{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:09:39Z","timestamp":1791317379281,"version":"4.3.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,21]]},"DOI":"10.7759\/cureus.34035","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T13:45:43Z","timestamp":1674308743000},"source":"Crossref","is-referenced-by-count":6,"title":["Study of Gonadal Hormones in Males With Liver Cirrhosis and Its Correlation With Child-Turcotte-Pugh and Model for End-Stage Liver Disease Scores"],"prefix":"10.7759","author":[{"given":"Bhumika","family":"Vaishnav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Tambile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartheek","family":"Minna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srivatsav","family":"Addepalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniruddh","family":"Wadivkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchitha","family":"Pailla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirali","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Balem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346393","article-title":"Male hypogonadism in cirrhosis and after liver transplantation","volume":"31","author":"Foresta C","year":"2008","unstructured":"Foresta C, Schipilliti M, Ciarleglio FA, Lenzi A, D'Amico D. Male hypogonadism in cirrhosis and after liver transplantation. J Endocrinol Invest. 2008, 31:470-8. 10.1007\/BF03346393","journal-title":"J Endocrinol Invest"},{"key":"ref2","article-title":"A study of the endocrine manifestations of hepatic cirrhosis","volume":"45","author":"Baker HW","year":"1976","unstructured":"Baker HW, Burger HG, de Kretser DM, et al.. A study of the endocrine manifestations of hepatic cirrhosis. Q J Med. 1976, 45:145-78.","journal-title":"Q J Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(94)80020-0","article-title":"Effect of liver transplantation on sex-hormone disorders in male patients with alcohol-induced or post-viral hepatitis advanced liver disease","volume":"20","author":"Gu\u00e9chot J","year":"1994","unstructured":"Gu\u00e9chot J, Chazouill\u00e8res O, Loria A, et al.. Effect of liver transplantation on sex-hormone disorders in male patients with alcohol-induced or post-viral hepatitis advanced liver disease. J Hepatol. 1994, 20:426-30. 10.1016\/s0168-8278(94)80020-0","journal-title":"J Hepatol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-28032014000100012","article-title":"Testosterone changes in patients with liver cirrhosis before and after orthotopic liver transplantation and its correlation with MELD","volume":"51","author":"Nitsche R","year":"2014","unstructured":"Nitsche R, Coelho JC, Freitas AC, Zeni Neto C, Martins E. Testosterone changes in patients with liver cirrhosis before and after orthotopic liver transplantation and its correlation with MELD. Arq Gastroenterol. 2014, 51:59-63. 10.1590\/s0004-28032014000100012","journal-title":"Arq Gastroenterol"},{"key":"ref5","article-title":"A study on endocrine dysfunction in adult males with liver cirrhosis","volume":"107","author":"Bandyopadhyay SK","year":"2009","unstructured":"Bandyopadhyay SK, Moulick A, Saha M, Dutta A, Bandyopadhyay R, Basu AK. A study on endocrine dysfunction in adult males with liver cirrhosis. J Indian Med Assoc. 2009, 107:866-9.","journal-title":"J Indian Med Assoc"},{"key":"ref6","article-title":"Use of the Child-Pugh score in liver disease","author":"Tsoris A","year":"2022","unstructured":"Tsoris A, Marlar CA. Use of the Child-Pugh score in liver disease. StatPearls [Internet]. StatPearls Publishing, Treasure Island, FL; 2022."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2009.03.002","article-title":"Diagnosis and epidemiology of cirrhosis","volume":"93","author":"Lefton HB","year":"2009","unstructured":"Lefton HB, Rosa A, Cohen M. Diagnosis and epidemiology of cirrhosis. Med Clin North Am. 2009, 93:787-99, vii. 10.1016\/j.mcna.2009.03.002","journal-title":"Med Clin North Am"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1996.698519.x","article-title":"The impact of liver transplantation on endocrine status in men","volume":"44","author":"Madersbacher S","year":"1996","unstructured":"Madersbacher S, Ludvik G, Stulnig T, Gr\u00fcnberger T, Maier U. The impact of liver transplantation on endocrine status in men. Clin Endocrinol (Oxf). 1996, 44:461-6. 10.1046\/j.1365-2265.1996.698519.