{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:06:57Z","timestamp":1773810417885,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,25]]},"DOI":"10.7759\/cureus.32912","type":"journal-article","created":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T08:47:12Z","timestamp":1671958032000},"source":"Crossref","is-referenced-by-count":1,"title":["Progressive Multifocal Leukoencephalopathy in a Chemotherapy-Naive Patient With Chronic Lymphocytic Leukemia: A Case Report"],"prefix":"10.7759","author":[{"given":"Nina","family":"Jancar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipa","family":"Sousa Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Duro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Lessa Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcio","family":"Aguiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285615602832","article-title":"Progressive multifocal leukoencephalopathy: current treatment options and future perspectives","volume":"8","author":"Pavlovic D","year":"2015","unstructured":"Pavlovic D, Patera AC, Nyberg F, Gerber M, Liu M. Progressive multifocal leukoencephalopathy: current treatment options and future perspectives. Ther Adv Neurol Disord. 2015, 8:255-73. 10.1177\/1756285615602832","journal-title":"Ther Adv Neurol Disord"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7071.1","article-title":"Progressive multifocal leukoencephalopathy","volume":"4","author":"Adang L","year":"2015","unstructured":"Adang L, Berger J. Progressive multifocal leukoencephalopathy. F1000Res. 2015, 4:10.12688\/f1000research.7071.1","journal-title":"F1000Res"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/11795735211037798","article-title":"A case of progressive multifocal leukoencephalopathy in a fumaric acid-treated psoriasis patient with severe lymphopenia among other risk factors","volume":"13","author":"Engel S","year":"2021","unstructured":"Engel S, Molina Galindo LS, Bittner S, Zipp F, Luessi F. A case of progressive multifocal leukoencephalopathy in a fumaric acid-treated psoriasis patient with severe lymphopenia among other risk factors. J Cent Nerv Syst Dis. 2021, 13:11795735211037798. 10.1177\/11795735211037798","journal-title":"J Cent Nerv Syst Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00427-y","article-title":"Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease","volume":"17","author":"Cortese I","year":"2021","unstructured":"Cortese I, Reich DS, Nath A. Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease. Nat Rev Neurol. 2021, 17:37-51. 10.1038\/s41582-020-00427-y","journal-title":"Nat Rev Neurol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-022-01125-0","article-title":"The classic form of progressive multifocal leukoencephalopathy in advanced prostate cancer: A case report","volume":"43","author":"Switlyk MD","year":"2022","unstructured":"Switlyk MD, Lilleby W. The classic form of progressive multifocal leukoencephalopathy in advanced prostate cancer: A case report. SN Compr Clin. 2022, 43:10.1007\/s42399-022-01125-0","journal-title":"SN Compr Clin"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.06.002","article-title":"Progressive multifocal leukoencephalopathy","volume":"36","author":"Grebenciucova E","year":"2018","unstructured":"Grebenciucova E, Berger JR. Progressive multifocal leukoencephalopathy. Neurol Clin. 2018, 36:739-50. 10.1016\/j.ncl.2018.06.002","journal-title":"Neurol Clin"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2147\/DNND.S203405","article-title":"Progressive multifocal leukoencephalopathy: Current insights","volume":"9","author":"Kartau M","year":"2019","unstructured":"Kartau M, Sipil\u00e4 JO, Auvinen E, Palom\u00e4ki M, Verkkoniemi-Ahola A. Progressive multifocal leukoencephalopathy: Current insights. Degener Neurol Neuromuscul Dis. 2019, 9:109-21. 10.2147\/DNND.S203405","journal-title":"Degener Neurol Neuromuscul Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26512","article-title":"Progressive multifocal leukoencephalopathy treated by immune checkpoint inhibitors","author":"Boumaza X","year":"2022","unstructured":"Boumaza X, Bonneau B, Roos-Weil D, et al.. Progressive multifocal leukoencephalopathy treated by immune checkpoint inhibitors. Ann Neurol. 