-1 receptor agonists. J Clin Endocrinol Metab. 2020, 105:10.1210\/clinem\/dgaa285","journal-title":"J Clin Endocrinol Metab"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e3282f1d6cb","article-title":"Obesity and infertility","volume":"14","author":"Pasquali R","year":"2007","unstructured":"Pasquali R, Patton L, Gambineri A. Obesity and infertility. Curr Opin Endocrinol Diabetes Obes. 2007, 14:482-7. 10.1097\/MED.0b013e3282f1d6cb","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.04.063","article-title":"Morbid obesity is associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome","volume":"92","author":"Jungheim ES","year":"2009","unstructured":"Jungheim ES, Lanzendorf SE, Odem RR, Moley KH, Chang AS, Ratts VS. Morbid obesity is associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome. Fertil Steril. 2009, 92:256-61. 10.1016\/j.fertnstert.2008.04.063","journal-title":"Fertil Steril"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/719050","article-title":"Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth","volume":"2014","author":"Rojas J","year":"2014","unstructured":"Rojas J, Ch\u00e1vez M, Olivar L, et al.. Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth. Int J Reprod Med. 2014, 2014:719050. 10.1155\/2014\/719050","journal-title":"Int J Reprod Med"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1365.014","article-title":"Polycystic ovary syndrome: a multifaceted disease from adolescence to adult age","volume":"1092","author":"Pasquali R","year":"2006","unstructured":"Pasquali R, Gambineri A. Polycystic ovary syndrome: a multifaceted disease from adolescence to adult age. Ann N Y Acad Sci. 2006, 1092:158-74. 10.1196\/annals.1365.014","journal-title":"Ann N Y Acad Sci"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02587.x","article-title":"Obesity and polycystic ovary syndrome","volume":"65","author":"Barber TM","year":"2006","unstructured":"Barber TM, McCarthy MI, Wass JA, Franks S. Obesity and polycystic ovary syndrome. Clin Endocrinol (Oxf). 2006, 65:137-45. 10.1111\/j.1365-2265.2006.02587.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.018","article-title":"Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society","volume":"92","author":"Moran LJ","year":"2009","unstructured":"Moran LJ, Pasquali R, Teede HJ, Hoeger KM, Norman RJ. Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society. Fertil Steril. 2009, 92:1966-82. 10.1016\/j.fertnstert.2008.09.018","journal-title":"Fertil Steril"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007506.pub2","article-title":"Lifestyle changes in women with polycystic ovary syndrome","author":"Moran LJ","year":"2011","unstructured":"Moran LJ, Hutchison SK, Norman RJ, Teede HJ. Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2011, CD007506. 10.1002\/14651858.CD007506.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-017-0262-y","article-title":"Weight loss and improvement in comorbidity: differences at 5%, 10%, 15%, and Over","volume":"6","author":"Ryan DH","year":"2017","unstructured":"Ryan DH, Yockey SR. Weight loss and improvement in comorbidity: differences at 5%, 10%, 15%, and Over. Curr Obes Rep. 2017, 6:187-94. 10.1007\/s13679-017-0262-y","journal-title":"Curr Obes Rep"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg367","article-title":"Overweight and obese anovulatory patients with polycystic ovaries: parallel improvements in anthropometric indices, ovarian physiology and fertility rate induced by diet","volume":"18","author":"Crosignani PG","year":"2003","unstructured":"Crosignani PG, Colombo M, Vegetti W, Somigliana E, Gessati A, Ragni G. Overweight and obese anovulatory patients with polycystic ovaries: parallel improvements in anthropometric indices, ovarian physiology and fertility rate induced by diet. Hum Reprod. 2003, 18:1928-32. 10.1093\/humrep\/deg367","journal-title":"Hum Reprod"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0692","article-title":"Heterogeneity in the responsiveness to long-term lifestyle intervention and predictability in obese women with polycystic ovary syndrome","volume":"164","author":"Pasquali R","year":"2011","unstructured":"Pasquali R, Gambineri A, Cavazza C, Ibarra Gasparini D, Ciampaglia W, Cognigni GE, Pagotto U. Heterogeneity in the responsiveness to long-term lifestyle intervention and predictability in obese women with polycystic ovary syndrome. Eur J Endocrinol. 2011, 164:53-60. 10.1530\/EJE-10-0692","journal-title":"Eur J Endocrinol"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-015-1902-5","article-title":"The impact of bariatric surgery on polycystic ovary syndrome: a systematic review and meta-analysis","volume":"26","author":"Skubleny D","year":"2016","unstructured":"Skubleny D, Switzer NJ, Gill RS, et al.. The impact of bariatric surgery on polycystic ovary syndrome: a systematic review and meta-analysis. Obes Surg. 2016, 26:169-76. 10.1007\/s11695-015-1902-5","journal-title":"Obes Surg"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00022","article-title":"Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease","volume":"7","author":"Chait A","year":"2020","unstructured":"Chait A, den Hartigh LJ. Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Front Cardiovasc Med. 2020, 7:22. 10.3389\/fcvm.2020.00022","journal-title":"Front Cardiovasc Med"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg SP","year":"2003","unstructured":"Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003, 112:1796-808. 10.1172\/JCI19246","journal-title":"J Clin Invest"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20192910","article-title":"Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I-III","volume":"40","author":"Mohamed AA","year":"2020","unstructured":"Mohamed AA, Shousha WG, Zaki ME, El-Bassyouni HT, El-Hanafi H, Abdo SM. Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I-III. Biosci Rep. 2020, 40:10.1042\/BSR20192910","journal-title":"Biosci Rep"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml024","article-title":"Obesity and the role of gut and adipose hormones in female reproduction","volume":"12","author":"Gosman GG","year":"2006","unstructured":"Gosman GG, Katcher HI, Legro RS. Obesity and the role of gut and adipose hormones in female reproduction. Hum Reprod Update. 2006, 12:585-601. 10.1093\/humupd\/dml024","journal-title":"Hum Reprod Update"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi210","article-title":"Role of receptor for advanced glycation end-products and signalling events in advanced glycation end-product-induced monocyte chemoattractant protein-1 expression in differentiated mouse podocytes","volume":"21","author":"Gu L","year":"2006","unstructured":"Gu L, Hagiwara S, Fan Q, et al.. Role of receptor for advanced glycation end-products and signalling events in advanced glycation end-product-induced monocyte chemoattractant protein-1 expression in differentiated mouse podocytes. Nephrol Dial Transplant. 2006, 21:299-313. 10.1093\/ndt\/gfi210","journal-title":"Nephrol Dial Transplant"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.3390\/biom5010194","article-title":"Advanced glycation end products and oxidative stress in type 2 diabetes mellitus","volume":"5","author":"Nowotny K","year":"2015","unstructured":"Nowotny K, Jung T, H\u00f6hn A, Weber D, Grune T. Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules. 2015, 5:194-222. 10.3390\/biom5010194","journal-title":"Biomolecules"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1177\/1535370215584937","article-title":"Advanced glycation end-products and insulin signaling in granulosa cells","volume":"241","author":"Diamanti-Kandarakis E","year":"2016","unstructured":"Diamanti-Kandarakis E, Chatzigeorgiou A, Papageorgiou E, Koundouras D, Koutsilieris M. Advanced glycation end-products and insulin signaling in granulosa cells. Exp Biol Med (Maywood). 2016, 241:1438-45. 