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000059115.41030.e0","article-title":"Dysfunction of the hypothalamic-pituitary-glandular axes and relation to Child-Pugh classification in male patients with alcoholic and virus-related cirrhosis","volume":"15","author":"Zietz B","year":"2003","unstructured":"Zietz B, Lock G, Plach B, Drobnik W, Grossmann J, Sch\u00f6lmerich J, Straub RH. Dysfunction of the hypothalamic-pituitary-glandular axes and relation to Child-Pugh classification in male patients with alcoholic and virus-related cirrhosis. Eur J Gastroenterol Hepatol. 2003, 15:495-501. 10.1097\/01.meg.0000059115.41030.e0","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2010.02355.x","article-title":"A practical guide to male hypogonadism in the primary care setting","volume":"64","author":"Dandona P","year":"2010","unstructured":"Dandona P, Rosenberg MT. A practical guide to male hypogonadism in the primary care setting. Int J Clin Pract. 2010, 64:682-96. 10.1111\/j.1742-1241.2010.02355.x","journal-title":"Int J Clin Pract"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1042\/cs0660369","article-title":"Sex hormones and the liver","volume":"66","author":"Johnson PJ","year":"1984","unstructured":"Johnson PJ. Sex hormones and the liver. Clin Sci (Lond). 1984, 66:369-76. 10.1042\/cs0660369","journal-title":"Clin Sci (Lond)"},{"key":"ref12","article-title":"Sex hormone changes in chronic liver disease: a matched study of alcoholic versus non-alcoholic liver disease","volume":"63","author":"Bannister P","year":"1987","unstructured":"Bannister P, Oakes J, Sheridan P, Losowsky MS. Sex hormone changes in chronic liver disease: a matched study of alcoholic versus non-alcoholic liver disease. Q J Med. 1987, 63:305-13.","journal-title":"Q J Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-40-6-1018","article-title":"Conversion of androgens to estrogens in cirrhosis of the liver","volume":"40","author":"Gordon GG","year":"1975","unstructured":"Gordon GG, Olivo J, Rafil F, Southren AL. Conversion of androgens to estrogens in cirrhosis of the liver. J Clin Endocrinol Metab. 1975, 40:1018-26. 10.1210\/jcem-40-6-1018","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-43-3-557","article-title":"Estrone and estradiol in patients with cirrhosis of the liver: effects of ACTH and dexamethasone","volume":"43","author":"Kley HK","year":"1976","unstructured":"Kley HK, Kr\u00fcskemper HL, Keck E. Estrone and estradiol in patients with cirrhosis of the liver: effects of ACTH and dexamethasone. J Clin Endocrinol Metab. 1976, 43:557-60. 10.1210\/jcem-43-3-557","journal-title":"J Clin Endocrinol Metab"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-79-2-198","article-title":"Estrogen-androgen imbalance in hepatic cirrhosis. Studies in 13 male patients","volume":"79","author":"Chopra IJ","year":"1973","unstructured":"Chopra IJ, Tulchinsky D, Greenway FL. Estrogen-androgen imbalance in hepatic cirrhosis. Studies in 13 male patients. Ann Intern Med. 1973, 79:198-203. 10.7326\/0003-4819-79-2-198","journal-title":"Ann Intern Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i12.2832","article-title":"Spider angiomas in patients with liver cirrhosis: role of vascular endothelial growth factor and basic fibroblast growth factor","volume":"9","author":"Li CP","year":"2003","unstructured":"Li CP, Lee FY, Hwang SJ, et al.. Spider angiomas in patients with liver cirrhosis: role of vascular endothelial growth factor and basic fibroblast growth factor. World J Gastroenterol. 2003, 9:2832-5. 10.3748\/wjg.v9.i12.2832","journal-title":"World J Gastroenterol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04347.x","article-title":"Low testosterone levels as an independent predictor of mortality in men with chronic liver disease","volume":"77","author":"Grossmann M","year":"2012","unstructured":"Grossmann M, Hoermann R, Gani L, et al.. Low testosterone levels as an independent predictor of mortality in men with chronic liver disease. Clin Endocrinol (Oxf). 2012, 77:323-8. 10.1111\/j.1365-2265.2012.04347.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.17.5.345","article-title":"Hypothalamic-pituitary-gonadal function in men with cirrhosis of the liver","volume":"17","author":"Mowat NA","year":"1976","unstructured":"Mowat NA, Edwards CR, Fisher R, McNeilly AS, Green JR, Dawson AM. Hypothalamic-pituitary-gonadal function in men with cirrhosis of the liver. Gut. 1976, 17:345-50. 10.1136\/gut.17.5.345","journal-title":"Gut"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1985.tb00221.x","article-title":"Sexual dysfunction in men with alcoholic liver cirrhosis. A comparative study","volume":"5","author":"Jensen SB","year":"1985","unstructured":"Jensen SB, Gluud C. Sexual dysfunction in men with alcoholic liver cirrhosis. A comparative study. Liver. 