{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:24:50Z","timestamp":1707524690984},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,27]]},"DOI":"10.7759\/cureus.30778","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T03:38:20Z","timestamp":1666928300000},"source":"Crossref","is-referenced-by-count":0,"title":["Phosphatase and Tensin Homolog Immunohistochemical Expression and Promoter Methylation Status in Endometrioid Endometrial Carcinoma and Its Precursor Lesions"],"prefix":"10.7759","author":[{"given":"Sunita","family":"Yadav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annu","family":"Makker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeti","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhu Mati","family":"Goel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.02.007","article-title":"Prognostic parameters of endometrial carcinoma","volume":"35","author":"Prat J","year":"2004","unstructured":"Prat J. Prognostic parameters of endometrial carcinoma. Hum Pathol. 2004, 35:649-62. 10.1016\/j.humpath.2004.02.007","journal-title":"Hum Pathol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1177\/107327480901600102","article-title":"The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies","volume":"16","author":"Bansal N","year":"2009","unstructured":"Bansal N, Yendluri V, Wenham RM. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Cancer Control. 2009, 16:8-13. 10.1177\/107327480901600102","journal-title":"Cancer Control"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.10.019","article-title":"Endometrioid uterine cancer: histopathological risk factors of local and distant recurrence","volume":"112","author":"Fujimoto T","year":"2009","unstructured":"Fujimoto T, Nanjyo H, Fukuda J, et al.. Endometrioid uterine cancer: histopathological risk factors of local and distant recurrence. Gynecol Oncol. 2009, 112:342-7. 10.1016\/j.ygyno.2008.10.019","journal-title":"Gynecol Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.11.924","article-title":"Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers","volume":"92","author":"Mutter GL","year":"2000","unstructured":"Mutter GL, Lin MC, Fitzgerald JT, et al.. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst. 2000, 92:924-30. 10.1093\/jnci\/92.11.924","journal-title":"J Natl Cancer Inst"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80674-1","article-title":"The multiple roles of PTEN in tumor suppression","volume":"100","author":"Di Cristofano A","year":"2000","unstructured":"Di Cristofano A, Pandolfi PP. The multiple roles of PTEN in tumor suppression. Cell. 2000, 100:387-90. 10.1016\/s0092-8674(00)80674-1","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3835(01)00815-1","article-title":"Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinoma and hyperplasias","volume":"178","author":"Konopka B","year":"2002","unstructured":"Konopka B, Paszko Z, Janiec-Jankowska A, Goluda M. Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinoma and hyperplasias. Cancer Lett. 2002, 178:43-51. 10.1016\/s0304-3835(01)00815-1","journal-title":"Cancer Lett"},{"key":"ref7","article-title":"Tumor suppressor PTEN in breast cancer: heterozygosity, mutations and protein expression","volume":"34","author":"Kechagioglou P","year":"2014","unstructured":"Kechagioglou P, Papi RM, Provatopoulou X, et al.. Tumor suppressor PTEN in breast cancer: heterozygosity, mutations and protein expression. Anticancer Res. 2014, 34:1387-400.","journal-title":"Anticancer Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-4-41","article-title":"Altered PTEN expression; a diagnostic marker for differentiating normal, hyperplastic and neoplastic endometrium","volume":"4","author":"Sarmadi S","year":"2009","unstructured":"Sarmadi S, Izadi-Mood N, Sotoudeh K, Tavangar SM. Altered PTEN expression; a diagnostic marker for differentiating normal, hyperplastic and neoplastic endometrium. Diagn Pathol. 2009, 4:41. 10.1186\/1746-1596-4-41","journal-title":"Diagn Pathol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20010101)91:1<22::aid-ijc1002>3.0.co;2-s","article-title":"PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma","volume":"91","author":"Salvesen HB","year":"2001","unstructured":"Salvesen HB, MacDonald N, Ryan A, Jacobs IJ, Lynch ED, Akslen LA, Das S. PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma. Int J Cancer. 2001, 91:22-6. 