{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T23:30:19Z","timestamp":1776295819708,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,2]]},"DOI":"10.7759\/cureus.31014","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:33:44Z","timestamp":1667406824000},"source":"Crossref","is-referenced-by-count":9,"title":["Double Trouble: A Primary Epstein-Barr Virus Infection Causing Cholestatic Hepatitis and Hemophagocytic Lymphohistiocytosis"],"prefix":"10.7759","author":[{"given":"Joanne","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetha","family":"Sivasubramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00211","article-title":"Epstein-Barr virus epidemiology, serology, and genetic variability of LMP-1 oncogene among healthy population: an update","volume":"8","author":"Smatti MK","year":"2018","unstructured":"Smatti MK, Al-Sadeq DW, Ali NH, Pintus G, Abou-Saleh H, Nasrallah GK. Epstein-Barr virus epidemiology, serology, and genetic variability of LMP-1 oncogene among healthy population: an update. Front Oncol. 2018, 8:211. 10.3389\/fonc.2018.00211","journal-title":"Front Oncol"},{"key":"ref2","article-title":"Mononucleosis","author":"Mohseni M","year":"2022","unstructured":"Mohseni M, Boniface MP, Graham C. Mononucleosis. StatPearls, Treasure Island, FL; 2022."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.07.016","article-title":"Epstein Barr virus hepatitis","volume":"22","author":"Kofteridis DP","year":"2011","unstructured":"Kofteridis DP, Koulentaki M, Valachis A, Christofaki M, Mazokopakis E, Papazoglou G, Samonis G. Epstein Barr virus hepatitis. Eur J Intern Med. 2011, 22:73-6. 10.1016\/j.ejim.2010.07.016","journal-title":"Eur J Intern Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-016-0859-x","article-title":"Acute cholestatic hepatitis induced by Epstein-Barr virus infection in an adult: a case report","volume":"10","author":"Khoo A","year":"2016","unstructured":"Khoo A. Acute cholestatic hepatitis induced by Epstein-Barr virus infection in an adult: a case report. J Med Case Rep. 2016, 10:75. 10.1186\/s13256-016-0859-x","journal-title":"J Med Case Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2009.24.4.381","article-title":"Infectious mononucleosis hepatitis in young adults: two case reports","volume":"24","author":"Kang MJ","year":"2009","unstructured":"Kang MJ, Kim TH, Shim KN, Jung SA, Cho MS, Yoo K, Chung KW. Infectious mononucleosis hepatitis in young adults: two case reports. Korean J Intern Med. 2009, 24:381-7. 10.3904\/kjim.2009.24.4.381","journal-title":"Korean J Intern Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14790","article-title":"Infectious mononucleosis: a case report with unusual features and abnormal laboratory findings","volume":"13","author":"Alli A","year":"2021","unstructured":"Alli A, Nabil F, Ortiz JF. Infectious mononucleosis: a case report with unusual features and abnormal laboratory findings. Cureus. 2021, 13:e14790. 10.7759\/cureus.14790","journal-title":"Cureus"},{"key":"ref7","article-title":"Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis","volume":"7","author":"Goudarzipour K","year":"2013","unstructured":"Goudarzipour K, Kajiyazdi M, Mahdaviyani A. Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis. Int J Hematol Oncol Stem Cell Res. 2013, 7:42-5.","journal-title":"Int J Hematol Oncol Stem Cell Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter JI","year":"2007","unstructured":"Henter JI, Horne A, Aric\u00f3 M, et al.. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007, 48:124-31. 10.1002\/pbc.21039","journal-title":"Pediatr Blood Cancer"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-278127","article-title":"How I treat hemophagocytic lymphohistiocytosis","volume":"118","author":"Jordan MB","year":"2011","unstructured":"Jordan MB, Allen CE, Weitzman S, Filipovich AH, McClain KL. How I treat hemophagocytic lymphohistiocytosis. Blood. 2011, 118:4041-52. 10.1182\/blood-2011-03-278127","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01902","article-title":"Epstein-Barr virus and hemophagocytic lymphohistiocytosis","volume":"8","author":"Marsh RA","year":"2017","unstructured":"Marsh RA. Epstein-Barr virus and hemophagocytic lymphohistiocytosis. Front Immunol. 2017, 8:1902. 10.3389\/fimmu.2017.01902","journal-title":"Front Immunol"},{"key":"ref11","unstructured":"X linked lymphoproliferative syndrome. (2007). Accessed. May 13, 2022: https:\/\/rarediseases.org\/rare-diseases\/x-linked-lymphoproliferative-syndrome\/."}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/115184-double-trouble-a-primary-epstein-barr-virus-infection-causing-cholestatic-hepatitis-and-hemophagocytic-lymphohistiocytosis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:47:53Z","timestamp":1707508073000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/115184-double-trouble-a-primary-epstein-barr-virus-infection-causing-cholestatic-hepatitis-and-hemophagocytic-lymphohistiocytosis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":11,"URL":"https:\/\/doi.org\/10.7759\/cureus.31014","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,2]]}}}