{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:59:52Z","timestamp":1775149192086,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,23]]},"DOI":"10.7759\/cureus.35342","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T08:31:22Z","timestamp":1677141082000},"source":"Crossref","is-referenced-by-count":4,"title":["Serum Asprosin Level as a New Biomarker in Differentiating Familial Mediterranean Fever Attacks"],"prefix":"10.7759","author":[{"given":"Hilal","family":"Sipahioglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcmeyra","family":"Koyuncu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Kuzug\u00fcden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2018.08.014","article-title":"Familial Mediterranean fever","volume":"48","author":"Ozdogan H","year":"2019","unstructured":"Ozdogan H, Ugurlu S. Familial Mediterranean fever. Presse Med. 2019, 48:e61-76. 10.1016\/j.lpm.2018.08.014","journal-title":"Presse Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3715-5","article-title":"Familial Mediterranean fever, review of the literature","volume":"36","author":"Alghamdi M","year":"2017","unstructured":"Alghamdi M. Familial Mediterranean fever, review of the literature. Clin Rheumatol. 2017, 36:1707-13. 10.1007\/s10067-017-3715-5","journal-title":"Clin Rheumatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200312000-00003","article-title":"Obesity, adiponectin and vascular inflammatory disease","volume":"14","author":"Ouchi N","year":"2003","unstructured":"Ouchi N, Kihara S, Funahashi T, Matsuzawa Y, Walsh K. Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol. 2003, 14:561-6. 10.1097\/00041433-200312000-00003","journal-title":"Curr Opin Lipidol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000163635.62927.34","article-title":"Adipose tissue, inflammation, and cardiovascular disease","volume":"96","author":"Berg AH","year":"2005","unstructured":"Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005, 96:939-49. 10.1161\/01.RES.0000163635.62927.34","journal-title":"Circ Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2006.00610.x","article-title":"Adiponectin in health and disease","volume":"9","author":"Oh DK","year":"2007","unstructured":"Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and disease. Diabetes Obes Metab. 2007, 9:282-9. 10.1111\/j.1463-1326.2006.00610.x","journal-title":"Diabetes Obes Metab"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116210","article-title":"Selectins","volume":"91","author":"Bevilacqua MP","year":"1993","unstructured":"Bevilacqua MP, Nelson RM. Selectins. J Clin Invest. 1993, 91:379-87. 10.1172\/JCI116210","journal-title":"J Clin Invest"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.063","article-title":"Asprosin, a fasting-induced glucogenic protein hormone","volume":"165","author":"Romere C","year":"2016","unstructured":"Romere C, Duerrschmid C, Bournat J, et al.. Asprosin, a fasting-induced glucogenic protein hormone. Cell. 2016, 165:566-79. 10.1016\/j.cell.2016.02.063","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206592","article-title":"Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype","volume":"70","author":"Birrell MA","year":"2015","unstructured":"Birrell MA, Maher SA, Dekkak B, Jones V, Wong S, Brook P, Belvisi MG. Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype. Thorax. 2015, 70:740-7. 10.1136\/thoraxjnl-2014-206592","journal-title":"Thorax"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000476","article-title":"IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR\/mgR mouse model of severe Marfan syndrome","volume":"3","author":"Ju X","year":"2014","unstructured":"Ju X, Ijaz T, Sun H, et al.. IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR\/mgR mouse model of severe Marfan syndrome. J Am Heart Assoc. 2014, 3:e000476. 10.1161\/JAHA.113.000476","journal-title":"J Am Heart Assoc"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9471583","article-title":"Plasma asprosin concentrations are increased in individuals with glucose dysregulation and correlated with insulin resistance and first-phase insulin secretion","volume":"2018","author":"Wang Y","year":"2018","unstructured":"Wang Y, Qu H, Xiong X, et al.. Plasma asprosin concentrations are increased in individuals with glucose dysregulation and correlated with insulin resistance and first-phase insulin secretion. Mediators Inflamm. 2018, 2018:9471583. 10.1155\/2018\/9471583","journal-title":"Mediators Inflamm"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.02.017","article-title":"Fibrillin-1 insufficiency alters periodontal wound healing failure in a mouse model of Marfan syndrome","volume":"90","author":"Handa K","year":"2018","unstructured":"Handa K, Abe S, Suresh VV, et al.. Fibrillin-1 insufficiency alters periodontal wound healing failure in a mouse model of Marfan syndrome. Arch Oral Biol. 2018, 90:53-60. 10.1016\/j.archoralbio.2018.02.017","journal-title":"Arch Oral Biol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.05.013","article-title":"MEFV mutations and their relation to major clinical symptoms of familial Mediterranean fever","volume":"626","author":"Cekin N","year":"2017","unstructured":"Cekin N, Akyurek ME, Pinarbasi E, Ozen F. MEFV mutations and their relation to major clinical symptoms of familial Mediterranean fever. Gene. 2017, 626:9-13. 10.1016\/j.gene.2017.05.013","journal-title":"Gene"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.06.002","article-title":"Response to Li and Zhang: infevers, a human gene mutation database for autoinflammatory diseases including disseminated superficial actinic porokeratosis","volume":"75","author":"Touitou I","year":"2014","unstructured":"Touitou I, Milhavet F, Cuisset L. Response to Li and Zhang: infevers, a human gene mutation database for autoinflammatory diseases including disseminated superficial actinic porokeratosis. J Dermatol Sci. 2014, 75:208-9. 