{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:58:26Z","timestamp":1785761906564,"version":"3.56.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,30]]},"DOI":"10.7759\/cureus.32035","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T08:21:48Z","timestamp":1669796508000},"source":"Crossref","is-referenced-by-count":7,"title":["Prospective, Open-Label, Multi-Centre, Randomized Study to Compare the Effectiveness, Safety, and Tolerability of Lulican\u2122 Shampoo Versus Ketoconazole Shampoo in Indian Adult Patients With Mild to Moderate Scalp Seborrheic Dermatitis (LEAD Study)"],"prefix":"10.7759","author":[{"given":"Srichand G","family":"Parasramani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishalakshi","family":"Vishwanath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Ghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miti R","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiraj","family":"Dhoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanmant","family":"Barkate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"The Myrtus communis L. solution versus ketoconazole shampoo in treatment of dandruff: a double blinded randomized clinical trial","volume":"68","author":"Chaijan MR","year":"2018","unstructured":"Chaijan MR, Handjani F, Zarshenas M, Rahimabadi MS, Tavakkoli A. The Myrtus communis L. solution versus ketoconazole shampoo in treatment of dandruff: a double blinded randomized clinical trial. J Pak Med Assoc. 2018, 68:715-20.","journal-title":"J Pak Med Assoc"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.82117","article-title":"A new postulate on two stages of dandruff: a clinical perspective","volume":"3","author":"Manuel F","year":"2011","unstructured":"Manuel F, Ranganathan S. A new postulate on two stages of dandruff: a clinical perspective. Int J Trichology. 2011, 3:3-6. 10.4103\/0974-7753.82117","journal-title":"Int J Trichology"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.603514","article-title":"Seasonal variation in pediatric dermatoses","volume":"55","author":"Banerjee S","year":"2010","unstructured":"Banerjee S, Gangopadhyay DN, Jana S, Chanda M. Seasonal variation in pediatric dermatoses. Indian J Dermatol. 2010, 55:44. 10.4103\/0019-5154.603514","journal-title":"Indian J Dermatol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000444682","article-title":"Treatment of seborrhoeic dermatitis in Asia: a consensus guide","volume":"1","author":"Cheong WK","year":"2016","unstructured":"Cheong WK, Yeung CK, Torsekar RG, et al.. Treatment of seborrhoeic dermatitis in Asia: a consensus guide. Skin Appendage Disord. 2016, 1:187-96. 10.1159\/000444682","journal-title":"Skin Appendage Disord"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102030-00005","article-title":"Psoriasis of the scalp. Diagnosis and management","volume":"2","author":"van de Kerkhof PC","year":"2001","unstructured":"van de Kerkhof PC, Franssen ME. Psoriasis of the scalp. Diagnosis and management. Am J Clin Dermatol. 2001, 2:159-65. 10.2165\/00128071-200102030-00005","journal-title":"Am J Clin Dermatol"},{"key":"ref6","article-title":"Optimizing treatment approaches in seborrheic dermatitis","volume":"6","author":"Goldenberg G","year":"2013","unstructured":"Goldenberg G. Optimizing treatment approaches in seborrheic dermatitis. J Clin Aesthet Dermatol. 2013, 6:44-9.","journal-title":"J Clin Aesthet Dermatol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.01.001","article-title":"Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies","volume":"31","author":"Dessinioti C","year":"2013","unstructured":"Dessinioti C, Katsambas A. Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies. Clin Dermatol. 2013, 31:343-51. 10.1016\/j.clindermatol.2013.01.001","journal-title":"Clin Dermatol"},{"key":"ref8","article-title":"Therapeutic update on seborrheic dermatitis","volume":"15","author":"Stefanaki I","year":"2010","unstructured":"Stefanaki I, Katsambas A. Therapeutic update on seborrheic dermatitis. Skin Therapy Lett. 2010, 15:1-4.","journal-title":"Skin Therapy Lett"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.1.21-57.2002","article-title":"Immunology of diseases associated with Malassezia species","volume":"15","author":"Ashbee HR","year":"2002","unstructured":"Ashbee HR, Evans EG. Immunology of diseases associated with Malassezia species. Clin Microbiol Rev. 2002, 15:21-57. 10.1128\/CMR.15.1.21-57.2002","journal-title":"Clin Microbiol Rev"},{"key":"ref10","article-title":"Treatment of seborrheic dermatitis","volume":"1","author":"Johnson BA","year":"2000","unstructured":"Johnson BA, Nunley JR. Treatment of seborrheic dermatitis. Am Fam Phys. 2000, 1:2703-10.","journal-title":"Am Fam Phys"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/s0924-8579(02)00362","article-title":"In vitro activity of novel imidazole antifungal agent NND-502 against Malassezia species","volume":"21","author":"Uchida K","year":"20031","unstructured":"Uchida K, Nishiyama Y, Tanaka T, Yamaguchi H. In vitro activity of novel imidazole antifungal agent NND-502 against Malassezia species. Int J Antimicrob Agents. 