10.1177\/1535370215584937","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq388","article-title":"Advanced glycation end-products accumulation compromises embryonic development and achievement of pregnancy by assisted reproductive technology","volume":"26","author":"Jinno M","year":"2011","unstructured":"Jinno M, Takeuchi M, Watanabe A, Teruya K, Hirohama J, Eguchi N, Miyazaki A. Advanced glycation end-products accumulation compromises embryonic development and achievement of pregnancy by assisted reproductive technology. Hum Reprod. 2011, 26:604-10. 10.1093\/humrep\/deq388","journal-title":"Hum Reprod"},{"key":"ref133","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.07.881","article-title":"MCP-1, a central mediator of obesity and diet-induced ovarian dysfunction","volume":"102","author":"Asemota OA","year":"2014","unstructured":"Asemota OA, Berger DS, Seki Y, Jindal SK, Charron MJ, Buyuk E. MCP-1, a central mediator of obesity and diet-induced ovarian dysfunction. Fertil Steril. 2014, 102:8. 10.1016\/j.fertnstert.2014.07.881","journal-title":"Fertil Steril"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.12.023","article-title":"Serum and follicular fluid monocyte chemotactic protein-1 levels are elevated in obese women and are associated with poorer clinical pregnancy rate after in\u00a0vitro fertilization: a\u00a0pilot study","volume":"107","author":"Buyuk E","year":"2017","unstructured":"Buyuk E, Asemota OA, Merhi Z, Charron MJ, Berger DS, Zapantis A, Jindal SK. Serum and follicular fluid monocyte chemotactic protein-1 levels are elevated in obese women and are associated with poorer clinical pregnancy rate after in\u00a0vitro fertilization: a\u00a0pilot study. Fertil Steril. 2017, 107:632-640.e3. 10.1016\/j.fertnstert.2016.12.023","journal-title":"Fertil Steril"},{"key":"ref135","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31821fd360","article-title":"Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization","volume":"118","author":"Shah DK","year":"2011","unstructured":"Shah DK, Missmer SA, Berry KF, Racowsky C, Ginsburg ES. Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization. Obstet Gynecol. 2011, 118:63-70. 10.1097\/AOG.0b013e31821fd360","journal-title":"Obstet Gynecol"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.11.008","article-title":"Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008-2010 Society for Assisted Reproductive Technology registry","volume":"105","author":"Provost MP","year":"2016","unstructured":"Provost MP, Acharya KS, Acharya CR, et al.. Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008-2010 Society for Assisted Reproductive Technology registry. Fertil Steril. 2016, 105:663-9. 10.1016\/j.fertnstert.2015.11.008","journal-title":"Fertil Steril"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.12.032","article-title":"Female obesity impairs in vitro fertilization outcome without affecting embryo quality","volume":"93","author":"Bellver J","year":"2010","unstructured":"Bellver J, Ayll\u00f3n Y, Ferrando M, et al.. Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil Steril. 2010, 93:447-54. 10.1016\/j.fertnstert.2008.12.032","journal-title":"Fertil Steril"},{"key":"ref138","doi-asserted-by":"publisher","DOI":"10.3109\/09513591003632100","article-title":"Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women","volume":"26","author":"Zhang D","year":"2010","unstructured":"Zhang D, Zhu Y, Gao H, et al.. Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women. Gynecol Endocrinol. 2010, 26:325-32. 10.3109\/09513591003632100","journal-title":"Gynecol Endocrinol"},{"key":"ref139","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu276","article-title":"Human embryos from overweight and obese women display phenotypic and metabolic abnormalities","volume":"30","author":"Leary C","year":"2015","unstructured":"Leary C, Leese HJ, Sturmey RG. Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Hum Reprod. 2015, 30:122-32. 10.1093\/humrep\/deu276","journal-title":"Hum Reprod"},{"key":"ref140","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.162","article-title":"Obesity and poor reproductive outcome: the potential role of the endometrium","volume":"88","author":"Bellver J","year":"2007","unstructured":"Bellver J, Melo MA, Bosch E, Serra V, Remoh\u00ed J, Pellicer A. Obesity and poor reproductive outcome: the potential role of the endometrium. Fertil Steril. 2007, 88:446-51. 10.1016\/j.fertnstert.2006.11.162","journal-title":"Fertil Steril"},{"key":"ref141","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00487","article-title":"Obesity, neuroinflammation, and reproductive function","volume":"160","author":"Lainez NM","year":"2019","unstructured":"Lainez NM, Coss D. Obesity, neuroinflammation, and reproductive function. Endocrinology. 2019, 160:2719-36. 10.1210\/en.2019-00487","journal-title":"Endocrinology"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.1111\/and.12881","article-title":"Semen quality and infertility status can be identified through measures of oxidation-reduction potential","volume":"50","author":"Arafa M","year":"2018","unstructured":"Arafa M, Agarwal A, Al Said S, et al.. Semen quality and infertility status can be identified through measures of oxidation-reduction potential. Andrologia. 2018, 50:10.1111\/and.12881","journal-title":"Andrologia"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.1080\/2090598X.2019.1599624","article-title":"Oxidative stress and sperm function: a systematic review on evaluation and management","volume":"17","author":"Dutta S","year":"2019","unstructured":"Dutta S, Majzoub A, Agarwal A. Oxidative stress and sperm function: a systematic review on evaluation and management. Arab J Urol. 2019, 17:87-97. 10.1080\/2090598X.2019.1599624","journal-title":"Arab J Urol"},{"key":"ref144","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211948","article-title":"Role of adipose tissue macrophages in obesity-related disorders","volume":"219","author":"Chakarov S","year":"2022","unstructured":"Chakarov S, Bl\u00e9riot C, Ginhoux F. Role of adipose tissue macrophages in obesity-related disorders. J Exp Med. 2022, 219:10.1084\/jem.20211948","journal-title":"J Exp Med"},{"key":"ref145","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.658432","article-title":"Impacts of immunometabolism on male reproduction","volume":"12","author":"Ye L","year":"2021","unstructured":"Ye L, Huang W, Liu S, et al.. Impacts of immunometabolism on male reproduction. Front Immunol. 2021, 12:658432. 10.3389\/fimmu.2021.658432","journal-title":"Front Immunol"},{"key":"ref146","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00653","article-title":"The gonadotropin-releasing hormone pulse generator","volume":"159","author":"Herbison AE","year":"2018","unstructured":"Herbison AE. The gonadotropin-releasing hormone pulse generator. Endocrinology. 2018, 159:3723-36. 10.1210\/en.2018-00653","journal-title":"Endocrinology"},{"key":"ref147","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-107835","article-title":"The effect of aromatase on the reproductive function of obese males","volume":"49","author":"Xu X","year":"2017","unstructured":"Xu X, Sun M, Ye J, et al.. The effect of aromatase on the reproductive function of obese males. Horm Metab Res. 2017, 49:572-9. 10.1055\/s-0043-107835","journal-title":"Horm Metab Res"},{"key":"ref148","article-title":"Laparoscopic sleeve gastrectomy improves reproductive hormone levels in morbidly obese males -- a series of 28 cases","volume":"109","author":"Mihalca R","year":"2014","unstructured":"Mihalca R, Cop\u0103escu C, Sirbu A, Florea S, Martin S, Barbu CG, Fica S. Laparoscopic sleeve gastrectomy improves reproductive hormone levels in morbidly obese males -- a series of 28 cases. Chirurgia (Bucur). 2014, 109:198-203.","journal-title":"Chirurgia (Bucur)"},{"key":"ref149","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.01.100","article-title":"Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic","volume":"93","author":"Chavarro JE","year":"2010","unstructured":"Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. 