{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:25:20Z","timestamp":1707524720116},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,23]]},"DOI":"10.7759\/cureus.31812","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T09:38:53Z","timestamp":1669196333000},"source":"Crossref","is-referenced-by-count":3,"title":["Comparative Efficacy of Topical Metronidazole and Glyceryl Trinitrate Versus Topical Glyceryl Trinitrate Alone in the Treatment of Acute Anal Fissure: A Randomized Clinical Trial"],"prefix":"10.7759","author":[{"given":"M Hasaan","family":"Shahid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidra","family":"Javed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saryia","family":"Javed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwar Zeb","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeel","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reda H","family":"Mithany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-020-03699-4","article-title":"Management options for chronic anal fissure: a systematic review of randomised controlled trials","volume":"35","author":"Boland PA","year":"2020","unstructured":"Boland PA, Kelly ME, Donlon NE, Bolger JC, Larkin JO, Mehigan BJ, McCormick PH. Management options for chronic anal fissure: a systematic review of randomised controlled trials. Int J Colorectal Dis. 2020, 35:1807-15. 10.1007\/s00384-020-03699-4","journal-title":"Int J Colorectal Dis"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.23922\/jarc.2022-012","article-title":"Trends in treatment for hemorrhoids, fistula, and anal fissure: go along the current trends","volume":"6","author":"Hwang SH","year":"2022","unstructured":"Hwang SH. Trends in treatment for hemorrhoids, fistula, and anal fissure: go along the current trends. J Anus Rectum Colon. 2022, 6:150-8. 10.23922\/jarc.2022-012","journal-title":"J Anus Rectum Colon"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30530","article-title":"Lateral internal anal sphincterotomy of chronic anal fissure: an experience of 165 cases","volume":"14","author":"AL-Ubaide AF","year":"2022","unstructured":"AL-Ubaide AF, Al-Rubaye SM, Al-Ani RM. Lateral internal anal sphincterotomy of chronic anal fissure: an experience of 165 cases. Cureus. 2022, 14:e30530. 10.7759\/cureus.30530","journal-title":"Cureus"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.12.002","article-title":"Anal advancement flap versus lateral internal sphincterotomy for chronic anal fissure- a systematic review and meta-analysis","volume":"49","author":"Sahebally SM","year":"2018","unstructured":"Sahebally SM, Walsh SR, Mahmood W, Aherne TM, Joyce MR. Anal advancement flap versus lateral internal sphincterotomy for chronic anal fissure- a systematic review and meta-analysis. Int J Surg. 2018, 49:16-21. 10.1016\/j.ijsu.2017.12.002","journal-title":"Int J Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0014.7879","article-title":"Anal fissure - an extensive update","volume":"93","author":"Salati SA","year":"2021","unstructured":"Salati SA. Anal fissure - an extensive update. Pol Przegl Chir. 2021, 93:46-56. 10.5604\/01.3001.0014.7879","journal-title":"Pol Przegl Chir"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v92i5.11200","article-title":"Fissurectomy and anoplasty in posterior normotensive chronic anal fissure","volume":"92","author":"D'Orazio B","year":"2021","unstructured":"D'Orazio B, Cudia B, Bonventre S, et al.. Fissurectomy and anoplasty in posterior normotensive chronic anal fissure. Acta Biomed. 2021, 92:e2021176. 10.23750\/abm.v92i5.11200","journal-title":"Acta Biomed"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp19X704957","article-title":"Anal fissure: diagnosis, management, and referral in primary care","volume":"69","author":"Newman M","year":"2019","unstructured":"Newman M, Collie M. Anal fissure: diagnosis, management, and referral in primary care. Br J Gen Pract. 2019, 69:409-10. 10.3399\/bjgp19X704957","journal-title":"Br J Gen Pract"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.47717\/turkjsurg.2020.4492","article-title":"Comparison of the effectiveness of two treatment modalities for chronic anal fissure: botox versus sphincterotomy","volume":"36","author":"Cakir C","year":"2020","unstructured":"Cakir C, Idiz UO, Aydin I, Firat D, Ulusoy A\u0130, Yazici P. Comparison of the effectiveness of two treatment modalities for chronic anal fissure: botox versus sphincterotomy. Turk J Surg. 2020, 36:264-70. 