2022, 10.1002\/ana.26512","journal-title":"Ann Neurol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000723","article-title":"Progressive multifocal leukoencephalopathy in B-CLL successfully treated with venetoclax and pembrolizumab","volume":"6","author":"Olivieri J","year":"2022","unstructured":"Olivieri J, Lauzzana P, Volpetti S, Girgenti M, Petruzzellis G, Candoni A, Fanin R. Progressive multifocal leukoencephalopathy in B-CLL successfully treated with venetoclax and pembrolizumab. Hemasphere. 2022, 6:e723. 10.1097\/HS9.0000000000000723","journal-title":"Hemasphere"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10682-8","article-title":"Pembrolizumab for treatment of progressive multifocal leukoencephalopathy in primary immunodeficiency and\/or hematologic malignancy: a case series of five patients","volume":"269","author":"Volk T","year":"2022","unstructured":"Volk T, Warnatz K, Marks R, et al.. Pembrolizumab for treatment of progressive multifocal leukoencephalopathy in primary immunodeficiency and\/or hematologic malignancy: a case series of five patients. J Neurol. 2022, 269:973-81. 10.1007\/s00415-021-10682-8","journal-title":"J Neurol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8217-x","article-title":"Drug-associated progressive multifocal leukoencephalopathy: a clinical, radiological, and cerebrospinal fluid analysis of 326 cases","volume":"263","author":"Maas RP","year":"2016","unstructured":"Maas RP, Muller-Hansma AH, Esselink RA, Murk JL, Warnke C, Killestein J, Wattjes MP. Drug-associated progressive multifocal leukoencephalopathy: a clinical, radiological, and cerebrospinal fluid analysis of 326 cases. J Neurol. 2016, 263:2004-21. 10.1007\/s00415-016-8217-x","journal-title":"J Neurol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.738915","article-title":"Secondary immunodeficiency in hematological malignancies: Focus on multiple myeloma and chronic lymphocytic leukemia","volume":"12","author":"Allegra A","year":"2021","unstructured":"Allegra A, Tonacci A, Musolino C, Pioggia G, Gangemi S. Secondary immunodeficiency in hematological malignancies: Focus on multiple myeloma and chronic lymphocytic leukemia. Front Immunol. 2021, 12:738915. 10.3389\/fimmu.2021.738915","journal-title":"Front Immunol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3816\/CLML.2010.n.009","article-title":"Progressive multifocal leukoencephalopathy in chronic lymphocytic leukemia: a report of three cases and review of the literature","volume":"10","author":"D'Souza A","year":"2010","unstructured":"D'Souza A, Wilson J, Mukherjee S, Jaiyesimi I. Progressive multifocal leukoencephalopathy in chronic lymphocytic leukemia: a report of three cases and review of the literature. Clin Lymphoma Myeloma Leuk. 2010, 10:E1-9. 10.3816\/CLML.2010.n.009","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1815039","article-title":"Pembrolizumab treatment for progressive multifocal leukoencephalopathy","volume":"380","author":"Cortese I","year":"2019","unstructured":"Cortese I, Muranski P, Enose-Akahata Y, et al.. Pembrolizumab treatment for progressive multifocal leukoencephalopathy. N Engl J Med. 2019, 380:1597-605. 10.1056\/NEJMoa1815039","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/ncn3.108","article-title":"Mirtazapine treatment ceased the progression of progressive multifocal leukoencephalopathy associated with systemic sarcoidosis","volume":"2","author":"Matsudaira T","year":"2014","unstructured":"Matsudaira T, Araki K, Oishi W, et al.. Mirtazapine treatment ceased the progression of progressive multifocal leukoencephalopathy associated with systemic sarcoidosis. Neurol Clin Neurosci. 2014, 2:158-160. 10.1111\/ncn3.108","journal-title":"Neurol Clin Neurosci"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/128741-progressive-multifocal-leukoencephalopathy-in-a-chemotherapy-naive-patient-with-chronic-lymphocytic-leukemia-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:48:28Z","timestamp":1707508108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/128741-progressive-multifocal-leukoencephalopathy-in-a-chemotherapy-naive-patient-with-chronic-lymphocytic-leukemia-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,25]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.32912","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12,25]]}}}