2010, 93:2222-31. 10.1016\/j.fertnstert.2009.01.100","journal-title":"Fertil Steril"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S41341","article-title":"Association of body mass index with some fertility markers among male partners of infertile couples","volume":"6","author":"Hajshafiha M","year":"2013","unstructured":"Hajshafiha M, Ghareaghaji R, Salemi S, Sadegh-Asadi N, Sadeghi-Bazargani H. Association of body mass index with some fertility markers among male partners of infertile couples. Int J Gen Med. 2013, 6:447-51. 10.2147\/IJGM.S41341","journal-title":"Int J Gen Med"},{"key":"ref151","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.122","article-title":"Testosterone and insulin resistance in the metabolic syndrome and T2DM in men","volume":"9","author":"Rao PM","year":"2013","unstructured":"Rao PM, Kelly DM, Jones TH. Testosterone and insulin resistance in the metabolic syndrome and T2DM in men. Nat Rev Endocrinol. 2013, 9:479-93. 10.1038\/nrendo.2013.122","journal-title":"Nat Rev Endocrinol"},{"key":"ref152","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2008.00863.x","article-title":"Testosterone and obesity in men under the age of 40 years","volume":"41","author":"Goncharov NP","year":"2009","unstructured":"Goncharov NP, Katsya GV, Chagina NA, Gooren LJ. Testosterone and obesity in men under the age of 40 years. Andrologia. 2009, 41:76-83. 10.1111\/j.1439-0272.2008.00863.x","journal-title":"Andrologia"},{"key":"ref153","doi-asserted-by":"publisher","DOI":"10.1038\/s41367-019-0008-2","article-title":"How much does obesity affect the male reproductive function?","volume":"9","author":"Bellastella G","year":"2019","unstructured":"Bellastella G, Menafra D, Puliani G, Colao A, Savastano S. How much does obesity affect the male reproductive function?. Int J Obes Suppl. 2019, 9:50-64. 10.1038\/s41367-019-0008-2","journal-title":"Int J Obes Suppl"},{"key":"ref154","doi-asserted-by":"publisher","DOI":"10.3109\/14647273.2015.1070438","article-title":"Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility","volume":"18","author":"Davidson LM","year":"2015","unstructured":"Davidson LM, Millar K, Jones C, Fatum M, Coward K. Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility. Hum Fertil (Camb). 2015, 18:184-93. 10.3109\/14647273.2015.1070438","journal-title":"Hum Fertil (Camb)"},{"key":"ref155","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.01.011","article-title":"Molecular mechanisms beyond glucose transport in diabetes-related male infertility","volume":"1832","author":"Alves MG","year":"2013","unstructured":"Alves MG, Martins AD, Rato L, Moreira PI, Socorro S, Oliveira PF. Molecular mechanisms beyond glucose transport in diabetes-related male infertility. Biochim Biophys Acta. 2013, 1832:626-35. 10.1016\/j.bbadis.2013.01.011","journal-title":"Biochim Biophys Acta"},{"key":"ref156","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem077","article-title":"Insulin dependant diabetes mellitus: implications for male reproductive function","volume":"22","author":"Agbaje IM","year":"2007","unstructured":"Agbaje IM, Rogers DA, McVicar CM, McClure N, Atkinson AB, Mallidis C, Lewis SE. Insulin dependant diabetes mellitus: implications for male reproductive function. Hum Reprod. 2007, 22:1871-7. 10.1093\/humrep\/dem077","journal-title":"Hum Reprod"},{"key":"ref157","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00190","article-title":"Insulin sensitivity and testicular function in a cohort of adult males suspected of being insulin-resistant","volume":"5","author":"Contreras PH","year":"2018","unstructured":"Contreras PH, Serrano FG, Salgado AM, Vigil P. Insulin sensitivity and testicular function in a cohort of adult males suspected of being insulin-resistant. Front Med (Lausanne). 2018, 5:190. 10.3389\/fmed.2018.00190","journal-title":"Front Med (Lausanne)"},{"key":"ref158","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00019.2013","article-title":"Testosterone induces cell proliferation and cell cycle gene overexpression in human visceral preadipocytes","volume":"305","author":"Barbosa-Desongles A","year":"2013","unstructured":"Barbosa-Desongles A, Hern\u00e1ndez C, Sim\u00f3 R, Selva DM. Testosterone induces cell proliferation and cell cycle gene overexpression in human visceral preadipocytes. Am J Physiol Cell Physiol. 2013, 305:C355-9. 10.1152\/ajpcell.00019.2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref159","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02518-8","article-title":"The ketogenic diet corrects metabolic hypogonadism and preserves pancreatic \u00df-cell function in overweight\/obese men: a single-arm uncontrolled study","volume":"72","author":"La Vignera S","year":"2021","unstructured":"La Vignera S, Cannarella R, Galvano F, et al.. The ketogenic diet corrects metabolic hypogonadism and preserves pancreatic \u00df-cell function in overweight\/obese men: a single-arm uncontrolled study. Endocrine. 2021, 72:392-9. 10.1007\/s12020-020-02518-8","journal-title":"Endocrine"},{"key":"ref160","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.110.012120","article-title":"Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters","volume":"33","author":"La Vignera S","year":"2012","unstructured":"La Vignera S, Condorelli RA, Vicari E, Calogero AE. Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters. J Androl. 2012, 33:53-8. 10.2164\/jandrol.110.012120","journal-title":"J Androl"},{"key":"ref161","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms050","article-title":"BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis","volume":"19","author":"Sermondade N","year":"2013","unstructured":"Sermondade N, Faure C, Fezeu L, et al.. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2013, 19:221-31. 10.1093\/humupd\/dms050","journal-title":"Hum Reprod Update"},{"key":"ref162","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0161","article-title":"Obesity, a serious etiologic factor for male subfertility in modern society","volume":"154","author":"Liu Y","year":"2017","unstructured":"Liu Y, Ding Z. Obesity, a serious etiologic factor for male subfertility in modern society. Reproduction. 2017, 154:R123-31. 10.1530\/REP-17-0161","journal-title":"Reproduction"},{"key":"ref163","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.135123","article-title":"Oxidative phosphorylation versus glycolysis: what fuel do spermatozoa use?","volume":"17","author":"du Plessis SS","year":"2015","unstructured":"du Plessis SS, Agarwal A, Mohanty G, van der Linde M. Oxidative phosphorylation versus glycolysis: what fuel do spermatozoa use?. Asian J Androl. 2015, 17:230-5. 10.4103\/1008-682X.135123","journal-title":"Asian J Androl"},{"key":"ref164","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2616","article-title":"Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa","volume":"93","author":"Koppers AJ","year":"2008","unstructured":"Koppers AJ, De Iuliis GN, Finnie JM, McLaughlin EA, Aitken RJ. Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa. J Clin Endocrinol Metab. 2008, 93:3199-207. 10.1210\/jc.2007-2616","journal-title":"J Clin Endocrinol Metab"},{"key":"ref165","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(03)00983-x","article-title":"Alterations in mitochondria membrane potential and oxidative stress in infertile men: a prospective observational study","volume":"2","author":"Wang X","year":"200380","unstructured":"Wang X, Sharma RK, Gupta A, George V, Thomas AJ, Falcone T, Agarwal A. Alterations in mitochondria membrane potential and oxidative stress in infertile men: a prospective observational study. Fertil Steril. 200380, 2:844-50. 10.1016\/s0015-0282(03)00983-x","journal-title":"Fertil Steril"},{"key":"ref166","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.558374","article-title":"Bio-functional sperm parameters: does age matter?","volume":"11","author":"Condorelli RA","year":"2020","unstructured":"Condorelli RA, La Vignera S, Barbagallo F, et al.. Bio-functional sperm parameters: does age matter?. Front Endocrinol (Lausanne). 