1985, 5:94-100. 10.1111\/j.1600-0676.1985.tb00221.x","journal-title":"Liver"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01886","article-title":"Gonadal dysfunction in systemic diseases","volume":"152","author":"Karagiannis A","year":"2005","unstructured":"Karagiannis A, Harsoulis F. Gonadal dysfunction in systemic diseases. Eur J Endocrinol. 2005, 152:501-13. 10.1530\/eje.1.01886","journal-title":"Eur J Endocrinol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20812","article-title":"Sexual functioning in patients with end-stage liver disease before and after transplantation","volume":"12","author":"Sorrell JH","year":"2006","unstructured":"Sorrell JH, Brown JR. Sexual functioning in patients with end-stage liver disease before and after transplantation. Liver Transpl. 2006, 12:1473-7. 10.1002\/lt.20812","journal-title":"Liver Transpl"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.33257","article-title":"Prevalence of sexual dysfunction in male subjects with alcohol dependence","volume":"49","author":"Arackal BS","year":"2007","unstructured":"Arackal BS, Benegal V. Prevalence of sexual dysfunction in male subjects with alcohol dependence. Indian J Psychiatry. 2007, 49:109-12. 10.4103\/0019-5545.33257","journal-title":"Indian J Psychiatry"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agl089","article-title":"Controlled study on the combined effect of alcohol and tobacco smoking on testosterone in alcohol-dependent men","volume":"42","author":"Walter M","year":"2007","unstructured":"Walter M, Gerhard U, Gerlach M, Weijers HG, Boening J, Wiesbeck GA. Controlled study on the combined effect of alcohol and tobacco smoking on testosterone in alcohol-dependent men. Alcohol Alcohol. 2007, 42:19-23. 10.1093\/alcalc\/agl089","journal-title":"Alcohol Alcohol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.131761","article-title":"Assessment of thyroid and gonadal function in liver diseases","volume":"19","author":"Kharb S","year":"2015","unstructured":"Kharb S, Garg MK, Puri P, Brar KS, Pandit A, Srivastava S. Assessment of thyroid and gonadal function in liver diseases. Indian J Endocrinol Metab. 2015, 19:89-94. 10.4103\/2230-8210.131761","journal-title":"Indian J Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1177\/1756287215612961","article-title":"Testosterone deficiency in the aging male","volume":"8","author":"McBride JA","year":"2016","unstructured":"McBride JA, Carson CC 3rd, Coward RM. Testosterone deficiency in the aging male. Ther Adv Urol. 2016, 8:47-60. 10.1177\/1756287215612961","journal-title":"Ther Adv Urol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1590\/0100-69912014006007","article-title":"Hypothalamic-pituitary-gonadal function in men with liver cirrhosis before and after liver transplantation","volume":"41","author":"Zacharias BT","year":"2014","unstructured":"Zacharias BT, Coelho JC, Parolin MB, Matias JE, Freitas AC, Godoy JL. Hypothalamic-pituitary-gonadal function in men with liver cirrhosis before and after liver transplantation. Rev Col Bras Cir. 2014, 41:421-5. 10.1590\/0100-69912014006007","journal-title":"Rev Col Bras Cir"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24607","article-title":"Low serum testosterone is associated with adverse outcome in men with cirrhosis independent of the model for end-stage liver disease score","volume":"22","author":"Sinclair M","year":"2016","unstructured":"Sinclair M, Gow PJ, Grossmann M, Shannon A, Hoermann R, Angus PW. Low serum testosterone is associated with adverse outcome in men with cirrhosis independent of the model for end-stage liver disease score. Liver Transpl. 2016, 22:1482-90. 10.1002\/lt.24607","journal-title":"Liver Transpl"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/134343-study-of-gonadal-hormones-in-males-with-liver-cirrhosis-and-its-correlation-with-child-turcotte-pugh-and-model-for-end-stage-liver-disease-scores","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:56:44Z","timestamp":1707508604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/134343-study-of-gonadal-hormones-in-males-with-liver-cirrhosis-and-its-correlation-with-child-turcotte-pugh-and-model-for-end-stage-liver-disease-scores"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,21]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.34035","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1,21]]}}}