10.1016\/j.jdermsci.2014.06.002","journal-title":"J Dermatol Sci"},{"key":"ref14","article-title":"Serum soluble intercellular adhesion molecule 1 and interleukin 8 levels in familial Mediterranean fever","volume":"26","author":"Direskeneli H","year":"1999","unstructured":"Direskeneli H, Ozdogan H, Korkmaz C, Akoglu T, Yazici H. Serum soluble intercellular adhesion molecule 1 and interleukin 8 levels in familial Mediterranean fever. J Rheumatol. 1999, 26:1983-6.","journal-title":"J Rheumatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.336","article-title":"Comprehensive analysis of mutations in the MEFV gene reveal that the location and not the substitution type determines symptom severity in FMF","volume":"5","author":"Moradian MM","year":"2017","unstructured":"Moradian MM, Babikyan D, Banoian D, Hayrapetyan H, Manvelyan H, Avanesian N, Sarkisian T. Comprehensive analysis of mutations in the MEFV gene reveal that the location and not the substitution type determines symptom severity in FMF. Mol Genet Genomic Med. 2017, 5:742-50. 10.1002\/mgg3.336","journal-title":"Mol Genet Genomic Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2018.07.008","article-title":"Asprosin: Possible target in connection with ghrelin and cytokine network expression in the post-burn treatment","volume":"118","author":"Donma MM","year":"2018","unstructured":"Donma MM, Donma O. Asprosin: Possible target in connection with ghrelin and cytokine network expression in the post-burn treatment. Med Hypotheses. 2018, 118:163-8. 10.1016\/j.mehy.2018.07.008","journal-title":"Med Hypotheses"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx108","article-title":"The role of infiltrating immune cells in dysfunctional adipose tissue","volume":"113","author":"Guzik TJ","year":"2017","unstructured":"Guzik TJ, Skiba DS, Touyz RM, Harrison DG. The role of infiltrating immune cells in dysfunctional adipose tissue. Cardiovasc Res. 2017, 113:1009-23. 10.1093\/cvr\/cvx108","journal-title":"Cardiovasc Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez FO","year":"2014","unstructured":"Martinez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 2014, 6:13. 10.12703\/P6-13","journal-title":"F1000Prime Rep"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.312321","article-title":"Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation","volume":"126","author":"Mouton AJ","year":"2020","unstructured":"Mouton AJ, Li X, Hall ME, Hall JE. Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation. Circ Res. 2020, 126:789-806. 10.1161\/CIRCRESAHA.119.312321","journal-title":"Circ Res"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934547","article-title":"Plasma asprosin, CCDC80 and ANGPTL4 levels are associated with metabolic and cardiovascular risk in patients with inflammatory bowel disease","volume":"70","author":"Wang HH","year":"2021","unstructured":"Wang HH, Luo WY, Lin M, Li XJ, Xiang GD, D Triganti S. Plasma asprosin, CCDC80 and ANGPTL4 levels are associated with metabolic and cardiovascular risk in patients with inflammatory bowel disease. Physiol Res. 2021, 70:203-11. 10.33549\/physiolres.934547","journal-title":"Physiol Res"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.21470\/1678-9741-2021-0003","article-title":"Evaluation of plasma asprosin concentration in patients with coronary artery disease","volume":"37","author":"Guven C","year":"2022","unstructured":"Guven C, Kafadar H. Evaluation of plasma asprosin concentration in patients with coronary artery disease. Braz J Cardiovasc Surg. 2022, 37:493-500.","journal-title":"Braz J Cardiovasc Surg"},{"key":"ref22","article-title":"[Study of the role and mechanism of asprosin\/spartin pathway in cardiac microvascular endothelial injury induced by diabetes mellitus]","volume":"50","author":"Chen S","year":"2019","unstructured":"Chen S, Wang X, Qiu CM, et al.. [Study of the role and mechanism of asprosin\/spartin pathway in cardiac microvascular endothelial injury induced by diabetes mellitus]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2019, 50:827-34.","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05249-3","article-title":"Is there a relationship between serum omentin level and acute phase response in patients with familial Mediterranean fever?","volume":"40","author":"Can Sandikci S","year":"2021","unstructured":"Can Sandikci S, Omma A, Yucel C, Omma T. Is there a relationship between serum omentin level and acute phase response in patients with familial Mediterranean fever?. Clin Rheumatol. 2021, 40:669-74. 10.1007\/s10067-020-05249-3","journal-title":"Clin Rheumatol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2094-5","article-title":"Down-regulation of adiponectin in patients with familial Mediterranean fever during attack-free period","volume":"32","author":"Gerdan V","year":"2012","unstructured":"Gerdan V, Sari I, Kozac\u0131 D, et al.. Down-regulation of adiponectin in patients with familial Mediterranean fever during attack-free period. Rheumatol Int. 2012, 32:2819-22. 10.1007\/s00296-011-2094-5","journal-title":"Rheumatol Int"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2021.210423","article-title":"Asprosin and oxidative stress level in COVID-19 patients","volume":"68","author":"Seyhanli ES","year":"2022","unstructured":"Seyhanli ES, Koyuncu I, Yasak IH, Demir HA, Temiz E. Asprosin and oxidative stress level in COVID-19 patients. Clin Lab. 2022, 68:10.7754\/Clin.Lab.2021.210423","journal-title":"Clin Lab"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/139935-serum-asprosin-level-as-a-new-biomarker-in-differentiating-familial-mediterranean-fever-attacks","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:50:40Z","timestamp":1707508240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/139935-serum-asprosin-level-as-a-new-biomarker-in-differentiating-familial-mediterranean-fever-attacks"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,23]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.35342","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2,23]]}}}