2020, 11:558374. 10.3389\/fendo.2020.558374","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref167","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.05124","article-title":"Impact of body mass index values on sperm quantity and quality","volume":"27","author":"Kort HI","year":"2006","unstructured":"Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA, Roudebush WE. Impact of body mass index values on sperm quantity and quality. J Androl. 2006, 27:450-2. 10.2164\/jandrol.05124","journal-title":"J Androl"},{"key":"ref168","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.45723","article-title":"Resistant dextrin reduces obesity and attenuates adipose tissue inflammation in high-fat diet-fed mice","volume":"17","author":"Hu Q","year":"2020","unstructured":"Hu Q, Lu Y, Hu F, et al.. Resistant dextrin reduces obesity and attenuates adipose tissue inflammation in high-fat diet-fed mice. Int J Med Sci. 2020, 17:2611-21. 10.7150\/ijms.45723","journal-title":"Int J Med Sci"},{"key":"ref169","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.10.068","article-title":"Sperm viability, apoptosis, and intracellular reactive oxygen species levels in human spermatozoa before and after induction of oxidative stress","volume":"93","author":"Mahfouz RZ","year":"2010","unstructured":"Mahfouz RZ, du Plessis SS, Aziz N, Sharma R, Sabanegh E, Agarwal A. Sperm viability, apoptosis, and intracellular reactive oxygen species levels in human spermatozoa before and after induction of oxidative stress. Fertil Steril. 2010, 93:814-21. 10.1016\/j.fertnstert.2008.10.068","journal-title":"Fertil Steril"},{"key":"ref170","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22871","article-title":"Reactive oxygen species as mediators of sperm capacitation and pathological damage","volume":"84","author":"Aitken RJ","year":"2017","unstructured":"Aitken RJ. Reactive oxygen species as mediators of sperm capacitation and pathological damage. Mol Reprod Dev. 2017, 84:1039-52. 10.1002\/mrd.22871","journal-title":"Mol Reprod Dev"},{"key":"ref171","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.799294","article-title":"The impact of oxidative stress in male infertility","volume":"8","author":"Mannucci A","year":"2021","unstructured":"Mannucci A, Argento FR, Fini E, Coccia ME, Taddei N, Becatti M, Fiorillo C. The impact of oxidative stress in male infertility. Front Mol Biosci. 2021, 8:799294. 10.3389\/fmolb.2021.799294","journal-title":"Front Mol Biosci"},{"key":"ref172","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn004","article-title":"Oxidative stress and male infertility--a clinical perspective","volume":"14","author":"Tremellen K","year":"2008","unstructured":"Tremellen K. Oxidative stress and male infertility--a clinical perspective. Hum Reprod Update. 2008, 14:243-58. 10.1093\/humupd\/dmn004","journal-title":"Hum Reprod Update"},{"key":"ref173","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmw167","article-title":"Proteomics: technologies and their applications","volume":"55","author":"Aslam B","year":"2017","unstructured":"Aslam B, Basit M, Nisar MA, Khurshid M, Rasool MH. Proteomics: technologies and their applications. J Chromatogr Sci. 2017, 55:182-96. 10.1093\/chromsci\/bmw167","journal-title":"J Chromatogr Sci"},{"key":"ref174","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239113","article-title":"Seminal plasma proteomic biomarkers of oxidative stress","volume":"21","author":"Cannarella R","year":"2020","unstructured":"Cannarella R, Crafa A, Barbagallo F, et al.. Seminal plasma proteomic biomarkers of oxidative stress. Int J Mol Sci. 2020, 21:10.3390\/ijms21239113","journal-title":"Int J Mol Sci"},{"key":"ref175","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.04.037","article-title":"Differences in the seminal plasma proteome are associated with oxidative stress levels in men with normal semen parameters","volume":"104","author":"Intasqui P","year":"2015","unstructured":"Intasqui P, Antoniassi MP, Camargo M, et al.. Differences in the seminal plasma proteome are associated with oxidative stress levels in men with normal semen parameters. Fertil Steril. 2015, 104:292-301. 10.1016\/j.fertnstert.2015.04.037","journal-title":"Fertil Steril"},{"key":"ref176","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.03.048","article-title":"Proteomic analysis of seminal plasma from infertile patients with oligoasthenoteratozoospermia due to oxidative stress and comparison with fertile volunteers","volume":"100","author":"Herwig R","year":"2013","unstructured":"Herwig R, Knoll C, Planyavsky M, Pourbiabany A, Greilberger J, Bennett KL. Proteomic analysis of seminal plasma from infertile patients with oligoasthenoteratozoospermia due to oxidative stress and comparison with fertile volunteers. Fertil Steril. 2013, 100:355-66.e2. 10.1016\/j.fertnstert.2013.03.048","journal-title":"Fertil Steril"},{"key":"ref177","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12606","article-title":"Sperm functional aspects and enriched proteomic pathways of seminal plasma of adult men with obesity","volume":"7","author":"Ferigolo PC","year":"2019","unstructured":"Ferigolo PC, Ribeiro de Andrade MB, Camargo M, Carvalho VM, Cardozo KH, Bertolla RP, Fraietta R. Sperm functional aspects and enriched proteomic pathways of seminal plasma of adult men with obesity. Andrology. 2019, 7:341-9. 10.1111\/andr.12606","journal-title":"Andrology"},{"key":"ref178","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103570","article-title":"Adipokines and obesity. Potential link to metabolic disorders and chronic complications","volume":"21","author":"Zorena K","year":"2020","unstructured":"Zorena K, Jachimowicz-Duda O, \u015al\u0119zak D, Robakowska M, Mrugacz M. Adipokines and obesity. Potential link to metabolic disorders and chronic complications. Int J Mol Sci. 2020, 21:10.3390\/ijms21103570","journal-title":"Int J Mol Sci"},{"key":"ref179","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-019-01273-5","article-title":"The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms","volume":"68","author":"Korbecki J","year":"2019","unstructured":"Korbecki J, Bajdak-Rusinek K. The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms. Inflamm Res. 2019, 68:915-32. 10.1007\/s00011-019-01273-5","journal-title":"Inflamm Res"},{"key":"ref180","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c170040","article-title":"Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus","volume":"9","author":"Burhans MS","year":"2018","unstructured":"Burhans MS, Hagman DK, Kuzma JN, Schmidt KA, Kratz M. Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus. Compr Physiol. 2018, 9:1-58. 10.1002\/cphy.c170040","journal-title":"Compr Physiol"},{"key":"ref181","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000183883.72263.13","article-title":"A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha","volume":"25","author":"Suganami T","year":"2005","unstructured":"Suganami T, Nishida J, Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol. 2005, 25:2062-8. 10.1161\/01.ATV.0000183883.72263.13","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref182","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2015-0034","article-title":"Adipokines in human reproduction","volume":"24","author":"Dupont J","year":"2015","unstructured":"Dupont J, Pollet-Villard X, Reverchon M, Mellouk N, Levy R. Adipokines in human reproduction. Horm Mol Biol Clin Investig. 2015, 24:11-24. 10.1515\/hmbci-2015-0034","journal-title":"Horm Mol Biol Clin Investig"},{"key":"ref183","doi-asserted-by":"publisher","DOI":"10.1111\/and.12325","article-title":"Effects of leptin on sperm count and morphology in Sprague-Dawley rats and their reversibility following a 6-week recovery period","volume":"47","author":"Almabhouh FA","year":"2015","unstructured":"Almabhouh FA, Osman K, Siti Fatimah I, Sergey G, Gnanou J, Singh HJ. Effects of leptin on sperm count and morphology in Sprague-Dawley rats and their reversibility following a 6-week recovery period. Andrologia. 