10.47717\/turkjsurg.2020.4492","journal-title":"Turk J Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-015-0559-2","article-title":"The effects of topical application of metronidazole for treatment of chronic anal fissure: a randomized, controlled pilot study","volume":"34","author":"Grekova NM","year":"2015","unstructured":"Grekova NM, Maleva EA, Lebedeva Y, Bordunovsky VN, Telesheva LF, Bychkovskikh VA. The effects of topical application of metronidazole for treatment of chronic anal fissure: a randomized, controlled pilot study. Indian J Gastroenterol. 2015, 34:152-7. 10.1007\/s12664-015-0559-2","journal-title":"Indian J Gastroenterol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2018.10.001","article-title":"Treatment of chronic anal fissure: is open lateral internal sphincterotomy (LIS) a safe\u00a0and adequate option?","volume":"42","author":"Acar T","year":"2019","unstructured":"Acar T, Acar N, G\u00fcng\u00f6r F, et al.. Treatment of chronic anal fissure: is open lateral internal sphincterotomy (LIS) a safe\u00a0and adequate option?. Asian J Surg. 2019, 42:628-33. 10.1016\/j.asjsur.2018.10.001","journal-title":"Asian J Surg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_383_19","article-title":"Comparative efficacy of medical treatment versus surgical sphincterotomy in the treatment of chronic anal fissure","volume":"23","author":"Acar T","year":"2020","unstructured":"Acar T, Acar N, G\u00fcng\u00f6r F, et al.. Comparative efficacy of medical treatment versus surgical sphincterotomy in the treatment of chronic anal fissure. Niger J Clin Pract. 2020, 23:539-44. 10.4103\/njcp.njcp_383_19","journal-title":"Niger J Clin Pract"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5152\/turkjsurg.2018.3988","article-title":"Could local antibiotics be included in the treatment of acute anal fissure?","volume":"34","author":"Karapolat B","year":"2018","unstructured":"Karapolat B. Could local antibiotics be included in the treatment of acute anal fissure?. Turk J Surg. 2018, 34:286-9. 10.5152\/turkjsurg.2018.3988","journal-title":"Turk J Surg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-003-0129-z","article-title":"Topical metronidazole (10 percent) decreases posthemorrhoidectomy pain and improves healing","volume":"47","author":"Nicholson TJ","year":"2004","unstructured":"Nicholson TJ, Armstrong D. Topical metronidazole (10 percent) decreases posthemorrhoidectomy pain and improves healing. Dis Colon Rectum. 2004, 47:711-6. 10.1007\/s10350-003-0129-z","journal-title":"Dis Colon Rectum"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2021.00675.0096","article-title":"The importance of topical metronidazole in the treatment of acute anal fissure: a double-blind study controlled for prospective randomization [PREPRINT]","author":"Mert T","year":"2022","unstructured":"Mert T. The importance of topical metronidazole in the treatment of acute anal fissure: a double-blind study controlled for prospective randomization [PREPRINT]. Ann Coloproctol. 2022, 10.3393\/ac.2021.00675.0096","journal-title":"Ann Coloproctol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.29309\/TPMJ\/2022.29.07.6762","article-title":"Role of local antibiotics in the treatment of acute anal fissure","volume":"29","author":"Saba S","year":"2022","unstructured":"Saba S, Saqib K. Role of local antibiotics in the treatment of acute anal fissure. TPMJ. 2022, 29:943-7. 10.29309\/TPMJ\/2022.29.07.6762","journal-title":"TPMJ"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30847","article-title":"The efficacy of sitz baths as compared to lateral internal sphincterotomy in patients with anal fissures: a systematic review","volume":"14","author":"Alnasser AR","year":"2022","unstructured":"Alnasser AR, Akram A, Kar S, et al.. The efficacy of sitz baths as compared to lateral internal sphincterotomy in patients with anal fissures: a systematic review. Cureus. 2022, 14:e30847. 10.7759\/cureus.30847","journal-title":"Cureus"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/125669-comparative-efficacy-of-topical-metronidazole-and-glyceryl-trinitrate-versus-topical-glyceryl-trinitrate-alone-in-the-treatment-of-acute-anal-fissure-a-randomized-clinical-trial","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:42:20Z","timestamp":1707507740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/125669-comparative-efficacy-of-topical-metronidazole-and-glyceryl-trinitrate-versus-topical-glyceryl-trinitrate-alone-in-the-treatment-of-acute-anal-fissure-a-randomized-clinical-trial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,23]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.31812","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,23]]}}}