20031, 21:234-8. 10.1016\/s0924-8579(02)00362","journal-title":"Int J Antimicrob Agents"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.6.2824-2829.2005","article-title":"Antifungal activities of tacrolimus and azole agents against the eleven currently accepted Malassezia species","volume":"43","author":"Sugita T","year":"2005","unstructured":"Sugita T, Tajima M, Ito T, Saito M, Tsuboi R, Nishikawa A. Antifungal activities of tacrolimus and azole agents against the eleven currently accepted Malassezia species. J Clin Microbiol. 2005, 43:2824-9. 10.1128\/JCM.43.6.2824-2829.2005","journal-title":"J Clin Microbiol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701017","article-title":"Molecular analysis of Malassezia microflora in seborrheic dermatitis patients: comparison with other diseases and healthy subjects","volume":"128","author":"Tajima M","year":"2008","unstructured":"Tajima M, Sugita T, Nishikawa A, Tsuboi R. Molecular analysis of Malassezia microflora in seborrheic dermatitis patients: comparison with other diseases and healthy subjects. J Invest Dermatol. 2008, 128:345-51. 10.1038\/sj.jid.5701017","journal-title":"J Invest Dermatol"},{"key":"ref14","article-title":"A randomized, multicenter, double-blind, vehicle-controlled study evaluating the efficacy and safety of luliconazole cream 1% once daily for 7 days in patients aged \u2265 12 years with tinea cruris","volume":"13","author":"Jones TM","year":"2014","unstructured":"Jones TM, Jarratt MT, Mendez-Moguel I, et al.. A randomized, multicenter, double-blind, vehicle-controlled study evaluating the efficacy and safety of luliconazole cream 1% once daily for 7 days in patients aged \u2265 12 years with tinea cruris. J Drugs Dermatol. 2014, 13:32-8.","journal-title":"J Drugs Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01218.x","article-title":"A comparative clinical study between 2 weeks of luliconazole 1% cream treatment and 4 weeks of bifonazole 1% cream treatment for tinea pedis","volume":"49","author":"Watanabe S","year":"2006","unstructured":"Watanabe S, Takahashi H, Nishikawa T, et al.. A comparative clinical study between 2 weeks of luliconazole 1% cream treatment and 4 weeks of bifonazole 1% cream treatment for tinea pedis. Mycoses. 2006, 49:236-41. 10.1111\/j.1439-0507.2006.01218.x","journal-title":"Mycoses"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01305.x","article-title":"Dose-finding comparative study of 2 weeks of luliconazole cream treatment for tinea pedis--comparison between three groups (1%, 0.5%, 0.1%) by a multi-center randomised double-blind study","volume":"50","author":"Watanabe S","year":"2007","unstructured":"Watanabe S, Takahashi H, Nishikawa T, et al.. Dose-finding comparative study of 2 weeks of luliconazole cream treatment for tinea pedis--comparison between three groups (1%, 0.5%, 0.1%) by a multi-center randomised double-blind study. Mycoses. 2007, 50:35-40. 10.1111\/j.1439-0507.2006.01305.x","journal-title":"Mycoses"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.4.7.999","article-title":"Butenafine and superficial mycoses: current status","volume":"4","author":"Singal A","year":"2008","unstructured":"Singal A. Butenafine and superficial mycoses: current status. Expert Opin Drug Metab Toxicol. 2008, 4:999-1005. 10.1517\/17425255.4.7.999","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000051628","article-title":"Effect of ketoconazole 1% and 2% shampoos on severe dandruff and seborrhoeic dermatitis: clinical, squamometric and mycological assessments","volume":"202","author":"Pi\u00e9rard-Franchimont C","year":"2001","unstructured":"Pi\u00e9rard-Franchimont C, Pi\u00e9rard GE, Arrese JE, De Doncker P. Effect of ketoconazole 1% and 2% shampoos on severe dandruff and seborrhoeic dermatitis: clinical, squamometric and mycological assessments. Dermatology. 2001, 202:171-6. 10.1159\/000051628","journal-title":"Dermatology"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb08680.x","article-title":"Successful treatment and prophylaxis of scalp seborrhoeic dermatitis and dandruff with 2% ketoconazole shampoo: results of a multicentre, double-blind, placebo-controlled trial","volume":"132","author":"Peter RU","year":"1995","unstructured":"Peter RU, Richarz-Barthauer U. Successful treatment and prophylaxis of scalp seborrhoeic dermatitis and dandruff with 2% ketoconazole shampoo: results of a multicentre, double-blind, placebo-controlled trial. Br J Dermatol. 1995, 132:441-5. 10.1111\/j.1365-2133.1995.tb08680.x","journal-title":"Br J Dermatol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080\/16537150601092944","article-title":"Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis","volume":"18","author":"Ratnavel RC","year":"2007","unstructured":"Ratnavel RC, Squire RA, Boorman GC. Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis. J Dermatolog Treat. 2007, 18:88-96. 10.1080\/16537150601092944","journal-title":"J Dermatolog Treat"},{"key":"ref21","article-title":"Ketoconazole","author":"Sinawe H","year":"202227","unstructured":"Sinawe H, Casadesus D. Ketoconazole. StatPearls Publishing, Treasure Island; 202227."