2015, 47:751-8. 10.1111\/and.12325","journal-title":"Andrologia"},{"key":"ref184","doi-asserted-by":"publisher","DOI":"10.1111\/and.12965","article-title":"Review of the role of leptin in the regulation of male reproductive function","author":"Zhang J","year":"2018","unstructured":"Zhang J, Gong M. Review of the role of leptin in the regulation of male reproductive function. Andrologia. 2018, 10.1111\/and.12965","journal-title":"Andrologia"},{"key":"ref185","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-18-0108","article-title":"The role of kisspeptin neurons in reproduction and metabolism","volume":"238","author":"Harter CJ","year":"2018","unstructured":"Harter CJ, Kavanagh GS, Smith JT. The role of kisspeptin neurons in reproduction and metabolism. J Endocrinol. 2018, 238:R173-83. 10.1530\/JOE-18-0108","journal-title":"J Endocrinol"},{"key":"ref186","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2004.01240.x","article-title":"Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis","volume":"16","author":"Thompson EL","year":"2004","unstructured":"Thompson EL, Patterson M, Murphy KG, et al.. Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis. J Neuroendocrinol. 2004, 16:850-8. 10.1111\/j.1365-2826.2004.01240.x","journal-title":"J Neuroendocrinol"},{"key":"ref187","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01149-x","article-title":"Signaling pathways in obesity: mechanisms and therapeutic interventions","volume":"7","author":"Wen X","year":"2022","unstructured":"Wen X, Zhang B, Wu B, et al.. Signaling pathways in obesity: mechanisms and therapeutic interventions. Signal Transduct Target Ther. 2022, 7:298. 10.1038\/s41392-022-01149-x","journal-title":"Signal Transduct Target Ther"},{"key":"ref188","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa204","article-title":"The importance of leptin to reproduction","volume":"162","author":"Childs GV","year":"2021","unstructured":"Childs GV, Odle AK, MacNicol MC, MacNicol AM. The importance of leptin to reproduction. Endocrinology. 2021, 162:10.1210\/endocr\/bqaa204","journal-title":"Endocrinology"},{"key":"ref189","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu009","article-title":"The kisspeptin-GnRH pathway in human reproductive health and disease","volume":"20","author":"Skorupskaite K","year":"2014","unstructured":"Skorupskaite K, George JT, Anderson RA. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 2014, 20:485-500. 10.1093\/humupd\/dmu009","journal-title":"Hum Reprod Update"},{"key":"ref190","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.06.072","article-title":"Expression and role of leptin under hypoxic conditions in human testis: organotypic in vitro culture experiment and clinical study on patients with varicocele","volume":"193","author":"Ni K","year":"2015","unstructured":"Ni K, Steger K, Yang H, Wang H, Hu K, Chen B. Expression and role of leptin under hypoxic conditions in human testis: organotypic in vitro culture experiment and clinical study on patients with varicocele. J Urol. 2015, 193:360-7. 10.1016\/j.juro.2014.06.072","journal-title":"J Urol"},{"key":"ref191","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-34","article-title":"Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort","volume":"12","author":"Leisegang K","year":"2014","unstructured":"Leisegang K, Bouic PJ, Menkveld R, Henkel RR. Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort. Reprod Biol Endocrinol. 2014, 12:34. 10.1186\/1477-7827-12-34","journal-title":"Reprod Biol Endocrinol"},{"key":"ref192","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2675-x","article-title":"Relationship of leptin administration with production of reactive oxygen species, sperm DNA fragmentation, sperm parameters and hormone profile in the adult rat","volume":"287","author":"Abbasihormozi S","year":"2013","unstructured":"Abbasihormozi S, Shahverdi A, Kouhkan A, Cheraghi J, Akhlaghi AA, Kheimeh A. Relationship of leptin administration with production of reactive oxygen species, sperm DNA fragmentation, sperm parameters and hormone profile in the adult rat. Arch Gynecol Obstet. 2013, 287:1241-9. 10.1007\/s00404-012-2675-x","journal-title":"Arch Gynecol Obstet"},{"key":"ref193","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/190945","article-title":"Leptin level and oxidative stress contribute to obesity-induced low testosterone in murine testicular tissue","volume":"2014","author":"Zhao J","year":"2014","unstructured":"Zhao J, Zhai L, Liu Z, Wu S, Xu L. Leptin level and oxidative stress contribute to obesity-induced low testosterone in murine testicular tissue. Oxid Med Cell Longev. 2014, 2014:190945. 10.1155\/2014\/190945","journal-title":"Oxid Med Cell Longev"},{"key":"ref194","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00698-0","article-title":"Leptin and inflammatory factors play a synergistic role in the regulation of reproduction in male mice through hypothalamic kisspeptin-mediated energy balance","volume":"19","author":"Chang B","year":"2021","unstructured":"Chang B, Song C, Gao H, et al.. Leptin and inflammatory factors play a synergistic role in the regulation of reproduction in male mice through hypothalamic kisspeptin-mediated energy balance. Reprod Biol Endocrinol. 2021, 19:12. 10.1186\/s12958-021-00698-0","journal-title":"Reprod Biol Endocrinol"},{"key":"ref195","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184431","article-title":"Involvement of novel adipokines, chemerin, visfatin, resistin and apelin in reproductive functions in normal and pathological conditions in humans and animal models","volume":"20","author":"Estienne A","year":"2019","unstructured":"Estienne A, Bongrani A, Reverchon M, Ram\u00e9 C, Ducluzeau PH, Froment P, Dupont J. Involvement of novel adipokines, chemerin, visfatin, resistin and apelin in reproductive functions in normal and pathological conditions in humans and animal models. Int J Mol Sci. 2019, 20:10.3390\/ijms20184431","journal-title":"Int J Mol Sci"},{"key":"ref196","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2020.01.003","article-title":"Could leptin be responsible for the reproductive dysfunction in obese men?","volume":"20","author":"Almabhouh F","year":"2020","unstructured":"Almabhouh F, Abdul Aziz NA, Durairajanayagam D, Singh HJ. Could leptin be responsible for the reproductive dysfunction in obese men?. Reprod Biol. 2020, 20:106-10. 10.1016\/j.repbio.2020.01.003","journal-title":"Reprod Biol"},{"key":"ref197","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3906490","article-title":"Adipokines in semen: physiopathology and effects on spermatozoas","volume":"2018","author":"Elfassy Y","year":"2018","unstructured":"Elfassy Y, Bastard JP, McAvoy C, Fellahi S, Dupont J, Levy R. Adipokines in semen: physiopathology and effects on spermatozoas. Int J Endocrinol. 2018, 2018:3906490. 10.1155\/2018\/3906490","journal-title":"Int J Endocrinol"},{"key":"ref198","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.12.022","article-title":"Seminal plasma adipokine levels are\u00a0correlated with functional characteristics of spermatozoa","volume":"99","author":"Thomas S","year":"2013","unstructured":"Thomas S, Kratzsch D, Schaab M, et al.. Seminal plasma adipokine levels are\u00a0correlated with functional characteristics of spermatozoa. Fertil Steril. 2013, 99:1256-1263.e3. 10.1016\/j.fertnstert.2012.12.022","journal-title":"Fertil Steril"},{"key":"ref199","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12391","article-title":"Adiponectin protects Leydig cells against proinflammatory cytokines by suppressing the nuclear factor-\u03baB signaling pathway","volume":"280","author":"Wu L","year":"2013","unstructured":"Wu L, Xu B, Fan W, Zhu X, Wang G, Zhang A. Adiponectin protects Leydig cells against proinflammatory cytokines by suppressing the nuclear factor-\u03baB signaling pathway. FEBS J. 2013, 280:3920-7. 