10.1002\/1097-0215(20010101)91:1&lt;22::aid-ijc1002&gt;3.0.co;2-s","journal-title":"Int J Cancer"},{"key":"ref10","article-title":"PTEN\/MMAC1 mutations in endometrial cancers","volume":"57","author":"Risinger JI","year":"1997","unstructured":"Risinger JI, Hayes AK, Berchuck A, Barrett JC. PTEN\/MMAC1 mutations in endometrial cancers. Cancer Res. 1997, 57:4736-8.","journal-title":"Cancer Res"},{"key":"ref11","article-title":"Epigenetic modifications and carcinogenesis of human endometrial cancer","volume":"1","author":"Ma X","year":"2014","unstructured":"Ma X, Gao X. Epigenetic modifications and carcinogenesis of human endometrial cancer. Austin J Clin Pathol. 2014, 1:1014.","journal-title":"Austin J Clin Pathol"},{"key":"ref12","unstructured":"Publication of the WHO Classification of Tumours, 5th Edition, Volume 4. Female Genital Tumours. (2020). Accessed: October 27, 2022: https:\/\/www.aws.iarc.who.int\/fr\/news-events\/publication-of-the-who-classification-of-tumours-5th-edition-volume-4-fem...."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138801","article-title":"Fibroblast growth factor (FGF-2) and its receptors FGFR-2 and FGFR-3 may be putative biomarkers of malignant transformation of potentially malignant oral lesions into oral squamous cell carcinoma","volume":"10","author":"Nayak S","year":"2015","unstructured":"Nayak S, Goel MM, Makker A, Bhatia V, Chandra S, Kumar S, Agarwal SP. Fibroblast growth factor (FGF-2) and its receptors FGFR-2 and FGFR-3 may be putative biomarkers of malignant transformation of potentially malignant oral lesions into oral squamous cell carcinoma. PLoS One. 2015, 10:e0138801. 10.1371\/journal.pone.0138801","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2010.11.001","article-title":"Promoter hypermethylation of CDH13, DAPK1 and TWIST1 genes in precancerous and cancerous lesions of the uterine cervix","volume":"207","author":"Missaoui N","year":"2011","unstructured":"Missaoui N, Hmissa S, Trabelsi A, Traor\u00e9 C, Mokni M, Dante R, Frappart L. Promoter hypermethylation of CDH13, DAPK1 and TWIST1 genes in precancerous and cancerous lesions of the uterine cervix. Pathol Res Pract. 2011, 207:37-42. 10.1016\/j.prp.2010.11.001","journal-title":"Pathol Res Pract"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.11.1427","article-title":"MethPrimer: designing primers for methylation PCRs","volume":"18","author":"Li LC","year":"2002","unstructured":"Li LC, Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics. 2002, 18:1427-31. 10.1093\/bioinformatics\/18.11.1427","journal-title":"Bioinformatics"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.02.018","article-title":"Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression","volume":"36","author":"Baak JP","year":"2005","unstructured":"Baak JP, Van Diermen B, Steinbakk A, et al.. Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression. Hum Pathol. 2005, 36:555-61. 10.1016\/j.humpath.2005.02.018","journal-title":"Hum Pathol"},{"key":"ref17","article-title":"Molecular identification of latent precancers in histologically normal endometrium","volume":"61","author":"Mutter GL","year":"2001","unstructured":"Mutter GL, Ince TA, Baak JP, Kust GA, Zhou XP, Eng C. Molecular identification of latent precancers in histologically normal endometrium. Cancer Res. 2001, 61:4311-4.","journal-title":"Cancer Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00541.x","article-title":"Expression of surviving, PTEN and p27 in normal, hyperplastic, and carcinomatous endometrium","volume":"1412","author":"Erkanli S","year":"2006","unstructured":"Erkanli S, Kayaselcuk F, Kuscu E, Bagis T, Bolat F, Haberal A, Demirhan B. Expression of surviving, PTEN and p27 in normal, hyperplastic, and carcinomatous endometrium. Int J Gynecol cancer. 2006, 1412:8. 10.1111\/j.1525-1438.2006.00541.x","journal-title":"Int J Gynecol cancer"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.31557\/APJCB.2022.7.1.21-27","article-title":"Diagnostic and prognostic values of PTEN expression in functional and pathological endometrial biopsies","author":"Allithy AM","year":"20227","unstructured":"Allithy AM, Ammar IMM, Mohammed MH. Diagnostic and prognostic values of PTEN expression in functional and pathological endometrial biopsies. Asian Pac J Cancer Biol. 20227, 21-7. 10.31557\/APJCB.2022.7.1.21-27","journal-title":"Asian Pac J Cancer Biol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/path.5628","article-title":"Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors","volume":"254","author":"Aguilar M","year":"2021","unstructured":"Aguilar M, Zhang H, Zhang M, et al.. Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors. J Pathol. 2021, 254:20-30. 10.1002\/path.5628","journal-title":"J Pathol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.17511\/jopm.2017.i01.07","article-title":"A study of PTEN expression in endometrial hyperplasia and endometrioid type of endometrial carcinoma","author":"Shanmugapriya DM","year":"20173","unstructured":"Shanmugapriya DM, Sudha DM, Prakash DG. A study of PTEN expression in endometrial hyperplasia and endometrioid type of endometrial carcinoma. Tropical J Pathol Microbiol. 20173, 39-45. 10.17511\/jopm.2017.i01.07","journal-title":"Tropical J Pathol Microbiol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000626","article-title":"Expression of PTEN and \u03b2-catenin and their relationship with clinicopathological and prognostic factors in endometrioid type endometrial cancer","volume":"26","author":"Sal V","year":"2016","unstructured":"Sal V, Demirkiran F, Erenel H, et al.. Expression of PTEN and \u03b2-catenin and their relationship with clinicopathological and prognostic factors in endometrioid type endometrial cancer. Int J Gynecol Cancer. 2016, 26:512-20. 10.1097\/IGC.0000000000000626","journal-title":"Int J Gynecol Cancer"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800347","article-title":"Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities","volume":"18","author":"Pallares J","year":"2005","unstructured":"Pallares J, Bussaglia E, Mart\u00ednez-Guitarte JL, et al.. Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities. Mod Pathol. 2005, 18:719-27. 10.1038\/modpathol.3800347","journal-title":"Mod Pathol"},{"key":"ref24","article-title":"Epigenetic mechanisms in endometrial cancer","volume":"21","author":"Stampoliou A","year":"2016","unstructured":"Stampoliou A, Arapantoni-Dadioti P, Pavlakis K. Epigenetic mechanisms in endometrial cancer. J BUON. 2016, 21:301-6.","journal-title":"J BUON"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1045","article-title":"The power and the promise of DNA methylation markers","volume":"3","author":"Laird PW","year":"2003","unstructured":"Laird PW. The power and the promise of DNA methylation markers. Nat Rev Cancer. 2003, 3:253-66. 10.1038\/nrc1045","journal-title":"Nat Rev Cancer"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.8.2259","article-title":"The relationship between the methylation of promoter region of tumor suppressor gene PTEN and APC with endometrial cancer","volume":"20","author":"Ghazanfari T","year":"2019","unstructured":"Ghazanfari T, Asaadi Tehrani G, Maziri P. The relationship between the methylation of promoter region of tumor suppressor gene PTEN and APC with endometrial cancer. Asian Pac J Cancer Prev. 2019, 20:2259-65. 10.31557\/APJCP.2019.20.8.2259","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1309\/7JX6-B9U9-3P0R-EQNY","article-title":"Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia","volume":"115","author":"Sun H","year":"2001","unstructured":"Sun H, Enomoto T, Fujita M, et al.. Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia. Am J Clin Pathol. 2001, 115:32-8. 10.1309\/7JX6-B9U9-3P0R-EQNY","journal-title":"Am J Clin Pathol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e318159b88e","article-title":"Immunohistochemical markers in endometrial hyperplasia: is there a panel with promise? A review","volume":"16","author":"Allison KH","year":"2008","unstructured":"Allison KH, Tenpenny E, Reed SD, Swisher EM, Garica RL. Immunohistochemical markers in endometrial hyperplasia: is there a panel with promise? A review. Appl Immunohistochem Mol Morphol. 2008, 16:329-43. 10.1097\/PAI.0b013e318159b88e","journal-title":"Appl Immunohistochem Mol Morphol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/119863-phosphatase-and-tensin-homolog-immunohistochemical-expression-and-promoter-methylation-status-in-endometrioid-endometrial-carcinoma-and-its-precursor-lesions","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:43:18Z","timestamp":1707507798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/119863-phosphatase-and-tensin-homolog-immunohistochemical-expression-and-promoter-methylation-status-in-endometrioid-endometrial-carcinoma-and-its-precursor-lesions"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.30778","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,27]]}}}