},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2019.10.010","article-title":"Ketoconazole shampoo-induced hair discoloration","volume":"6","author":"Kubicki SL","year":"2020","unstructured":"Kubicki SL, Damanpour S, Mann R. Ketoconazole shampoo-induced hair discoloration. Int J Womens Dermatol. 2020, 6:121-2. 10.1016\/j.ijwd.2019.10.010","journal-title":"Int J Womens Dermatol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s41702-019-0046-y","article-title":"Trichogenic effect of topical ketoconazole versus minoxidil 2% in female pattern hair loss: a clinical and trichoscopic evaluation","volume":"3","author":"El-Garf A","year":"2019","unstructured":"El-Garf A, Mohie M, Salah E. Trichogenic effect of topical ketoconazole versus minoxidil 2% in female pattern hair loss: a clinical and trichoscopic evaluation. Biomed Dermatol. 2019, 3:1-8. 10.1186\/s41702-019-0046-y","journal-title":"Biomed Dermatol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2147\/CE.S49629","article-title":"Luliconazole for the treatment of fungal infections: an evidence-based review","volume":"9","author":"Khanna D","year":"2014","unstructured":"Khanna D, Bharti S. Luliconazole for the treatment of fungal infections: an evidence-based review. Core Evid. 2014, 9:113-24. 10.2147\/CE.S49629","journal-title":"Core Evid"},{"key":"ref25","unstructured":"Seborrheic dermatitis. ketoconazole 2% foam versus ketoconazole 2% shampoo - study results. (2017). Accessed: November 14, 2022: https:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT01203189."},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.164410","article-title":"Clinical characteristics and quality of life of seborrheic dermatitis patients in a tropical country","volume":"60","author":"Araya M","year":"2015","unstructured":"Araya M, Kulthanan K, Jiamton S. Clinical characteristics and quality of life of seborrheic dermatitis patients in a tropical country. Indian J Dermatol. 2015, 60:519. 10.4103\/0019-5154.164410","journal-title":"Indian J Dermatol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01624.x","article-title":"Quality of life in patients suffering from seborrheic dermatitis: influence of age, gender and education level","volume":"52","author":"Szepietowski JC","year":"2009","unstructured":"Szepietowski JC, Reich A, Weso\u0142owska-Szepietowska E, Baran E. Quality of life in patients suffering from seborrheic dermatitis: influence of age, gender and education level. Mycoses. 2009, 52:357-63. 10.1111\/j.1439-0507.2008.01624.x","journal-title":"Mycoses"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1080\/00015550410021574","article-title":"Psychiatric tests in seborrhoeic dermatitis","volume":"85","author":"Oztas P","year":"2005","unstructured":"Oztas P, Calikoglu E, Cetin I. Psychiatric tests in seborrhoeic dermatitis. Acta Derm Venereol. 2005, 85:68-9. 10.1080\/00015550410021574","journal-title":"Acta Derm Venereol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-7310(07)70111-4","article-title":"Perfil cl\u00ednico, terap\u00e9utico y calidad de vida de los pacientes con dermatitis seborreica [Clinical and therapeutic profile and quality of life of patients with seborrheic dermatitis]","volume":"98","author":"Peyr\u00ed J","year":"2007","unstructured":"Peyr\u00ed J, Lleonart M; Grupo espa\u00f1ol del Estudio SEBDERM. Perfil cl\u00ednico, terap\u00e9utico y calidad de vida de los pacientes con dermatitis seborreica [Clinical and therapeutic profile and quality of life of patients with seborrheic dermatitis]. Actas Dermosifiliogr. 2007, 98:476-82. 10.1016\/S0001-7310(07)70111-4","journal-title":"Actas Dermosifiliogr"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-020-01558-y","article-title":"Clinical characteristics and quality of life in seborrheic dermatitis patients: a cross-sectional study in China","volume":"18","author":"Xuan M","year":"2020","unstructured":"Xuan M, Lu C, He Z. Clinical characteristics and quality of life in seborrheic dermatitis patients: a cross-sectional study in China. Health Qual Life Outcomes. 2020, 18:308. 10.1186\/s12955-020-01558-y","journal-title":"Health Qual Life Outcomes"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/125029-prospective-open-label-multi-centre-randomized-study-to-compare-the-effectiveness-safety-and-tolerability-of-lulican-shampoo-versus-ketoconazole-shampoo-in-indian-adult-patients-with-mild-to-moderate-scalp-seborrheic-dermatitis-lead-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:50:42Z","timestamp":1707508242000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/125029-prospective-open-label-multi-centre-randomized-study-to-compare-the-effectiveness-safety-and-tolerability-of-lulican-shampoo-versus-ketoconazole-shampoo-in-indian-adult-patients-with-mild-to-moderate-scalp-seborrheic-dermatitis-lead-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.32035","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,30]]}}}