10.1111\/febs.12391","journal-title":"FEBS J"},{"key":"ref200","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-016-0202-y","article-title":"Adiponectin improves NF-\u03baB-mediated inflammation and abates atherosclerosis progression in apolipoprotein E-deficient mice","volume":"15","author":"Wang X","year":"2016","unstructured":"Wang X, Chen Q, Pu H, et al.. Adiponectin improves NF-\u03baB-mediated inflammation and abates atherosclerosis progression in apolipoprotein E-deficient mice. Lipids Health Dis. 2016, 15:33. 10.1186\/s12944-016-0202-y","journal-title":"Lipids Health Dis"},{"key":"ref201","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1649","article-title":"The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis","volume":"14","author":"Tsatsanis C","year":"2015","unstructured":"Tsatsanis C, Dermitzaki E, Avgoustinaki P, Malliaraki N, Mytaras V, Margioris AN. The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis. Hormones (Athens). 2015, 14:549-62. 10.14310\/horm.2002.1649","journal-title":"Hormones (Athens)"},{"key":"ref202","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-022-01102-7","article-title":"An association between adropin hormone and total testosterone in obese men: a case-control study","volume":"22","author":"Muhammed AA","year":"2022","unstructured":"Muhammed AA, Eid RM, Mohammed WS, Abdel-Fadeil MR. An association between adropin hormone and total testosterone in obese men: a case-control study. BMC Endocr Disord. 2022, 22:192. 10.1186\/s12902-022-01102-7","journal-title":"BMC Endocr Disord"},{"key":"ref203","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-021-00715-7","article-title":"Resistin levels and inflammatory and endothelial dysfunction markers in obese postmenopausal women with type 2 diabetes mellitus","volume":"13","author":"Giandalia A","year":"2021","unstructured":"Giandalia A, Alibrandi A, Giorgianni L, et al.. Resistin levels and inflammatory and endothelial dysfunction markers in obese postmenopausal women with type 2 diabetes mellitus. Diabetol Metab Syndr. 2021, 13:98. 10.1186\/s13098-021-00715-7","journal-title":"Diabetol Metab Syndr"},{"key":"ref204","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.04.017","article-title":"Resistin, interleukin-6, tumor necrosis factor-alpha, and human semen parameters in the presence of leukocytospermia, smoking habit, and varicocele","volume":"102","author":"Moretti E","year":"2014","unstructured":"Moretti E, Collodel G, Mazzi L, Campagna M, Iacoponi F, Figura N. Resistin, interleukin-6, tumor necrosis factor-alpha, and human semen parameters in the presence of leukocytospermia, smoking habit, and varicocele. Fertil Steril. 2014, 102:354-60. 10.1016\/j.fertnstert.2014.04.017","journal-title":"Fertil Steril"},{"key":"ref205","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2428","article-title":"Effects of basal insulin application on serum visfatin and adiponectin levels in type 2 diabetes","volume":"9","author":"Wang WD","year":"2015","unstructured":"Wang WD, Xing L, Teng JR, Li S, Mi NA. Effects of basal insulin application on serum visfatin and adiponectin levels in type 2 diabetes. Exp Ther Med. 2015, 9:2219-24. 10.3892\/etm.2015.2428","journal-title":"Exp Ther Med"},{"key":"ref206","doi-asserted-by":"publisher","DOI":"10.1159\/000443433","article-title":"Chronic administration of visfatin ameliorated diabetic nephropathy in type 2 diabetic mice","volume":"41","author":"Kang YS","year":"2016","unstructured":"Kang YS, Lee MH, Song HK, et al.. Chronic administration of visfatin ameliorated diabetic nephropathy in type 2 diabetic mice. Kidney Blood Press Res. 2016, 41:311-24. 10.1159\/000443433","journal-title":"Kidney Blood Press Res"},{"key":"ref207","article-title":"Effect of visfatin on testicular steroidogenesis in purified Leydig cells","volume":"24","author":"Hameed W","year":"2012","unstructured":"Hameed W, Yousaf I, Latif R, Aslam M. Effect of visfatin on testicular steroidogenesis in purified Leydig cells. J Ayub Med Coll Abbottabad. 2012, 24:62-4.","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"ref208","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2013-0166","article-title":"Chemerin concentrations in maternal and fetal compartments: implications for metabolic adaptations to normal human pregnancy","volume":"42","author":"Kasher-Meron M","year":"2014","unstructured":"Kasher-Meron M, Mazaki-Tovi S, Barhod E, et al.. Chemerin concentrations in maternal and fetal compartments: implications for metabolic adaptations to normal human pregnancy. J Perinat Med. 2014, 42:371-8. 10.1515\/jpm-2013-0166","journal-title":"J Perinat Med"},{"key":"ref209","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12164","article-title":"Chemerin-derived peptide C-20 suppressed gonadal steroidogenesis","volume":"71","author":"Li L","year":"2014","unstructured":"Li L, Huang C, Zhang X, et al.. Chemerin-derived peptide C-20 suppressed gonadal steroidogenesis. Am J Reprod Immunol. 2014, 71:265-77. 10.1111\/aji.12164","journal-title":"Am J Reprod Immunol"},{"key":"ref210","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-13-0275","article-title":"Expression of chemerin and its receptors in rat testes and its action on testosterone secretion","volume":"220","author":"Li L","year":"2014","unstructured":"Li L, Ma P, Huang C, et al.. Expression of chemerin and its receptors in rat testes and its action on testosterone secretion. J Endocrinol. 2014, 220:155-63. 10.1530\/JOE-13-0275","journal-title":"J Endocrinol"},{"key":"ref211","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26759","article-title":"Intergenerational influences on childhood body mass index: the effect of parental body mass index trajectories","volume":"89","author":"Li L","year":"2009","unstructured":"Li L, Law C, Lo Conte R, Power C. Intergenerational influences on childhood body mass index: the effect of parental body mass index trajectories. Am J Clin Nutr. 2009, 89:551-7. 10.3945\/ajcn.2008.26759","journal-title":"Am J Clin Nutr"},{"key":"ref212","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00370","article-title":"Mechanistic insights into the interaction between transcription factors and epigenetic modifications and the contribution to the development of obesity","volume":"9","author":"Huang Q","year":"2018","unstructured":"Huang Q, Ma C, Chen L, Luo D, Chen R, Liang F. Mechanistic insights into the interaction between transcription factors and epigenetic modifications and the contribution to the development of obesity. Front Endocrinol (Lausanne). 2018, 9:370. 10.3389\/fendo.2018.00370","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref213","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1237423","article-title":"Epigenetics: definition, mechanisms and clinical perspective","volume":"27","author":"Dupont C","year":"2009","unstructured":"Dupont C, Armant DR, Brenner CA. Epigenetics: definition, mechanisms and clinical perspective. Semin Reprod Med. 2009, 27:351-7. 10.1055\/s-0029-1237423","journal-title":"Semin Reprod Med"},{"key":"ref214","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3569","article-title":"DNA methylation in spermatogenesis and male infertility","volume":"12","author":"Cui X","year":"2016","unstructured":"Cui X, Jing X, Wu X, Yan M, Li Q, Shen Y, Wang Z. DNA methylation in spermatogenesis and male infertility. Exp Ther Med. 2016, 12:1973-9. 10.3892\/etm.2016.3569","journal-title":"Exp Ther Med"},{"key":"ref215","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2007.04.015","article-title":"Germline histone dynamics and epigenetics","volume":"19","author":"Ooi SL","year":"2007","unstructured":"Ooi SL, Henikoff S. Germline histone dynamics and epigenetics. Curr Opin Cell Biol. 2007, 19:257-65. 10.1016\/j.ceb.2007.04.015","journal-title":"Curr Opin Cell Biol"},{"key":"ref216","doi-asserted-by":"publisher","DOI":"10.1080\/19396368.2021.1909667","article-title":"Relevance of sperm imprinted gene methylation on assisted reproductive technique outcomes and pregnancy loss: a systematic review","volume":"67","author":"Cannarella R","year":"2021","unstructured":"Cannarella R, Crafa A, Condorelli RA, Mongio\u00ec LM, La Vignera S, Calogero AE. Relevance of sperm imprinted gene methylation on assisted reproductive technique outcomes and pregnancy loss: a systematic review. Syst Biol Reprod Med. 2021, 67:251-259. 10.1080\/19396368.2021.1909667","journal-title":"Syst Biol Reprod Med"},{"key":"ref217","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-00997-0","article-title":"Male obesity impacts DNA methylation reprogramming in sperm","volume":"13","author":"Keyhan S","year":"2021","unstructured":"Keyhan S, Burke E, Schrott R, et al.. Male obesity impacts DNA methylation reprogramming in sperm. Clin Epigenetics. 2021, 13:17. 10.1186\/s13148-020-00997-0","journal-title":"Clin Epigenetics"},{"key":"ref218","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0217-2","article-title":"Obesity-related DNA methylation at imprinted genes in human sperm: results from the TIEGER study","volume":"8","author":"Soubry A","year":"2016","unstructured":"Soubry A, Guo L, Huang Z, Hoyo C, Romanus S, Price T, Murphy SK. Obesity-related DNA methylation at imprinted genes in human sperm: results from the TIEGER study. Clin Epigenetics. 2016, 8:51. 10.1186\/s13148-016-0217-2","journal-title":"Clin Epigenetics"},{"key":"ref219","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.11.004","article-title":"Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans","volume":"23","author":"Donkin I","year":"2016","unstructured":"Donkin I, Versteyhe S, Ingerslev LR, et al.. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab. 2016, 23:369-78. 10.1016\/j.cmet.2015.11.004","journal-title":"Cell Metab"},{"key":"ref220","doi-asserted-by":"publisher","DOI":"10.1159\/000323806","article-title":"Methylation status of imprinted genes and repetitive elements in sperm DNA from infertile males","volume":"5","author":"El Hajj N","year":"2011","unstructured":"El Hajj N, Zechner U, Schneider E, et al.. Methylation status of imprinted genes and repetitive elements in sperm DNA from infertile males. Sex Dev. 2011, 5:60-9. 10.1159\/000323806","journal-title":"Sex Dev"},{"key":"ref221","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2009.01032.x","article-title":"Impact of body mass index on seminal oxidative stress","volume":"43","author":"Tunc O","year":"2011","unstructured":"Tunc O, Bakos HW, Tremellen K. Impact of body mass index on seminal oxidative stress. Andrologia. 2011, 43:121-8. 10.1111\/j.1439-0272.2009.01032.x","journal-title":"Andrologia"},{"key":"ref222","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0521-0","article-title":"DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1\u00a0year, and 3\u00a0years","volume":"10","author":"Gonzalez-Nahm S","year":"2018","unstructured":"Gonzalez-Nahm S, Mendez MA, Benjamin-Neelon SE, Murphy SK, Hogan VK, Rowley DL, Hoyo C. DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1\u00a0year, and 3\u00a0years. Clin Epigenetics. 2018, 10:90. 10.1186\/s13148-018-0521-0","journal-title":"Clin Epigenetics"},{"key":"ref223","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071459","article-title":"Improving metabolic health in obese male mice via diet and exercise restores embryo development and fetal growth","volume":"8","author":"McPherson NO","year":"2013","unstructured":"McPherson NO, Bakos HW, Owens JA, Setchell BP, Lane M. Improving metabolic health in obese male mice via diet and exercise restores embryo development and fetal growth. PLoS One. 2013, 8:e71459. 10.1371\/journal.pone.0071459","journal-title":"PLoS One"},{"key":"ref224","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.856667","article-title":"Abnormal BMI in male and\/or female partners are deleterious for embryonic development and pregnancy outcome during art process: a retrospective study","volume":"13","author":"Qi L","year":"2022","unstructured":"Qi L, Liu YP, Wang SM, Shi H, Chen XL, Wang NN, Su YC. Abnormal BMI in male and\/or female partners are deleterious for embryonic development and pregnancy outcome during art process: a retrospective study. Front Endocrinol (Lausanne). 2022, 13:856667. 10.3389\/fendo.2022.856667","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref225","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-00978-0","article-title":"Impact of body mass index (BMI) on the success rate of fresh embryo transfer in women undergoing first in vitro fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) treatment","volume":"46","author":"Chen H","year":"2022","unstructured":"Chen H, Li J, Cai S, et al.. Impact of body mass index (BMI) on the success rate of fresh embryo transfer in women undergoing first in vitro fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) treatment. Int J Obes (Lond). 2022, 46:202-10. 10.1038\/s41366-021-00978-0","journal-title":"Int J Obes (Lond)"},{"key":"ref226","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2012.00012.x","article-title":"The BMI of men and not sperm parameters impact on embryo quality and the IVF outcome","volume":"1","author":"Anifandis G","year":"2013","unstructured":"Anifandis G, Dafopoulos K, Messini CI, Polyzos N, Messinis IE. The BMI of men and not sperm parameters impact on embryo quality and the IVF outcome. Andrology. 2013, 1:85-9. 10.1111\/j.2047-2927.2012.00012.x","journal-title":"Andrology"},{"key":"ref227","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.06.033","article-title":"Whether sperm deoxyribonucleic acid fragmentation has an effect on\u00a0pregnancy and miscarriage after in\u00a0vitro fertilization\/intracytoplasmic sperm injection: a systematic review and meta-analysis","volume":"102","author":"Zhao J","year":"2014","unstructured":"Zhao J, Zhang Q, Wang Y, Li Y. Whether sperm deoxyribonucleic acid fragmentation has an effect on\u00a0pregnancy and miscarriage after in\u00a0vitro fertilization\/intracytoplasmic sperm injection: a systematic review and meta-analysis. Fertil Steril. 2014, 102:998-1005.e8. 10.1016\/j.fertnstert.2014.06.033","journal-title":"Fertil Steril"},{"key":"ref228","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9439-y","article-title":"Overweight men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles","volume":"27","author":"Keltz J","year":"2010","unstructured":"Keltz J, Zapantis A, Jindal SK, Lieman HJ, Santoro N, Polotsky AJ. Overweight men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. J Assist Reprod Genet. 2010, 27:539-44. 10.1007\/s10815-010-9439-y","journal-title":"J Assist Reprod Genet"},{"key":"ref229","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.11.044","article-title":"Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology","volume":"95","author":"Bakos HW","year":"2011","unstructured":"Bakos HW, Henshaw RC, Mitchell M, Lane M. Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology. Fertil Steril. 2011, 95:1700-4. 10.1016\/j.fertnstert.2010.11.044","journal-title":"Fertil Steril"},{"key":"ref230","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20164","article-title":"Male adiposity impairs clinical pregnancy rate by in vitro fertilization without affecting day 3 embryo quality","volume":"21","author":"Merhi ZO","year":"2013","unstructured":"Merhi ZO, Keltz J, Zapantis A, et al.. Male adiposity impairs clinical pregnancy rate by in vitro fertilization without affecting day 3 embryo quality. Obesity (Silver Spring). 2013, 21:1608-12. 10.1002\/oby.20164","journal-title":"Obesity (Silver Spring)"},{"key":"ref231","doi-asserted-by":"publisher","DOI":"10.1111\/and.12272","article-title":"Effect of increasing paternal body mass index on pregnancy and live birth rates in couples undergoing intracytoplasmic sperm injection","volume":"47","author":"Umul M","year":"2015","unstructured":"Umul M, K\u00f6se SA, Bilen E, Altuncu AG, Oksay T, G\u00fcney M. Effect of increasing paternal body mass index on pregnancy and live birth rates in couples undergoing intracytoplasmic sperm injection. Andrologia. 2015, 47:360-4. 10.1111\/and.12272","journal-title":"Andrologia"},{"key":"ref232","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.10.048","article-title":"Effect of male and female body mass index on pregnancy and live birth success after in vitro fertilization","volume":"103","author":"Schliep KC","year":"2015","unstructured":"Schliep KC, Mumford SL, Ahrens KA, et al.. Effect of male and female body mass index on pregnancy and live birth success after in vitro fertilization. Fertil Steril. 2015, 103:388-95. 10.1016\/j.fertnstert.2014.10.048","journal-title":"Fertil Steril"},{"key":"ref233","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.125398","article-title":"The impact of male overweight on semen quality and outcome of assisted reproduction","volume":"16","author":"Thomsen L","year":"2014","unstructured":"Thomsen L, Humaidan P, Bungum L, Bungum M. The impact of male overweight on semen quality and outcome of assisted reproduction. Asian J Androl. 2014, 16:749-54. 10.4103\/1008-682X.125398","journal-title":"Asian J Androl"},{"key":"ref234","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1795","article-title":"Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab)","volume":"31","author":"Healy GN","year":"2008","unstructured":"Healy GN, Wijndaele K, Dunstan DW, Shaw JE, Salmon J, Zimmet PZ, Owen N. Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Diabetes Care. 2008, 31:369-71. 10.2337\/dc07-1795","journal-title":"Diabetes Care"},{"key":"ref235","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100338","article-title":"Increased weight loading reduces body weight and body fat in obese subjects - a proof of concept randomized clinical trial","volume":"22","author":"Ohlsson C","year":"2020","unstructured":"Ohlsson C, Gidestrand E, Bellman J, et al.. Increased weight loading reduces body weight and body fat in obese subjects - a proof of concept randomized clinical trial. EClinicalMedicine. 2020, 22:100338. 10.1016\/j.eclinm.2020.100338","journal-title":"EClinicalMedicine"},{"key":"ref236","doi-asserted-by":"publisher","DOI":"10.1530\/RAF-20-0046","article-title":"Effects of lifestyle factors on fertility: practical recommendations for modification","volume":"2","author":"Emokpae MA","year":"2021","unstructured":"Emokpae MA, Brown SI. Effects of lifestyle factors on fertility: practical recommendations for modification. Reprod Fertil. 2021, 2:R13-26. 10.1530\/RAF-20-0046","journal-title":"Reprod Fertil"},{"key":"ref237","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505297","article-title":"Randomized trial of a lifestyle program in obese infertile women","volume":"374","author":"Mutsaerts MA","year":"2016","unstructured":"Mutsaerts MA, van Oers AM, Groen H, et al.. Randomized trial of a lifestyle program in obese infertile women. N Engl J Med. 2016, 374:1942-53. 10.1056\/NEJMoa1505297","journal-title":"N Engl J Med"},{"key":"ref238","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.02.025","article-title":"A prospective cohort study of physical activity and time to pregnancy","volume":"97","author":"Wise LA","year":"2012","unstructured":"Wise LA, Rothman KJ, Mikkelsen EM, S\u00f8rensen HT, Riis AH, Hatch EE. A prospective cohort study of physical activity and time to pregnancy. Fertil Steril. 2012, 97:1136-42.e1-4. 10.1016\/j.fertnstert.2012.02.025","journal-title":"Fertil Steril"},{"key":"ref239","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12226","article-title":"High-energy diets: a threat for male fertility?","volume":"15","author":"Rato L","year":"2014","unstructured":"Rato L, Alves MG, Cavaco JE, Oliveira PF. High-energy diets: a threat for male fertility?. Obes Rev. 2014, 15:996-1007. 10.1111\/obr.12226","journal-title":"Obes Rev"},{"key":"ref240","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00807","article-title":"A high fat diet during adolescence in male rats negatively programs reproductive and metabolic function which is partially ameliorated by exercise","volume":"8","author":"Ib\u00e1\u00f1ez CA","year":"2017","unstructured":"Ib\u00e1\u00f1ez CA, Erthal RP, Ogo FM, et al.. A high fat diet during adolescence in male rats negatively programs reproductive and metabolic function which is partially ameliorated by exercise. Front Physiol. 2017, 8:807. 10.3389\/fphys.2017.00807","journal-title":"Front Physiol"},{"key":"ref241","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew288","article-title":"Association between adherence to the Mediterranean diet and semen quality parameters in male partners of couples attempting fertility","volume":"32","author":"Karayiannis D","year":"2017","unstructured":"Karayiannis D, Kontogianni MD, Mendorou C, Douka L, Mastrominas M, Yiannakouris N. Association between adherence to the Mediterranean diet and semen quality parameters in male partners of couples attempting fertility. Hum Reprod. 2017, 32:215-22. 10.1093\/humrep\/dew288","journal-title":"Hum Reprod"},{"key":"ref242","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew252","article-title":"Effectiveness of lifestyle intervention in subgroups of obese infertile women: a subgroup analysis of a RCT","volume":"31","author":"van Oers AM","year":"2016","unstructured":"van Oers AM, Groen H, Mutsaerts MA, et al.. Effectiveness of lifestyle intervention in subgroups of obese infertile women: a subgroup analysis of a RCT. Hum Reprod. 2016, 31:2704-13. 10.1093\/humrep\/dew252","journal-title":"Hum Reprod"},{"key":"ref243","doi-asserted-by":"publisher","DOI":"10.12659\/MSMBR.910862","article-title":"Effect of bariatric surgery on semen parameters: a systematic review and meta-analysis","volume":"24","author":"Wei Y","year":"2018","unstructured":"Wei Y, Chen Q, Qian W. Effect of bariatric surgery on semen parameters: a systematic review and meta-analysis. Med Sci Monit Basic Res. 2018, 24:188-97. 10.12659\/MSMBR.910862","journal-title":"Med Sci Monit Basic Res"},{"key":"ref244","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.20388","article-title":"Decrease in sperm count after bariatric surgery: case reports","volume":"13","author":"Razzaq A","year":"2021","unstructured":"Razzaq A, Soomro FH, Siddiq G, Khizar S, Ali Khan M. Decrease in sperm count after bariatric surgery: case reports. Cureus. 2021, 13:e20388. 10.7759\/cureus.20388","journal-title":"Cureus"},{"key":"ref245","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2802-7","article-title":"Massive weight loss obtained by bariatric surgery affects semen quality in morbid male obesity: a preliminary prospective double-armed study","volume":"28","author":"Samavat J","year":"2018","unstructured":"Samavat J, Cantini G, Lotti F, et al.. Massive weight loss obtained by bariatric surgery affects semen quality in morbid male obesity: a preliminary prospective double-armed study. Obes Surg. 2018, 28:69-76. 10.1007\/s11695-017-2802-7","journal-title":"Obes Surg"},{"key":"ref246","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00346","article-title":"Nutrition and female fertility: an interdependent correlation","volume":"10","author":"Silvestris E","year":"2019","unstructured":"Silvestris E, Lovero D, Palmirotta R. Nutrition and female fertility: an interdependent correlation. Front Endocrinol (Lausanne). 2019, 10:346. 10.3389\/fendo.2019.00346","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/121483-obesity-a-doorway-to-a-molecular-path-leading-to-infertility","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T14:42:21Z","timestamp":1707489741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/121483-obesity-a-doorway-to-a-molecular-path-leading-to-infertility"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":246,"URL":"https:\/\/doi.org\/10.7759\/cureus.30770","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,27]]}}}